CXXC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ISWI complex protein

Species:

Leishmania braziliensis

UniProt:

A4HEU2_LEIBR

TriTrypDb:

LbrM.26.0880 , LBRM2903_260013600

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0031010	ISWI-type complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1

Expansion

Sequence features

A4HEU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	435	439	PF00656	0.794
CLV_C14_Caspase3-7	634	638	PF00656	0.698
CLV_C14_Caspase3-7	765	769	PF00656	0.624
CLV_NRD_NRD_1	103	105	PF00675	0.585
CLV_NRD_NRD_1	239	241	PF00675	0.758
CLV_NRD_NRD_1	278	280	PF00675	0.708
CLV_NRD_NRD_1	315	317	PF00675	0.737
CLV_NRD_NRD_1	397	399	PF00675	0.723
CLV_NRD_NRD_1	402	404	PF00675	0.729
CLV_NRD_NRD_1	450	452	PF00675	0.616
CLV_NRD_NRD_1	485	487	PF00675	0.730
CLV_NRD_NRD_1	592	594	PF00675	0.730
CLV_PCSK_FUR_1	450	454	PF00082	0.744
CLV_PCSK_FUR_1	590	594	PF00082	0.613
CLV_PCSK_KEX2_1	233	235	PF00082	0.746
CLV_PCSK_KEX2_1	239	241	PF00082	0.724
CLV_PCSK_KEX2_1	277	279	PF00082	0.716
CLV_PCSK_KEX2_1	313	315	PF00082	0.684
CLV_PCSK_KEX2_1	321	323	PF00082	0.683
CLV_PCSK_KEX2_1	402	404	PF00082	0.730
CLV_PCSK_KEX2_1	450	452	PF00082	0.683
CLV_PCSK_KEX2_1	478	480	PF00082	0.741
CLV_PCSK_KEX2_1	581	583	PF00082	0.702
CLV_PCSK_KEX2_1	590	592	PF00082	0.724
CLV_PCSK_KEX2_1	685	687	PF00082	0.569
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.746
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.716
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.684
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.683
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.746
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.589
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.702
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.569
CLV_PCSK_PC7_1	398	404	PF00082	0.723
CLV_PCSK_SKI1_1	104	108	PF00082	0.455
CLV_PCSK_SKI1_1	233	237	PF00082	0.690
CLV_PCSK_SKI1_1	35	39	PF00082	0.438
CLV_PCSK_SKI1_1	486	490	PF00082	0.813
CLV_PCSK_SKI1_1	689	693	PF00082	0.561
CLV_PCSK_SKI1_1	698	702	PF00082	0.616
CLV_PCSK_SKI1_1	72	76	PF00082	0.569
CLV_PCSK_SKI1_1	97	101	PF00082	0.513
DEG_Nend_Nbox_1	1	3	PF02207	0.476
DEG_SPOP_SBC_1	11	15	PF00917	0.639
DEG_SPOP_SBC_1	53	57	PF00917	0.622
DEG_SPOP_SBC_1	656	660	PF00917	0.574
DOC_ANK_TNKS_1	452	459	PF00023	0.598
DOC_CYCLIN_RxL_1	685	696	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	536	542	PF00134	0.753
DOC_MAPK_gen_1	383	393	PF00069	0.727
DOC_MAPK_RevD_3	568	582	PF00069	0.670
DOC_PP2B_LxvP_1	191	194	PF13499	0.595
DOC_PP2B_LxvP_1	356	359	PF13499	0.663
DOC_PP2B_LxvP_1	536	539	PF13499	0.669
DOC_PP4_FxxP_1	21	24	PF00568	0.624
DOC_USP7_MATH_1	228	232	PF00917	0.695
DOC_USP7_MATH_1	235	239	PF00917	0.749
DOC_USP7_MATH_1	249	253	PF00917	0.674
DOC_USP7_MATH_1	297	301	PF00917	0.634
DOC_USP7_MATH_1	468	472	PF00917	0.781
DOC_USP7_MATH_1	480	484	PF00917	0.637
DOC_USP7_MATH_1	492	496	PF00917	0.593
DOC_USP7_MATH_2	221	227	PF00917	0.822
DOC_USP7_UBL2_3	448	452	PF12436	0.724
DOC_USP7_UBL2_3	717	721	PF12436	0.596
DOC_WW_Pin1_4	208	213	PF00397	0.673
DOC_WW_Pin1_4	233	238	PF00397	0.749
DOC_WW_Pin1_4	245	250	PF00397	0.703
DOC_WW_Pin1_4	314	319	PF00397	0.668
DOC_WW_Pin1_4	342	347	PF00397	0.560
DOC_WW_Pin1_4	652	657	PF00397	0.730
DOC_WW_Pin1_4	716	721	PF00397	0.726
LIG_14-3-3_CanoR_1	186	191	PF00244	0.686
LIG_14-3-3_CanoR_1	239	244	PF00244	0.762
LIG_14-3-3_CanoR_1	491	497	PF00244	0.571
LIG_14-3-3_CanoR_1	537	543	PF00244	0.649
LIG_Actin_WH2_2	129	146	PF00022	0.486
LIG_Actin_WH2_2	255	270	PF00022	0.558
LIG_APCC_ABBAyCdc20_2	23	29	PF00400	0.463
LIG_BIR_III_2	246	250	PF00653	0.710
LIG_BIR_III_2	521	525	PF00653	0.526
LIG_DCNL_PONY_1	1	4	PF03556	0.570
LIG_FHA_1	186	192	PF00498	0.711
LIG_FHA_1	251	257	PF00498	0.727
LIG_FHA_1	497	503	PF00498	0.680
LIG_FHA_1	66	72	PF00498	0.364
LIG_FHA_1	678	684	PF00498	0.520
LIG_FHA_1	759	765	PF00498	0.614
LIG_FHA_1	77	83	PF00498	0.568
LIG_FHA_2	297	303	PF00498	0.578
LIG_FHA_2	415	421	PF00498	0.646
LIG_FHA_2	539	545	PF00498	0.732
LIG_FHA_2	697	703	PF00498	0.726
LIG_LIR_Apic_2	47	53	PF02991	0.682
LIG_LIR_Gen_1	699	709	PF02991	0.583
LIG_LIR_Gen_1	90	99	PF02991	0.362
LIG_LIR_Nem_3	532	536	PF02991	0.791
LIG_LIR_Nem_3	699	704	PF02991	0.586
LIG_LIR_Nem_3	90	96	PF02991	0.369
LIG_LRP6_Inhibitor_1	131	137	PF00058	0.472
LIG_LYPXL_yS_3	533	536	PF13949	0.684
LIG_MYND_1	354	358	PF01753	0.658
LIG_MYND_1	534	538	PF01753	0.675
LIG_NRBOX	699	705	PF00104	0.479
LIG_Pex14_1	556	560	PF04695	0.615
LIG_Pex14_1	73	77	PF04695	0.359
LIG_SH2_CRK	50	54	PF00017	0.707
LIG_SH2_SRC	217	220	PF00017	0.590
LIG_SH2_SRC	633	636	PF00017	0.556
LIG_SH2_STAT5	139	142	PF00017	0.317
LIG_SH2_STAT5	16	19	PF00017	0.485
LIG_SH2_STAT5	31	34	PF00017	0.376
LIG_SH2_STAT5	66	69	PF00017	0.548
LIG_SH2_STAT5	694	697	PF00017	0.717
LIG_SH2_STAT5	93	96	PF00017	0.509
LIG_SH3_1	717	723	PF00018	0.741
LIG_SH3_3	148	154	PF00018	0.397
LIG_SH3_3	332	338	PF00018	0.701
LIG_SH3_3	34	40	PF00018	0.511
LIG_SH3_3	351	357	PF00018	0.445
LIG_SH3_3	388	394	PF00018	0.730
LIG_SH3_3	491	497	PF00018	0.777
LIG_SH3_3	517	523	PF00018	0.721
LIG_SH3_3	532	538	PF00018	0.659
LIG_SH3_3	561	567	PF00018	0.577
LIG_SH3_3	650	656	PF00018	0.730
LIG_SH3_3	661	667	PF00018	0.697
LIG_SH3_3	717	723	PF00018	0.741
LIG_SH3_4	448	455	PF00018	0.798
LIG_SUMO_SIM_par_1	538	544	PF11976	0.741
LIG_SUMO_SIM_par_1	671	676	PF11976	0.648
LIG_TRAF2_1	605	608	PF00917	0.711
LIG_UBA3_1	700	705	PF00899	0.487
LIG_WRC_WIRS_1	77	82	PF05994	0.320
MOD_CDK_SPK_2	716	721	PF00069	0.636
MOD_CDK_SPxK_1	233	239	PF00069	0.589
MOD_CDK_SPxxK_3	208	215	PF00069	0.828
MOD_CDK_SPxxK_3	233	240	PF00069	0.693
MOD_CDK_SPxxK_3	314	321	PF00069	0.590
MOD_CK1_1	189	195	PF00069	0.821
MOD_CK1_1	227	233	PF00069	0.816
MOD_CK1_1	252	258	PF00069	0.560
MOD_CK1_1	300	306	PF00069	0.610
MOD_CK1_1	495	501	PF00069	0.812
MOD_CK1_1	655	661	PF00069	0.682
MOD_CK1_1	696	702	PF00069	0.619
MOD_CK1_1	748	754	PF00069	0.831
MOD_CK1_1	756	762	PF00069	0.697
MOD_CK1_1	98	104	PF00069	0.462
MOD_CK2_1	213	219	PF00069	0.583
MOD_CK2_1	296	302	PF00069	0.578
MOD_CK2_1	414	420	PF00069	0.649
MOD_CK2_1	538	544	PF00069	0.741
MOD_CK2_1	602	608	PF00069	0.585
MOD_CK2_1	748	754	PF00069	0.790
MOD_Cter_Amidation	683	686	PF01082	0.569
MOD_Cter_Amidation	715	718	PF01082	0.836
MOD_DYRK1A_RPxSP_1	208	212	PF00069	0.581
MOD_GlcNHglycan	173	176	PF01048	0.622
MOD_GlcNHglycan	191	194	PF01048	0.772
MOD_GlcNHglycan	226	229	PF01048	0.672
MOD_GlcNHglycan	299	302	PF01048	0.563
MOD_GlcNHglycan	342	345	PF01048	0.619
MOD_GlcNHglycan	377	380	PF01048	0.534
MOD_GlcNHglycan	433	437	PF01048	0.808
MOD_GlcNHglycan	463	466	PF01048	0.755
MOD_GlcNHglycan	494	497	PF01048	0.598
MOD_GlcNHglycan	56	59	PF01048	0.605
MOD_GlcNHglycan	604	607	PF01048	0.745
MOD_GlcNHglycan	629	632	PF01048	0.665
MOD_GlcNHglycan	639	642	PF01048	0.660
MOD_GlcNHglycan	646	649	PF01048	0.745
MOD_GlcNHglycan	707	710	PF01048	0.647
MOD_GlcNHglycan	727	730	PF01048	0.662
MOD_GlcNHglycan	746	750	PF01048	0.837
MOD_GlcNHglycan	97	100	PF01048	0.483
MOD_GSK3_1	122	129	PF00069	0.415
MOD_GSK3_1	182	189	PF00069	0.748
MOD_GSK3_1	193	200	PF00069	0.679
MOD_GSK3_1	219	226	PF00069	0.725
MOD_GSK3_1	235	242	PF00069	0.713
MOD_GSK3_1	245	252	PF00069	0.647
MOD_GSK3_1	254	261	PF00069	0.500
MOD_GSK3_1	289	296	PF00069	0.570
MOD_GSK3_1	422	429	PF00069	0.695
MOD_GSK3_1	457	464	PF00069	0.656
MOD_GSK3_1	468	475	PF00069	0.566
MOD_GSK3_1	492	499	PF00069	0.654
MOD_GSK3_1	598	605	PF00069	0.591
MOD_GSK3_1	637	644	PF00069	0.678
MOD_GSK3_1	648	655	PF00069	0.698
MOD_GSK3_1	673	680	PF00069	0.584
MOD_GSK3_1	692	699	PF00069	0.494
MOD_GSK3_1	78	85	PF00069	0.487
MOD_GSK3_1	91	98	PF00069	0.480
MOD_N-GLC_1	2	7	PF02516	0.572
MOD_NEK2_1	124	129	PF00069	0.424
MOD_NEK2_1	2	7	PF00069	0.480
MOD_NEK2_1	256	261	PF00069	0.698
MOD_NEK2_1	347	352	PF00069	0.701
MOD_NEK2_1	529	534	PF00069	0.549
MOD_NEK2_1	54	59	PF00069	0.616
MOD_NEK2_1	552	557	PF00069	0.601
MOD_NEK2_1	65	70	PF00069	0.351
MOD_NEK2_1	673	678	PF00069	0.594
MOD_NEK2_1	703	708	PF00069	0.554
MOD_PIKK_1	193	199	PF00454	0.824
MOD_PIKK_1	261	267	PF00454	0.652
MOD_PIKK_1	426	432	PF00454	0.601
MOD_PIKK_1	673	679	PF00454	0.640
MOD_PIKK_1	753	759	PF00454	0.578
MOD_PK_1	239	245	PF00069	0.731
MOD_PKA_1	239	245	PF00069	0.733
MOD_PKA_1	402	408	PF00069	0.819
MOD_PKA_1	685	691	PF00069	0.574
MOD_PKA_2	185	191	PF00069	0.683
MOD_PKA_2	239	245	PF00069	0.707
MOD_PKA_2	402	408	PF00069	0.819
MOD_PKA_2	480	486	PF00069	0.736
MOD_PKA_2	609	615	PF00069	0.577
MOD_PKA_2	685	691	PF00069	0.574
MOD_PKB_1	314	322	PF00069	0.840
MOD_Plk_1	2	8	PF00069	0.572
MOD_Plk_1	293	299	PF00069	0.573
MOD_Plk_1	673	679	PF00069	0.640
MOD_Plk_1	696	702	PF00069	0.619
MOD_Plk_2-3	29	35	PF00069	0.562
MOD_Plk_4	186	192	PF00069	0.775
MOD_Plk_4	422	428	PF00069	0.576
MOD_Plk_4	514	520	PF00069	0.565
MOD_Plk_4	665	671	PF00069	0.665
MOD_Plk_4	678	684	PF00069	0.563
MOD_ProDKin_1	208	214	PF00069	0.671
MOD_ProDKin_1	233	239	PF00069	0.749
MOD_ProDKin_1	245	251	PF00069	0.702
MOD_ProDKin_1	314	320	PF00069	0.668
MOD_ProDKin_1	342	348	PF00069	0.550
MOD_ProDKin_1	652	658	PF00069	0.730
MOD_ProDKin_1	716	722	PF00069	0.726
MOD_SUMO_for_1	61	64	PF00179	0.452
MOD_SUMO_rev_2	120	129	PF00179	0.405
MOD_SUMO_rev_2	319	329	PF00179	0.578
MOD_SUMO_rev_2	441	449	PF00179	0.584
MOD_SUMO_rev_2	613	623	PF00179	0.748
MOD_SUMO_rev_2	90	99	PF00179	0.540
TRG_ENDOCYTIC_2	533	536	PF00928	0.684
TRG_ENDOCYTIC_2	77	80	PF00928	0.322
TRG_ENDOCYTIC_2	93	96	PF00928	0.297
TRG_ER_diArg_1	314	316	PF00400	0.682
TRG_ER_diArg_1	401	403	PF00400	0.733
TRG_ER_diArg_1	449	451	PF00400	0.778
TRG_ER_diArg_1	590	593	PF00400	0.724
TRG_NLS_MonoCore_2	312	317	PF00514	0.740
TRG_NLS_MonoExtC_3	450	455	PF00514	0.828
TRG_NLS_MonoExtN_4	275	281	PF00514	0.596
TRG_NLS_MonoExtN_4	448	455	PF00514	0.738
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	698	702	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK0	Leptomonas seymouri	40%	97%
A0A3Q8IC42	Leishmania donovani	68%	98%
A4I217	Leishmania infantum	67%	96%
E9AY65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	99%
Q4Q9A7	Leishmania major	67%	100%