Mcp5_PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meiotic cell cortex C-terminal pleckstrin homology, putative

Species:

Leishmania braziliensis

UniProt:

A4HEV0_LEIBR

TriTrypDb:

LbrM.26.0960 , LBRM2903_260014400

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005938	cell cortex	3	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A4HEV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEV0

Function

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Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	6
GO:0032065	maintenance of protein location in cell cortex	4	6
GO:0032507	maintenance of protein location in cell	3	6
GO:0045185	maintenance of protein location	3	6
GO:0051179	localization	1	6
GO:0051235	maintenance of location	2	6
GO:0051651	maintenance of location in cell	2	6

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005543	phospholipid binding	3	6
GO:0008289	lipid binding	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.486
CLV_NRD_NRD_1	113	115	PF00675	0.849
CLV_NRD_NRD_1	338	340	PF00675	0.277
CLV_PCSK_KEX2_1	113	115	PF00082	0.849
CLV_PCSK_KEX2_1	338	340	PF00082	0.277
CLV_PCSK_PC7_1	109	115	PF00082	0.603
CLV_PCSK_SKI1_1	293	297	PF00082	0.397
CLV_PCSK_SKI1_1	311	315	PF00082	0.390
CLV_PCSK_SKI1_1	358	362	PF00082	0.266
DEG_SCF_FBW7_1	1	7	PF00400	0.652

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IP29	Leishmania donovani	58%	79%
A4I224	Leishmania infantum	58%	79%
E9AY73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	79%
Q4Q999	Leishmania major	57%	100%

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