J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain/Domain of unknown function (DUF3395), putative

Species:

Leishmania braziliensis

UniProt:

A4HEU9_LEIBR

TriTrypDb:

LbrM.26.0950 , LBRM2903_260014300

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HEU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEU9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0007007	inner mitochondrial membrane organization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0042407	cristae formation	7	1
GO:0061024	membrane organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.595
CLV_C14_Caspase3-7	179	183	PF00656	0.548
CLV_C14_Caspase3-7	22	26	PF00656	0.565
CLV_C14_Caspase3-7	85	89	PF00656	0.341
CLV_NRD_NRD_1	122	124	PF00675	0.467
CLV_NRD_NRD_1	337	339	PF00675	0.695
CLV_NRD_NRD_1	451	453	PF00675	0.479
CLV_NRD_NRD_1	504	506	PF00675	0.308
CLV_NRD_NRD_1	53	55	PF00675	0.335
CLV_NRD_NRD_1	646	648	PF00675	0.279
CLV_NRD_NRD_1	680	682	PF00675	0.393
CLV_NRD_NRD_1	734	736	PF00675	0.349
CLV_NRD_NRD_1	812	814	PF00675	0.321
CLV_PCSK_FUR_1	335	339	PF00082	0.506
CLV_PCSK_KEX2_1	122	124	PF00082	0.463
CLV_PCSK_KEX2_1	337	339	PF00082	0.498
CLV_PCSK_KEX2_1	451	453	PF00082	0.502
CLV_PCSK_KEX2_1	53	55	PF00082	0.335
CLV_PCSK_KEX2_1	725	727	PF00082	0.426
CLV_PCSK_KEX2_1	814	816	PF00082	0.277
CLV_PCSK_PC1ET2_1	725	727	PF00082	0.319
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.337
CLV_PCSK_SKI1_1	112	116	PF00082	0.483
CLV_PCSK_SKI1_1	141	145	PF00082	0.483
CLV_PCSK_SKI1_1	337	341	PF00082	0.533
CLV_PCSK_SKI1_1	353	357	PF00082	0.497
CLV_PCSK_SKI1_1	383	387	PF00082	0.436
CLV_PCSK_SKI1_1	506	510	PF00082	0.526
CLV_PCSK_SKI1_1	53	57	PF00082	0.301
CLV_PCSK_SKI1_1	722	726	PF00082	0.319
DEG_Nend_UBRbox_2	1	3	PF02207	0.594
DEG_SCF_FBW7_1	365	370	PF00400	0.365
DEG_SPOP_SBC_1	319	323	PF00917	0.687
DEG_SPOP_SBC_1	435	439	PF00917	0.321
DOC_CKS1_1	240	245	PF01111	0.620
DOC_CKS1_1	364	369	PF01111	0.453
DOC_CKS1_1	798	803	PF01111	0.393
DOC_CYCLIN_RxL_1	306	317	PF00134	0.434
DOC_CYCLIN_RxL_1	332	343	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	617	623	PF00134	0.480
DOC_MAPK_DCC_7	597	605	PF00069	0.475
DOC_MAPK_gen_1	505	511	PF00069	0.491
DOC_MAPK_gen_1	53	59	PF00069	0.305
DOC_MAPK_gen_1	550	558	PF00069	0.464
DOC_MAPK_gen_1	660	668	PF00069	0.393
DOC_MAPK_gen_1	678	688	PF00069	0.393
DOC_MAPK_gen_1	813	820	PF00069	0.291
DOC_MAPK_HePTP_8	590	602	PF00069	0.389
DOC_MAPK_MEF2A_6	593	602	PF00069	0.440
DOC_MAPK_MEF2A_6	757	765	PF00069	0.341
DOC_PP1_RVXF_1	342	349	PF00149	0.499
DOC_PP1_RVXF_1	805	812	PF00149	0.327
DOC_PP2B_LxvP_1	617	620	PF13499	0.410
DOC_PP2B_LxvP_1	780	783	PF13499	0.276
DOC_PP4_FxxP_1	364	367	PF00568	0.394
DOC_PP4_FxxP_1	793	796	PF00568	0.276
DOC_USP7_MATH_1	184	188	PF00917	0.695
DOC_USP7_MATH_1	226	230	PF00917	0.743
DOC_USP7_MATH_1	318	322	PF00917	0.533
DOC_USP7_MATH_1	435	439	PF00917	0.429
DOC_USP7_MATH_1	535	539	PF00917	0.553
DOC_USP7_MATH_1	592	596	PF00917	0.546
DOC_USP7_MATH_1	667	671	PF00917	0.365
DOC_USP7_MATH_1	739	743	PF00917	0.334
DOC_USP7_MATH_1	755	759	PF00917	0.165
DOC_WW_Pin1_4	205	210	PF00397	0.637
DOC_WW_Pin1_4	239	244	PF00397	0.797
DOC_WW_Pin1_4	251	256	PF00397	0.807
DOC_WW_Pin1_4	363	368	PF00397	0.384
DOC_WW_Pin1_4	41	46	PF00397	0.393
DOC_WW_Pin1_4	529	534	PF00397	0.487
DOC_WW_Pin1_4	564	569	PF00397	0.511
DOC_WW_Pin1_4	700	705	PF00397	0.379
DOC_WW_Pin1_4	797	802	PF00397	0.393
LIG_14-3-3_CanoR_1	337	347	PF00244	0.512
LIG_14-3-3_CanoR_1	358	362	PF00244	0.601
LIG_14-3-3_CanoR_1	368	374	PF00244	0.527
LIG_14-3-3_CanoR_1	407	411	PF00244	0.383
LIG_14-3-3_CanoR_1	451	459	PF00244	0.454
LIG_14-3-3_CanoR_1	474	478	PF00244	0.545
LIG_14-3-3_CanoR_1	597	601	PF00244	0.420
LIG_14-3-3_CanoR_1	641	649	PF00244	0.375
LIG_Actin_WH2_2	126	143	PF00022	0.466
LIG_Actin_WH2_2	392	409	PF00022	0.328
LIG_APCC_ABBA_1	818	823	PF00400	0.393
LIG_BIR_III_2	759	763	PF00653	0.365
LIG_BIR_III_4	103	107	PF00653	0.456
LIG_BRCT_BRCA1_1	320	324	PF00533	0.487
LIG_BRCT_BRCA1_1	353	357	PF00533	0.587
LIG_BRCT_BRCA1_1	369	373	PF00533	0.407
LIG_BRCT_BRCA1_1	577	581	PF00533	0.567
LIG_BRCT_BRCA1_1	79	83	PF00533	0.199
LIG_deltaCOP1_diTrp_1	543	547	PF00928	0.408
LIG_EH1_1	623	631	PF00400	0.510
LIG_EVH1_2	571	575	PF00568	0.469
LIG_FHA_1	135	141	PF00498	0.553
LIG_FHA_1	156	162	PF00498	0.645
LIG_FHA_1	225	231	PF00498	0.542
LIG_FHA_1	364	370	PF00498	0.507
LIG_FHA_1	418	424	PF00498	0.385
LIG_FHA_1	454	460	PF00498	0.486
LIG_FHA_1	537	543	PF00498	0.463
LIG_FHA_1	557	563	PF00498	0.316
LIG_FHA_1	701	707	PF00498	0.199
LIG_FHA_1	766	772	PF00498	0.216
LIG_FHA_2	280	286	PF00498	0.617
LIG_FHA_2	388	394	PF00498	0.490
LIG_FHA_2	46	52	PF00498	0.393
LIG_Integrin_RGD_1	14	16	PF01839	0.449
LIG_LIR_Gen_1	359	369	PF02991	0.496
LIG_LIR_Gen_1	475	484	PF02991	0.504
LIG_LIR_Gen_1	489	499	PF02991	0.389
LIG_LIR_Gen_1	578	589	PF02991	0.433
LIG_LIR_Gen_1	696	707	PF02991	0.393
LIG_LIR_Gen_1	80	90	PF02991	0.277
LIG_LIR_Nem_3	359	364	PF02991	0.594
LIG_LIR_Nem_3	475	480	PF02991	0.510
LIG_LIR_Nem_3	489	494	PF02991	0.448
LIG_LIR_Nem_3	578	584	PF02991	0.434
LIG_LIR_Nem_3	628	634	PF02991	0.521
LIG_LIR_Nem_3	696	702	PF02991	0.393
LIG_LIR_Nem_3	80	86	PF02991	0.283
LIG_LIR_Nem_3	88	93	PF02991	0.280
LIG_PCNA_PIPBox_1	485	494	PF02747	0.286
LIG_PCNA_yPIPBox_3	658	672	PF02747	0.393
LIG_Pex14_2	357	361	PF04695	0.516
LIG_Pex14_2	473	477	PF04695	0.363
LIG_PTB_Apo_2	686	693	PF02174	0.276
LIG_PTB_Phospho_1	686	692	PF10480	0.276
LIG_REV1ctd_RIR_1	571	581	PF16727	0.524
LIG_SH2_CRK	38	42	PF00017	0.300
LIG_SH2_CRK	90	94	PF00017	0.205
LIG_SH2_STAP1	402	406	PF00017	0.408
LIG_SH2_STAT3	642	645	PF00017	0.390
LIG_SH2_STAT5	129	132	PF00017	0.464
LIG_SH2_STAT5	472	475	PF00017	0.489
LIG_SH2_STAT5	491	494	PF00017	0.254
LIG_SH2_STAT5	546	549	PF00017	0.513
LIG_SH2_STAT5	643	646	PF00017	0.341
LIG_SH2_STAT5	799	802	PF00017	0.335
LIG_SH2_STAT5	90	93	PF00017	0.300
LIG_SH3_1	267	273	PF00018	0.541
LIG_SH3_3	215	221	PF00018	0.527
LIG_SH3_3	237	243	PF00018	0.770
LIG_SH3_3	267	273	PF00018	0.740
LIG_SH3_3	292	298	PF00018	0.523
LIG_SH3_3	513	519	PF00018	0.589
LIG_SH3_3	565	571	PF00018	0.527
LIG_SH3_3	691	697	PF00018	0.276
LIG_SH3_3	795	801	PF00018	0.352
LIG_SH3_3	824	830	PF00018	0.276
LIG_Sin3_3	558	565	PF02671	0.413
LIG_SUMO_SIM_anti_2	669	675	PF11976	0.393
LIG_SUMO_SIM_par_1	129	134	PF11976	0.504
LIG_SUMO_SIM_par_1	28	33	PF11976	0.365
LIG_SUMO_SIM_par_1	293	299	PF11976	0.402
LIG_SUMO_SIM_par_1	761	766	PF11976	0.307
LIG_TRAF2_1	298	301	PF00917	0.537
LIG_TRAF2_1	48	51	PF00917	0.390
LIG_TRAF2_1	677	680	PF00917	0.393
LIG_UBA3_1	602	609	PF00899	0.442
LIG_WRC_WIRS_1	477	482	PF05994	0.414
LIG_WRPW_2	631	634	PF00400	0.440
LIG_WW_1	519	522	PF00397	0.555
MOD_CDK_SPK_2	363	368	PF00069	0.415
MOD_CDK_SPK_2	41	46	PF00069	0.341
MOD_CK1_1	147	153	PF00069	0.532
MOD_CK1_1	174	180	PF00069	0.737
MOD_CK1_1	192	198	PF00069	0.584
MOD_CK1_1	207	213	PF00069	0.631
MOD_CK1_1	225	231	PF00069	0.723
MOD_CK1_1	256	262	PF00069	0.684
MOD_CK1_1	322	328	PF00069	0.673
MOD_CK1_1	387	393	PF00069	0.506
MOD_CK1_1	476	482	PF00069	0.433
MOD_CK1_1	548	554	PF00069	0.385
MOD_CK1_1	77	83	PF00069	0.313
MOD_CK1_1	778	784	PF00069	0.335
MOD_CK2_1	279	285	PF00069	0.536
MOD_CK2_1	387	393	PF00069	0.467
MOD_CK2_1	45	51	PF00069	0.380
MOD_CK2_1	463	469	PF00069	0.439
MOD_Cter_Amidation	503	506	PF01082	0.447
MOD_GlcNHglycan	146	149	PF01048	0.584
MOD_GlcNHglycan	185	189	PF01048	0.697
MOD_GlcNHglycan	20	24	PF01048	0.632
MOD_GlcNHglycan	224	227	PF01048	0.803
MOD_GlcNHglycan	255	258	PF01048	0.651
MOD_GlcNHglycan	324	327	PF01048	0.690
MOD_GlcNHglycan	340	343	PF01048	0.430
MOD_GlcNHglycan	438	441	PF01048	0.622
MOD_GlcNHglycan	453	456	PF01048	0.365
MOD_GlcNHglycan	577	580	PF01048	0.638
MOD_GlcNHglycan	741	744	PF01048	0.199
MOD_GlcNHglycan	777	780	PF01048	0.393
MOD_GSK3_1	146	153	PF00069	0.560
MOD_GSK3_1	160	167	PF00069	0.676
MOD_GSK3_1	170	177	PF00069	0.694
MOD_GSK3_1	204	211	PF00069	0.715
MOD_GSK3_1	220	227	PF00069	0.803
MOD_GSK3_1	235	242	PF00069	0.777
MOD_GSK3_1	249	256	PF00069	0.680
MOD_GSK3_1	318	325	PF00069	0.633
MOD_GSK3_1	363	370	PF00069	0.459
MOD_GSK3_1	383	390	PF00069	0.480
MOD_GSK3_1	398	405	PF00069	0.340
MOD_GSK3_1	41	48	PF00069	0.250
MOD_GSK3_1	431	438	PF00069	0.526
MOD_GSK3_1	447	454	PF00069	0.397
MOD_GSK3_1	472	479	PF00069	0.474
MOD_GSK3_1	525	532	PF00069	0.412
MOD_GSK3_1	592	599	PF00069	0.438
MOD_GSK3_1	604	611	PF00069	0.481
MOD_GSK3_1	67	74	PF00069	0.434
MOD_GSK3_1	705	712	PF00069	0.289
MOD_GSK3_1	734	741	PF00069	0.449
MOD_GSK3_1	761	768	PF00069	0.408
MOD_N-GLC_1	154	159	PF02516	0.457
MOD_N-GLC_1	257	262	PF02516	0.739
MOD_N-GLC_1	529	534	PF02516	0.487
MOD_NEK2_1	139	144	PF00069	0.565
MOD_NEK2_1	146	151	PF00069	0.603
MOD_NEK2_1	340	345	PF00069	0.648
MOD_NEK2_1	357	362	PF00069	0.468
MOD_NEK2_1	369	374	PF00069	0.411
MOD_NEK2_1	381	386	PF00069	0.495
MOD_NEK2_1	406	411	PF00069	0.464
MOD_NEK2_1	436	441	PF00069	0.470
MOD_NEK2_1	447	452	PF00069	0.352
MOD_NEK2_1	463	468	PF00069	0.308
MOD_NEK2_1	473	478	PF00069	0.363
MOD_NEK2_1	497	502	PF00069	0.425
MOD_NEK2_1	525	530	PF00069	0.390
MOD_NEK2_1	556	561	PF00069	0.401
MOD_NEK2_1	57	62	PF00069	0.348
MOD_NEK2_1	575	580	PF00069	0.382
MOD_NEK2_1	608	613	PF00069	0.436
MOD_NEK2_1	615	620	PF00069	0.404
MOD_NEK2_2	402	407	PF00069	0.505
MOD_NEK2_2	425	430	PF00069	0.440
MOD_PIKK_1	134	140	PF00454	0.547
MOD_PIKK_1	147	153	PF00454	0.632
MOD_PIKK_1	296	302	PF00454	0.389
MOD_PIKK_1	415	421	PF00454	0.276
MOD_PIKK_1	45	51	PF00454	0.384
MOD_PIKK_1	548	554	PF00454	0.468
MOD_PIKK_1	57	63	PF00454	0.270
MOD_PIKK_1	641	647	PF00454	0.199
MOD_PIKK_1	67	73	PF00454	0.335
MOD_PIKK_1	714	720	PF00454	0.393
MOD_PKA_1	451	457	PF00069	0.443
MOD_PKA_1	735	741	PF00069	0.261
MOD_PKA_2	134	140	PF00069	0.475
MOD_PKA_2	164	170	PF00069	0.502
MOD_PKA_2	174	180	PF00069	0.525
MOD_PKA_2	357	363	PF00069	0.599
MOD_PKA_2	367	373	PF00069	0.535
MOD_PKA_2	406	412	PF00069	0.514
MOD_PKA_2	451	457	PF00069	0.408
MOD_PKA_2	473	479	PF00069	0.457
MOD_PKA_2	592	598	PF00069	0.485
MOD_PKA_2	734	740	PF00069	0.496
MOD_PKA_2	775	781	PF00069	0.300
MOD_PKB_1	733	741	PF00069	0.199
MOD_Plk_1	402	408	PF00069	0.531
MOD_Plk_1	745	751	PF00069	0.199
MOD_Plk_1	765	771	PF00069	0.276
MOD_Plk_2-3	398	404	PF00069	0.471
MOD_Plk_4	487	493	PF00069	0.474
MOD_Plk_4	625	631	PF00069	0.519
MOD_Plk_4	667	673	PF00069	0.286
MOD_Plk_4	74	80	PF00069	0.301
MOD_Plk_4	786	792	PF00069	0.393
MOD_Plk_4	88	94	PF00069	0.299
MOD_ProDKin_1	205	211	PF00069	0.634
MOD_ProDKin_1	239	245	PF00069	0.792
MOD_ProDKin_1	251	257	PF00069	0.808
MOD_ProDKin_1	363	369	PF00069	0.375
MOD_ProDKin_1	41	47	PF00069	0.393
MOD_ProDKin_1	529	535	PF00069	0.489
MOD_ProDKin_1	564	570	PF00069	0.510
MOD_ProDKin_1	700	706	PF00069	0.379
MOD_ProDKin_1	797	803	PF00069	0.393
MOD_SUMO_rev_2	512	519	PF00179	0.536
TRG_DiLeu_BaEn_1	669	674	PF01217	0.393
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.480
TRG_ENDOCYTIC_2	38	41	PF00928	0.303
TRG_ENDOCYTIC_2	491	494	PF00928	0.483
TRG_ENDOCYTIC_2	522	525	PF00928	0.495
TRG_ENDOCYTIC_2	692	695	PF00928	0.276
TRG_ENDOCYTIC_2	90	93	PF00928	0.276
TRG_ER_diArg_1	306	309	PF00400	0.617
TRG_ER_diArg_1	334	337	PF00400	0.515
TRG_ER_diArg_1	451	453	PF00400	0.580
TRG_ER_diArg_1	52	54	PF00400	0.335
TRG_ER_diArg_1	660	663	PF00400	0.419
TRG_ER_diArg_1	732	735	PF00400	0.383
TRG_ER_diArg_1	812	815	PF00400	0.306
TRG_NES_CRM1_1	458	469	PF08389	0.442
TRG_NLS_MonoCore_2	812	817	PF00514	0.393
TRG_NLS_MonoExtN_4	813	818	PF00514	0.393
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P653	Leptomonas seymouri	60%	91%
A0A1X0NU14	Trypanosomatidae	34%	100%
A0A3S7WZV8	Leishmania donovani	79%	99%
A0A422MXE6	Trypanosoma rangeli	35%	100%
A4I223	Leishmania infantum	78%	99%
C9ZRY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AY72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q9A0	Leishmania major	78%	100%