Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEU0_LEIBR

TriTrypDb:

LbrM.26.0860 , LBRM2903_260013400

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.521
CLV_C14_Caspase3-7	177	181	PF00656	0.351
CLV_C14_Caspase3-7	77	81	PF00656	0.587
CLV_NRD_NRD_1	108	110	PF00675	0.357
CLV_NRD_NRD_1	195	197	PF00675	0.428
CLV_NRD_NRD_1	318	320	PF00675	0.397
CLV_NRD_NRD_1	87	89	PF00675	0.472
CLV_PCSK_FUR_1	106	110	PF00082	0.354
CLV_PCSK_KEX2_1	108	110	PF00082	0.342
CLV_PCSK_KEX2_1	280	282	PF00082	0.403
CLV_PCSK_KEX2_1	318	320	PF00082	0.487
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.337
CLV_PCSK_SKI1_1	265	269	PF00082	0.445
CLV_PCSK_SKI1_1	79	83	PF00082	0.540
DEG_APCC_DBOX_1	69	77	PF00400	0.564
DOC_MAPK_gen_1	196	203	PF00069	0.338
DOC_MAPK_MEF2A_6	196	205	PF00069	0.335
DOC_PP2B_LxvP_1	24	27	PF13499	0.538
DOC_PP2B_LxvP_1	252	255	PF13499	0.410
DOC_PP4_FxxP_1	208	211	PF00568	0.359
DOC_USP7_MATH_1	13	17	PF00917	0.506
DOC_USP7_MATH_1	133	137	PF00917	0.710
DOC_USP7_MATH_1	257	261	PF00917	0.550
DOC_USP7_MATH_1	27	31	PF00917	0.517
DOC_USP7_MATH_1	289	293	PF00917	0.458
DOC_WW_Pin1_4	207	212	PF00397	0.297
DOC_WW_Pin1_4	250	255	PF00397	0.423
DOC_WW_Pin1_4	71	76	PF00397	0.416
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_BIR_III_4	149	153	PF00653	0.525
LIG_BRCT_BRCA1_1	259	263	PF00533	0.498
LIG_BRCT_BRCA1_2	259	265	PF00533	0.396
LIG_deltaCOP1_diTrp_1	110	115	PF00928	0.406
LIG_EH1_1	43	51	PF00400	0.360
LIG_FHA_1	165	171	PF00498	0.547
LIG_FHA_1	237	243	PF00498	0.434
LIG_FHA_1	308	314	PF00498	0.566
LIG_FHA_1	46	52	PF00498	0.489
LIG_FHA_2	202	208	PF00498	0.378
LIG_FHA_2	56	62	PF00498	0.360
LIG_FHA_2	63	69	PF00498	0.441
LIG_Integrin_RGD_1	98	100	PF01839	0.458
LIG_LIR_Apic_2	207	211	PF02991	0.368
LIG_LIR_Gen_1	101	112	PF02991	0.366
LIG_LIR_Nem_3	101	107	PF02991	0.357
LIG_PCNA_yPIPBox_3	36	50	PF02747	0.392
LIG_SH2_CRK	104	108	PF00017	0.335
LIG_SH2_STAT3	40	43	PF00017	0.377
LIG_SH2_STAT5	104	107	PF00017	0.337
LIG_SH2_STAT5	163	166	PF00017	0.578
LIG_SH2_STAT5	295	298	PF00017	0.498
LIG_SH2_STAT5	40	43	PF00017	0.374
LIG_SH3_3	264	270	PF00018	0.485
LIG_TYR_ITIM	102	107	PF00017	0.358
MOD_CK1_1	126	132	PF00069	0.634
MOD_CK1_1	16	22	PF00069	0.546
MOD_CK1_1	253	259	PF00069	0.461
MOD_CK2_1	16	22	PF00069	0.564
MOD_CK2_1	268	274	PF00069	0.529
MOD_CK2_1	55	61	PF00069	0.350
MOD_CK2_1	62	68	PF00069	0.435
MOD_Cter_Amidation	316	319	PF01082	0.385
MOD_GlcNHglycan	125	128	PF01048	0.614
MOD_GlcNHglycan	149	153	PF01048	0.750
MOD_GlcNHglycan	259	262	PF01048	0.550
MOD_GlcNHglycan	291	294	PF01048	0.428
MOD_GSK3_1	246	253	PF00069	0.406
MOD_GSK3_1	257	264	PF00069	0.345
MOD_GSK3_1	291	298	PF00069	0.443
MOD_N-GLC_1	257	262	PF02516	0.628
MOD_N-GLC_1	27	32	PF02516	0.633
MOD_NEK2_1	263	268	PF00069	0.529
MOD_NEK2_2	275	280	PF00069	0.403
MOD_Plk_1	134	140	PF00069	0.486
MOD_Plk_1	246	252	PF00069	0.414
MOD_Plk_4	16	22	PF00069	0.555
MOD_Plk_4	237	243	PF00069	0.412
MOD_Plk_4	291	297	PF00069	0.445
MOD_Plk_4	45	51	PF00069	0.410
MOD_ProDKin_1	207	213	PF00069	0.297
MOD_ProDKin_1	250	256	PF00069	0.433
MOD_ProDKin_1	71	77	PF00069	0.411
MOD_SUMO_rev_2	74	81	PF00179	0.405
TRG_DiLeu_BaEn_4	68	74	PF01217	0.483
TRG_ENDOCYTIC_2	104	107	PF00928	0.337
TRG_ENDOCYTIC_2	235	238	PF00928	0.284
TRG_ER_diArg_1	106	109	PF00400	0.346
TRG_ER_diArg_1	318	320	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0T3	Leptomonas seymouri	69%	76%
A0A0S4JP39	Bodo saltans	41%	87%
A0A1X0NTU5	Trypanosomatidae	44%	80%
A0A3R7RM36	Trypanosoma rangeli	50%	86%
A0A3S7WZT0	Leishmania donovani	88%	100%
A4I215	Leishmania infantum	88%	100%
C9ZRZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	89%
E9AY63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9A9	Leishmania major	86%	100%
V5B9C8	Trypanosoma cruzi	54%	85%