RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HEW2_LEIBR

TriTrypDb:

LbrM.26.1080 , LBRM2903_260015800

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEW2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.592
CLV_C14_Caspase3-7	347	351	PF00656	0.716
CLV_NRD_NRD_1	259	261	PF00675	0.683
CLV_PCSK_KEX2_1	259	261	PF00082	0.683
CLV_PCSK_SKI1_1	101	105	PF00082	0.317
CLV_PCSK_SKI1_1	171	175	PF00082	0.730
CLV_PCSK_SKI1_1	54	58	PF00082	0.518
DEG_Nend_UBRbox_4	1	3	PF02207	0.460
DEG_SCF_FBW7_2	321	328	PF00400	0.816
DEG_SCF_TRCP1_1	234	239	PF00400	0.462
DOC_CKS1_1	322	327	PF01111	0.741
DOC_USP7_MATH_1	122	126	PF00917	0.517
DOC_USP7_MATH_1	211	215	PF00917	0.744
DOC_USP7_MATH_1	311	315	PF00917	0.718
DOC_USP7_MATH_1	331	335	PF00917	0.755
DOC_USP7_MATH_1	346	350	PF00917	0.635
DOC_USP7_MATH_1	96	100	PF00917	0.485
DOC_WW_Pin1_4	321	326	PF00397	0.741
DOC_WW_Pin1_4	41	46	PF00397	0.601
DOC_WW_Pin1_4	9	14	PF00397	0.452
LIG_14-3-3_CanoR_1	293	302	PF00244	0.562
LIG_14-3-3_CanoR_1	68	76	PF00244	0.454
LIG_BRCT_BRCA1_1	106	110	PF00533	0.509
LIG_BRCT_BRCA1_1	169	173	PF00533	0.734
LIG_FHA_1	216	222	PF00498	0.595
LIG_FHA_1	224	230	PF00498	0.626
LIG_FHA_1	57	63	PF00498	0.515
LIG_FHA_1	82	88	PF00498	0.593
LIG_FHA_2	336	342	PF00498	0.727
LIG_FHA_2	352	358	PF00498	0.748
LIG_FHA_2	42	48	PF00498	0.715
LIG_Integrin_RGD_1	198	200	PF01839	0.544
LIG_LIR_Apic_2	117	121	PF02991	0.517
LIG_LIR_Gen_1	241	247	PF02991	0.560
LIG_LIR_Nem_3	283	289	PF02991	0.588
LIG_LIR_Nem_3	42	46	PF02991	0.607
LIG_LIR_Nem_3	90	94	PF02991	0.515
LIG_LIR_Nem_3	98	103	PF02991	0.513
LIG_PDZ_Class_3	360	365	PF00595	0.784
LIG_SH2_CRK	118	122	PF00017	0.517
LIG_SH2_NCK_1	308	312	PF00017	0.520
LIG_SH2_STAP1	308	312	PF00017	0.579
LIG_SH2_STAT3	70	73	PF00017	0.458
LIG_SH2_STAT5	129	132	PF00017	0.555
LIG_SH2_STAT5	19	22	PF00017	0.495
LIG_SH2_STAT5	289	292	PF00017	0.574
LIG_SH2_STAT5	308	311	PF00017	0.580
LIG_SH2_STAT5	70	73	PF00017	0.423
LIG_SH3_3	24	30	PF00018	0.453
LIG_SH3_3	90	96	PF00018	0.555
LIG_SUMO_SIM_par_1	150	156	PF11976	0.648
LIG_TRAF2_1	360	363	PF00917	0.514
LIG_WRC_WIRS_1	40	45	PF05994	0.653
MOD_CK1_1	155	161	PF00069	0.661
MOD_CK1_1	17	23	PF00069	0.628
MOD_CK1_1	232	238	PF00069	0.478
MOD_CK1_1	307	313	PF00069	0.706
MOD_CK1_1	316	322	PF00069	0.723
MOD_CK2_1	292	298	PF00069	0.558
MOD_CK2_1	331	337	PF00069	0.727
MOD_CK2_1	351	357	PF00069	0.563
MOD_GlcNHglycan	105	109	PF01048	0.314
MOD_GlcNHglycan	112	115	PF01048	0.321
MOD_GlcNHglycan	155	158	PF01048	0.703
MOD_GlcNHglycan	233	237	PF01048	0.720
MOD_GlcNHglycan	270	273	PF01048	0.629
MOD_GSK3_1	110	117	PF00069	0.517
MOD_GSK3_1	152	159	PF00069	0.644
MOD_GSK3_1	211	218	PF00069	0.741
MOD_GSK3_1	232	239	PF00069	0.550
MOD_GSK3_1	300	307	PF00069	0.670
MOD_GSK3_1	331	338	PF00069	0.735
MOD_NEK2_1	110	115	PF00069	0.517
MOD_NEK2_1	136	141	PF00069	0.494
MOD_NEK2_1	153	158	PF00069	0.635
MOD_NEK2_2	300	305	PF00069	0.502
MOD_PIKK_1	174	180	PF00454	0.796
MOD_PIKK_1	69	75	PF00454	0.449
MOD_PKA_2	292	298	PF00069	0.440
MOD_PKB_1	196	204	PF00069	0.544
MOD_Plk_1	122	128	PF00069	0.542
MOD_Plk_1	331	337	PF00069	0.543
MOD_Plk_2-3	215	221	PF00069	0.534
MOD_ProDKin_1	321	327	PF00069	0.743
MOD_ProDKin_1	41	47	PF00069	0.604
MOD_ProDKin_1	9	15	PF00069	0.455
MOD_SUMO_for_1	87	90	PF00179	0.555
TRG_ENDOCYTIC_2	100	103	PF00928	0.505
TRG_ENDOCYTIC_2	243	246	PF00928	0.553
TRG_ENDOCYTIC_2	94	97	PF00928	0.527
TRG_ER_diArg_1	258	260	PF00400	0.660
TRG_ER_FFAT_2	303	314	PF00635	0.517
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I9	Leptomonas seymouri	58%	100%
A0A3Q8ICS1	Leishmania donovani	82%	100%
A0A422NSU1	Trypanosoma rangeli	44%	100%
A4I235	Leishmania infantum	82%	100%
E9AY85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q988	Leishmania major	82%	100%