Glutathione peroxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutathione peroxidase-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HET5_LEIBR

TriTrypDb:

LbrM.26.0810 , LBRM2903_260012900

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HET5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HET5

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	3
GO:0006979	response to oxidative stress	3	3
GO:0050896	response to stimulus	1	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004601	peroxidase activity	2	3
GO:0004602	glutathione peroxidase activity	3	3
GO:0016209	antioxidant activity	1	3
GO:0016491	oxidoreductase activity	2	3
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.680
CLV_NRD_NRD_1	94	96	PF00675	0.227
CLV_PCSK_SKI1_1	164	168	PF00082	0.344
CLV_PCSK_SKI1_1	254	258	PF00082	0.541
DEG_APCC_DBOX_1	55	63	PF00400	0.280
DEG_Nend_Nbox_1	1	3	PF02207	0.460
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.383
DOC_PP1_RVXF_1	134	140	PF00149	0.227
DOC_PP4_MxPP_1	256	259	PF00568	0.536
DOC_USP7_MATH_1	106	110	PF00917	0.227
DOC_USP7_MATH_1	193	197	PF00917	0.313
DOC_USP7_MATH_1	223	227	PF00917	0.450
DOC_USP7_MATH_1	234	238	PF00917	0.510
DOC_USP7_MATH_1	8	12	PF00917	0.486
DOC_WW_Pin1_4	254	259	PF00397	0.568
DOC_WW_Pin1_4	297	302	PF00397	0.552
DOC_WW_Pin1_4	4	9	PF00397	0.479
LIG_14-3-3_CanoR_1	173	181	PF00244	0.263
LIG_BRCT_BRCA1_1	108	112	PF00533	0.227
LIG_BRCT_BRCA1_1	271	275	PF00533	0.508
LIG_FHA_1	175	181	PF00498	0.232
LIG_FHA_1	272	278	PF00498	0.515
LIG_FHA_1	29	35	PF00498	0.503
LIG_FHA_1	42	48	PF00498	0.292
LIG_FHA_1	7	13	PF00498	0.523
LIG_FHA_1	86	92	PF00498	0.227
LIG_FHA_2	313	319	PF00498	0.546
LIG_FHA_2	329	335	PF00498	0.496
LIG_FHA_2	44	50	PF00498	0.213
LIG_LIR_Gen_1	100	108	PF02991	0.202
LIG_LIR_Gen_1	23	29	PF02991	0.384
LIG_LIR_Gen_1	267	275	PF02991	0.516
LIG_LIR_Gen_1	84	94	PF02991	0.216
LIG_LIR_Nem_3	100	105	PF02991	0.202
LIG_LIR_Nem_3	128	134	PF02991	0.297
LIG_LIR_Nem_3	23	28	PF02991	0.379
LIG_LIR_Nem_3	267	271	PF02991	0.522
LIG_LIR_Nem_3	49	53	PF02991	0.213
LIG_LIR_Nem_3	84	90	PF02991	0.216
LIG_LYPXL_S_1	130	134	PF13949	0.227
LIG_LYPXL_yS_3	131	134	PF13949	0.227
LIG_PTB_Apo_2	262	269	PF02174	0.533
LIG_SH2_CRK	87	91	PF00017	0.213
LIG_SH2_STAP1	188	192	PF00017	0.286
LIG_SH2_STAP1	25	29	PF00017	0.385
LIG_SH2_STAP1	48	52	PF00017	0.213
LIG_SH2_STAP1	87	91	PF00017	0.227
LIG_SH2_STAT3	48	51	PF00017	0.213
LIG_SH2_STAT5	82	85	PF00017	0.213
LIG_SH2_STAT5	87	90	PF00017	0.213
LIG_SH2_STAT5	98	101	PF00017	0.213
LIG_SH3_3	134	140	PF00018	0.213
LIG_SH3_3	207	213	PF00018	0.383
LIG_SH3_3	255	261	PF00018	0.539
LIG_SH3_3	33	39	PF00018	0.454
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.213
LIG_TRAF2_1	327	330	PF00917	0.550
MOD_CDK_SPxxK_3	257	264	PF00069	0.538
MOD_CK1_1	289	295	PF00069	0.616
MOD_CK1_1	7	13	PF00069	0.616
MOD_CK1_1	85	91	PF00069	0.227
MOD_CK2_1	193	199	PF00069	0.302
MOD_CK2_1	20	26	PF00069	0.486
MOD_CK2_1	245	251	PF00069	0.517
MOD_CK2_1	328	334	PF00069	0.558
MOD_GlcNHglycan	169	172	PF01048	0.301
MOD_GlcNHglycan	22	25	PF01048	0.480
MOD_GlcNHglycan	224	228	PF01048	0.558
MOD_GlcNHglycan	240	243	PF01048	0.442
MOD_GlcNHglycan	324	327	PF01048	0.559
MOD_GlcNHglycan	84	87	PF01048	0.227
MOD_GSK3_1	121	128	PF00069	0.227
MOD_GSK3_1	20	27	PF00069	0.320
MOD_GSK3_1	234	241	PF00069	0.500
MOD_GSK3_1	267	274	PF00069	0.574
MOD_GSK3_1	4	11	PF00069	0.644
MOD_GSK3_1	82	89	PF00069	0.213
MOD_N-GLC_1	174	179	PF02516	0.269
MOD_N-GLC_1	41	46	PF02516	0.495
MOD_NEK2_1	158	163	PF00069	0.274
MOD_NEK2_1	167	172	PF00069	0.305
MOD_NEK2_1	275	280	PF00069	0.524
MOD_NEK2_1	28	33	PF00069	0.500
MOD_NEK2_1	309	314	PF00069	0.545
MOD_NEK2_1	321	326	PF00069	0.518
MOD_NEK2_2	174	179	PF00069	0.244
MOD_NEK2_2	43	48	PF00069	0.309
MOD_PIKK_1	18	24	PF00454	0.383
MOD_PKA_2	238	244	PF00069	0.519
MOD_Plk_1	174	180	PF00069	0.267
MOD_Plk_1	244	250	PF00069	0.530
MOD_Plk_1	309	315	PF00069	0.544
MOD_Plk_2-3	245	251	PF00069	0.529
MOD_Plk_4	304	310	PF00069	0.550
MOD_Plk_4	43	49	PF00069	0.310
MOD_Plk_4	65	71	PF00069	0.213
MOD_Plk_4	86	92	PF00069	0.298
MOD_ProDKin_1	254	260	PF00069	0.569
MOD_ProDKin_1	297	303	PF00069	0.553
MOD_ProDKin_1	4	10	PF00069	0.479
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.447
TRG_ENDOCYTIC_2	131	134	PF00928	0.227
TRG_ENDOCYTIC_2	188	191	PF00928	0.276
TRG_ENDOCYTIC_2	25	28	PF00928	0.378
TRG_ENDOCYTIC_2	87	90	PF00928	0.213

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P533	Leptomonas seymouri	60%	100%