Nicalin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nicalin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEW0_LEIBR

TriTrypDb:

LbrM.26.1060 , LBRM2903_260015600

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A4HEW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEW0

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	11
GO:0010646	regulation of cell communication	4	11
GO:0023051	regulation of signaling	3	11
GO:0048583	regulation of response to stimulus	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.433
CLV_NRD_NRD_1	153	155	PF00675	0.632
CLV_NRD_NRD_1	240	242	PF00675	0.485
CLV_NRD_NRD_1	300	302	PF00675	0.405
CLV_NRD_NRD_1	389	391	PF00675	0.608
CLV_PCSK_KEX2_1	153	155	PF00082	0.632
CLV_PCSK_KEX2_1	240	242	PF00082	0.485
CLV_PCSK_KEX2_1	300	302	PF00082	0.405
CLV_PCSK_KEX2_1	320	322	PF00082	0.553
CLV_PCSK_KEX2_1	389	391	PF00082	0.617
CLV_PCSK_KEX2_1	403	405	PF00082	0.516
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.562
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.597
CLV_PCSK_SKI1_1	154	158	PF00082	0.606
CLV_PCSK_SKI1_1	159	163	PF00082	0.587
CLV_PCSK_SKI1_1	240	244	PF00082	0.562
CLV_PCSK_SKI1_1	289	293	PF00082	0.537
CLV_PCSK_SKI1_1	413	417	PF00082	0.481
CLV_PCSK_SKI1_1	478	482	PF00082	0.641
CLV_PCSK_SKI1_1	52	56	PF00082	0.593
CLV_PCSK_SKI1_1	86	90	PF00082	0.561
CLV_Separin_Metazoa	59	63	PF03568	0.397
DEG_SCF_FBW7_1	493	499	PF00400	0.447
DEG_SCF_FBW7_1	61	68	PF00400	0.282
DEG_SPOP_SBC_1	271	275	PF00917	0.362
DOC_CDC14_PxL_1	540	548	PF14671	0.533
DOC_CKS1_1	493	498	PF01111	0.450
DOC_CYCLIN_RxL_1	163	172	PF00134	0.288
DOC_MAPK_MEF2A_6	336	344	PF00069	0.298
DOC_MAPK_RevD_3	288	301	PF00069	0.205
DOC_USP7_MATH_1	152	156	PF00917	0.435
DOC_USP7_MATH_1	418	422	PF00917	0.499
DOC_USP7_MATH_1	443	447	PF00917	0.375
DOC_USP7_MATH_1	480	484	PF00917	0.378
DOC_USP7_MATH_1	65	69	PF00917	0.440
DOC_WW_Pin1_4	217	222	PF00397	0.389
DOC_WW_Pin1_4	242	247	PF00397	0.391
DOC_WW_Pin1_4	446	451	PF00397	0.356
DOC_WW_Pin1_4	492	497	PF00397	0.436
DOC_WW_Pin1_4	61	66	PF00397	0.269
LIG_14-3-3_CanoR_1	146	151	PF00244	0.403
LIG_14-3-3_CanoR_1	153	162	PF00244	0.418
LIG_14-3-3_CanoR_1	240	246	PF00244	0.342
LIG_14-3-3_CanoR_1	257	261	PF00244	0.205
LIG_14-3-3_CanoR_1	390	400	PF00244	0.429
LIG_14-3-3_CanoR_1	413	420	PF00244	0.385
LIG_14-3-3_CanoR_1	460	466	PF00244	0.425
LIG_14-3-3_CanoR_1	478	487	PF00244	0.365
LIG_Actin_WH2_2	527	543	PF00022	0.227
LIG_APCC_ABBA_1	501	506	PF00400	0.364
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_BRCT_BRCA1_1	119	123	PF00533	0.433
LIG_BRCT_BRCA1_1	514	518	PF00533	0.330
LIG_EH1_1	255	263	PF00400	0.316
LIG_eIF4E_1	256	262	PF01652	0.313
LIG_FHA_1	12	18	PF00498	0.598
LIG_FHA_1	155	161	PF00498	0.410
LIG_FHA_1	165	171	PF00498	0.459
LIG_FHA_1	257	263	PF00498	0.336
LIG_FHA_1	272	278	PF00498	0.285
LIG_FHA_1	305	311	PF00498	0.205
LIG_FHA_1	376	382	PF00498	0.385
LIG_FHA_1	493	499	PF00498	0.393
LIG_FHA_1	505	511	PF00498	0.364
LIG_FHA_1	73	79	PF00498	0.316
LIG_FHA_2	111	117	PF00498	0.349
LIG_FHA_2	279	285	PF00498	0.376
LIG_FHA_2	392	398	PF00498	0.411
LIG_FHA_2	487	493	PF00498	0.437
LIG_GBD_Chelix_1	290	298	PF00786	0.460
LIG_LIR_Gen_1	211	222	PF02991	0.282
LIG_LIR_Gen_1	309	319	PF02991	0.292
LIG_LIR_Gen_1	488	498	PF02991	0.442
LIG_LIR_Nem_3	211	217	PF02991	0.282
LIG_LIR_Nem_3	237	242	PF02991	0.282
LIG_LIR_Nem_3	265	271	PF02991	0.274
LIG_LIR_Nem_3	286	291	PF02991	0.275
LIG_LIR_Nem_3	309	314	PF02991	0.284
LIG_LIR_Nem_3	349	354	PF02991	0.282
LIG_LIR_Nem_3	488	493	PF02991	0.441
LIG_LIR_Nem_3	499	504	PF02991	0.376
LIG_LIR_Nem_3	68	74	PF02991	0.436
LIG_LIR_Nem_3	93	98	PF02991	0.326
LIG_MLH1_MIPbox_1	119	123	PF16413	0.433
LIG_NBox_RRM_1	518	528	PF00076	0.349
LIG_NRBOX	143	149	PF00104	0.436
LIG_NRBOX	526	532	PF00104	0.459
LIG_PCNA_PIPBox_1	207	216	PF02747	0.386
LIG_SH2_CRK	63	67	PF00017	0.282
LIG_SH2_SRC	311	314	PF00017	0.362
LIG_SH2_STAP1	354	358	PF00017	0.282
LIG_SH2_STAP1	504	508	PF00017	0.318
LIG_SH2_STAP1	74	78	PF00017	0.384
LIG_SH2_STAT3	247	250	PF00017	0.386
LIG_SH2_STAT5	133	136	PF00017	0.327
LIG_SH2_STAT5	270	273	PF00017	0.249
LIG_SH2_STAT5	311	314	PF00017	0.336
LIG_SH2_STAT5	435	438	PF00017	0.409
LIG_SH2_STAT5	461	464	PF00017	0.256
LIG_SH2_STAT5	516	519	PF00017	0.496
LIG_SH2_STAT5	63	66	PF00017	0.388
LIG_SH2_STAT5	74	77	PF00017	0.294
LIG_SH3_3	316	322	PF00018	0.292
LIG_SUMO_SIM_par_1	104	114	PF11976	0.410
LIG_SUMO_SIM_par_1	258	266	PF11976	0.312
LIG_SUMO_SIM_par_1	8	14	PF11976	0.564
LIG_TRAF2_1	140	143	PF00917	0.249
LIG_TRAF2_1	248	251	PF00917	0.386
LIG_TRAF2_1	503	506	PF00917	0.374
LIG_TYR_ITIM	61	66	PF00017	0.269
LIG_WRC_WIRS_1	118	123	PF05994	0.408
MOD_CDK_SPxxK_3	217	224	PF00069	0.386
MOD_CDK_SPxxK_3	242	249	PF00069	0.386
MOD_CK1_1	124	130	PF00069	0.250
MOD_CK1_1	220	226	PF00069	0.328
MOD_CK1_1	227	233	PF00069	0.321
MOD_CK1_1	275	281	PF00069	0.386
MOD_CK1_1	304	310	PF00069	0.259
MOD_CK1_1	346	352	PF00069	0.334
MOD_CK1_1	446	452	PF00069	0.357
MOD_CK1_1	483	489	PF00069	0.382
MOD_CK1_1	97	103	PF00069	0.274
MOD_CK2_1	110	116	PF00069	0.354
MOD_CK2_1	152	158	PF00069	0.405
MOD_CK2_1	278	284	PF00069	0.317
MOD_GlcNHglycan	126	129	PF01048	0.447
MOD_GlcNHglycan	180	183	PF01048	0.583
MOD_GlcNHglycan	200	203	PF01048	0.507
MOD_GlcNHglycan	226	229	PF01048	0.507
MOD_GlcNHglycan	251	254	PF01048	0.518
MOD_GlcNHglycan	332	335	PF01048	0.405
MOD_GlcNHglycan	373	376	PF01048	0.514
MOD_GlcNHglycan	420	423	PF01048	0.716
MOD_GlcNHglycan	482	485	PF01048	0.649
MOD_GlcNHglycan	67	70	PF01048	0.637
MOD_GlcNHglycan	86	89	PF01048	0.608
MOD_GlcNHglycan	92	95	PF01048	0.527
MOD_GlcNHglycan	99	102	PF01048	0.485
MOD_GSK3_1	117	124	PF00069	0.404
MOD_GSK3_1	138	145	PF00069	0.387
MOD_GSK3_1	160	167	PF00069	0.407
MOD_GSK3_1	174	181	PF00069	0.415
MOD_GSK3_1	213	220	PF00069	0.350
MOD_GSK3_1	223	230	PF00069	0.276
MOD_GSK3_1	271	278	PF00069	0.362
MOD_GSK3_1	371	378	PF00069	0.306
MOD_GSK3_1	476	483	PF00069	0.360
MOD_GSK3_1	492	499	PF00069	0.360
MOD_GSK3_1	61	68	PF00069	0.389
MOD_GSK3_1	78	85	PF00069	0.389
MOD_GSK3_1	90	97	PF00069	0.388
MOD_LATS_1	196	202	PF00433	0.376
MOD_N-GLC_1	175	180	PF02516	0.555
MOD_NEK2_1	10	15	PF00069	0.467
MOD_NEK2_1	121	126	PF00069	0.407
MOD_NEK2_1	261	266	PF00069	0.303
MOD_NEK2_1	338	343	PF00069	0.386
MOD_NEK2_1	371	376	PF00069	0.383
MOD_NEK2_1	385	390	PF00069	0.327
MOD_NEK2_1	48	53	PF00069	0.383
MOD_NEK2_1	512	517	PF00069	0.357
MOD_NEK2_1	84	89	PF00069	0.342
MOD_NEK2_2	375	380	PF00069	0.412
MOD_NEK2_2	496	501	PF00069	0.416
MOD_PIKK_1	138	144	PF00454	0.357
MOD_PIKK_1	183	189	PF00454	0.247
MOD_PIKK_1	275	281	PF00454	0.344
MOD_PIKK_1	304	310	PF00454	0.205
MOD_PK_1	146	152	PF00069	0.448
MOD_PKA_1	240	246	PF00069	0.340
MOD_PKA_2	152	158	PF00069	0.419
MOD_PKA_2	168	174	PF00069	0.440
MOD_PKA_2	223	229	PF00069	0.372
MOD_PKA_2	240	246	PF00069	0.231
MOD_PKA_2	256	262	PF00069	0.205
MOD_PKA_2	385	391	PF00069	0.369
MOD_Plk_1	142	148	PF00069	0.366
MOD_Plk_1	174	180	PF00069	0.356
MOD_Plk_1	354	360	PF00069	0.326
MOD_Plk_1	504	510	PF00069	0.409
MOD_Plk_4	117	123	PF00069	0.436
MOD_Plk_4	175	181	PF00069	0.347
MOD_Plk_4	256	262	PF00069	0.313
MOD_Plk_4	272	278	PF00069	0.313
MOD_Plk_4	424	430	PF00069	0.465
MOD_Plk_4	431	437	PF00069	0.370
MOD_Plk_4	512	518	PF00069	0.374
MOD_Plk_4	72	78	PF00069	0.308
MOD_Plk_4	94	100	PF00069	0.445
MOD_ProDKin_1	217	223	PF00069	0.389
MOD_ProDKin_1	242	248	PF00069	0.391
MOD_ProDKin_1	446	452	PF00069	0.355
MOD_ProDKin_1	492	498	PF00069	0.432
MOD_ProDKin_1	61	67	PF00069	0.273
TRG_DiLeu_BaEn_1	143	148	PF01217	0.432
TRG_DiLeu_BaEn_1	175	180	PF01217	0.264
TRG_DiLeu_LyEn_5	143	148	PF01217	0.432
TRG_ENDOCYTIC_2	311	314	PF00928	0.303
TRG_ENDOCYTIC_2	490	493	PF00928	0.417
TRG_ENDOCYTIC_2	63	66	PF00928	0.277
TRG_ER_diArg_1	239	241	PF00400	0.285
TRG_ER_diArg_1	299	301	PF00400	0.205
TRG_ER_diArg_1	389	391	PF00400	0.417
TRG_NES_CRM1_1	284	296	PF08389	0.323
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P650	Leptomonas seymouri	58%	100%
A0A1X0NSR2	Trypanosomatidae	34%	86%
A0A3R7MV36	Trypanosoma rangeli	34%	91%
A0A3S7WZU9	Leishmania donovani	79%	100%
A4I233	Leishmania infantum	79%	100%
C9ZRX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	92%
E9AY83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q990	Leishmania major	79%	100%
V5BPU6	Trypanosoma cruzi	35%	91%