Aldo_ket_red domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEV9_LEIBR

TriTrypDb:

LbrM.26.1050 , LBRM2903_260015500

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.472
CLV_C14_Caspase3-7	750	754	PF00656	0.537
CLV_NRD_NRD_1	3	5	PF00675	0.702
CLV_NRD_NRD_1	310	312	PF00675	0.427
CLV_NRD_NRD_1	48	50	PF00675	0.656
CLV_NRD_NRD_1	576	578	PF00675	0.417
CLV_NRD_NRD_1	73	75	PF00675	0.598
CLV_PCSK_FUR_1	574	578	PF00082	0.417
CLV_PCSK_KEX2_1	3	5	PF00082	0.695
CLV_PCSK_KEX2_1	310	312	PF00082	0.427
CLV_PCSK_KEX2_1	48	50	PF00082	0.635
CLV_PCSK_KEX2_1	576	578	PF00082	0.436
CLV_PCSK_PC7_1	306	312	PF00082	0.453
CLV_PCSK_PC7_1	44	50	PF00082	0.662
CLV_PCSK_SKI1_1	104	108	PF00082	0.622
CLV_PCSK_SKI1_1	124	128	PF00082	0.380
CLV_PCSK_SKI1_1	374	378	PF00082	0.536
CLV_PCSK_SKI1_1	4	8	PF00082	0.661
CLV_PCSK_SKI1_1	519	523	PF00082	0.416
CLV_PCSK_SKI1_1	555	559	PF00082	0.422
CLV_PCSK_SKI1_1	577	581	PF00082	0.429
DEG_APCC_DBOX_1	305	313	PF00400	0.456
DEG_APCC_DBOX_1	518	526	PF00400	0.430
DEG_Nend_Nbox_1	1	3	PF02207	0.735
DEG_SPOP_SBC_1	37	41	PF00917	0.506
DEG_SPOP_SBC_1	747	751	PF00917	0.528
DOC_CKS1_1	412	417	PF01111	0.632
DOC_CKS1_1	570	575	PF01111	0.524
DOC_CYCLIN_RxL_1	470	478	PF00134	0.419
DOC_MAPK_gen_1	48	56	PF00069	0.614
DOC_MAPK_MEF2A_6	337	345	PF00069	0.376
DOC_MAPK_MEF2A_6	49	58	PF00069	0.488
DOC_PP1_RVXF_1	641	648	PF00149	0.367
DOC_PP2B_LxvP_1	35	38	PF13499	0.509
DOC_PP2B_LxvP_1	391	394	PF13499	0.513
DOC_PP2B_LxvP_1	679	682	PF13499	0.431
DOC_PP4_FxxP_1	167	170	PF00568	0.553
DOC_USP7_MATH_1	106	110	PF00917	0.443
DOC_USP7_MATH_1	135	139	PF00917	0.566
DOC_USP7_MATH_1	194	198	PF00917	0.388
DOC_USP7_MATH_1	286	290	PF00917	0.590
DOC_USP7_MATH_1	747	751	PF00917	0.528
DOC_USP7_MATH_1	761	765	PF00917	0.734
DOC_USP7_UBL2_3	591	595	PF12436	0.422
DOC_USP7_UBL2_3	7	11	PF12436	0.521
DOC_USP7_UBL2_3	719	723	PF12436	0.647
DOC_WW_Pin1_4	20	25	PF00397	0.742
DOC_WW_Pin1_4	318	323	PF00397	0.406
DOC_WW_Pin1_4	33	38	PF00397	0.719
DOC_WW_Pin1_4	385	390	PF00397	0.378
DOC_WW_Pin1_4	411	416	PF00397	0.636
DOC_WW_Pin1_4	455	460	PF00397	0.550
DOC_WW_Pin1_4	480	485	PF00397	0.370
DOC_WW_Pin1_4	569	574	PF00397	0.535
DOC_WW_Pin1_4	628	633	PF00397	0.375
DOC_WW_Pin1_4	698	703	PF00397	0.453
LIG_14-3-3_CanoR_1	146	150	PF00244	0.417
LIG_14-3-3_CanoR_1	158	162	PF00244	0.365
LIG_14-3-3_CanoR_1	3	7	PF00244	0.754
LIG_14-3-3_CanoR_1	314	322	PF00244	0.430
LIG_14-3-3_CanoR_1	426	431	PF00244	0.272
LIG_14-3-3_CanoR_1	48	52	PF00244	0.633
LIG_BRCT_BRCA1_1	158	162	PF00533	0.410
LIG_BRCT_BRCA1_1	16	20	PF00533	0.518
LIG_BRCT_BRCA1_1	661	665	PF00533	0.393
LIG_Clathr_ClatBox_1	728	732	PF01394	0.717
LIG_deltaCOP1_diTrp_1	163	167	PF00928	0.560
LIG_deltaCOP1_diTrp_1	323	329	PF00928	0.410
LIG_eIF4E_1	650	656	PF01652	0.460
LIG_eIF4E_1	706	712	PF01652	0.650
LIG_FHA_1	30	36	PF00498	0.768
LIG_FHA_1	419	425	PF00498	0.518
LIG_FHA_1	51	57	PF00498	0.686
LIG_FHA_2	158	164	PF00498	0.422
LIG_FHA_2	257	263	PF00498	0.594
LIG_FHA_2	334	340	PF00498	0.391
LIG_FHA_2	349	355	PF00498	0.371
LIG_FHA_2	513	519	PF00498	0.407
LIG_GBD_Chelix_1	222	230	PF00786	0.529
LIG_LIR_Apic_2	410	415	PF02991	0.647
LIG_LIR_Apic_2	628	632	PF02991	0.538
LIG_LIR_Gen_1	23	33	PF02991	0.662
LIG_LIR_Gen_1	326	334	PF02991	0.399
LIG_LIR_Gen_1	495	504	PF02991	0.487
LIG_LIR_Gen_1	696	705	PF02991	0.548
LIG_LIR_Nem_3	23	28	PF02991	0.637
LIG_LIR_Nem_3	326	332	PF02991	0.392
LIG_LIR_Nem_3	438	444	PF02991	0.522
LIG_LIR_Nem_3	495	500	PF02991	0.497
LIG_LIR_Nem_3	564	569	PF02991	0.420
LIG_LIR_Nem_3	696	700	PF02991	0.511
LIG_LYPXL_yS_3	399	402	PF13949	0.506
LIG_MLH1_MIPbox_1	661	665	PF16413	0.393
LIG_MYND_1	389	393	PF01753	0.439
LIG_MYND_3	538	542	PF01753	0.475
LIG_Pex14_1	324	328	PF04695	0.405
LIG_Pex14_1	566	570	PF04695	0.414
LIG_Pex14_1	593	597	PF04695	0.384
LIG_Pex14_2	557	561	PF04695	0.377
LIG_Pex14_2	562	566	PF04695	0.383
LIG_PTB_Apo_2	161	168	PF02174	0.305
LIG_PTB_Apo_2	328	335	PF02174	0.394
LIG_PTB_Apo_2	556	563	PF02174	0.384
LIG_PTB_Phospho_1	328	334	PF10480	0.393
LIG_Rb_pABgroove_1	347	355	PF01858	0.474
LIG_SH2_CRK	412	416	PF00017	0.630
LIG_SH2_CRK	570	574	PF00017	0.403
LIG_SH2_CRK	629	633	PF00017	0.287
LIG_SH2_CRK	697	701	PF00017	0.554
LIG_SH2_GRB2like	497	500	PF00017	0.400
LIG_SH2_GRB2like	697	700	PF00017	0.475
LIG_SH2_NCK_1	629	633	PF00017	0.287
LIG_SH2_NCK_1	697	701	PF00017	0.554
LIG_SH2_SRC	697	700	PF00017	0.514
LIG_SH2_STAP1	597	601	PF00017	0.415
LIG_SH2_STAT5	154	157	PF00017	0.399
LIG_SH2_STAT5	371	374	PF00017	0.387
LIG_SH2_STAT5	550	553	PF00017	0.386
LIG_SH2_STAT5	664	667	PF00017	0.391
LIG_SH3_1	397	403	PF00018	0.480
LIG_SH3_1	413	419	PF00018	0.483
LIG_SH3_1	86	92	PF00018	0.488
LIG_SH3_3	383	389	PF00018	0.459
LIG_SH3_3	390	396	PF00018	0.422
LIG_SH3_3	397	403	PF00018	0.392
LIG_SH3_3	413	419	PF00018	0.483
LIG_SH3_3	441	447	PF00018	0.382
LIG_SH3_3	697	703	PF00018	0.432
LIG_SH3_3	727	733	PF00018	0.607
LIG_SH3_3	736	742	PF00018	0.563
LIG_SH3_3	86	92	PF00018	0.488
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.350
LIG_SUMO_SIM_anti_2	53	58	PF11976	0.483
LIG_SUMO_SIM_par_1	29	34	PF11976	0.767
LIG_SUMO_SIM_par_1	342	347	PF11976	0.364
LIG_TRAF2_1	682	685	PF00917	0.501
LIG_TRAF2_1	76	79	PF00917	0.649
LIG_TRFH_1	706	710	PF08558	0.535
LIG_TYR_ITIM	381	386	PF00017	0.382
LIG_TYR_ITIM	480	485	PF00017	0.413
LIG_TYR_ITIM	695	700	PF00017	0.537
LIG_UBA3_1	273	281	PF00899	0.661
LIG_UBA3_1	368	377	PF00899	0.417
LIG_UBA3_1	686	691	PF00899	0.299
LIG_UBA3_1	707	716	PF00899	0.603
MOD_CDK_SPK_2	569	574	PF00069	0.535
MOD_CDK_SPxK_1	411	417	PF00069	0.637
MOD_CDK_SPxxK_3	569	576	PF00069	0.537
MOD_CK1_1	23	29	PF00069	0.545
MOD_CK1_1	284	290	PF00069	0.489
MOD_CK1_1	36	42	PF00069	0.704
MOD_CK1_1	458	464	PF00069	0.509
MOD_CK1_1	5	11	PF00069	0.766
MOD_CK1_1	61	67	PF00069	0.705
MOD_CK1_1	722	728	PF00069	0.506
MOD_CK1_1	73	79	PF00069	0.612
MOD_CK1_1	749	755	PF00069	0.650
MOD_CK2_1	157	163	PF00069	0.405
MOD_CK2_1	256	262	PF00069	0.587
MOD_CK2_1	333	339	PF00069	0.398
MOD_CK2_1	426	432	PF00069	0.278
MOD_CK2_1	480	486	PF00069	0.374
MOD_CK2_1	512	518	PF00069	0.387
MOD_CK2_1	73	79	PF00069	0.664
MOD_GlcNHglycan	108	111	PF01048	0.433
MOD_GlcNHglycan	120	123	PF01048	0.486
MOD_GlcNHglycan	16	19	PF01048	0.755
MOD_GlcNHglycan	291	294	PF01048	0.540
MOD_GlcNHglycan	756	759	PF01048	0.702
MOD_GSK3_1	145	152	PF00069	0.403
MOD_GSK3_1	16	23	PF00069	0.552
MOD_GSK3_1	175	182	PF00069	0.416
MOD_GSK3_1	256	263	PF00069	0.468
MOD_GSK3_1	280	287	PF00069	0.530
MOD_GSK3_1	29	36	PF00069	0.748
MOD_GSK3_1	454	461	PF00069	0.306
MOD_GSK3_1	57	64	PF00069	0.702
MOD_GSK3_1	715	722	PF00069	0.638
MOD_N-GLC_1	448	453	PF02516	0.365
MOD_N-GLC_1	464	469	PF02516	0.395
MOD_N-GLC_1	698	703	PF02516	0.438
MOD_NEK2_1	156	161	PF00069	0.458
MOD_NEK2_1	179	184	PF00069	0.498
MOD_NEK2_1	2	7	PF00069	0.581
MOD_NEK2_1	299	304	PF00069	0.485
MOD_NEK2_1	31	36	PF00069	0.750
MOD_NEK2_1	448	453	PF00069	0.384
MOD_NEK2_1	47	52	PF00069	0.540
MOD_NEK2_1	475	480	PF00069	0.376
MOD_NEK2_1	485	490	PF00069	0.413
MOD_NEK2_1	545	550	PF00069	0.376
MOD_NEK2_1	57	62	PF00069	0.607
MOD_NEK2_1	659	664	PF00069	0.390
MOD_NEK2_2	181	186	PF00069	0.399
MOD_NEK2_2	286	291	PF00069	0.602
MOD_NEK2_2	348	353	PF00069	0.402
MOD_PIKK_1	299	305	PF00454	0.501
MOD_PIKK_1	448	454	PF00454	0.392
MOD_PKA_2	135	141	PF00069	0.521
MOD_PKA_2	145	151	PF00069	0.393
MOD_PKA_2	157	163	PF00069	0.371
MOD_PKA_2	2	8	PF00069	0.766
MOD_PKA_2	294	300	PF00069	0.454
MOD_PKA_2	313	319	PF00069	0.441
MOD_PKA_2	47	53	PF00069	0.682
MOD_PKA_2	73	79	PF00069	0.565
MOD_Plk_1	156	162	PF00069	0.454
MOD_Plk_1	256	262	PF00069	0.610
MOD_Plk_1	299	305	PF00069	0.478
MOD_Plk_1	464	470	PF00069	0.483
MOD_Plk_1	517	523	PF00069	0.497
MOD_Plk_2-3	157	163	PF00069	0.435
MOD_Plk_4	157	163	PF00069	0.435
MOD_Plk_4	175	181	PF00069	0.392
MOD_Plk_4	348	354	PF00069	0.413
MOD_Plk_4	52	58	PF00069	0.556
MOD_Plk_4	545	551	PF00069	0.367
MOD_ProDKin_1	20	26	PF00069	0.741
MOD_ProDKin_1	318	324	PF00069	0.406
MOD_ProDKin_1	33	39	PF00069	0.719
MOD_ProDKin_1	385	391	PF00069	0.376
MOD_ProDKin_1	411	417	PF00069	0.637
MOD_ProDKin_1	455	461	PF00069	0.558
MOD_ProDKin_1	480	486	PF00069	0.374
MOD_ProDKin_1	569	575	PF00069	0.531
MOD_ProDKin_1	628	634	PF00069	0.369
MOD_ProDKin_1	698	704	PF00069	0.462
MOD_SUMO_for_1	766	769	PF00179	0.540
MOD_SUMO_rev_2	503	509	PF00179	0.407
MOD_SUMO_rev_2	520	530	PF00179	0.461
MOD_SUMO_rev_2	709	718	PF00179	0.575
TRG_DiLeu_BaEn_1	486	491	PF01217	0.414
TRG_DiLeu_BaEn_4	684	690	PF01217	0.507
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.439
TRG_ENDOCYTIC_2	227	230	PF00928	0.404
TRG_ENDOCYTIC_2	383	386	PF00928	0.373
TRG_ENDOCYTIC_2	399	402	PF00928	0.402
TRG_ENDOCYTIC_2	425	428	PF00928	0.387
TRG_ENDOCYTIC_2	482	485	PF00928	0.412
TRG_ENDOCYTIC_2	497	500	PF00928	0.334
TRG_ENDOCYTIC_2	597	600	PF00928	0.378
TRG_ENDOCYTIC_2	697	700	PF00928	0.546
TRG_ER_diArg_1	2	4	PF00400	0.766
TRG_ER_diArg_1	270	273	PF00400	0.545
TRG_ER_diArg_1	309	311	PF00400	0.415
TRG_ER_diArg_1	47	49	PF00400	0.629
TRG_ER_diArg_1	575	577	PF00400	0.412
TRG_ER_diArg_1	605	608	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK7	Leptomonas seymouri	81%	100%
A0A0S4JUK7	Bodo saltans	65%	100%
A0A1X0NTZ9	Trypanosomatidae	75%	100%
A0A3Q8IH01	Leishmania donovani	90%	100%
C9ZRX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AY82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q991	Leishmania major	89%	100%
V5BUF5	Trypanosoma cruzi	73%	100%