60S ribosomal export protein NMD3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NMD3 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HEV2_LEIBR

TriTrypDb:

LbrM.26.0980 , LBRM2903_260014600

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HEV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEV2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000055	ribosomal large subunit export from nucleus	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051640	organelle localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043023	ribosomal large subunit binding	4	12
GO:0044877	protein-containing complex binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.421
CLV_C14_Caspase3-7	44	48	PF00656	0.443
CLV_C14_Caspase3-7	446	450	PF00656	0.368
CLV_C14_Caspase3-7	546	550	PF00656	0.766
CLV_NRD_NRD_1	233	235	PF00675	0.225
CLV_NRD_NRD_1	412	414	PF00675	0.327
CLV_NRD_NRD_1	422	424	PF00675	0.362
CLV_NRD_NRD_1	425	427	PF00675	0.377
CLV_NRD_NRD_1	477	479	PF00675	0.431
CLV_NRD_NRD_1	556	558	PF00675	0.566
CLV_PCSK_FUR_1	423	427	PF00082	0.389
CLV_PCSK_KEX2_1	120	122	PF00082	0.221
CLV_PCSK_KEX2_1	192	194	PF00082	0.307
CLV_PCSK_KEX2_1	233	235	PF00082	0.225
CLV_PCSK_KEX2_1	422	424	PF00082	0.365
CLV_PCSK_KEX2_1	425	427	PF00082	0.375
CLV_PCSK_KEX2_1	87	89	PF00082	0.221
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.221
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.307
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.221
CLV_PCSK_SKI1_1	120	124	PF00082	0.221
CLV_PCSK_SKI1_1	130	134	PF00082	0.221
CLV_PCSK_SKI1_1	158	162	PF00082	0.221
CLV_PCSK_SKI1_1	180	184	PF00082	0.227
CLV_PCSK_SKI1_1	413	417	PF00082	0.495
CLV_PCSK_SKI1_1	79	83	PF00082	0.232
CLV_PCSK_SKI1_1	87	91	PF00082	0.232
DEG_APCC_DBOX_1	263	271	PF00400	0.295
DEG_COP1_1	506	518	PF00400	0.540
DEG_Nend_UBRbox_2	1	3	PF02207	0.585
DEG_ODPH_VHL_1	259	270	PF01847	0.328
DOC_CYCLIN_yClb1_LxF_4	219	225	PF00134	0.432
DOC_MAPK_gen_1	120	128	PF00069	0.421
DOC_MAPK_gen_1	179	185	PF00069	0.421
DOC_MAPK_gen_1	233	239	PF00069	0.430
DOC_MAPK_gen_1	425	435	PF00069	0.363
DOC_MAPK_MEF2A_6	120	128	PF00069	0.421
DOC_MAPK_MEF2A_6	79	86	PF00069	0.423
DOC_MAPK_NFAT4_5	121	129	PF00069	0.517
DOC_PP2B_LxvP_1	65	68	PF13499	0.434
DOC_PP4_FxxP_1	298	301	PF00568	0.386
DOC_USP7_MATH_1	10	14	PF00917	0.558
DOC_USP7_MATH_1	213	217	PF00917	0.446
DOC_USP7_MATH_1	318	322	PF00917	0.443
DOC_USP7_MATH_1	454	458	PF00917	0.495
DOC_USP7_UBL2_3	175	179	PF12436	0.421
LIG_14-3-3_CanoR_1	12	16	PF00244	0.572
LIG_14-3-3_CanoR_1	125	129	PF00244	0.517
LIG_14-3-3_CanoR_1	173	183	PF00244	0.401
LIG_Actin_WH2_2	289	307	PF00022	0.333
LIG_APCC_ABBA_1	269	274	PF00400	0.481
LIG_APCC_ABBAyCdc20_2	180	186	PF00400	0.421
LIG_BRCT_BRCA1_1	294	298	PF00533	0.397
LIG_FAT_LD_1	520	528	PF03623	0.469
LIG_FHA_1	226	232	PF00498	0.512
LIG_FHA_1	252	258	PF00498	0.421
LIG_FHA_1	308	314	PF00498	0.471
LIG_FHA_1	343	349	PF00498	0.371
LIG_FHA_1	350	356	PF00498	0.278
LIG_FHA_1	44	50	PF00498	0.427
LIG_FHA_1	81	87	PF00498	0.421
LIG_FHA_2	230	236	PF00498	0.421
LIG_FHA_2	322	328	PF00498	0.454
LIG_LIR_Apic_2	295	301	PF02991	0.377
LIG_LIR_Apic_2	312	318	PF02991	0.281
LIG_LIR_Gen_1	131	141	PF02991	0.474
LIG_LIR_Gen_1	181	190	PF02991	0.421
LIG_LIR_Gen_1	196	205	PF02991	0.435
LIG_LIR_Gen_1	52	59	PF02991	0.421
LIG_LIR_Nem_3	131	136	PF02991	0.474
LIG_LIR_Nem_3	181	185	PF02991	0.421
LIG_LIR_Nem_3	196	201	PF02991	0.435
LIG_LIR_Nem_3	330	334	PF02991	0.323
LIG_LIR_Nem_3	52	56	PF02991	0.421
LIG_LRP6_Inhibitor_1	194	200	PF00058	0.317
LIG_PCNA_yPIPBox_3	12	26	PF02747	0.525
LIG_Pex14_1	315	319	PF04695	0.355
LIG_PTB_Apo_2	340	347	PF02174	0.361
LIG_PTB_Phospho_1	340	346	PF10480	0.382
LIG_REV1ctd_RIR_1	209	219	PF16727	0.432
LIG_SH2_PTP2	53	56	PF00017	0.421
LIG_SH2_STAT3	184	187	PF00017	0.446
LIG_SH2_STAT5	146	149	PF00017	0.432
LIG_SH2_STAT5	184	187	PF00017	0.446
LIG_SH2_STAT5	276	279	PF00017	0.375
LIG_SH2_STAT5	332	335	PF00017	0.339
LIG_SH2_STAT5	384	387	PF00017	0.326
LIG_SH2_STAT5	53	56	PF00017	0.422
LIG_SH2_STAT5	64	67	PF00017	0.438
LIG_SH3_3	371	377	PF00018	0.474
LIG_SH3_5	271	275	PF00018	0.506
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.293
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.345
LIG_TRAF2_1	519	522	PF00917	0.519
LIG_TRAF2_2	403	408	PF00917	0.455
LIG_UBA3_1	267	273	PF00899	0.495
LIG_UBA3_1	81	87	PF00899	0.421
LIG_WW_1	67	70	PF00397	0.421
MOD_CK1_1	241	247	PF00069	0.494
MOD_CK1_1	29	35	PF00069	0.455
MOD_CK1_1	321	327	PF00069	0.415
MOD_CK1_1	541	547	PF00069	0.513
MOD_CK1_1	95	101	PF00069	0.517
MOD_CK2_1	321	327	PF00069	0.383
MOD_CK2_1	545	551	PF00069	0.722
MOD_GlcNHglycan	100	103	PF01048	0.317
MOD_GlcNHglycan	445	448	PF01048	0.504
MOD_GlcNHglycan	456	459	PF01048	0.609
MOD_GlcNHglycan	94	97	PF01048	0.317
MOD_GSK3_1	112	119	PF00069	0.425
MOD_GSK3_1	174	181	PF00069	0.390
MOD_GSK3_1	225	232	PF00069	0.498
MOD_GSK3_1	241	248	PF00069	0.362
MOD_GSK3_1	318	325	PF00069	0.350
MOD_GSK3_1	349	356	PF00069	0.323
MOD_GSK3_1	443	450	PF00069	0.348
MOD_GSK3_1	541	548	PF00069	0.509
MOD_GSK3_1	91	98	PF00069	0.511
MOD_N-GLC_1	225	230	PF02516	0.312
MOD_N-GLC_1	245	250	PF02516	0.232
MOD_N-GLC_1	29	34	PF02516	0.312
MOD_N-GLC_1	342	347	PF02516	0.437
MOD_N-GLC_1	454	459	PF02516	0.634
MOD_N-GLC_1	92	97	PF02516	0.317
MOD_N-GLC_1	98	103	PF02516	0.317
MOD_N-GLC_2	33	35	PF02516	0.221
MOD_NEK2_1	124	129	PF00069	0.486
MOD_NEK2_1	225	230	PF00069	0.512
MOD_NEK2_1	92	97	PF00069	0.520
MOD_PIKK_1	415	421	PF00454	0.460
MOD_PIKK_1	435	441	PF00454	0.251
MOD_PKA_2	11	17	PF00069	0.565
MOD_PKA_2	124	130	PF00069	0.517
MOD_Plk_1	10	16	PF00069	0.447
MOD_Plk_1	245	251	PF00069	0.440
MOD_Plk_1	538	544	PF00069	0.724
MOD_Plk_2-3	545	551	PF00069	0.649
MOD_Plk_4	178	184	PF00069	0.432
MOD_Plk_4	292	298	PF00069	0.313
MOD_Plk_4	309	315	PF00069	0.332
MOD_Plk_4	376	382	PF00069	0.244
MOD_Plk_4	538	544	PF00069	0.644
TRG_DiLeu_BaEn_1	265	270	PF01217	0.305
TRG_DiLeu_BaEn_1	77	82	PF01217	0.421
TRG_ENDOCYTIC_2	484	487	PF00928	0.443
TRG_ENDOCYTIC_2	53	56	PF00928	0.421
TRG_ER_diArg_1	422	425	PF00400	0.391
TRG_NLS_Bipartite_1	179	195	PF00514	0.517
TRG_NLS_MonoExtC_3	190	196	PF00514	0.517
TRG_NLS_MonoExtC_3	556	561	PF00514	0.583
TRG_NLS_MonoExtN_4	117	124	PF00514	0.421
TRG_NLS_MonoExtN_4	557	562	PF00514	0.529
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P651	Leptomonas seymouri	84%	100%
A0A0S4IPD8	Bodo saltans	58%	100%
A0A1X0NSC0	Trypanosomatidae	62%	100%
A0A3S5IRS4	Trypanosoma rangeli	67%	100%
A0A3S7WZS7	Leishmania donovani	91%	100%
A4I226	Leishmania infantum	91%	100%
C9ZRY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AY75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
G0S488	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	38%	100%
P38861	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
Q08DS5	Bos taurus	37%	100%
Q09817	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
Q4Q997	Leishmania major	88%	100%
Q55BF2	Dictyostelium discoideum	42%	100%
Q5BLF0	Danio rerio	36%	100%
Q5RC82	Pongo abelii	37%	100%
Q6GNS3	Xenopus laevis	36%	100%
Q6P2Z6	Xenopus tropicalis	36%	100%
Q96D46	Homo sapiens	37%	100%
Q99L48	Mus musculus	37%	100%
V5BUG5	Trypanosoma cruzi	64%	100%