2Fe-2S ferredoxin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2Fe-2S iron-sulfur cluster binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEW1_LEIBR

TriTrypDb:

LbrM.26.1070 , LBRM2903_260015700

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEW1

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0022900	electron transport chain	4	11
GO:0044237	cellular metabolic process	2	11
GO:0140647	P450-containing electron transport chain	5	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11
GO:0003824	catalytic activity	1	1
GO:0009055	electron transfer activity	3	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.416
CLV_C14_Caspase3-7	77	81	PF00656	0.583
CLV_NRD_NRD_1	2	4	PF00675	0.661
CLV_NRD_NRD_1	59	61	PF00675	0.629
CLV_PCSK_KEX2_1	160	162	PF00082	0.662
CLV_PCSK_KEX2_1	2	4	PF00082	0.661
CLV_PCSK_KEX2_1	59	61	PF00082	0.629
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.662
CLV_PCSK_SKI1_1	34	38	PF00082	0.655
CLV_PCSK_SKI1_1	9	13	PF00082	0.481
DEG_Nend_UBRbox_1	1	4	PF02207	0.465
DOC_MAPK_gen_1	170	180	PF00069	0.566
DOC_MAPK_gen_1	68	76	PF00069	0.511
DOC_MAPK_MEF2A_6	68	76	PF00069	0.511
DOC_PP4_FxxP_1	130	133	PF00568	0.318
DOC_PP4_FxxP_1	76	79	PF00568	0.550
DOC_WW_Pin1_4	38	43	PF00397	0.587
LIG_14-3-3_CanoR_1	20	25	PF00244	0.674
LIG_APCC_ABBA_1	127	132	PF00400	0.341
LIG_BRCT_BRCA1_1	57	61	PF00533	0.642
LIG_eIF4E_1	89	95	PF01652	0.318
LIG_FHA_1	115	121	PF00498	0.298
LIG_FHA_1	148	154	PF00498	0.318
LIG_FHA_1	38	44	PF00498	0.648
LIG_FHA_2	132	138	PF00498	0.298
LIG_FHA_2	24	30	PF00498	0.412
LIG_FHA_2	75	81	PF00498	0.495
LIG_FHA_2	91	97	PF00498	0.212
LIG_LIR_Apic_2	128	133	PF02991	0.319
LIG_LIR_Apic_2	75	79	PF02991	0.485
LIG_LIR_Nem_3	13	18	PF02991	0.525
LIG_SH2_CRK	15	19	PF00017	0.673
LIG_SH2_SRC	179	182	PF00017	0.577
LIG_SH2_STAT3	89	92	PF00017	0.298
LIG_SH2_STAT5	121	124	PF00017	0.298
LIG_SH2_STAT5	179	182	PF00017	0.577
LIG_SH3_3	166	172	PF00018	0.525
LIG_TRAF2_1	134	137	PF00917	0.294
MOD_CK1_1	23	29	PF00069	0.576
MOD_CK1_1	51	57	PF00069	0.482
MOD_CK2_1	131	137	PF00069	0.298
MOD_GlcNHglycan	50	53	PF01048	0.551
MOD_GSK3_1	109	116	PF00069	0.299
MOD_GSK3_1	19	26	PF00069	0.634
MOD_GSK3_1	34	41	PF00069	0.583
MOD_GSK3_1	44	51	PF00069	0.388
MOD_NEK2_1	14	19	PF00069	0.629
MOD_NEK2_1	55	60	PF00069	0.699
MOD_NEK2_2	114	119	PF00069	0.298
MOD_OFUCOSY	113	118	PF10250	0.299
MOD_PKA_2	172	178	PF00069	0.578
MOD_PKA_2	19	25	PF00069	0.593
MOD_Plk_1	74	80	PF00069	0.560
MOD_Plk_2-3	90	96	PF00069	0.318
MOD_Plk_4	51	57	PF00069	0.662
MOD_Plk_4	90	96	PF00069	0.318
MOD_ProDKin_1	38	44	PF00069	0.590
MOD_SUMO_rev_2	80	86	PF00179	0.371
TRG_DiLeu_BaEn_1	90	95	PF01217	0.318
TRG_ENDOCYTIC_2	15	18	PF00928	0.678
TRG_ER_diArg_1	1	3	PF00400	0.680
TRG_ER_diArg_1	59	61	PF00400	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	30%	100%
A0A0N1HYR7	Leptomonas seymouri	29%	100%
A0A0N1HZ74	Leptomonas seymouri	71%	100%
A0A0S4JS28	Bodo saltans	63%	100%
A0A1X0NSB1	Trypanosomatidae	58%	100%
A0A3R7NM96	Trypanosoma rangeli	64%	98%
A0A3S7WZQ5	Leishmania donovani	85%	100%
A4HJN3	Leishmania braziliensis	36%	100%
A4HJN4	Leishmania braziliensis	32%	100%
A4HJN8	Leishmania braziliensis	33%	100%
A4I234	Leishmania infantum	85%	100%
C9ZRX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AY84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
P00258	Sus scrofa	39%	100%
Q4Q610	Leishmania major	29%	100%
Q4Q611	Leishmania major	30%	100%
Q4Q989	Leishmania major	85%	100%
Q6P4F2	Homo sapiens	37%	100%
Q9M0V0	Arabidopsis thaliana	42%	95%