Glutathione peroxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutathione peroxidase-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HET6_LEIBR

TriTrypDb:

LbrM.26.0820 , LBRM2903_260013100

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HET6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HET6

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	25
GO:0006979	response to oxidative stress	3	25
GO:0050896	response to stimulus	1	25

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004601	peroxidase activity	2	25
GO:0004602	glutathione peroxidase activity	3	25
GO:0016209	antioxidant activity	1	25
GO:0016491	oxidoreductase activity	2	25
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	25
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.626
CLV_PCSK_SKI1_1	55	59	PF00082	0.342
DOC_MAPK_gen_1	53	62	PF00069	0.393
DOC_USP7_MATH_1	161	165	PF00917	0.648
DOC_USP7_UBL2_3	111	115	PF12436	0.719
LIG_14-3-3_CanoR_1	55	60	PF00244	0.227
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_FHA_1	118	124	PF00498	0.591
LIG_FHA_1	126	132	PF00498	0.557
LIG_FHA_2	145	151	PF00498	0.691
LIG_FHA_2	45	51	PF00498	0.337
LIG_FHA_2	72	78	PF00498	0.374
LIG_LIR_Nem_3	46	52	PF02991	0.340
LIG_PDZ_Class_1	162	167	PF00595	0.557
LIG_Pex14_2	86	90	PF04695	0.343
LIG_SH2_CRK	107	111	PF00017	0.471
LIG_SH2_NCK_1	29	33	PF00017	0.358
LIG_SH2_NCK_1	42	46	PF00017	0.335
LIG_SH2_STAP1	4	8	PF00017	0.358
LIG_SH2_STAT3	4	7	PF00017	0.256
LIG_SH2_STAT5	107	110	PF00017	0.387
LIG_SH2_STAT5	37	40	PF00017	0.230
LIG_TRAF2_1	147	150	PF00917	0.606
LIG_TRAF2_1	68	71	PF00917	0.379
LIG_WRC_WIRS_1	127	132	PF05994	0.459
LIG_WRC_WIRS_1	78	83	PF05994	0.357
MOD_CK2_1	144	150	PF00069	0.657
MOD_CK2_1	37	43	PF00069	0.342
MOD_CK2_1	44	50	PF00069	0.300
MOD_CK2_1	71	77	PF00069	0.356
MOD_GlcNHglycan	39	42	PF01048	0.227
MOD_GSK3_1	37	44	PF00069	0.377
MOD_GSK3_1	77	84	PF00069	0.357
MOD_N-GLC_1	125	130	PF02516	0.573
MOD_N-GLC_1	16	21	PF02516	0.411
MOD_N-GLC_1	8	13	PF02516	0.457
MOD_N-GLC_2	112	114	PF02516	0.621
MOD_NEK2_1	110	115	PF00069	0.603
MOD_NEK2_1	118	123	PF00069	0.612
MOD_NEK2_1	81	86	PF00069	0.366
MOD_OFUCOSY	108	114	PF10250	0.187
MOD_PIKK_1	16	22	PF00454	0.281
MOD_Plk_1	125	131	PF00069	0.576
MOD_Plk_2-3	71	77	PF00069	0.452
MOD_Plk_4	118	124	PF00069	0.636
MOD_Plk_4	126	132	PF00069	0.535
MOD_Plk_4	44	50	PF00069	0.300
MOD_SUMO_rev_2	149	156	PF00179	0.647
MOD_SUMO_rev_2	71	81	PF00179	0.332
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.628
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.347
TRG_ENDOCYTIC_2	107	110	PF00928	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD2	Leptomonas seymouri	30%	100%
A0A0S4IL06	Bodo saltans	69%	92%
A0A0S4IL19	Bodo saltans	70%	91%
A0A0S4IZF2	Bodo saltans	68%	92%
A0A0S4JV67	Bodo saltans	34%	100%
A0A1X0NS99	Trypanosomatidae	37%	100%
A0A1X0NSC3	Trypanosomatidae	71%	100%
A0A1X0NSD3	Trypanosomatidae	76%	95%
A0A1X0NSE0	Trypanosomatidae	73%	89%
A0A3Q8IDK7	Leishmania donovani	84%	96%
A0A3Q8IDS3	Leishmania donovani	83%	91%
A0A3Q8IKY0	Leishmania donovani	33%	100%
A0A422NMY9	Trypanosoma rangeli	71%	100%
A0A422NMZ4	Trypanosoma rangeli	70%	100%
A0A422NNB6	Trypanosoma rangeli	73%	87%
A0A422NZP6	Trypanosoma rangeli	34%	100%
A1KV41	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	39%	94%
A4HET7	Leishmania braziliensis	97%	97%
A4HPG7	Leishmania braziliensis	33%	100%
A4I211	Leishmania infantum	83%	91%
A4I212	Leishmania infantum	84%	96%
A4ID89	Leishmania infantum	33%	100%
A6QLY2	Bos taurus	36%	90%
C9ZRZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
C9ZS00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	95%
D0AAG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AT79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AY59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	91%
E9AY60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	96%
G9JJU2	Procambarus clarkii	31%	97%
O02621	Caenorhabditis elegans	44%	100%
O04922	Arabidopsis thaliana	50%	99%
O08368	Pseudomonas wisconsinensis	30%	75%
O18994	Sus scrofa	37%	76%
O22850	Arabidopsis thaliana	49%	81%
O23814	Spinacia oleracea	53%	98%
O23968	Helianthus annuus	53%	93%
O23970	Helianthus annuus	49%	100%
O24031	Solanum lycopersicum	48%	99%
O24296	Pisum sativum	53%	71%
O32770	Lactococcus lactis subsp. cremoris (strain MG1363)	42%	100%
O46607	Canis lupus familiaris	34%	76%
O48646	Arabidopsis thaliana	54%	72%
O49069	Gossypium hirsutum	49%	98%
O59858	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
O62327	Caenorhabditis elegans	40%	100%
O70325	Mus musculus	40%	85%
O75715	Homo sapiens	35%	76%
P00435	Bos taurus	35%	81%
P04041	Rattus norvegicus	34%	83%
P06610	Escherichia coli (strain K12)	40%	91%
P07203	Homo sapiens	33%	82%
P0A0T4	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	39%	94%
P0A0T5	Neisseria meningitidis serogroup B (strain MC58)	39%	94%
P0C2T0	Neisseria meningitidis serogroup C	39%	94%
P11352	Mus musculus	35%	83%
P11909	Oryctolagus cuniculus	32%	84%
P18283	Homo sapiens	29%	88%
P21765	Mus musculus	33%	76%
P22352	Homo sapiens	34%	74%
P23764	Rattus norvegicus	33%	74%
P28714	Macaca fascicularis	36%	76%
P30708	Nicotiana sylvestris	50%	99%
P30710	Rattus norvegicus	31%	76%
P35666	Wuchereria bancrofti	34%	75%
P36014	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P36968	Sus scrofa	41%	85%
P36969	Homo sapiens	41%	85%
P36970	Rattus norvegicus	40%	85%
P37141	Bos taurus	34%	74%
P38143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P40581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P46412	Mus musculus	33%	74%
P52032	Arabidopsis thaliana	52%	71%
P52033	Dirofilaria immitis	36%	76%
P52035	Bacillus subtilis (strain 168)	44%	100%
P59796	Homo sapiens	34%	76%
P64290	Staphylococcus aureus (strain Mu50 / ATCC 700699)	43%	100%
P64291	Staphylococcus aureus (strain MW2)	43%	100%
P67877	Brugia malayi	35%	75%
P67878	Brugia pahangi	35%	75%
P73824	Synechocystis sp. (strain PCC 6803 / Kazusa)	38%	100%
P74250	Synechocystis sp. (strain PCC 6803 / Kazusa)	44%	99%
P83564	Chlamydomonas reinhardtii	42%	83%
P83645	Rattus norvegicus	30%	88%
P99097	Staphylococcus aureus (strain N315)	43%	100%
Q00277	Schistosoma mansoni	40%	99%
Q06652	Citrus sinensis	51%	100%
Q0EF98	Callithrix jacchus	29%	88%
Q0EF99	Callithrix jacchus	29%	83%
Q0EFA0	Pan troglodytes	32%	83%
Q2NL01	Bos taurus	34%	80%
Q32QL6	Callithrix jacchus	41%	85%
Q4AEG9	Sapajus apella	41%	85%
Q4AEH0	Macaca fuscata fuscata	40%	85%
Q4AEH1	Hylobates lar	40%	85%
Q4AEH2	Pongo pygmaeus	41%	85%
Q4AEH3	Sapajus apella	33%	74%
Q4AEH4	Macaca fuscata fuscata	33%	74%
Q4AEH5	Hylobates lar	34%	74%
Q4AEH7	Sapajus apella	29%	88%
Q4AEH8	Macaca fuscata fuscata	29%	88%
Q4AEH9	Hylobates lar	29%	88%
Q4AEI0	Pongo pygmaeus	29%	88%
Q4AEI1	Sapajus apella	29%	83%
Q4AEI2	Hylobates lar	33%	83%
Q4AEI3	Pongo pygmaeus	33%	83%
Q4Q1B8	Leishmania major	33%	100%
Q4Q9B2	Leishmania major	85%	100%
Q4Q9B3	Leishmania major	85%	100%
Q4Q9B4	Leishmania major	84%	100%
Q4RSM6	Tetraodon nigroviridis	28%	80%
Q59WD3	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	98%
Q5HGC7	Staphylococcus aureus (strain COL)	43%	100%
Q5HKZ3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	42%	100%
Q5RFG3	Pongo pygmaeus	34%	74%
Q5U583	Xenopus laevis	34%	80%
Q64625	Rattus norvegicus	32%	76%
Q6G9Q8	Staphylococcus aureus (strain MSSA476)	43%	100%
Q6GHD0	Staphylococcus aureus (strain MRSA252)	43%	100%
Q6IRC8	Xenopus laevis	33%	80%
Q7ZV14	Danio rerio	31%	80%
Q865R2	Macaca fuscata fuscata	34%	83%
Q8CSR9	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	43%	100%
Q8L910	Arabidopsis thaliana	48%	98%
Q8LBU2	Arabidopsis thaliana	47%	100%
Q8MJ14	Sus scrofa	32%	81%
Q8SSH7	Encephalitozoon cuniculi (strain GB-M1)	34%	94%
Q8TED1	Homo sapiens	33%	80%
Q91WR8	Mus musculus	32%	76%
Q95003	Caenorhabditis elegans	35%	75%
Q96SL4	Homo sapiens	36%	89%
Q98234	Molluscum contagiosum virus subtype 1	33%	76%
Q99LJ6	Mus musculus	38%	90%
Q9CFV1	Lactococcus lactis subsp. lactis (strain IL1403)	40%	100%
Q9D7B7	Mus musculus	34%	80%
Q9FXS3	Nicotiana tabacum	50%	99%
Q9JHC0	Mus musculus	30%	88%
Q9LEF0	Mesembryanthemum crystallinum	52%	98%
Q9LYB4	Arabidopsis thaliana	50%	97%
Q9N2J2	Bos taurus	42%	85%
Q9SZ54	Arabidopsis thaliana	54%	72%
Q9Z9N7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	45%	100%
V5B9J0	Trypanosoma cruzi	71%	94%
V5BZH0	Trypanosoma cruzi	72%	94%