PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HET2_LEIBR

TriTrypDb:

LbrM.26.0780 , LBRM2903_260012600

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HET2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HET2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	279	281	PF00675	0.547
CLV_NRD_NRD_1	326	328	PF00675	0.682
CLV_NRD_NRD_1	369	371	PF00675	0.573
CLV_NRD_NRD_1	374	376	PF00675	0.556
CLV_NRD_NRD_1	390	392	PF00675	0.472
CLV_NRD_NRD_1	401	403	PF00675	0.483
CLV_NRD_NRD_1	486	488	PF00675	0.531
CLV_PCSK_KEX2_1	208	210	PF00082	0.723
CLV_PCSK_KEX2_1	368	370	PF00082	0.563
CLV_PCSK_KEX2_1	374	376	PF00082	0.550
CLV_PCSK_KEX2_1	390	392	PF00082	0.472
CLV_PCSK_KEX2_1	401	403	PF00082	0.483
CLV_PCSK_KEX2_1	439	441	PF00082	0.476
CLV_PCSK_KEX2_1	521	523	PF00082	0.532
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.573
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.594
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.531
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.532
CLV_PCSK_PC7_1	370	376	PF00082	0.505
CLV_PCSK_SKI1_1	280	284	PF00082	0.543
CLV_PCSK_SKI1_1	494	498	PF00082	0.399
CLV_PCSK_SKI1_1	549	553	PF00082	0.487
DEG_Nend_UBRbox_2	1	3	PF02207	0.648
DOC_PP4_FxxP_1	397	400	PF00568	0.630
DOC_USP7_MATH_1	103	107	PF00917	0.500
DOC_USP7_MATH_1	147	151	PF00917	0.622
DOC_USP7_MATH_1	172	176	PF00917	0.512
DOC_USP7_MATH_1	204	208	PF00917	0.778
DOC_USP7_MATH_1	227	231	PF00917	0.522
DOC_USP7_MATH_1	481	485	PF00917	0.675
DOC_USP7_MATH_1	486	490	PF00917	0.662
DOC_USP7_MATH_1	89	93	PF00917	0.493
DOC_USP7_MATH_2	128	134	PF00917	0.549
DOC_USP7_UBL2_3	208	212	PF12436	0.555
DOC_USP7_UBL2_3	452	456	PF12436	0.509
LIG_14-3-3_CanoR_1	105	114	PF00244	0.551
LIG_14-3-3_CanoR_1	141	146	PF00244	0.542
LIG_14-3-3_CanoR_1	229	233	PF00244	0.533
LIG_14-3-3_CanoR_1	24	29	PF00244	0.572
LIG_14-3-3_CanoR_1	391	400	PF00244	0.602
LIG_14-3-3_CanoR_1	487	497	PF00244	0.434
LIG_14-3-3_CanoR_1	499	503	PF00244	0.598
LIG_14-3-3_CanoR_1	75	83	PF00244	0.441
LIG_14-3-3_CanoR_1	8	12	PF00244	0.494
LIG_APCC_ABBA_1	416	421	PF00400	0.445
LIG_BRCT_BRCA1_1	241	245	PF00533	0.544
LIG_FHA_1	480	486	PF00498	0.550
LIG_FHA_2	153	159	PF00498	0.537
LIG_FHA_2	212	218	PF00498	0.533
LIG_FHA_2	333	339	PF00498	0.673
LIG_FHA_2	401	407	PF00498	0.487
LIG_FHA_2	550	556	PF00498	0.481
LIG_Integrin_RGD_1	215	217	PF01839	0.544
LIG_Integrin_RGD_1	349	351	PF01839	0.534
LIG_LIR_Apic_2	10	14	PF02991	0.454
LIG_LIR_Apic_2	395	400	PF02991	0.621
LIG_LIR_Gen_1	168	174	PF02991	0.500
LIG_LIR_Gen_1	302	311	PF02991	0.537
LIG_LIR_Gen_1	355	364	PF02991	0.556
LIG_LIR_Gen_1	412	422	PF02991	0.449
LIG_LIR_Gen_1	552	561	PF02991	0.489
LIG_LIR_Nem_3	168	173	PF02991	0.501
LIG_LIR_Nem_3	27	31	PF02991	0.495
LIG_LIR_Nem_3	412	418	PF02991	0.454
LIG_LIR_Nem_3	45	49	PF02991	0.485
LIG_LIR_Nem_3	552	556	PF02991	0.480
LIG_LIR_Nem_3	77	83	PF02991	0.573
LIG_OCRL_FandH_1	45	57	PF00620	0.527
LIG_PCNA_PIPBox_1	219	228	PF02747	0.525
LIG_PCNA_yPIPBox_3	212	226	PF02747	0.530
LIG_REV1ctd_RIR_1	494	502	PF16727	0.387
LIG_SH2_CRK	11	15	PF00017	0.526
LIG_SH2_CRK	170	174	PF00017	0.503
LIG_SH2_CRK	41	45	PF00017	0.509
LIG_SH2_NCK_1	11	15	PF00017	0.526
LIG_SH2_NCK_1	41	45	PF00017	0.605
LIG_SH2_NCK_1	419	423	PF00017	0.443
LIG_SH2_SRC	419	422	PF00017	0.443
LIG_SH2_STAP1	352	356	PF00017	0.522
LIG_SH2_STAT3	268	271	PF00017	0.660
LIG_SH2_STAT5	142	145	PF00017	0.545
LIG_SH2_STAT5	20	23	PF00017	0.483
LIG_SH2_STAT5	268	271	PF00017	0.527
LIG_SH2_STAT5	336	339	PF00017	0.546
LIG_SH2_STAT5	83	86	PF00017	0.682
LIG_SH3_2	323	328	PF14604	0.545
LIG_SH3_3	320	326	PF00018	0.538
LIG_SH3_4	255	262	PF00018	0.525
LIG_TRAF2_1	257	260	PF00917	0.530
LIG_TRAF2_1	430	433	PF00917	0.456
LIG_TRAF2_1	517	520	PF00917	0.514
LIG_UBA3_1	435	439	PF00899	0.523
MOD_CK1_1	101	107	PF00069	0.635
MOD_CK1_1	129	135	PF00069	0.632
MOD_CK1_1	175	181	PF00069	0.529
MOD_CK1_1	228	234	PF00069	0.609
MOD_CK1_1	239	245	PF00069	0.548
MOD_CK1_1	339	345	PF00069	0.596
MOD_CK2_1	152	158	PF00069	0.536
MOD_CK2_1	332	338	PF00069	0.675
MOD_CK2_1	406	412	PF00069	0.593
MOD_CK2_1	427	433	PF00069	0.387
MOD_CK2_1	468	474	PF00069	0.735
MOD_CK2_1	486	492	PF00069	0.395
MOD_GlcNHglycan	240	244	PF01048	0.572
MOD_GlcNHglycan	289	293	PF01048	0.568
MOD_GlcNHglycan	32	36	PF01048	0.517
MOD_GlcNHglycan	470	473	PF01048	0.571
MOD_GlcNHglycan	488	491	PF01048	0.632
MOD_GSK3_1	126	133	PF00069	0.596
MOD_GSK3_1	148	155	PF00069	0.557
MOD_GSK3_1	172	179	PF00069	0.519
MOD_GSK3_1	20	27	PF00069	0.515
MOD_GSK3_1	227	234	PF00069	0.666
MOD_GSK3_1	3	10	PF00069	0.650
MOD_GSK3_1	312	319	PF00069	0.524
MOD_GSK3_1	332	339	PF00069	0.708
MOD_GSK3_1	498	505	PF00069	0.481
MOD_GSK3_1	551	558	PF00069	0.429
MOD_GSK3_1	89	96	PF00069	0.507
MOD_GSK3_1	99	106	PF00069	0.521
MOD_N-GLC_1	166	171	PF02516	0.497
MOD_N-GLC_1	194	199	PF02516	0.564
MOD_N-GLC_1	312	317	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.646
MOD_NEK2_1	166	171	PF00069	0.513
MOD_NEK2_1	225	230	PF00069	0.611
MOD_NEK2_1	241	246	PF00069	0.592
MOD_NEK2_1	31	36	PF00069	0.516
MOD_PIKK_1	109	115	PF00454	0.676
MOD_PIKK_1	121	127	PF00454	0.543
MOD_PIKK_1	178	184	PF00454	0.542
MOD_PIKK_1	194	200	PF00454	0.588
MOD_PIKK_1	244	250	PF00454	0.649
MOD_PIKK_1	3	9	PF00454	0.508
MOD_PIKK_1	498	504	PF00454	0.451
MOD_PIKK_1	59	65	PF00454	0.599
MOD_PK_1	141	147	PF00069	0.540
MOD_PKA_1	148	154	PF00069	0.537
MOD_PKA_1	370	376	PF00069	0.551
MOD_PKA_1	452	458	PF00069	0.513
MOD_PKA_2	228	234	PF00069	0.531
MOD_PKA_2	386	392	PF00069	0.476
MOD_PKA_2	393	399	PF00069	0.609
MOD_PKA_2	400	406	PF00069	0.552
MOD_PKA_2	486	492	PF00069	0.497
MOD_PKA_2	498	504	PF00069	0.487
MOD_PKA_2	7	13	PF00069	0.486
MOD_PKA_2	74	80	PF00069	0.452
MOD_PKB_1	139	147	PF00069	0.540
MOD_Plk_1	109	115	PF00069	0.576
MOD_Plk_1	166	172	PF00069	0.499
MOD_Plk_1	312	318	PF00069	0.580
MOD_Plk_1	65	71	PF00069	0.529
MOD_Plk_2-3	406	412	PF00069	0.427
MOD_Plk_4	228	234	PF00069	0.522
MOD_Plk_4	264	270	PF00069	0.714
MOD_Plk_4	316	322	PF00069	0.528
MOD_Plk_4	93	99	PF00069	0.519
MOD_SUMO_for_1	508	511	PF00179	0.524
MOD_SUMO_rev_2	144	150	PF00179	0.539
MOD_SUMO_rev_2	474	482	PF00179	0.601
MOD_SUMO_rev_2	520	529	PF00179	0.498
MOD_SUMO_rev_2	86	94	PF00179	0.483
TRG_DiLeu_BaEn_1	431	436	PF01217	0.465
TRG_DiLeu_LyEn_5	431	436	PF01217	0.465
TRG_ENDOCYTIC_2	142	145	PF00928	0.545
TRG_ENDOCYTIC_2	170	173	PF00928	0.505
TRG_ENDOCYTIC_2	304	307	PF00928	0.537
TRG_ENDOCYTIC_2	357	360	PF00928	0.595
TRG_ENDOCYTIC_2	542	545	PF00928	0.381
TRG_ER_diArg_1	139	142	PF00400	0.540
TRG_ER_diArg_1	400	402	PF00400	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2U8	Leptomonas seymouri	31%	99%
A0A3Q8IP13	Leishmania donovani	50%	100%
A4I208	Leishmania infantum	50%	100%
E9AY56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4Q9B7	Leishmania major	50%	96%