Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEW5_LEIBR

TriTrypDb:

LbrM.26.1110 , LBRM2903_260016100

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.478
CLV_NRD_NRD_1	101	103	PF00675	0.578
CLV_NRD_NRD_1	113	115	PF00675	0.520
CLV_NRD_NRD_1	12	14	PF00675	0.498
CLV_NRD_NRD_1	334	336	PF00675	0.547
CLV_NRD_NRD_1	402	404	PF00675	0.303
CLV_NRD_NRD_1	48	50	PF00675	0.549
CLV_PCSK_KEX2_1	101	103	PF00082	0.578
CLV_PCSK_KEX2_1	112	114	PF00082	0.531
CLV_PCSK_KEX2_1	12	14	PF00082	0.498
CLV_PCSK_KEX2_1	402	404	PF00082	0.303
CLV_PCSK_KEX2_1	48	50	PF00082	0.550
CLV_PCSK_KEX2_1	70	72	PF00082	0.467
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.467
CLV_PCSK_SKI1_1	102	106	PF00082	0.548
CLV_PCSK_SKI1_1	12	16	PF00082	0.504
CLV_PCSK_SKI1_1	261	265	PF00082	0.528
CLV_PCSK_SKI1_1	341	345	PF00082	0.368
CLV_PCSK_SKI1_1	370	374	PF00082	0.322
CLV_PCSK_SKI1_1	455	459	PF00082	0.429
CLV_PCSK_SKI1_1	478	482	PF00082	0.572
CLV_PCSK_SKI1_1	90	94	PF00082	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DOC_CKS1_1	119	124	PF01111	0.741
DOC_CKS1_1	125	130	PF01111	0.686
DOC_CKS1_1	292	297	PF01111	0.517
DOC_CYCLIN_RxL_1	87	97	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.642
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.388
DOC_MAPK_MEF2A_6	341	348	PF00069	0.275
DOC_PP2B_LxvP_1	385	388	PF13499	0.390
DOC_USP7_MATH_1	173	177	PF00917	0.549
DOC_USP7_MATH_1	207	211	PF00917	0.632
DOC_USP7_MATH_1	267	271	PF00917	0.696
DOC_USP7_MATH_1	414	418	PF00917	0.426
DOC_USP7_MATH_1	47	51	PF00917	0.584
DOC_USP7_MATH_1	492	496	PF00917	0.588
DOC_USP7_MATH_1	59	63	PF00917	0.508
DOC_USP7_MATH_1	79	83	PF00917	0.410
DOC_WW_Pin1_4	118	123	PF00397	0.677
DOC_WW_Pin1_4	124	129	PF00397	0.649
DOC_WW_Pin1_4	141	146	PF00397	0.579
DOC_WW_Pin1_4	185	190	PF00397	0.597
DOC_WW_Pin1_4	192	197	PF00397	0.540
DOC_WW_Pin1_4	263	268	PF00397	0.560
DOC_WW_Pin1_4	291	296	PF00397	0.524
DOC_WW_Pin1_4	317	322	PF00397	0.573
DOC_WW_Pin1_4	352	357	PF00397	0.499
DOC_WW_Pin1_4	433	438	PF00397	0.459
DOC_WW_Pin1_4	54	59	PF00397	0.616
LIG_14-3-3_CanoR_1	135	141	PF00244	0.733
LIG_14-3-3_CanoR_1	146	156	PF00244	0.734
LIG_14-3-3_CanoR_1	282	287	PF00244	0.462
LIG_14-3-3_CanoR_1	310	317	PF00244	0.423
LIG_14-3-3_CanoR_1	335	339	PF00244	0.504
LIG_14-3-3_CanoR_1	370	379	PF00244	0.439
LIG_14-3-3_CanoR_1	403	413	PF00244	0.402
LIG_14-3-3_CanoR_1	455	464	PF00244	0.402
LIG_14-3-3_CanoR_1	48	58	PF00244	0.579
LIG_14-3-3_CanoR_1	78	86	PF00244	0.459
LIG_Actin_WH2_2	355	372	PF00022	0.376
LIG_FHA_1	118	124	PF00498	0.597
LIG_FHA_1	148	154	PF00498	0.650
LIG_FHA_1	226	232	PF00498	0.380
LIG_FHA_1	237	243	PF00498	0.413
LIG_FHA_1	380	386	PF00498	0.492
LIG_FHA_1	406	412	PF00498	0.439
LIG_FHA_1	446	452	PF00498	0.477
LIG_FHA_2	119	125	PF00498	0.726
LIG_FHA_2	196	202	PF00498	0.439
LIG_FHA_2	221	227	PF00498	0.332
LIG_FHA_2	292	298	PF00498	0.507
LIG_FHA_2	318	324	PF00498	0.579
LIG_FHA_2	414	420	PF00498	0.455
LIG_GBD_Chelix_1	485	493	PF00786	0.453
LIG_HP1_1	443	447	PF01393	0.367
LIG_Integrin_RGD_1	243	245	PF01839	0.399
LIG_LIR_Apic_2	271	277	PF02991	0.448
LIG_LIR_Gen_1	210	221	PF02991	0.583
LIG_LIR_Gen_1	488	494	PF02991	0.461
LIG_LIR_Nem_3	210	216	PF02991	0.584
LIG_LIR_Nem_3	488	493	PF02991	0.453
LIG_MYND_1	317	321	PF01753	0.415
LIG_NRBOX	359	365	PF00104	0.454
LIG_NRBOX	88	94	PF00104	0.552
LIG_PDZ_Class_1	495	500	PF00595	0.395
LIG_Pex14_1	213	217	PF04695	0.464
LIG_PTAP_UEV_1	226	231	PF05743	0.379
LIG_PTB_Apo_2	427	434	PF02174	0.303
LIG_SH2_CRK	186	190	PF00017	0.591
LIG_SH2_GRB2like	428	431	PF00017	0.457
LIG_SH2_SRC	108	111	PF00017	0.511
LIG_SH2_SRC	286	289	PF00017	0.364
LIG_SH2_STAT3	301	304	PF00017	0.419
LIG_SH2_STAT5	204	207	PF00017	0.482
LIG_SH2_STAT5	222	225	PF00017	0.429
LIG_SH2_STAT5	286	289	PF00017	0.377
LIG_SH2_STAT5	428	431	PF00017	0.547
LIG_SH3_1	224	230	PF00018	0.390
LIG_SH3_3	11	17	PF00018	0.577
LIG_SH3_3	119	125	PF00018	0.755
LIG_SH3_3	224	230	PF00018	0.390
LIG_SUMO_SIM_par_1	341	347	PF11976	0.369
LIG_SUMO_SIM_par_1	443	450	PF11976	0.388
LIG_TRAF2_1	155	158	PF00917	0.525
LIG_TRAF2_1	294	297	PF00917	0.352
LIG_UBA3_1	359	367	PF00899	0.465
LIG_WRC_WIRS_1	153	158	PF05994	0.537
LIG_WW_3	30	34	PF00397	0.636
MOD_CDK_SPK_2	141	146	PF00069	0.579
MOD_CDK_SPxxK_3	192	199	PF00069	0.423
MOD_CK1_1	139	145	PF00069	0.670
MOD_CK1_1	195	201	PF00069	0.399
MOD_CK1_1	268	274	PF00069	0.506
MOD_CK1_1	417	423	PF00069	0.424
MOD_CK1_1	50	56	PF00069	0.550
MOD_CK1_1	63	69	PF00069	0.525
MOD_CK1_1	7	13	PF00069	0.516
MOD_CK2_1	118	124	PF00069	0.554
MOD_CK2_1	152	158	PF00069	0.529
MOD_CK2_1	173	179	PF00069	0.571
MOD_CK2_1	21	27	PF00069	0.508
MOD_CK2_1	220	226	PF00069	0.379
MOD_CK2_1	291	297	PF00069	0.497
MOD_CK2_1	317	323	PF00069	0.430
MOD_CK2_1	352	358	PF00069	0.488
MOD_CK2_1	40	46	PF00069	0.607
MOD_CK2_1	413	419	PF00069	0.447
MOD_CK2_1	94	100	PF00069	0.526
MOD_GlcNHglycan	23	26	PF01048	0.505
MOD_GlcNHglycan	253	256	PF01048	0.682
MOD_GlcNHglycan	257	260	PF01048	0.676
MOD_GlcNHglycan	267	270	PF01048	0.542
MOD_GlcNHglycan	331	334	PF01048	0.609
MOD_GlcNHglycan	35	38	PF01048	0.494
MOD_GlcNHglycan	419	422	PF01048	0.395
MOD_GlcNHglycan	61	65	PF01048	0.501
MOD_GlcNHglycan	79	82	PF01048	0.637
MOD_GlcNHglycan	96	99	PF01048	0.383
MOD_GSK3_1	126	133	PF00069	0.726
MOD_GSK3_1	169	176	PF00069	0.666
MOD_GSK3_1	17	24	PF00069	0.499
MOD_GSK3_1	203	210	PF00069	0.521
MOD_GSK3_1	251	258	PF00069	0.726
MOD_GSK3_1	261	268	PF00069	0.562
MOD_GSK3_1	324	331	PF00069	0.498
MOD_GSK3_1	4	11	PF00069	0.544
MOD_GSK3_1	413	420	PF00069	0.415
MOD_GSK3_1	47	54	PF00069	0.553
MOD_GSK3_1	59	66	PF00069	0.544
MOD_N-GLC_1	414	419	PF02516	0.425
MOD_N-GLC_1	84	89	PF02516	0.522
MOD_NEK2_1	136	141	PF00069	0.696
MOD_NEK2_1	147	152	PF00069	0.690
MOD_NEK2_1	220	225	PF00069	0.335
MOD_NEK2_1	257	262	PF00069	0.539
MOD_NEK2_1	309	314	PF00069	0.465
MOD_NEK2_1	362	367	PF00069	0.305
MOD_NEK2_1	40	45	PF00069	0.528
MOD_NEK2_1	413	418	PF00069	0.495
MOD_NEK2_1	423	428	PF00069	0.381
MOD_NEK2_1	493	498	PF00069	0.490
MOD_NEK2_1	92	97	PF00069	0.520
MOD_NEK2_2	393	398	PF00069	0.371
MOD_NEK2_2	405	410	PF00069	0.362
MOD_PIKK_1	236	242	PF00454	0.319
MOD_PIKK_1	334	340	PF00454	0.560
MOD_PIKK_1	493	499	PF00454	0.573
MOD_PKA_1	48	54	PF00069	0.557
MOD_PKA_2	309	315	PF00069	0.402
MOD_PKA_2	334	340	PF00069	0.498
MOD_PKA_2	4	10	PF00069	0.539
MOD_PKA_2	47	53	PF00069	0.550
MOD_PKA_2	77	83	PF00069	0.558
MOD_Plk_1	26	32	PF00069	0.537
MOD_Plk_1	414	420	PF00069	0.425
MOD_Plk_1	84	90	PF00069	0.554
MOD_Plk_4	187	193	PF00069	0.532
MOD_Plk_4	282	288	PF00069	0.604
MOD_Plk_4	393	399	PF00069	0.427
MOD_Plk_4	424	430	PF00069	0.369
MOD_Plk_4	63	69	PF00069	0.484
MOD_ProDKin_1	118	124	PF00069	0.677
MOD_ProDKin_1	126	132	PF00069	0.658
MOD_ProDKin_1	141	147	PF00069	0.580
MOD_ProDKin_1	185	191	PF00069	0.584
MOD_ProDKin_1	192	198	PF00069	0.531
MOD_ProDKin_1	263	269	PF00069	0.558
MOD_ProDKin_1	291	297	PF00069	0.520
MOD_ProDKin_1	317	323	PF00069	0.584
MOD_ProDKin_1	352	358	PF00069	0.500
MOD_ProDKin_1	433	439	PF00069	0.458
MOD_ProDKin_1	54	60	PF00069	0.614
MOD_SUMO_rev_2	291	300	PF00179	0.511
TRG_DiLeu_BaEn_1	419	424	PF01217	0.395
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.378
TRG_ENDOCYTIC_2	490	493	PF00928	0.459
TRG_ER_diArg_1	112	114	PF00400	0.583
TRG_ER_diArg_1	12	14	PF00400	0.498
TRG_ER_diArg_1	71	74	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7E4	Leptomonas seymouri	41%	100%
A0A3Q8ICX1	Leishmania donovani	76%	100%
A4I238	Leishmania infantum	76%	100%
E9AY88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q985	Leishmania major	74%	100%