Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEU6_LEIBR

TriTrypDb:

LbrM.26.0920 , LBRM2903_260014000

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HEU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0001653	peptide receptor activity	3	11
GO:0038023	signaling receptor activity	2	11
GO:0060089	molecular transducer activity	1	11
GO:0140625	opioid growth factor receptor activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.495
CLV_C14_Caspase3-7	18	22	PF00656	0.494
CLV_C14_Caspase3-7	383	387	PF00656	0.452
CLV_C14_Caspase3-7	62	66	PF00656	0.527
CLV_PCSK_KEX2_1	377	379	PF00082	0.493
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.555
CLV_PCSK_SKI1_1	236	240	PF00082	0.573
CLV_PCSK_SKI1_1	248	252	PF00082	0.366
CLV_PCSK_SKI1_1	319	323	PF00082	0.316
CLV_PCSK_SKI1_1	345	349	PF00082	0.313
DEG_APCC_DBOX_1	247	255	PF00400	0.384
DEG_Nend_UBRbox_2	1	3	PF02207	0.551
DEG_SPOP_SBC_1	60	64	PF00917	0.509
DOC_CYCLIN_RxL_1	316	323	PF00134	0.305
DOC_CYCLIN_yCln2_LP_2	87	90	PF00134	0.382
DOC_MAPK_DCC_7	120	129	PF00069	0.226
DOC_MAPK_gen_1	118	127	PF00069	0.278
DOC_MAPK_gen_1	316	326	PF00069	0.344
DOC_MAPK_HePTP_8	117	129	PF00069	0.233
DOC_MAPK_MEF2A_6	118	127	PF00069	0.334
DOC_MAPK_MEF2A_6	319	326	PF00069	0.362
DOC_PP1_RVXF_1	116	122	PF00149	0.332
DOC_PP1_RVXF_1	330	337	PF00149	0.354
DOC_PP1_RVXF_1	343	349	PF00149	0.291
DOC_PP2B_LxvP_1	297	300	PF13499	0.529
DOC_PP2B_LxvP_1	87	90	PF13499	0.382
DOC_PP4_FxxP_1	348	351	PF00568	0.430
DOC_USP7_MATH_1	100	104	PF00917	0.394
DOC_USP7_MATH_1	109	113	PF00917	0.341
DOC_USP7_MATH_1	140	144	PF00917	0.470
DOC_USP7_MATH_1	180	184	PF00917	0.523
DOC_USP7_MATH_1	91	95	PF00917	0.527
DOC_WW_Pin1_4	298	303	PF00397	0.385
LIG_14-3-3_CanoR_1	215	221	PF00244	0.302
LIG_14-3-3_CanoR_1	256	262	PF00244	0.335
LIG_Actin_WH2_2	314	330	PF00022	0.407
LIG_AP2alpha_1	57	61	PF02296	0.409
LIG_BRCT_BRCA1_1	38	42	PF00533	0.373
LIG_eIF4E_1	218	224	PF01652	0.426
LIG_FHA_1	70	76	PF00498	0.473
LIG_FHA_2	139	145	PF00498	0.639
LIG_FHA_2	270	276	PF00498	0.445
LIG_FHA_2	381	387	PF00498	0.558
LIG_FHA_2	53	59	PF00498	0.450
LIG_GBD_Chelix_1	329	337	PF00786	0.319
LIG_GSK3_LRP6_1	298	303	PF00069	0.385
LIG_LIR_Gen_1	115	124	PF02991	0.390
LIG_LIR_Gen_1	189	199	PF02991	0.531
LIG_LIR_Gen_1	219	227	PF02991	0.305
LIG_LIR_Gen_1	247	255	PF02991	0.487
LIG_LIR_Gen_1	323	334	PF02991	0.415
LIG_LIR_Gen_1	54	61	PF02991	0.466
LIG_LIR_Nem_3	115	119	PF02991	0.406
LIG_LIR_Nem_3	189	194	PF02991	0.432
LIG_LIR_Nem_3	214	220	PF02991	0.354
LIG_LIR_Nem_3	247	252	PF02991	0.379
LIG_LIR_Nem_3	301	307	PF02991	0.504
LIG_LIR_Nem_3	323	329	PF02991	0.331
LIG_LIR_Nem_3	54	60	PF02991	0.670
LIG_MYND_1	126	130	PF01753	0.406
LIG_NRBOX	189	195	PF00104	0.486
LIG_NRBOX	317	323	PF00104	0.266
LIG_Pex14_1	245	249	PF04695	0.344
LIG_Pex14_2	57	61	PF04695	0.409
LIG_REV1ctd_RIR_1	224	234	PF16727	0.548
LIG_SH2_CRK	218	222	PF00017	0.358
LIG_SH2_PTP2	220	223	PF00017	0.416
LIG_SH2_STAP1	104	108	PF00017	0.493
LIG_SH2_STAP1	191	195	PF00017	0.369
LIG_SH2_STAP1	218	222	PF00017	0.295
LIG_SH2_STAT3	104	107	PF00017	0.501
LIG_SH2_STAT3	291	294	PF00017	0.470
LIG_SH2_STAT5	10	13	PF00017	0.546
LIG_SH2_STAT5	220	223	PF00017	0.297
LIG_SH3_3	120	126	PF00018	0.457
LIG_SH3_3	296	302	PF00018	0.592
LIG_SH3_3	359	365	PF00018	0.474
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.553
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.448
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.524
LIG_SUMO_SIM_par_1	67	76	PF11976	0.428
LIG_TRAF2_1	244	247	PF00917	0.395
LIG_TYR_ITIM	216	221	PF00017	0.299
LIG_WRC_WIRS_1	304	309	PF05994	0.426
MOD_CDK_SPxxK_3	298	305	PF00069	0.385
MOD_CK1_1	143	149	PF00069	0.456
MOD_CK1_1	183	189	PF00069	0.406
MOD_CK1_1	370	376	PF00069	0.358
MOD_CK1_1	76	82	PF00069	0.426
MOD_CK2_1	109	115	PF00069	0.348
MOD_CK2_1	145	151	PF00069	0.502
MOD_CK2_1	168	174	PF00069	0.531
MOD_CK2_1	183	189	PF00069	0.458
MOD_CK2_1	269	275	PF00069	0.552
MOD_GlcNHglycan	111	114	PF01048	0.271
MOD_GlcNHglycan	147	150	PF01048	0.633
MOD_GlcNHglycan	182	185	PF01048	0.563
MOD_GlcNHglycan	311	314	PF01048	0.472
MOD_GlcNHglycan	75	78	PF01048	0.540
MOD_GlcNHglycan	93	96	PF01048	0.431
MOD_GSK3_1	139	146	PF00069	0.602
MOD_GSK3_1	170	177	PF00069	0.455
MOD_GSK3_1	255	262	PF00069	0.531
MOD_GSK3_1	366	373	PF00069	0.485
MOD_GSK3_1	380	387	PF00069	0.464
MOD_GSK3_1	60	67	PF00069	0.586
MOD_GSK3_1	69	76	PF00069	0.529
MOD_N-GLC_1	47	52	PF02516	0.296
MOD_N-GLC_2	9	11	PF02516	0.472
MOD_NEK2_1	108	113	PF00069	0.454
MOD_NEK2_1	254	259	PF00069	0.418
MOD_NEK2_1	309	314	PF00069	0.523
MOD_NEK2_1	52	57	PF00069	0.345
MOD_PIKK_1	47	53	PF00454	0.585
MOD_PK_1	71	77	PF00069	0.409
MOD_PKA_2	149	155	PF00069	0.582
MOD_PKA_2	255	261	PF00069	0.375
MOD_PKA_2	380	386	PF00069	0.466
MOD_Plk_1	100	106	PF00069	0.463
MOD_Plk_1	286	292	PF00069	0.457
MOD_Plk_1	353	359	PF00069	0.359
MOD_Plk_1	47	53	PF00069	0.504
MOD_Plk_1	69	75	PF00069	0.431
MOD_Plk_4	216	222	PF00069	0.309
MOD_Plk_4	353	359	PF00069	0.371
MOD_Plk_4	52	58	PF00069	0.507
MOD_Plk_4	76	82	PF00069	0.416
MOD_ProDKin_1	298	304	PF00069	0.383
MOD_SUMO_rev_2	63	73	PF00179	0.503
TRG_DiLeu_BaEn_1	189	194	PF01217	0.367
TRG_DiLeu_BaEn_1	234	239	PF01217	0.558
TRG_DiLeu_BaEn_1	247	252	PF01217	0.505
TRG_DiLeu_BaEn_4	234	240	PF01217	0.431
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.327
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.320
TRG_ENDOCYTIC_2	191	194	PF00928	0.531
TRG_ENDOCYTIC_2	218	221	PF00928	0.360
TRG_ENDOCYTIC_2	249	252	PF00928	0.342
TRG_ENDOCYTIC_2	304	307	PF00928	0.478
TRG_ENDOCYTIC_2	43	46	PF00928	0.418
TRG_ER_diArg_1	117	120	PF00400	0.254
TRG_NES_CRM1_1	323	335	PF08389	0.310
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ78	Leptomonas seymouri	50%	100%
A0A1X0NT07	Trypanosomatidae	36%	100%
A0A3Q8IFS6	Leishmania donovani	73%	97%
A0A422MXD1	Trypanosoma rangeli	35%	100%
A4I220	Leishmania infantum	73%	97%
C9ZRY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AY69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	96%
Q4Q9A3	Leishmania major	73%	98%
V5BUN4	Trypanosoma cruzi	34%	100%