AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEU8_LEIBR

TriTrypDb:

LbrM.26.0940 , LBRM2903_260014200

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.733
CLV_MEL_PAP_1	101	107	PF00089	0.584
CLV_NRD_NRD_1	165	167	PF00675	0.502
CLV_NRD_NRD_1	229	231	PF00675	0.461
CLV_NRD_NRD_1	487	489	PF00675	0.679
CLV_NRD_NRD_1	510	512	PF00675	0.648
CLV_PCSK_KEX2_1	165	167	PF00082	0.502
CLV_PCSK_KEX2_1	229	231	PF00082	0.515
CLV_PCSK_KEX2_1	385	387	PF00082	0.587
CLV_PCSK_KEX2_1	489	491	PF00082	0.696
CLV_PCSK_KEX2_1	510	512	PF00082	0.648
CLV_PCSK_KEX2_1	668	670	PF00082	0.567
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.587
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.696
CLV_PCSK_PC1ET2_1	668	670	PF00082	0.567
CLV_PCSK_SKI1_1	229	233	PF00082	0.450
CLV_PCSK_SKI1_1	363	367	PF00082	0.755
CLV_PCSK_SKI1_1	382	386	PF00082	0.439
CLV_PCSK_SKI1_1	78	82	PF00082	0.553
DEG_MDM2_SWIB_1	582	590	PF02201	0.433
DEG_Nend_Nbox_1	1	3	PF02207	0.694
DEG_SPOP_SBC_1	338	342	PF00917	0.646
DEG_SPOP_SBC_1	398	402	PF00917	0.609
DEG_SPOP_SBC_1	577	581	PF00917	0.319
DOC_CYCLIN_RxL_1	655	663	PF00134	0.529
DOC_MAPK_gen_1	226	236	PF00069	0.580
DOC_MAPK_gen_1	488	496	PF00069	0.659
DOC_MAPK_gen_1	612	621	PF00069	0.627
DOC_MAPK_gen_1	74	81	PF00069	0.483
DOC_MAPK_JIP1_4	444	450	PF00069	0.561
DOC_MAPK_MEF2A_6	151	160	PF00069	0.410
DOC_MAPK_MEF2A_6	444	452	PF00069	0.439
DOC_MAPK_MEF2A_6	612	621	PF00069	0.491
DOC_MAPK_MEF2A_6	656	664	PF00069	0.529
DOC_PP1_RVXF_1	623	630	PF00149	0.487
DOC_PP1_RVXF_1	76	82	PF00149	0.563
DOC_PP2B_LxvP_1	240	243	PF13499	0.566
DOC_USP7_MATH_1	275	279	PF00917	0.763
DOC_USP7_MATH_1	336	340	PF00917	0.753
DOC_USP7_MATH_1	355	359	PF00917	0.704
DOC_USP7_MATH_1	578	582	PF00917	0.520
DOC_USP7_MATH_1	80	84	PF00917	0.422
DOC_USP7_UBL2_3	556	560	PF12436	0.663
DOC_WW_Pin1_4	334	339	PF00397	0.542
LIG_14-3-3_CanoR_1	229	237	PF00244	0.492
LIG_14-3-3_CanoR_1	260	265	PF00244	0.710
LIG_14-3-3_CanoR_1	534	542	PF00244	0.546
LIG_14-3-3_CanoR_1	636	643	PF00244	0.517
LIG_APCC_ABBA_1	608	613	PF00400	0.499
LIG_BRCT_BRCA1_1	258	262	PF00533	0.718
LIG_BRCT_BRCA1_1	355	359	PF00533	0.719
LIG_BRCT_BRCA1_1	448	452	PF00533	0.671
LIG_BRCT_BRCA1_1	579	583	PF00533	0.319
LIG_BRCT_BRCA1_1	6	10	PF00533	0.727
LIG_Clathr_ClatBox_1	157	161	PF01394	0.490
LIG_Clathr_ClatBox_1	201	205	PF01394	0.573
LIG_deltaCOP1_diTrp_1	205	211	PF00928	0.403
LIG_deltaCOP1_diTrp_1	567	576	PF00928	0.550
LIG_deltaCOP1_diTrp_1	628	632	PF00928	0.469
LIG_EH1_1	391	399	PF00400	0.591
LIG_FHA_1	153	159	PF00498	0.518
LIG_FHA_1	217	223	PF00498	0.382
LIG_FHA_1	271	277	PF00498	0.642
LIG_FHA_1	298	304	PF00498	0.520
LIG_FHA_1	456	462	PF00498	0.568
LIG_FHA_1	500	506	PF00498	0.510
LIG_FHA_1	513	519	PF00498	0.523
LIG_FHA_1	57	63	PF00498	0.435
LIG_FHA_1	585	591	PF00498	0.505
LIG_FHA_1	600	606	PF00498	0.606
LIG_FHA_1	655	661	PF00498	0.526
LIG_FHA_2	267	273	PF00498	0.720
LIG_FHA_2	275	281	PF00498	0.799
LIG_FHA_2	307	313	PF00498	0.586
LIG_Integrin_isoDGR_2	508	510	PF01839	0.620
LIG_LIR_Apic_2	185	190	PF02991	0.435
LIG_LIR_Apic_2	428	433	PF02991	0.603
LIG_LIR_Gen_1	205	213	PF02991	0.426
LIG_LIR_Gen_1	502	512	PF02991	0.408
LIG_LIR_Gen_1	527	533	PF02991	0.497
LIG_LIR_Gen_1	536	546	PF02991	0.537
LIG_LIR_Gen_1	7	17	PF02991	0.627
LIG_LIR_Nem_3	185	189	PF02991	0.440
LIG_LIR_Nem_3	205	210	PF02991	0.411
LIG_LIR_Nem_3	25	29	PF02991	0.405
LIG_LIR_Nem_3	502	507	PF02991	0.501
LIG_LIR_Nem_3	527	531	PF02991	0.510
LIG_LIR_Nem_3	536	542	PF02991	0.515
LIG_LIR_Nem_3	649	655	PF02991	0.546
LIG_LIR_Nem_3	7	13	PF02991	0.616
LIG_LYPXL_S_1	472	476	PF13949	0.563
LIG_LYPXL_yS_3	473	476	PF13949	0.543
LIG_MLH1_MIPbox_1	579	583	PF16413	0.319
LIG_MLH1_MIPbox_1	6	10	PF16413	0.623
LIG_NRBOX	517	523	PF00104	0.612
LIG_PCNA_PIPBox_1	3	12	PF02747	0.723
LIG_PCNA_yPIPBox_3	3	15	PF02747	0.724
LIG_Pex14_1	207	211	PF04695	0.388
LIG_Pex14_2	22	26	PF04695	0.635
LIG_Pex14_2	499	503	PF04695	0.425
LIG_Pex14_2	582	586	PF04695	0.424
LIG_Pex14_2	95	99	PF04695	0.330
LIG_SH2_CRK	237	241	PF00017	0.565
LIG_SH2_CRK	381	385	PF00017	0.751
LIG_SH2_CRK	430	434	PF00017	0.701
LIG_SH2_CRK	554	558	PF00017	0.510
LIG_SH2_NCK_1	181	185	PF00017	0.469
LIG_SH2_STAT3	200	203	PF00017	0.427
LIG_SH2_STAT3	478	481	PF00017	0.541
LIG_SH2_STAT5	200	203	PF00017	0.414
LIG_SH2_STAT5	302	305	PF00017	0.519
LIG_SH3_1	168	174	PF00018	0.549
LIG_SH3_2	484	489	PF14604	0.678
LIG_SH3_3	168	174	PF00018	0.540
LIG_SH3_3	187	193	PF00018	0.325
LIG_SH3_3	366	372	PF00018	0.632
LIG_SH3_3	456	462	PF00018	0.606
LIG_SH3_3	468	474	PF00018	0.509
LIG_SH3_3	481	487	PF00018	0.472
LIG_SH3_3	543	549	PF00018	0.547
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.379
LIG_SUMO_SIM_anti_2	339	353	PF11976	0.771
LIG_SUMO_SIM_par_1	142	147	PF11976	0.401
LIG_SUMO_SIM_par_1	154	159	PF11976	0.431
LIG_TRAF2_1	111	114	PF00917	0.605
LIG_TYR_ITIM	379	384	PF00017	0.760
LIG_TYR_ITIM	552	557	PF00017	0.486
MOD_CK1_1	134	140	PF00069	0.432
MOD_CK1_1	263	269	PF00069	0.710
MOD_CK1_1	337	343	PF00069	0.687
MOD_CK1_1	402	408	PF00069	0.672
MOD_CK2_1	103	109	PF00069	0.619
MOD_CK2_1	249	255	PF00069	0.643
MOD_CK2_1	264	270	PF00069	0.558
MOD_CK2_1	274	280	PF00069	0.708
MOD_CK2_1	578	584	PF00069	0.503
MOD_CMANNOS	629	632	PF00535	0.474
MOD_Cter_Amidation	508	511	PF01082	0.635
MOD_GlcNHglycan	277	280	PF01048	0.827
MOD_GlcNHglycan	312	316	PF01048	0.675
MOD_GlcNHglycan	344	347	PF01048	0.660
MOD_GlcNHglycan	401	404	PF01048	0.693
MOD_GlcNHglycan	562	565	PF01048	0.490
MOD_GlcNHglycan	82	85	PF01048	0.430
MOD_GSK3_1	126	133	PF00069	0.567
MOD_GSK3_1	152	159	PF00069	0.392
MOD_GSK3_1	212	219	PF00069	0.407
MOD_GSK3_1	256	263	PF00069	0.617
MOD_GSK3_1	266	273	PF00069	0.628
MOD_GSK3_1	334	341	PF00069	0.704
MOD_GSK3_1	355	362	PF00069	0.713
MOD_GSK3_1	398	405	PF00069	0.669
MOD_GSK3_1	529	536	PF00069	0.550
MOD_GSK3_1	673	680	PF00069	0.723
MOD_N-GLC_1	217	222	PF02516	0.357
MOD_N-GLC_1	599	604	PF02516	0.582
MOD_NEK2_1	126	131	PF00069	0.489
MOD_NEK2_1	2	7	PF00069	0.625
MOD_NEK2_1	216	221	PF00069	0.565
MOD_NEK2_1	262	267	PF00069	0.706
MOD_NEK2_1	359	364	PF00069	0.683
MOD_NEK2_1	397	402	PF00069	0.539
MOD_NEK2_2	529	534	PF00069	0.440
MOD_NEK2_2	578	583	PF00069	0.539
MOD_NEK2_2	589	594	PF00069	0.558
MOD_PIKK_1	109	115	PF00454	0.545
MOD_PIKK_1	34	40	PF00454	0.454
MOD_PKA_1	229	235	PF00069	0.491
MOD_PKA_2	103	109	PF00069	0.602
MOD_PKA_2	229	235	PF00069	0.491
MOD_PKA_2	533	539	PF00069	0.577
MOD_PKA_2	635	641	PF00069	0.503
MOD_Plk_1	127	133	PF00069	0.494
MOD_Plk_1	217	223	PF00069	0.359
MOD_Plk_1	249	255	PF00069	0.581
MOD_Plk_1	529	535	PF00069	0.478
MOD_Plk_1	599	605	PF00069	0.589
MOD_Plk_2-3	249	255	PF00069	0.657
MOD_Plk_2-3	280	286	PF00069	0.758
MOD_Plk_2-3	410	416	PF00069	0.650
MOD_Plk_2-3	455	461	PF00069	0.686
MOD_Plk_4	152	158	PF00069	0.412
MOD_Plk_4	212	218	PF00069	0.512
MOD_Plk_4	355	361	PF00069	0.697
MOD_Plk_4	499	505	PF00069	0.420
MOD_Plk_4	578	584	PF00069	0.458
MOD_ProDKin_1	334	340	PF00069	0.539
TRG_DiLeu_BaEn_2	387	393	PF01217	0.672
TRG_ENDOCYTIC_2	237	240	PF00928	0.502
TRG_ENDOCYTIC_2	381	384	PF00928	0.757
TRG_ENDOCYTIC_2	469	472	PF00928	0.523
TRG_ENDOCYTIC_2	473	476	PF00928	0.538
TRG_ENDOCYTIC_2	554	557	PF00928	0.491
TRG_ER_diArg_1	165	168	PF00400	0.450
TRG_ER_diArg_1	228	230	PF00400	0.551
TRG_ER_diArg_1	462	465	PF00400	0.538
TRG_ER_diArg_1	487	490	PF00400	0.651
TRG_ER_diArg_1	510	512	PF00400	0.648
TRG_ER_diArg_1	655	658	PF00400	0.534
TRG_NES_CRM1_1	114	128	PF08389	0.573
TRG_NES_CRM1_1	410	425	PF08389	0.553
TRG_NLS_MonoExtN_4	487	492	PF00514	0.689
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	658	663	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F1	Leptomonas seymouri	68%	99%
A0A1X0NSL8	Trypanosomatidae	53%	94%
A0A3S7WZQ1	Leishmania donovani	89%	100%
A0A422MXA7	Trypanosoma rangeli	51%	95%
A4I222	Leishmania infantum	89%	100%
C9ZRY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AY71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q9A1	Leishmania major	88%	100%
Q57VU6	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	52%	100%
V5DR06	Trypanosoma cruzi	51%	95%