Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HET9_LEIBR

TriTrypDb:

LbrM.26.0850 , LBRM2903_260013300

Length:

939

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HET9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HET9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.653
CLV_C14_Caspase3-7	674	678	PF00656	0.712
CLV_NRD_NRD_1	110	112	PF00675	0.749
CLV_NRD_NRD_1	184	186	PF00675	0.580
CLV_NRD_NRD_1	270	272	PF00675	0.783
CLV_NRD_NRD_1	585	587	PF00675	0.596
CLV_NRD_NRD_1	63	65	PF00675	0.625
CLV_NRD_NRD_1	724	726	PF00675	0.707
CLV_NRD_NRD_1	849	851	PF00675	0.614
CLV_PCSK_KEX2_1	110	112	PF00082	0.749
CLV_PCSK_KEX2_1	435	437	PF00082	0.593
CLV_PCSK_KEX2_1	585	587	PF00082	0.596
CLV_PCSK_KEX2_1	61	63	PF00082	0.658
CLV_PCSK_KEX2_1	724	726	PF00082	0.658
CLV_PCSK_KEX2_1	849	851	PF00082	0.614
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.695
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.658
CLV_PCSK_PC7_1	58	64	PF00082	0.651
CLV_PCSK_SKI1_1	212	216	PF00082	0.588
CLV_PCSK_SKI1_1	449	453	PF00082	0.516
CLV_PCSK_SKI1_1	486	490	PF00082	0.642
CLV_PCSK_SKI1_1	53	57	PF00082	0.647
CLV_PCSK_SKI1_1	739	743	PF00082	0.580
CLV_PCSK_SKI1_1	77	81	PF00082	0.633
CLV_PCSK_SKI1_1	816	820	PF00082	0.559
CLV_PCSK_SKI1_1	821	825	PF00082	0.564
CLV_PCSK_SKI1_1	843	847	PF00082	0.699
CLV_PCSK_SKI1_1	861	865	PF00082	0.555
CLV_PCSK_SKI1_1	87	91	PF00082	0.654
DEG_APCC_DBOX_1	762	770	PF00400	0.583
DEG_SPOP_SBC_1	252	256	PF00917	0.838
DEG_SPOP_SBC_1	528	532	PF00917	0.648
DOC_ANK_TNKS_1	790	797	PF00023	0.660
DOC_CKS1_1	481	486	PF01111	0.630
DOC_CYCLIN_RxL_1	50	60	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.809
DOC_MAPK_DCC_7	644	654	PF00069	0.737
DOC_MAPK_gen_1	269	276	PF00069	0.697
DOC_MAPK_gen_1	446	454	PF00069	0.558
DOC_MAPK_gen_1	61	69	PF00069	0.621
DOC_MAPK_gen_1	97	106	PF00069	0.611
DOC_MAPK_HePTP_8	94	106	PF00069	0.609
DOC_MAPK_MEF2A_6	458	466	PF00069	0.589
DOC_MAPK_MEF2A_6	97	106	PF00069	0.611
DOC_PP1_RVXF_1	51	58	PF00149	0.651
DOC_PP1_RVXF_1	533	539	PF00149	0.622
DOC_PP1_RVXF_1	878	884	PF00149	0.608
DOC_PP2B_LxvP_1	323	326	PF13499	0.581
DOC_PP2B_LxvP_1	328	331	PF13499	0.584
DOC_USP7_MATH_1	157	161	PF00917	0.731
DOC_USP7_MATH_1	252	256	PF00917	0.838
DOC_USP7_MATH_1	279	283	PF00917	0.482
DOC_USP7_MATH_1	364	368	PF00917	0.750
DOC_USP7_MATH_1	512	516	PF00917	0.641
DOC_USP7_MATH_1	528	532	PF00917	0.648
DOC_USP7_MATH_1	595	599	PF00917	0.793
DOC_USP7_MATH_1	624	628	PF00917	0.586
DOC_USP7_MATH_1	869	873	PF00917	0.430
DOC_USP7_MATH_1	897	901	PF00917	0.614
DOC_USP7_UBL2_3	671	675	PF12436	0.586
DOC_USP7_UBL2_3	876	880	PF12436	0.696
DOC_USP7_UBL2_3	93	97	PF12436	0.618
DOC_WW_Pin1_4	215	220	PF00397	0.693
DOC_WW_Pin1_4	426	431	PF00397	0.647
DOC_WW_Pin1_4	480	485	PF00397	0.625
DOC_WW_Pin1_4	609	614	PF00397	0.832
DOC_WW_Pin1_4	615	620	PF00397	0.716
DOC_WW_Pin1_4	647	652	PF00397	0.746
DOC_WW_Pin1_4	864	869	PF00397	0.609
LIG_14-3-3_CanoR_1	436	441	PF00244	0.568
LIG_14-3-3_CanoR_1	496	505	PF00244	0.604
LIG_14-3-3_CanoR_1	708	713	PF00244	0.699
LIG_14-3-3_CanoR_1	77	82	PF00244	0.637
LIG_14-3-3_CanoR_1	896	902	PF00244	0.613
LIG_BRCT_BRCA1_1	523	527	PF00533	0.662
LIG_CaM_IQ_9	69	84	PF13499	0.736
LIG_Clathr_ClatBox_1	451	455	PF01394	0.566
LIG_Clathr_ClatBox_1	562	566	PF01394	0.625
LIG_EH1_1	244	252	PF00400	0.809
LIG_FHA_1	21	27	PF00498	0.728
LIG_FHA_1	377	383	PF00498	0.605
LIG_FHA_1	426	432	PF00498	0.579
LIG_FHA_1	531	537	PF00498	0.623
LIG_FHA_1	78	84	PF00498	0.643
LIG_FHA_1	787	793	PF00498	0.648
LIG_FHA_1	795	801	PF00498	0.641
LIG_FHA_1	802	808	PF00498	0.584
LIG_FHA_1	876	882	PF00498	0.595
LIG_FHA_1	907	913	PF00498	0.678
LIG_FHA_2	137	143	PF00498	0.770
LIG_FHA_2	227	233	PF00498	0.810
LIG_FHA_2	487	493	PF00498	0.633
LIG_FHA_2	865	871	PF00498	0.694
LIG_FHA_2	919	925	PF00498	0.616
LIG_GBD_Chelix_1	737	745	PF00786	0.597
LIG_HCF-1_HBM_1	749	752	PF13415	0.624
LIG_LIR_Apic_2	215	220	PF02991	0.632
LIG_LIR_Apic_2	480	484	PF02991	0.629
LIG_LIR_Gen_1	571	579	PF02991	0.560
LIG_LIR_Gen_1	659	670	PF02991	0.576
LIG_LIR_Gen_1	758	769	PF02991	0.594
LIG_LIR_Nem_3	39	44	PF02991	0.669
LIG_LIR_Nem_3	447	451	PF02991	0.551
LIG_LIR_Nem_3	489	493	PF02991	0.634
LIG_LIR_Nem_3	558	563	PF02991	0.602
LIG_LIR_Nem_3	571	577	PF02991	0.504
LIG_LIR_Nem_3	717	723	PF02991	0.692
LIG_LIR_Nem_3	824	828	PF02991	0.578
LIG_PCNA_yPIPBox_3	90	102	PF02747	0.613
LIG_PDZ_Class_3	934	939	PF00595	0.811
LIG_Pex14_2	444	448	PF04695	0.542
LIG_Pex14_2	716	720	PF04695	0.689
LIG_Pex14_2	808	812	PF04695	0.570
LIG_REV1ctd_RIR_1	881	891	PF16727	0.614
LIG_SH2_CRK	217	221	PF00017	0.759
LIG_SH2_CRK	472	476	PF00017	0.611
LIG_SH2_CRK	481	485	PF00017	0.626
LIG_SH2_CRK	65	69	PF00017	0.606
LIG_SH2_CRK	825	829	PF00017	0.585
LIG_SH2_NCK_1	217	221	PF00017	0.642
LIG_SH2_SRC	752	755	PF00017	0.758
LIG_SH2_STAP1	422	426	PF00017	0.690
LIG_SH2_STAT5	217	220	PF00017	0.747
LIG_SH2_STAT5	399	402	PF00017	0.693
LIG_SH2_STAT5	443	446	PF00017	0.545
LIG_SH2_STAT5	472	475	PF00017	0.610
LIG_SH2_STAT5	505	508	PF00017	0.625
LIG_SH2_STAT5	65	68	PF00017	0.598
LIG_SH2_STAT5	752	755	PF00017	0.656
LIG_SH3_3	287	293	PF00018	0.706
LIG_SH3_3	303	309	PF00018	0.752
LIG_SH3_3	355	361	PF00018	0.828
LIG_SH3_3	607	613	PF00018	0.646
LIG_SH3_3	631	637	PF00018	0.748
LIG_SH3_3	655	661	PF00018	0.703
LIG_SH3_3	709	715	PF00018	0.694
LIG_SH3_3	730	736	PF00018	0.646
LIG_SH3_3	871	877	PF00018	0.567
LIG_SH3_4	876	883	PF00018	0.702
LIG_SUMO_SIM_par_1	561	566	PF11976	0.626
LIG_TRAF2_1	133	136	PF00917	0.824
LIG_TRAF2_1	141	144	PF00917	0.702
LIG_TRAF2_1	229	232	PF00917	0.552
LIG_TRAF2_1	687	690	PF00917	0.837
LIG_TRAF2_1	900	903	PF00917	0.594
LIG_TRAF2_2	220	225	PF00917	0.698
LIG_WW_3	633	637	PF00397	0.580
MOD_CDK_SPxK_1	480	486	PF00069	0.628
MOD_CK1_1	18	24	PF00069	0.647
MOD_CK1_1	226	232	PF00069	0.815
MOD_CK1_1	254	260	PF00069	0.839
MOD_CK1_1	425	431	PF00069	0.501
MOD_CK1_1	480	486	PF00069	0.628
MOD_CK1_1	530	536	PF00069	0.625
MOD_CK1_1	575	581	PF00069	0.621
MOD_CK1_1	609	615	PF00069	0.606
MOD_CK1_1	680	686	PF00069	0.722
MOD_CK1_1	757	763	PF00069	0.508
MOD_CK1_1	879	885	PF00069	0.613
MOD_CK1_1	886	892	PF00069	0.609
MOD_CK2_1	138	144	PF00069	0.760
MOD_CK2_1	157	163	PF00069	0.519
MOD_CK2_1	226	232	PF00069	0.815
MOD_CK2_1	252	258	PF00069	0.815
MOD_CK2_1	278	284	PF00069	0.746
MOD_CK2_1	486	492	PF00069	0.640
MOD_CK2_1	575	581	PF00069	0.621
MOD_CK2_1	743	749	PF00069	0.594
MOD_CK2_1	864	870	PF00069	0.601
MOD_CK2_1	896	902	PF00069	0.617
MOD_CK2_1	918	924	PF00069	0.716
MOD_GlcNHglycan	163	166	PF01048	0.724
MOD_GlcNHglycan	365	369	PF01048	0.738
MOD_GlcNHglycan	521	524	PF01048	0.675
MOD_GlcNHglycan	596	600	PF01048	0.756
MOD_GlcNHglycan	613	616	PF01048	0.632
MOD_GlcNHglycan	625	629	PF01048	0.662
MOD_GlcNHglycan	8	11	PF01048	0.701
MOD_GlcNHglycan	855	858	PF01048	0.532
MOD_GlcNHglycan	928	931	PF01048	0.685
MOD_GSK3_1	157	164	PF00069	0.790
MOD_GSK3_1	16	23	PF00069	0.629
MOD_GSK3_1	333	340	PF00069	0.832
MOD_GSK3_1	421	428	PF00069	0.687
MOD_GSK3_1	568	575	PF00069	0.617
MOD_GSK3_1	595	602	PF00069	0.709
MOD_GSK3_1	611	618	PF00069	0.672
MOD_GSK3_1	624	631	PF00069	0.780
MOD_GSK3_1	677	684	PF00069	0.624
MOD_GSK3_1	73	80	PF00069	0.638
MOD_GSK3_1	875	882	PF00069	0.590
MOD_GSK3_1	883	890	PF00069	0.622
MOD_GSK3_1	906	913	PF00069	0.680
MOD_N-GLC_1	102	107	PF02516	0.621
MOD_N-GLC_1	188	193	PF02516	0.567
MOD_N-GLC_1	236	241	PF02516	0.783
MOD_N-GLC_1	460	465	PF02516	0.579
MOD_N-GLC_1	48	53	PF02516	0.670
MOD_N-GLC_1	572	577	PF02516	0.579
MOD_N-GLC_1	599	604	PF02516	0.609
MOD_N-GLC_1	708	713	PF02516	0.699
MOD_N-GLC_1	73	78	PF02516	0.746
MOD_N-GLC_1	802	807	PF02516	0.583
MOD_N-GLC_1	897	902	PF02516	0.563
MOD_N-GLC_2	768	770	PF02516	0.566
MOD_NEK2_1	20	25	PF00069	0.709
MOD_NEK2_1	224	229	PF00069	0.830
MOD_NEK2_1	421	426	PF00069	0.794
MOD_NEK2_1	572	577	PF00069	0.595
MOD_NEK2_1	579	584	PF00069	0.574
MOD_NEK2_1	764	769	PF00069	0.571
MOD_NEK2_1	841	846	PF00069	0.686
MOD_NEK2_1	883	888	PF00069	0.623
MOD_PIKK_1	224	230	PF00454	0.828
MOD_PKA_1	110	116	PF00069	0.737
MOD_PKA_2	110	116	PF00069	0.737
MOD_PKA_2	542	548	PF00069	0.650
MOD_PKA_2	853	859	PF00069	0.520
MOD_PKA_2	886	892	PF00069	0.609
MOD_PKA_2	926	932	PF00069	0.685
MOD_PKB_1	885	893	PF00069	0.611
MOD_Plk_1	102	108	PF00069	0.625
MOD_Plk_1	422	428	PF00069	0.684
MOD_Plk_1	460	466	PF00069	0.576
MOD_Plk_1	572	578	PF00069	0.580
MOD_Plk_1	579	585	PF00069	0.559
MOD_Plk_1	708	714	PF00069	0.683
MOD_Plk_1	743	749	PF00069	0.594
MOD_Plk_1	802	808	PF00069	0.584
MOD_Plk_1	897	903	PF00069	0.612
MOD_Plk_2-3	136	142	PF00069	0.825
MOD_Plk_2-3	294	300	PF00069	0.845
MOD_Plk_2-3	677	683	PF00069	0.667
MOD_Plk_2-3	743	749	PF00069	0.594
MOD_Plk_4	579	585	PF00069	0.578
MOD_Plk_4	780	786	PF00069	0.620
MOD_Plk_4	803	809	PF00069	0.580
MOD_Plk_4	879	885	PF00069	0.566
MOD_Plk_4	910	916	PF00069	0.591
MOD_ProDKin_1	215	221	PF00069	0.695
MOD_ProDKin_1	426	432	PF00069	0.643
MOD_ProDKin_1	480	486	PF00069	0.628
MOD_ProDKin_1	609	615	PF00069	0.831
MOD_ProDKin_1	647	653	PF00069	0.744
MOD_ProDKin_1	864	870	PF00069	0.601
MOD_SUMO_for_1	792	795	PF00179	0.666
MOD_SUMO_rev_2	689	694	PF00179	0.838
TRG_DiLeu_BaEn_1	447	452	PF01217	0.546
TRG_DiLeu_BaEn_1	749	754	PF01217	0.739
TRG_DiLeu_BaEn_1	795	800	PF01217	0.648
TRG_DiLeu_BaEn_2	909	915	PF01217	0.589
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.617
TRG_DiLeu_LyEn_5	405	410	PF01217	0.514
TRG_ENDOCYTIC_2	472	475	PF00928	0.610
TRG_ENDOCYTIC_2	65	68	PF00928	0.598
TRG_ENDOCYTIC_2	761	764	PF00928	0.602
TRG_ENDOCYTIC_2	825	828	PF00928	0.581
TRG_ER_diArg_1	109	111	PF00400	0.745
TRG_ER_diArg_1	584	586	PF00400	0.589
TRG_ER_diArg_1	62	64	PF00400	0.635
TRG_ER_diArg_1	644	647	PF00400	0.631
TRG_ER_diArg_1	723	725	PF00400	0.713
TRG_ER_diArg_1	884	887	PF00400	0.639
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	816	820	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I256	Leptomonas seymouri	63%	95%
A0A3S7WZV1	Leishmania donovani	82%	99%
A4I214	Leishmania infantum	82%	99%
E9AY62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4Q9B0	Leishmania major	81%	100%