RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HET1_LEIBR

TriTrypDb:

LbrM.26.0770 , LBRM2903_260012500

Length:

163

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HET1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HET1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1	3	PF00675	0.608
CLV_NRD_NRD_1	29	31	PF00675	0.463
CLV_NRD_NRD_1	71	73	PF00675	0.292
CLV_PCSK_KEX2_1	29	31	PF00082	0.451
CLV_PCSK_SKI1_1	124	128	PF00082	0.559
CLV_PCSK_SKI1_1	29	33	PF00082	0.565
DEG_APCC_DBOX_1	32	40	PF00400	0.420
DEG_Nend_UBRbox_1	1	4	PF02207	0.708
DOC_MAPK_MEF2A_6	153	160	PF00069	0.376
DOC_PP2B_LxvP_1	32	35	PF13499	0.394
DOC_USP7_MATH_1	118	122	PF00917	0.440
DOC_WW_Pin1_4	42	47	PF00397	0.640
LIG_FHA_1	43	49	PF00498	0.430
LIG_FHA_1	78	84	PF00498	0.440
LIG_FHA_2	140	146	PF00498	0.379
LIG_LIR_Gen_1	13	23	PF02991	0.438
LIG_LIR_Gen_1	55	64	PF02991	0.442
LIG_LIR_Gen_1	80	88	PF02991	0.450
LIG_LIR_Nem_3	13	19	PF02991	0.458
LIG_LIR_Nem_3	55	60	PF02991	0.442
LIG_LIR_Nem_3	80	85	PF02991	0.439
LIG_SH2_CRK	16	20	PF00017	0.453
LIG_SH2_STAP1	12	16	PF00017	0.390
LIG_SH2_STAP1	147	151	PF00017	0.436
LIG_SH2_STAT5	12	15	PF00017	0.484
LIG_SH3_3	131	137	PF00018	0.504
LIG_SUMO_SIM_par_1	52	58	PF11976	0.541
LIG_TRAF2_1	112	115	PF00917	0.501
MOD_CK1_1	113	119	PF00069	0.666
MOD_CK1_1	6	12	PF00069	0.559
MOD_CK2_1	116	122	PF00069	0.552
MOD_CK2_1	139	145	PF00069	0.446
MOD_CK2_1	97	103	PF00069	0.381
MOD_GlcNHglycan	110	113	PF01048	0.541
MOD_GlcNHglycan	5	8	PF01048	0.577
MOD_GlcNHglycan	89	92	PF01048	0.241
MOD_GSK3_1	110	117	PF00069	0.534
MOD_GSK3_1	139	146	PF00069	0.494
MOD_GSK3_1	37	44	PF00069	0.600
MOD_GSK3_1	6	13	PF00069	0.514
MOD_NEK2_1	108	113	PF00069	0.454
MOD_NEK2_1	77	82	PF00069	0.450
MOD_PIKK_1	110	116	PF00454	0.579
MOD_PIKK_1	55	61	PF00454	0.439
MOD_PKA_2	71	77	PF00069	0.478
MOD_Plk_2-3	143	149	PF00069	0.515
MOD_Plk_4	52	58	PF00069	0.439
MOD_ProDKin_1	42	48	PF00069	0.522
MOD_SUMO_rev_2	119	126	PF00179	0.552
TRG_DiLeu_BaEn_1	15	20	PF01217	0.474
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.524
TRG_ENDOCYTIC_2	16	19	PF00928	0.445
TRG_ER_diArg_1	28	30	PF00400	0.446
TRG_ER_diArg_1	69	72	PF00400	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP8	Leptomonas seymouri	70%	100%
A0A0S4J184	Bodo saltans	38%	100%
A0A1X0NSD2	Trypanosomatidae	54%	100%
A0A3R7KI07	Trypanosoma rangeli	52%	100%
A0A3S7WZQ4	Leishmania donovani	84%	100%
A4I207	Leishmania infantum	84%	100%
C9ZS05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	96%
E9AY55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q9B8	Leishmania major	82%	100%
V5BUP6	Trypanosoma cruzi	52%	100%