Axonemal_dynein_light_chain_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

axonemal dynein light chain, putative

Species:

Leishmania braziliensis

UniProt:

A4HEW7_LEIBR

TriTrypDb:

LbrM.26.1140 , LBRM2903_260016400

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEW7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.577
CLV_C14_Caspase3-7	254	258	PF00656	0.744
CLV_NRD_NRD_1	298	300	PF00675	0.353
CLV_NRD_NRD_1	388	390	PF00675	0.404
CLV_NRD_NRD_1	413	415	PF00675	0.362
CLV_PCSK_KEX2_1	298	300	PF00082	0.353
CLV_PCSK_KEX2_1	412	414	PF00082	0.364
CLV_PCSK_KEX2_1	430	432	PF00082	0.286
CLV_PCSK_KEX2_1	451	453	PF00082	0.465
CLV_PCSK_KEX2_1	462	464	PF00082	0.485
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.411
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.465
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.485
CLV_PCSK_SKI1_1	160	164	PF00082	0.557
CLV_PCSK_SKI1_1	349	353	PF00082	0.393
CLV_PCSK_SKI1_1	358	362	PF00082	0.370
CLV_PCSK_SKI1_1	404	408	PF00082	0.261
DOC_CYCLIN_RxL_1	355	364	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.657
DOC_MAPK_MEF2A_6	43	52	PF00069	0.531
DOC_PP4_FxxP_1	331	334	PF00568	0.378
DOC_USP7_MATH_1	106	110	PF00917	0.809
DOC_USP7_MATH_1	111	115	PF00917	0.736
DOC_USP7_MATH_1	120	124	PF00917	0.778
DOC_USP7_MATH_1	127	131	PF00917	0.584
DOC_USP7_MATH_1	203	207	PF00917	0.672
DOC_USP7_MATH_1	216	220	PF00917	0.531
DOC_USP7_MATH_1	273	277	PF00917	0.732
DOC_USP7_MATH_1	286	290	PF00917	0.531
DOC_USP7_MATH_1	300	304	PF00917	0.252
DOC_USP7_MATH_1	437	441	PF00917	0.261
DOC_USP7_UBL2_3	256	260	PF12436	0.581
DOC_WW_Pin1_4	122	127	PF00397	0.819
DOC_WW_Pin1_4	266	271	PF00397	0.801
DOC_WW_Pin1_4	290	295	PF00397	0.711
LIG_14-3-3_CanoR_1	320	328	PF00244	0.290
LIG_14-3-3_CanoR_1	349	354	PF00244	0.411
LIG_14-3-3_CanoR_1	389	396	PF00244	0.411
LIG_14-3-3_CanoR_1	417	425	PF00244	0.358
LIG_Actin_RPEL_3	360	379	PF02755	0.513
LIG_APCC_ABBAyCdc20_2	336	342	PF00400	0.411
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BIR_III_1	1	5	PF00653	0.664
LIG_BIR_III_3	1	5	PF00653	0.664
LIG_Clathr_ClatBox_1	238	242	PF01394	0.760
LIG_FHA_1	113	119	PF00498	0.760
LIG_FHA_1	147	153	PF00498	0.644
LIG_FHA_1	266	272	PF00498	0.802
LIG_FHA_1	282	288	PF00498	0.529
LIG_FHA_1	373	379	PF00498	0.369
LIG_FHA_2	174	180	PF00498	0.738
LIG_FHA_2	390	396	PF00498	0.411
LIG_LIR_Gen_1	374	383	PF02991	0.378
LIG_LIR_Gen_1	8	18	PF02991	0.632
LIG_LIR_Nem_3	130	136	PF02991	0.588
LIG_LIR_Nem_3	15	21	PF02991	0.656
LIG_LIR_Nem_3	261	267	PF02991	0.576
LIG_LIR_Nem_3	374	379	PF02991	0.378
LIG_LIR_Nem_3	8	13	PF02991	0.626
LIG_PCNA_yPIPBox_3	336	348	PF02747	0.513
LIG_Pex14_1	421	425	PF04695	0.411
LIG_Rb_LxCxE_1	352	371	PF01857	0.429
LIG_RPA_C_Fungi	66	78	PF08784	0.499
LIG_SH2_CRK	133	137	PF00017	0.553
LIG_SH2_CRK	18	22	PF00017	0.695
LIG_SH2_CRK	264	268	PF00017	0.574
LIG_SH2_CRK	376	380	PF00017	0.411
LIG_SH2_CRK	425	429	PF00017	0.411
LIG_SH2_STAP1	376	380	PF00017	0.378
LIG_SH2_STAP1	449	453	PF00017	0.411
LIG_SH2_STAP1	54	58	PF00017	0.587
LIG_SH2_STAT5	18	21	PF00017	0.539
LIG_SH2_STAT5	192	195	PF00017	0.670
LIG_SH2_STAT5	72	75	PF00017	0.726
LIG_SH3_2	117	122	PF14604	0.830
LIG_SH3_3	113	119	PF00018	0.722
LIG_SH3_3	237	243	PF00018	0.505
LIG_SH3_3	45	51	PF00018	0.531
LIG_SUMO_SIM_anti_2	306	312	PF11976	0.416
LIG_SUMO_SIM_par_1	21	26	PF11976	0.499
LIG_TYR_ITIM	16	21	PF00017	0.653
LIG_TYR_ITIM	312	317	PF00017	0.411
MOD_CK1_1	154	160	PF00069	0.678
MOD_CK1_1	166	172	PF00069	0.714
MOD_CK1_1	263	269	PF00069	0.750
MOD_CK1_1	289	295	PF00069	0.529
MOD_CK1_1	303	309	PF00069	0.261
MOD_CK1_1	372	378	PF00069	0.290
MOD_CK2_1	166	172	PF00069	0.671
MOD_CK2_1	365	371	PF00069	0.261
MOD_CK2_1	463	469	PF00069	0.436
MOD_CK2_1	5	11	PF00069	0.723
MOD_DYRK1A_RPxSP_1	122	126	PF00069	0.822
MOD_GlcNHglycan	108	111	PF01048	0.639
MOD_GlcNHglycan	122	125	PF01048	0.666
MOD_GlcNHglycan	129	132	PF01048	0.682
MOD_GlcNHglycan	153	156	PF01048	0.609
MOD_GlcNHglycan	168	171	PF01048	0.602
MOD_GlcNHglycan	205	208	PF01048	0.730
MOD_GlcNHglycan	223	226	PF01048	0.577
MOD_GlcNHglycan	252	256	PF01048	0.753
MOD_GlcNHglycan	271	274	PF01048	0.756
MOD_GlcNHglycan	275	278	PF01048	0.760
MOD_GlcNHglycan	288	291	PF01048	0.502
MOD_GlcNHglycan	324	327	PF01048	0.384
MOD_GlcNHglycan	381	384	PF01048	0.411
MOD_GlcNHglycan	81	84	PF01048	0.660
MOD_GSK3_1	203	210	PF00069	0.790
MOD_GSK3_1	216	223	PF00069	0.615
MOD_GSK3_1	247	254	PF00069	0.796
MOD_GSK3_1	259	266	PF00069	0.653
MOD_GSK3_1	269	276	PF00069	0.809
MOD_GSK3_1	281	288	PF00069	0.581
MOD_GSK3_1	365	372	PF00069	0.261
MOD_NEK2_1	163	168	PF00069	0.562
MOD_NEK2_1	217	222	PF00069	0.652
MOD_NEK2_1	365	370	PF00069	0.388
MOD_NEK2_1	379	384	PF00069	0.454
MOD_PIKK_1	146	152	PF00454	0.761
MOD_PIKK_1	173	179	PF00454	0.814
MOD_PIKK_1	185	191	PF00454	0.644
MOD_PKA_1	389	395	PF00069	0.411
MOD_PKA_2	217	223	PF00069	0.824
MOD_PKA_2	319	325	PF00069	0.416
MOD_PKA_2	369	375	PF00069	0.502
MOD_PKA_2	388	394	PF00069	0.391
MOD_PKA_2	416	422	PF00069	0.358
MOD_PKA_2	70	76	PF00069	0.470
MOD_Plk_1	260	266	PF00069	0.575
MOD_Plk_1	300	306	PF00069	0.261
MOD_Plk_2-3	5	11	PF00069	0.729
MOD_Plk_4	12	18	PF00069	0.634
MOD_Plk_4	349	355	PF00069	0.513
MOD_ProDKin_1	122	128	PF00069	0.820
MOD_ProDKin_1	266	272	PF00069	0.799
MOD_ProDKin_1	290	296	PF00069	0.701
MOD_SUMO_rev_2	434	442	PF00179	0.411
MOD_SUMO_rev_2	459	464	PF00179	0.513
TRG_DiLeu_BaEn_1	357	362	PF01217	0.411
TRG_ENDOCYTIC_2	10	13	PF00928	0.624
TRG_ENDOCYTIC_2	133	136	PF00928	0.555
TRG_ENDOCYTIC_2	18	21	PF00928	0.660
TRG_ENDOCYTIC_2	264	267	PF00928	0.577
TRG_ENDOCYTIC_2	314	317	PF00928	0.411
TRG_ENDOCYTIC_2	376	379	PF00928	0.378
TRG_ENDOCYTIC_2	425	428	PF00928	0.411
TRG_ER_diArg_1	297	299	PF00400	0.353
TRG_ER_diArg_1	411	414	PF00400	0.364
TRG_ER_diLys_1	470	474	PF00400	0.741
TRG_NES_CRM1_1	11	26	PF08389	0.705
TRG_NES_CRM1_1	342	357	PF08389	0.459
TRG_Pf-PMV_PEXEL_1	345	350	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	358	363	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P322	Leptomonas seymouri	48%	96%
A0A3S7WZS2	Leishmania donovani	75%	100%
A4I241	Leishmania infantum	76%	100%
E9AY91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q982	Leishmania major	73%	98%