Mcp5_PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meiotic cell cortex C-terminal pleckstrin homology, putative

Species:

Leishmania braziliensis

UniProt:

A4HEV0_LEIBR

TriTrypDb:

LbrM.26.0960 , LBRM2903_260014400

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005938	cell cortex	3	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HEV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEV0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	6
GO:0032065	maintenance of protein location in cell cortex	4	6
GO:0032507	maintenance of protein location in cell	3	6
GO:0045185	maintenance of protein location	3	6
GO:0051179	localization	1	6
GO:0051235	maintenance of location	2	6
GO:0051651	maintenance of location in cell	2	6

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005543	phospholipid binding	3	6
GO:0008289	lipid binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.486
CLV_NRD_NRD_1	113	115	PF00675	0.849
CLV_NRD_NRD_1	338	340	PF00675	0.277
CLV_PCSK_KEX2_1	113	115	PF00082	0.849
CLV_PCSK_KEX2_1	338	340	PF00082	0.277
CLV_PCSK_PC7_1	109	115	PF00082	0.603
CLV_PCSK_SKI1_1	293	297	PF00082	0.397
CLV_PCSK_SKI1_1	311	315	PF00082	0.390
CLV_PCSK_SKI1_1	358	362	PF00082	0.266
DEG_SCF_FBW7_1	1	7	PF00400	0.652
DEG_SPOP_SBC_1	479	483	PF00917	0.803
DOC_CKS1_1	1	6	PF01111	0.660
DOC_CYCLIN_RxL_1	290	297	PF00134	0.394
DOC_CYCLIN_RxL_1	307	317	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.595
DOC_MAPK_gen_1	113	123	PF00069	0.608
DOC_MAPK_gen_1	307	314	PF00069	0.399
DOC_MAPK_gen_1	338	345	PF00069	0.485
DOC_MAPK_MEF2A_6	307	314	PF00069	0.554
DOC_MAPK_MEF2A_6	338	345	PF00069	0.485
DOC_PP2B_LxvP_1	93	96	PF13499	0.810
DOC_USP7_MATH_1	11	15	PF00917	0.606
DOC_USP7_MATH_1	141	145	PF00917	0.690
DOC_USP7_MATH_1	299	303	PF00917	0.670
DOC_USP7_MATH_1	356	360	PF00917	0.401
DOC_USP7_MATH_1	42	46	PF00917	0.818
DOC_USP7_MATH_1	436	440	PF00917	0.781
DOC_USP7_MATH_1	468	472	PF00917	0.662
DOC_USP7_MATH_1	49	53	PF00917	0.746
DOC_USP7_MATH_1	96	100	PF00917	0.852
DOC_WW_Pin1_4	121	126	PF00397	0.870
DOC_WW_Pin1_4	174	179	PF00397	0.705
DOC_WW_Pin1_4	22	27	PF00397	0.769
DOC_WW_Pin1_4	372	377	PF00397	0.530
DOC_WW_Pin1_4	44	49	PF00397	0.698
DOC_WW_Pin1_4	453	458	PF00397	0.665
DOC_WW_Pin1_4	462	467	PF00397	0.631
DOC_WW_Pin1_4	6	11	PF00397	0.568
LIG_14-3-3_CanoR_1	116	122	PF00244	0.709
LIG_14-3-3_CanoR_1	154	159	PF00244	0.761
LIG_14-3-3_CanoR_1	187	193	PF00244	0.833
LIG_14-3-3_CanoR_1	19	27	PF00244	0.592
LIG_14-3-3_CanoR_1	247	252	PF00244	0.461
LIG_14-3-3_CanoR_1	276	281	PF00244	0.585
LIG_14-3-3_CanoR_1	284	292	PF00244	0.656
LIG_14-3-3_CanoR_1	398	403	PF00244	0.528
LIG_14-3-3_CanoR_1	435	441	PF00244	0.784
LIG_14-3-3_CanoR_1	450	458	PF00244	0.454
LIG_14-3-3_CanoR_1	61	70	PF00244	0.637
LIG_Actin_WH2_2	306	324	PF00022	0.277
LIG_BRCT_BRCA1_1	163	167	PF00533	0.602
LIG_BRCT_BRCA1_1	358	362	PF00533	0.277
LIG_deltaCOP1_diTrp_1	325	330	PF00928	0.530
LIG_EH_1	243	247	PF12763	0.745
LIG_EVH1_2	262	266	PF00568	0.745
LIG_FHA_1	1	7	PF00498	0.820
LIG_FHA_1	424	430	PF00498	0.624
LIG_FHA_1	95	101	PF00498	0.598
LIG_FHA_2	217	223	PF00498	0.604
LIG_FHA_2	301	307	PF00498	0.666
LIG_FHA_2	63	69	PF00498	0.554
LIG_Integrin_isoDGR_2	135	137	PF01839	0.618
LIG_Integrin_RGD_1	137	139	PF01839	0.607
LIG_LIR_Gen_1	248	258	PF02991	0.690
LIG_LIR_Gen_1	411	422	PF02991	0.530
LIG_LIR_Nem_3	248	254	PF02991	0.684
LIG_LIR_Nem_3	411	417	PF02991	0.530
LIG_LIR_Nem_3	452	458	PF02991	0.745
LIG_LIR_Nem_3	9	15	PF02991	0.685
LIG_Pex14_1	451	455	PF04695	0.756
LIG_PTAP_UEV_1	162	167	PF05743	0.601
LIG_PTB_Apo_2	254	261	PF02174	0.723
LIG_PTB_Apo_2	469	476	PF02174	0.551
LIG_PTB_Phospho_1	254	260	PF10480	0.720
LIG_PTB_Phospho_1	469	475	PF10480	0.552
LIG_REV1ctd_RIR_1	385	394	PF16727	0.530
LIG_SH2_CRK	12	16	PF00017	0.595
LIG_SH2_CRK	260	264	PF00017	0.484
LIG_SH2_CRK	414	418	PF00017	0.455
LIG_SH2_CRK	455	459	PF00017	0.763
LIG_SH2_GRB2like	475	478	PF00017	0.559
LIG_SH2_NCK_1	12	16	PF00017	0.583
LIG_SH2_PTP2	340	343	PF00017	0.530
LIG_SH2_SRC	475	478	PF00017	0.811
LIG_SH2_STAP1	269	273	PF00017	0.483
LIG_SH2_STAT3	234	237	PF00017	0.793
LIG_SH2_STAT3	36	39	PF00017	0.608
LIG_SH2_STAT5	12	15	PF00017	0.724
LIG_SH2_STAT5	234	237	PF00017	0.793
LIG_SH2_STAT5	240	243	PF00017	0.677
LIG_SH2_STAT5	340	343	PF00017	0.530
LIG_SH3_2	125	130	PF14604	0.608
LIG_SH3_3	122	128	PF00018	0.671
LIG_SH3_3	160	166	PF00018	0.754
LIG_SH3_3	202	208	PF00018	0.678
LIG_SH3_3	252	258	PF00018	0.467
LIG_SH3_3	378	384	PF00018	0.277
LIG_TRAF2_1	250	253	PF00917	0.470
LIG_TRAF2_1	303	306	PF00917	0.666
LIG_TRAF2_1	65	68	PF00917	0.551
LIG_TYR_ITIM	412	417	PF00017	0.530
LIG_WRC_WIRS_1	277	282	PF05994	0.491
MOD_CK1_1	119	125	PF00069	0.713
MOD_CK1_1	149	155	PF00069	0.671
MOD_CK1_1	18	24	PF00069	0.822
MOD_CK1_1	279	285	PF00069	0.600
MOD_CK1_1	392	398	PF00069	0.416
MOD_CK1_1	401	407	PF00069	0.495
MOD_CK1_1	449	455	PF00069	0.711
MOD_CK2_1	109	115	PF00069	0.818
MOD_CK2_1	216	222	PF00069	0.607
MOD_CK2_1	247	253	PF00069	0.462
MOD_CK2_1	299	305	PF00069	0.674
MOD_CK2_1	313	319	PF00069	0.299
MOD_CK2_1	62	68	PF00069	0.553
MOD_GlcNHglycan	104	107	PF01048	0.690
MOD_GlcNHglycan	143	146	PF01048	0.646
MOD_GlcNHglycan	15	18	PF01048	0.652
MOD_GlcNHglycan	163	166	PF01048	0.519
MOD_GlcNHglycan	354	357	PF01048	0.480
MOD_GlcNHglycan	358	361	PF01048	0.514
MOD_GlcNHglycan	42	45	PF01048	0.818
MOD_GlcNHglycan	51	54	PF01048	0.712
MOD_GSK3_1	117	124	PF00069	0.856
MOD_GSK3_1	141	148	PF00069	0.741
MOD_GSK3_1	149	156	PF00069	0.819
MOD_GSK3_1	170	177	PF00069	0.647
MOD_GSK3_1	18	25	PF00069	0.616
MOD_GSK3_1	216	223	PF00069	0.605
MOD_GSK3_1	272	279	PF00069	0.470
MOD_GSK3_1	346	353	PF00069	0.420
MOD_GSK3_1	366	373	PF00069	0.401
MOD_GSK3_1	40	47	PF00069	0.710
MOD_GSK3_1	418	425	PF00069	0.382
MOD_GSK3_1	446	453	PF00069	0.690
MOD_GSK3_1	6	13	PF00069	0.588
MOD_N-GLC_1	149	154	PF02516	0.589
MOD_N-GLC_1	423	428	PF02516	0.608
MOD_N-GLC_1	468	473	PF02516	0.740
MOD_N-GLC_2	71	73	PF02516	0.540
MOD_NEK2_1	140	145	PF00069	0.640
MOD_NEK2_1	153	158	PF00069	0.604
MOD_NEK2_1	188	193	PF00069	0.590
MOD_NEK2_1	280	285	PF00069	0.587
MOD_NEK2_1	291	296	PF00069	0.427
MOD_NEK2_1	313	318	PF00069	0.348
MOD_NEK2_1	35	40	PF00069	0.859
MOD_NEK2_1	350	355	PF00069	0.394
MOD_NEK2_1	418	423	PF00069	0.277
MOD_PIKK_1	170	176	PF00454	0.617
MOD_PIKK_1	238	244	PF00454	0.772
MOD_PIKK_1	245	251	PF00454	0.605
MOD_PIKK_1	267	273	PF00454	0.540
MOD_PIKK_1	283	289	PF00454	0.634
MOD_PIKK_1	35	41	PF00454	0.746
MOD_PIKK_1	392	398	PF00454	0.277
MOD_PIKK_1	85	91	PF00454	0.710
MOD_PKA_1	220	226	PF00069	0.593
MOD_PKA_2	117	123	PF00069	0.653
MOD_PKA_2	153	159	PF00069	0.703
MOD_PKA_2	18	24	PF00069	0.763
MOD_PKA_2	186	192	PF00069	0.833
MOD_PKA_2	283	289	PF00069	0.696
MOD_PKA_2	346	352	PF00069	0.491
MOD_PKA_2	389	395	PF00069	0.277
MOD_PKA_2	434	440	PF00069	0.780
MOD_PKA_2	449	455	PF00069	0.456
MOD_PKB_1	114	122	PF00069	0.606
MOD_Plk_1	149	155	PF00069	0.590
MOD_Plk_1	200	206	PF00069	0.592
MOD_Plk_4	200	206	PF00069	0.667
MOD_Plk_4	346	352	PF00069	0.530
MOD_Plk_4	367	373	PF00069	0.277
MOD_ProDKin_1	121	127	PF00069	0.868
MOD_ProDKin_1	174	180	PF00069	0.704
MOD_ProDKin_1	22	28	PF00069	0.785
MOD_ProDKin_1	372	378	PF00069	0.530
MOD_ProDKin_1	44	50	PF00069	0.698
MOD_ProDKin_1	453	459	PF00069	0.664
MOD_ProDKin_1	462	468	PF00069	0.633
MOD_ProDKin_1	6	12	PF00069	0.572
MOD_SUMO_rev_2	25	35	PF00179	0.588
MOD_SUMO_rev_2	359	369	PF00179	0.530
TRG_ENDOCYTIC_2	12	15	PF00928	0.724
TRG_ENDOCYTIC_2	340	343	PF00928	0.530
TRG_ENDOCYTIC_2	414	417	PF00928	0.455
TRG_ENDOCYTIC_2	455	458	PF00928	0.766
TRG_ER_diArg_1	338	340	PF00400	0.277
TRG_NES_CRM1_1	382	397	PF08389	0.277
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IP29	Leishmania donovani	58%	79%
A4I224	Leishmania infantum	58%	79%
E9AY73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	79%
Q4Q999	Leishmania major	57%	100%