Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEW3_LEIBR

TriTrypDb:

LbrM.26.1090 , LBRM2903_260015900

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.662
CLV_C14_Caspase3-7	472	476	PF00656	0.664
CLV_MEL_PAP_1	249	255	PF00089	0.617
CLV_NRD_NRD_1	523	525	PF00675	0.514
CLV_PCSK_KEX2_1	42	44	PF00082	0.649
CLV_PCSK_KEX2_1	523	525	PF00082	0.514
CLV_PCSK_KEX2_1	59	61	PF00082	0.734
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.704
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.774
CLV_PCSK_SKI1_1	119	123	PF00082	0.623
CLV_Separin_Metazoa	120	124	PF03568	0.475
DEG_APCC_DBOX_1	153	161	PF00400	0.782
DEG_SPOP_SBC_1	191	195	PF00917	0.541
DOC_CDC14_PxL_1	84	92	PF14671	0.529
DOC_MAPK_MEF2A_6	352	360	PF00069	0.557
DOC_MAPK_MEF2A_6	361	368	PF00069	0.556
DOC_MAPK_MEF2A_6	441	448	PF00069	0.304
DOC_PP2B_LxvP_1	173	176	PF13499	0.565
DOC_PP2B_LxvP_1	550	553	PF13499	0.616
DOC_USP7_MATH_1	106	110	PF00917	0.713
DOC_USP7_MATH_1	136	140	PF00917	0.729
DOC_USP7_MATH_1	299	303	PF00917	0.590
DOC_USP7_MATH_1	419	423	PF00917	0.699
DOC_USP7_MATH_1	47	51	PF00917	0.605
DOC_USP7_MATH_1	553	557	PF00917	0.571
DOC_USP7_MATH_1	64	68	PF00917	0.689
DOC_WW_Pin1_4	104	109	PF00397	0.536
DOC_WW_Pin1_4	177	182	PF00397	0.775
DOC_WW_Pin1_4	205	210	PF00397	0.713
DOC_WW_Pin1_4	215	220	PF00397	0.649
DOC_WW_Pin1_4	28	33	PF00397	0.691
DOC_WW_Pin1_4	428	433	PF00397	0.578
DOC_WW_Pin1_4	473	478	PF00397	0.639
DOC_WW_Pin1_4	481	486	PF00397	0.586
DOC_WW_Pin1_4	59	64	PF00397	0.755
LIG_14-3-3_CanoR_1	12	21	PF00244	0.548
LIG_14-3-3_CanoR_1	30	38	PF00244	0.636
LIG_14-3-3_CanoR_1	49	54	PF00244	0.569
LIG_14-3-3_CanoR_1	497	502	PF00244	0.716
LIG_14-3-3_CanoR_1	83	88	PF00244	0.538
LIG_BRCT_BRCA1_1	138	142	PF00533	0.723
LIG_BRCT_BRCA1_1	226	230	PF00533	0.665
LIG_BRCT_BRCA1_1	249	253	PF00533	0.728
LIG_BRCT_BRCA1_1	310	314	PF00533	0.423
LIG_BRCT_BRCA1_1	80	84	PF00533	0.541
LIG_deltaCOP1_diTrp_1	242	246	PF00928	0.622
LIG_deltaCOP1_diTrp_1	279	288	PF00928	0.586
LIG_EH_1	227	231	PF12763	0.484
LIG_eIF4E_1	310	316	PF01652	0.283
LIG_FHA_1	132	138	PF00498	0.663
LIG_FHA_1	387	393	PF00498	0.664
LIG_FHA_1	394	400	PF00498	0.531
LIG_FHA_1	516	522	PF00498	0.435
LIG_FHA_1	67	73	PF00498	0.563
LIG_FHA_1	93	99	PF00498	0.516
LIG_FHA_2	284	290	PF00498	0.584
LIG_FHA_2	369	375	PF00498	0.510
LIG_FHA_2	399	405	PF00498	0.602
LIG_LIR_Gen_1	16	24	PF02991	0.516
LIG_LIR_Gen_1	242	251	PF02991	0.556
LIG_LIR_Gen_1	450	460	PF02991	0.617
LIG_LIR_Nem_3	16	21	PF02991	0.646
LIG_LIR_Nem_3	227	233	PF02991	0.633
LIG_LIR_Nem_3	242	246	PF02991	0.511
LIG_LIR_Nem_3	450	456	PF02991	0.606
LIG_MYND_3	164	168	PF01753	0.536
LIG_SH2_CRK	132	136	PF00017	0.630
LIG_SH2_CRK	18	22	PF00017	0.695
LIG_SH2_NCK_1	132	136	PF00017	0.630
LIG_SH2_NCK_1	18	22	PF00017	0.520
LIG_SH2_NCK_1	400	404	PF00017	0.606
LIG_SH2_STAP1	233	237	PF00017	0.492
LIG_SH2_STAP1	310	314	PF00017	0.284
LIG_SH2_STAT3	233	236	PF00017	0.727
LIG_SH2_STAT3	346	349	PF00017	0.607
LIG_SH2_STAT5	124	127	PF00017	0.625
LIG_SH2_STAT5	318	321	PF00017	0.496
LIG_SH2_STAT5	400	403	PF00017	0.464
LIG_SH2_STAT5	532	535	PF00017	0.547
LIG_SH3_3	102	108	PF00018	0.579
LIG_SH3_3	159	165	PF00018	0.570
LIG_SH3_3	21	27	PF00018	0.533
LIG_SH3_3	223	229	PF00018	0.535
LIG_SH3_3	546	552	PF00018	0.791
LIG_SH3_3	58	64	PF00018	0.802
LIG_SUMO_SIM_anti_2	421	427	PF11976	0.491
LIG_TRAF2_1	113	116	PF00917	0.738
LIG_TRAF2_1	287	290	PF00917	0.492
LIG_TRFH_1	440	444	PF08558	0.309
LIG_WRC_WIRS_1	498	503	PF05994	0.504
MOD_CK1_1	111	117	PF00069	0.739
MOD_CK1_1	174	180	PF00069	0.723
MOD_CK1_1	193	199	PF00069	0.647
MOD_CK1_1	254	260	PF00069	0.665
MOD_CK1_1	308	314	PF00069	0.390
MOD_CK1_1	31	37	PF00069	0.732
MOD_CK1_1	367	373	PF00069	0.507
MOD_CK1_1	464	470	PF00069	0.703
MOD_CK1_1	484	490	PF00069	0.662
MOD_CK1_1	66	72	PF00069	0.640
MOD_CK1_1	86	92	PF00069	0.656
MOD_CK2_1	110	116	PF00069	0.710
MOD_CK2_1	283	289	PF00069	0.580
MOD_CK2_1	398	404	PF00069	0.558
MOD_CK2_1	519	525	PF00069	0.568
MOD_GlcNHglycan	138	141	PF01048	0.719
MOD_GlcNHglycan	15	18	PF01048	0.662
MOD_GlcNHglycan	168	172	PF01048	0.787
MOD_GlcNHglycan	249	252	PF01048	0.734
MOD_GlcNHglycan	301	304	PF01048	0.619
MOD_GlcNHglycan	471	474	PF01048	0.671
MOD_GlcNHglycan	486	489	PF01048	0.585
MOD_GlcNHglycan	66	69	PF01048	0.813
MOD_GlcNHglycan	85	88	PF01048	0.642
MOD_GSK3_1	104	111	PF00069	0.691
MOD_GSK3_1	167	174	PF00069	0.745
MOD_GSK3_1	22	29	PF00069	0.652
MOD_GSK3_1	247	254	PF00069	0.691
MOD_GSK3_1	280	287	PF00069	0.481
MOD_GSK3_1	291	298	PF00069	0.463
MOD_GSK3_1	364	371	PF00069	0.578
MOD_GSK3_1	386	393	PF00069	0.461
MOD_GSK3_1	398	405	PF00069	0.425
MOD_GSK3_1	424	431	PF00069	0.600
MOD_GSK3_1	469	476	PF00069	0.633
MOD_GSK3_1	515	522	PF00069	0.541
MOD_GSK3_1	539	546	PF00069	0.677
MOD_GSK3_1	59	66	PF00069	0.665
MOD_GSK3_1	72	79	PF00069	0.681
MOD_GSK3_1	82	89	PF00069	0.706
MOD_LATS_1	35	41	PF00433	0.586
MOD_N-GLC_1	259	264	PF02516	0.464
MOD_NEK2_1	131	136	PF00069	0.734
MOD_NEK2_1	167	172	PF00069	0.722
MOD_NEK2_1	280	285	PF00069	0.323
MOD_NEK2_1	368	373	PF00069	0.685
MOD_NEK2_1	402	407	PF00069	0.564
MOD_NEK2_1	449	454	PF00069	0.438
MOD_NEK2_1	463	468	PF00069	0.552
MOD_NEK2_1	469	474	PF00069	0.438
MOD_NEK2_1	90	95	PF00069	0.679
MOD_NEK2_2	156	161	PF00069	0.682
MOD_PIKK_1	318	324	PF00454	0.470
MOD_PIKK_1	359	365	PF00454	0.433
MOD_PIKK_1	72	78	PF00454	0.729
MOD_PKA_2	11	17	PF00069	0.538
MOD_PKA_2	145	151	PF00069	0.727
MOD_PKA_2	251	257	PF00069	0.717
MOD_PKA_2	419	425	PF00069	0.717
MOD_PKA_2	519	525	PF00069	0.576
MOD_PKA_2	82	88	PF00069	0.542
MOD_Plk_1	259	265	PF00069	0.623
MOD_Plk_1	380	386	PF00069	0.581
MOD_Plk_1	464	470	PF00069	0.729
MOD_Plk_4	156	162	PF00069	0.684
MOD_Plk_4	449	455	PF00069	0.495
MOD_Plk_4	464	470	PF00069	0.627
MOD_Plk_4	497	503	PF00069	0.652
MOD_ProDKin_1	104	110	PF00069	0.537
MOD_ProDKin_1	177	183	PF00069	0.774
MOD_ProDKin_1	205	211	PF00069	0.714
MOD_ProDKin_1	215	221	PF00069	0.650
MOD_ProDKin_1	28	34	PF00069	0.690
MOD_ProDKin_1	428	434	PF00069	0.577
MOD_ProDKin_1	473	479	PF00069	0.639
MOD_ProDKin_1	481	487	PF00069	0.586
MOD_ProDKin_1	59	65	PF00069	0.755
TRG_DiLeu_BaEn_1	184	189	PF01217	0.648
TRG_DiLeu_BaEn_2	442	448	PF01217	0.551
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.734
TRG_ENDOCYTIC_2	132	135	PF00928	0.628
TRG_ENDOCYTIC_2	18	21	PF00928	0.693
TRG_NLS_Bipartite_1	42	62	PF00514	0.629
TRG_NLS_MonoExtN_4	56	62	PF00514	0.800
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P648	Leptomonas seymouri	33%	100%
A0A3S7WZS1	Leishmania donovani	66%	99%
A4I236	Leishmania infantum	66%	99%
E9AY86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
Q4Q987	Leishmania major	67%	100%