C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEV6_LEIBR

TriTrypDb:

LbrM.26.1020 , LBRM2903_260015100

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEV6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.507
CLV_NRD_NRD_1	282	284	PF00675	0.587
CLV_PCSK_KEX2_1	217	219	PF00082	0.550
CLV_PCSK_KEX2_1	282	284	PF00082	0.587
CLV_PCSK_KEX2_1	5	7	PF00082	0.632
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.550
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.711
CLV_PCSK_SKI1_1	129	133	PF00082	0.415
CLV_PCSK_SKI1_1	161	165	PF00082	0.498
CLV_PCSK_SKI1_1	217	221	PF00082	0.568
DEG_APCC_DBOX_1	26	34	PF00400	0.512
DEG_SCF_FBW7_1	374	381	PF00400	0.620
DEG_SPOP_SBC_1	378	382	PF00917	0.735
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.694
DOC_MAPK_gen_1	217	225	PF00069	0.467
DOC_MAPK_gen_1	5	13	PF00069	0.556
DOC_MAPK_MEF2A_6	384	392	PF00069	0.493
DOC_MAPK_MEF2A_6	5	13	PF00069	0.596
DOC_PP1_RVXF_1	192	198	PF00149	0.514
DOC_PP2B_LxvP_1	11	14	PF13499	0.573
DOC_USP7_MATH_1	256	260	PF00917	0.419
DOC_USP7_MATH_1	361	365	PF00917	0.545
DOC_USP7_MATH_1	396	400	PF00917	0.644
DOC_WW_Pin1_4	122	127	PF00397	0.543
DOC_WW_Pin1_4	328	333	PF00397	0.587
DOC_WW_Pin1_4	334	339	PF00397	0.497
DOC_WW_Pin1_4	374	379	PF00397	0.601
DOC_WW_Pin1_4	383	388	PF00397	0.587
LIG_14-3-3_CanoR_1	129	138	PF00244	0.495
LIG_14-3-3_CanoR_1	344	348	PF00244	0.476
LIG_14-3-3_CanoR_1	6	12	PF00244	0.632
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BRCT_BRCA1_1	221	225	PF00533	0.454
LIG_Clathr_ClatBox_1	389	393	PF01394	0.483
LIG_FHA_1	130	136	PF00498	0.425
LIG_FHA_1	286	292	PF00498	0.714
LIG_FHA_1	337	343	PF00498	0.617
LIG_FHA_1	384	390	PF00498	0.592
LIG_FHA_1	57	63	PF00498	0.395
LIG_FHA_1	78	84	PF00498	0.477
LIG_FHA_1	8	14	PF00498	0.590
LIG_FHA_2	344	350	PF00498	0.469
LIG_FHA_2	366	372	PF00498	0.575
LIG_LIR_Gen_1	133	141	PF02991	0.282
LIG_LIR_Gen_1	85	94	PF02991	0.418
LIG_LIR_Nem_3	133	139	PF02991	0.273
LIG_LIR_Nem_3	222	228	PF02991	0.456
LIG_LIR_Nem_3	25	29	PF02991	0.487
LIG_LIR_Nem_3	85	89	PF02991	0.403
LIG_MLH1_MIPbox_1	221	225	PF16413	0.454
LIG_MYND_1	321	325	PF01753	0.480
LIG_PAM2_1	334	346	PF00658	0.620
LIG_Pex14_1	240	244	PF04695	0.530
LIG_Pex14_1	82	86	PF04695	0.354
LIG_PTB_Apo_2	391	398	PF02174	0.657
LIG_REV1ctd_RIR_1	222	231	PF16727	0.461
LIG_REV1ctd_RIR_1	241	249	PF16727	0.513
LIG_SH2_CRK	86	90	PF00017	0.430
LIG_SH2_NCK_1	108	112	PF00017	0.496
LIG_SH2_NCK_1	86	90	PF00017	0.351
LIG_SH2_STAP1	108	112	PF00017	0.426
LIG_SH2_STAT3	262	265	PF00017	0.600
LIG_SH2_STAT3	350	353	PF00017	0.480
LIG_SH2_STAT3	93	96	PF00017	0.546
LIG_SH2_STAT5	248	251	PF00017	0.552
LIG_SH2_STAT5	29	32	PF00017	0.504
LIG_SH2_STAT5	350	353	PF00017	0.480
LIG_SH2_STAT5	93	96	PF00017	0.436
LIG_SH3_1	154	160	PF00018	0.513
LIG_SH3_1	318	324	PF00018	0.671
LIG_SH3_3	145	151	PF00018	0.521
LIG_SH3_3	154	160	PF00018	0.450
LIG_SH3_3	318	324	PF00018	0.625
LIG_SH3_3	332	338	PF00018	0.628
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.628
LIG_SUMO_SIM_par_1	331	337	PF11976	0.632
LIG_SUMO_SIM_par_1	386	391	PF11976	0.490
LIG_SUMO_SIM_par_1	9	16	PF11976	0.495
LIG_UBA3_1	365	373	PF00899	0.630
MOD_CDK_SPxxK_3	122	129	PF00069	0.530
MOD_CK1_1	28	34	PF00069	0.515
MOD_CK1_1	331	337	PF00069	0.595
MOD_CK1_1	399	405	PF00069	0.691
MOD_CK1_1	75	81	PF00069	0.414
MOD_CK2_1	309	315	PF00069	0.582
MOD_CK2_1	316	322	PF00069	0.713
MOD_CK2_1	377	383	PF00069	0.731
MOD_GlcNHglycan	142	145	PF01048	0.440
MOD_GlcNHglycan	311	314	PF01048	0.533
MOD_GlcNHglycan	318	321	PF01048	0.600
MOD_GlcNHglycan	34	38	PF01048	0.593
MOD_GlcNHglycan	353	356	PF01048	0.613
MOD_GlcNHglycan	72	75	PF01048	0.414
MOD_GlcNHglycan	77	80	PF01048	0.369
MOD_GSK3_1	256	263	PF00069	0.592
MOD_GSK3_1	361	368	PF00069	0.553
MOD_GSK3_1	374	381	PF00069	0.590
MOD_GSK3_1	396	403	PF00069	0.621
MOD_GSK3_1	68	75	PF00069	0.434
MOD_N-GLC_1	267	272	PF02516	0.462
MOD_N-GLC_1	397	402	PF02516	0.656
MOD_NEK2_1	115	120	PF00069	0.502
MOD_NEK2_1	243	248	PF00069	0.529
MOD_NEK2_1	365	370	PF00069	0.553
MOD_NEK2_1	397	402	PF00069	0.621
MOD_NEK2_1	62	67	PF00069	0.358
MOD_NEK2_1	70	75	PF00069	0.391
MOD_NEK2_2	343	348	PF00069	0.468
MOD_OFUCOSY	174	180	PF10250	0.614
MOD_PIKK_1	115	121	PF00454	0.470
MOD_PIKK_1	149	155	PF00454	0.489
MOD_PIKK_1	397	403	PF00454	0.706
MOD_PIKK_1	68	74	PF00454	0.463
MOD_PKA_2	343	349	PF00069	0.483
MOD_PKA_2	351	357	PF00069	0.509
MOD_Plk_1	361	367	PF00069	0.550
MOD_Plk_4	219	225	PF00069	0.432
MOD_Plk_4	243	249	PF00069	0.563
MOD_Plk_4	331	337	PF00069	0.668
MOD_Plk_4	361	367	PF00069	0.550
MOD_Plk_4	62	68	PF00069	0.379
MOD_Plk_4	77	83	PF00069	0.303
MOD_ProDKin_1	122	128	PF00069	0.532
MOD_ProDKin_1	328	334	PF00069	0.580
MOD_ProDKin_1	374	380	PF00069	0.601
MOD_ProDKin_1	383	389	PF00069	0.586
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.585
TRG_ENDOCYTIC_2	175	178	PF00928	0.522
TRG_ENDOCYTIC_2	86	89	PF00928	0.354
TRG_ER_diArg_1	191	194	PF00400	0.463
TRG_ER_diArg_1	282	284	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL9	Leptomonas seymouri	83%	100%
A0A0S4II62	Bodo saltans	51%	100%
A0A1X0NSZ7	Trypanosomatidae	63%	100%
A0A3Q8IDL6	Leishmania donovani	95%	100%
A0A3R7NVU2	Trypanosoma rangeli	60%	100%
A4I230	Leishmania infantum	95%	100%
C9ZRX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	93%
E9AY79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q993	Leishmania major	95%	100%