RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HET3_LEIBR

TriTrypDb:

LbrM.26.0790 , LBRM2903_260012700

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HET3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HET3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	100	106	PF00089	0.188
CLV_NRD_NRD_1	15	17	PF00675	0.541
CLV_NRD_NRD_1	18	20	PF00675	0.542
CLV_PCSK_FUR_1	16	20	PF00082	0.537
CLV_PCSK_KEX2_1	15	17	PF00082	0.522
CLV_PCSK_KEX2_1	150	152	PF00082	0.607
CLV_PCSK_KEX2_1	18	20	PF00082	0.523
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.607
DEG_Nend_UBRbox_2	1	3	PF02207	0.724
DEG_SPOP_SBC_1	53	57	PF00917	0.478
DOC_USP7_MATH_1	38	42	PF00917	0.393
LIG_14-3-3_CanoR_1	18	27	PF00244	0.619
LIG_deltaCOP1_diTrp_1	43	49	PF00928	0.348
LIG_FHA_2	20	26	PF00498	0.657
LIG_FHA_2	54	60	PF00498	0.462
LIG_FHA_2	76	82	PF00498	0.458
LIG_LIR_Gen_1	22	30	PF02991	0.543
LIG_LIR_Gen_1	43	53	PF02991	0.307
LIG_LIR_Nem_3	22	27	PF02991	0.561
LIG_LIR_Nem_3	43	48	PF02991	0.370
LIG_LIR_Nem_3	74	79	PF02991	0.519
LIG_PCNA_PIPBox_1	58	67	PF02747	0.541
LIG_PCNA_yPIPBox_3	58	69	PF02747	0.541
LIG_Pex14_1	45	49	PF04695	0.417
LIG_SH2_NCK_1	95	99	PF00017	0.462
LIG_SH2_STAP1	106	110	PF00017	0.513
LIG_SH2_STAT5	64	67	PF00017	0.513
LIG_SH2_STAT5	75	78	PF00017	0.541
LIG_SH3_3	141	147	PF00018	0.517
LIG_SH3_3	32	38	PF00018	0.477
LIG_TRAF2_1	56	59	PF00917	0.541
LIG_WRC_WIRS_1	65	70	PF05994	0.541
MOD_CK2_1	19	25	PF00069	0.577
MOD_CK2_1	53	59	PF00069	0.539
MOD_CK2_1	64	70	PF00069	0.544
MOD_GlcNHglycan	112	116	PF01048	0.296
MOD_GlcNHglycan	119	122	PF01048	0.502
MOD_GSK3_1	113	120	PF00069	0.534
MOD_NEK2_1	113	118	PF00069	0.528
MOD_NEK2_1	47	52	PF00069	0.453
MOD_NEK2_2	64	69	PF00069	0.513
MOD_PIKK_1	19	25	PF00454	0.681
MOD_PIKK_1	54	60	PF00454	0.543
MOD_PKA_2	17	23	PF00069	0.578
MOD_Plk_4	113	119	PF00069	0.479
MOD_Plk_4	127	133	PF00069	0.425
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.406
TRG_ENDOCYTIC_2	24	27	PF00928	0.651
TRG_ENDOCYTIC_2	95	98	PF00928	0.462
TRG_ER_diArg_1	14	16	PF00400	0.538
TRG_ER_diArg_1	17	19	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVV4	Leptomonas seymouri	73%	100%
A0A0S4J314	Bodo saltans	32%	100%
A0A1X0NU33	Trypanosomatidae	36%	77%
A0A3R7NI30	Trypanosoma rangeli	46%	95%
A0A3S7WZQ8	Leishmania donovani	87%	100%
A4I209	Leishmania infantum	87%	100%
C9ZS03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
E9AY57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q9B6	Leishmania major	88%	100%