Glucosidase 2 subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucosidase II beta subunit-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEV5_LEIBR

TriTrypDb:

LbrM.26.1010 , LBRM2903_260014900 , LBRM2903_260015000

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0017177	glucosidase II complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HEV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEV5

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	9
GO:0009100	glycoprotein metabolic process	4	7
GO:0009987	cellular process	1	9
GO:0019538	protein metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0016310	phosphorylation	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.287
CLV_C14_Caspase3-7	356	360	PF00656	0.352
CLV_C14_Caspase3-7	65	69	PF00656	0.188
CLV_NRD_NRD_1	154	156	PF00675	0.386
CLV_NRD_NRD_1	159	161	PF00675	0.352
CLV_NRD_NRD_1	171	173	PF00675	0.338
CLV_NRD_NRD_1	198	200	PF00675	0.609
CLV_NRD_NRD_1	279	281	PF00675	0.451
CLV_NRD_NRD_1	460	462	PF00675	0.381
CLV_PCSK_KEX2_1	170	172	PF00082	0.408
CLV_PCSK_KEX2_1	279	281	PF00082	0.460
CLV_PCSK_KEX2_1	370	372	PF00082	0.399
CLV_PCSK_KEX2_1	460	462	PF00082	0.381
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.399
CLV_PCSK_SKI1_1	293	297	PF00082	0.501
CLV_PCSK_SKI1_1	366	370	PF00082	0.503
DOC_CKS1_1	489	494	PF01111	0.250
DOC_CYCLIN_yCln2_LP_2	88	91	PF00134	0.193
DOC_MAPK_gen_1	160	166	PF00069	0.284
DOC_MAPK_gen_1	460	466	PF00069	0.181
DOC_PP1_RVXF_1	399	406	PF00149	0.181
DOC_PP2B_LxvP_1	372	375	PF13499	0.446
DOC_PP2B_LxvP_1	88	91	PF13499	0.193
DOC_PP4_FxxP_1	489	492	PF00568	0.237
DOC_USP7_MATH_1	248	252	PF00917	0.627
DOC_USP7_MATH_1	67	71	PF00917	0.245
DOC_USP7_MATH_1	73	77	PF00917	0.274
DOC_USP7_UBL2_3	366	370	PF12436	0.320
DOC_WW_Pin1_4	125	130	PF00397	0.289
DOC_WW_Pin1_4	370	375	PF00397	0.372
DOC_WW_Pin1_4	488	493	PF00397	0.250
LIG_14-3-3_CanoR_1	5	13	PF00244	0.446
LIG_14-3-3_CanoR_1	82	87	PF00244	0.449
LIG_BIR_II_1	1	5	PF00653	0.415
LIG_BRCT_BRCA1_1	103	107	PF00533	0.193
LIG_BRCT_BRCA1_1	485	489	PF00533	0.209
LIG_Clathr_ClatBox_1	383	387	PF01394	0.181
LIG_Clathr_ClatBox_1	474	478	PF01394	0.293
LIG_deltaCOP1_diTrp_1	273	278	PF00928	0.445
LIG_deltaCOP1_diTrp_1	92	95	PF00928	0.210
LIG_FHA_1	126	132	PF00498	0.193
LIG_FHA_1	342	348	PF00498	0.376
LIG_FHA_1	377	383	PF00498	0.298
LIG_FHA_1	397	403	PF00498	0.162
LIG_FHA_1	489	495	PF00498	0.214
LIG_FHA_1	83	89	PF00498	0.315
LIG_FHA_2	147	153	PF00498	0.193
LIG_FHA_2	344	350	PF00498	0.602
LIG_FHA_2	376	382	PF00498	0.385
LIG_HCF-1_HBM_1	397	400	PF13415	0.181
LIG_LIR_Apic_2	486	492	PF02991	0.193
LIG_LIR_Gen_1	259	265	PF02991	0.299
LIG_LIR_Gen_1	273	282	PF02991	0.340
LIG_LIR_Gen_1	417	422	PF02991	0.181
LIG_LIR_Gen_1	440	448	PF02991	0.184
LIG_LIR_Gen_1	53	63	PF02991	0.293
LIG_LIR_Nem_3	259	264	PF02991	0.419
LIG_LIR_Nem_3	273	278	PF02991	0.357
LIG_LIR_Nem_3	349	354	PF02991	0.287
LIG_LIR_Nem_3	397	403	PF02991	0.292
LIG_LIR_Nem_3	417	421	PF02991	0.318
LIG_LIR_Nem_3	44	48	PF02991	0.233
LIG_LIR_Nem_3	479	485	PF02991	0.220
LIG_LIR_Nem_3	53	59	PF02991	0.193
LIG_Pex14_2	236	240	PF04695	0.285
LIG_SH2_CRK	22	26	PF00017	0.193
LIG_SH2_CRK	400	404	PF00017	0.285
LIG_SH2_CRK	418	422	PF00017	0.163
LIG_SH2_NCK_1	22	26	PF00017	0.193
LIG_SH2_SRC	448	451	PF00017	0.332
LIG_SH2_STAP1	22	26	PF00017	0.219
LIG_SH2_STAP1	418	422	PF00017	0.181
LIG_SH2_STAP1	485	489	PF00017	0.183
LIG_SH2_STAT5	271	274	PF00017	0.406
LIG_SH2_STAT5	322	325	PF00017	0.566
LIG_SH2_STAT5	35	38	PF00017	0.222
LIG_SH2_STAT5	352	355	PF00017	0.286
LIG_SH3_3	14	20	PF00018	0.233
LIG_SH3_3	464	470	PF00018	0.259
LIG_SH3_3	474	480	PF00018	0.213
LIG_SUMO_SIM_anti_2	191	198	PF11976	0.307
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.193
LIG_SUMO_SIM_par_1	343	350	PF11976	0.331
LIG_SUMO_SIM_par_1	378	387	PF11976	0.310
LIG_SUMO_SIM_par_1	473	479	PF11976	0.277
LIG_TRAF2_1	149	152	PF00917	0.274
LIG_TRAF2_1	378	381	PF00917	0.337
LIG_TYR_ITIM	416	421	PF00017	0.181
MOD_CK1_1	221	227	PF00069	0.653
MOD_CK1_1	251	257	PF00069	0.512
MOD_CK1_1	266	272	PF00069	0.345
MOD_CK1_1	343	349	PF00069	0.439
MOD_CK1_1	373	379	PF00069	0.504
MOD_CK1_1	431	437	PF00069	0.279
MOD_CK1_1	84	90	PF00069	0.290
MOD_CK2_1	146	152	PF00069	0.392
MOD_CK2_1	221	227	PF00069	0.509
MOD_CK2_1	343	349	PF00069	0.486
MOD_CK2_1	375	381	PF00069	0.370
MOD_CK2_1	424	430	PF00069	0.343
MOD_GlcNHglycan	156	159	PF01048	0.273
MOD_GlcNHglycan	265	268	PF01048	0.492
MOD_GlcNHglycan	456	459	PF01048	0.399
MOD_GlcNHglycan	49	53	PF01048	0.250
MOD_GlcNHglycan	75	78	PF01048	0.197
MOD_GSK3_1	259	266	PF00069	0.480
MOD_GSK3_1	305	312	PF00069	0.534
MOD_GSK3_1	424	431	PF00069	0.272
MOD_GSK3_1	437	444	PF00069	0.208
MOD_GSK3_1	50	57	PF00069	0.273
MOD_LATS_1	186	192	PF00433	0.300
MOD_N-GLC_1	218	223	PF02516	0.597
MOD_N-GLC_1	248	253	PF02516	0.529
MOD_N-GLC_1	309	314	PF02516	0.540
MOD_N-GLC_2	134	136	PF02516	0.188
MOD_NEK2_1	4	9	PF00069	0.560
MOD_NEK2_1	428	433	PF00069	0.310
MOD_NEK2_1	48	53	PF00069	0.260
MOD_NEK2_1	81	86	PF00069	0.193
MOD_OFUCOSY	313	320	PF10250	0.375
MOD_PIKK_1	101	107	PF00454	0.193
MOD_PKA_2	146	152	PF00069	0.193
MOD_PKA_2	154	160	PF00069	0.405
MOD_PKA_2	240	246	PF00069	0.369
MOD_PKA_2	251	257	PF00069	0.503
MOD_PKA_2	4	10	PF00069	0.398
MOD_PKA_2	81	87	PF00069	0.193
MOD_Plk_1	221	227	PF00069	0.543
MOD_Plk_1	396	402	PF00069	0.316
MOD_Plk_1	429	435	PF00069	0.237
MOD_Plk_1	441	447	PF00069	0.237
MOD_Plk_2-3	259	265	PF00069	0.299
MOD_Plk_4	416	422	PF00069	0.288
MOD_Plk_4	483	489	PF00069	0.193
MOD_Plk_4	84	90	PF00069	0.462
MOD_ProDKin_1	125	131	PF00069	0.289
MOD_ProDKin_1	370	376	PF00069	0.372
MOD_ProDKin_1	488	494	PF00069	0.250
MOD_SUMO_rev_2	157	162	PF00179	0.363
MOD_SUMO_rev_2	197	202	PF00179	0.413
MOD_SUMO_rev_2	221	231	PF00179	0.467
MOD_SUMO_rev_2	387	393	PF00179	0.324
TRG_DiLeu_BaEn_4	206	212	PF01217	0.474
TRG_ENDOCYTIC_2	22	25	PF00928	0.386
TRG_ENDOCYTIC_2	351	354	PF00928	0.276
TRG_ENDOCYTIC_2	400	403	PF00928	0.285
TRG_ENDOCYTIC_2	418	421	PF00928	0.163
TRG_ENDOCYTIC_2	485	488	PF00928	0.237
TRG_ER_diArg_1	170	172	PF00400	0.402
TRG_ER_diArg_1	278	280	PF00400	0.438
TRG_ER_diArg_1	460	462	PF00400	0.181
TRG_NLS_MonoExtN_4	366	373	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.193

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ILH9	Bodo saltans	33%	100%
A0A1X0NSB3	Trypanosomatidae	34%	100%
A0A3Q8IDT4	Leishmania donovani	52%	100%
A0A3R7L6D4	Trypanosoma rangeli	33%	100%
A4I229	Leishmania infantum	52%	100%
C9ZRX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AY78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q4Q994	Leishmania major	52%	100%
V5DQZ5	Trypanosoma cruzi	31%	100%