Regulator of chromosome condensation (RCC1) family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HES9_LEIBR

TriTrypDb:

LbrM.26.0750 , LBRM2903_260012300

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HES9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HES9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.397
CLV_C14_Caspase3-7	775	779	PF00656	0.507
CLV_NRD_NRD_1	22	24	PF00675	0.432
CLV_NRD_NRD_1	357	359	PF00675	0.385
CLV_NRD_NRD_1	469	471	PF00675	0.428
CLV_NRD_NRD_1	835	837	PF00675	0.432
CLV_PCSK_KEX2_1	306	308	PF00082	0.280
CLV_PCSK_KEX2_1	469	471	PF00082	0.426
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.271
CLV_PCSK_SKI1_1	254	258	PF00082	0.448
CLV_PCSK_SKI1_1	298	302	PF00082	0.262
CLV_PCSK_SKI1_1	492	496	PF00082	0.330
CLV_PCSK_SKI1_1	562	566	PF00082	0.351
CLV_PCSK_SKI1_1	726	730	PF00082	0.406
CLV_PCSK_SKI1_1	795	799	PF00082	0.455
CLV_PCSK_SKI1_1	83	87	PF00082	0.422
DEG_APCC_DBOX_1	82	90	PF00400	0.485
DEG_Nend_UBRbox_3	1	3	PF02207	0.591
DOC_CKS1_1	55	60	PF01111	0.477
DOC_CKS1_1	727	732	PF01111	0.489
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.478
DOC_MAPK_DCC_7	625	634	PF00069	0.467
DOC_MAPK_gen_1	304	311	PF00069	0.434
DOC_MAPK_MEF2A_6	239	248	PF00069	0.481
DOC_MAPK_MEF2A_6	726	734	PF00069	0.384
DOC_PP1_RVXF_1	505	511	PF00149	0.343
DOC_PP1_RVXF_1	560	567	PF00149	0.330
DOC_PP2B_LxvP_1	423	426	PF13499	0.361
DOC_PP2B_LxvP_1	434	437	PF13499	0.382
DOC_USP7_MATH_1	137	141	PF00917	0.451
DOC_USP7_MATH_1	144	148	PF00917	0.395
DOC_USP7_MATH_1	267	271	PF00917	0.375
DOC_USP7_MATH_1	312	316	PF00917	0.359
DOC_WW_Pin1_4	230	235	PF00397	0.559
DOC_WW_Pin1_4	54	59	PF00397	0.459
DOC_WW_Pin1_4	627	632	PF00397	0.457
DOC_WW_Pin1_4	677	682	PF00397	0.309
DOC_WW_Pin1_4	726	731	PF00397	0.480
LIG_14-3-3_CanoR_1	367	373	PF00244	0.329
LIG_14-3-3_CanoR_1	492	501	PF00244	0.186
LIG_14-3-3_CanoR_1	513	523	PF00244	0.341
LIG_14-3-3_CanoR_1	557	561	PF00244	0.354
LIG_14-3-3_CanoR_1	683	690	PF00244	0.426
LIG_Actin_WH2_2	438	453	PF00022	0.463
LIG_BRCT_BRCA1_1	752	756	PF00533	0.385
LIG_BRCT_BRCA1_1	770	774	PF00533	0.421
LIG_FHA_1	20	26	PF00498	0.518
LIG_FHA_1	275	281	PF00498	0.379
LIG_FHA_1	316	322	PF00498	0.291
LIG_FHA_1	368	374	PF00498	0.274
LIG_FHA_1	416	422	PF00498	0.415
LIG_FHA_1	428	434	PF00498	0.412
LIG_FHA_1	462	468	PF00498	0.369
LIG_FHA_1	622	628	PF00498	0.468
LIG_FHA_1	727	733	PF00498	0.357
LIG_FHA_1	753	759	PF00498	0.430
LIG_FHA_1	775	781	PF00498	0.382
LIG_FHA_1	819	825	PF00498	0.554
LIG_FHA_2	11	17	PF00498	0.286
LIG_FHA_2	126	132	PF00498	0.556
LIG_FHA_2	528	534	PF00498	0.494
LIG_FHA_2	770	776	PF00498	0.291
LIG_HCF-1_HBM_1	676	679	PF13415	0.343
LIG_IRF3_LxIS_1	463	468	PF10401	0.368
LIG_LIR_Apic_2	343	347	PF02991	0.343
LIG_LIR_Gen_1	140	148	PF02991	0.430
LIG_LIR_Gen_1	191	200	PF02991	0.337
LIG_LIR_Gen_1	315	322	PF02991	0.399
LIG_LIR_Nem_3	140	146	PF02991	0.430
LIG_LIR_Nem_3	191	196	PF02991	0.337
LIG_LIR_Nem_3	315	319	PF02991	0.393
LIG_LIR_Nem_3	406	411	PF02991	0.328
LIG_LIR_Nem_3	579	583	PF02991	0.440
LIG_LIR_Nem_3	593	597	PF02991	0.320
LIG_LIR_Nem_3	676	682	PF02991	0.472
LIG_LIR_Nem_3	76	82	PF02991	0.376
LIG_Pex14_2	316	320	PF04695	0.316
LIG_PTB_Apo_2	98	105	PF02174	0.549
LIG_REV1ctd_RIR_1	508	517	PF16727	0.387
LIG_REV1ctd_RIR_1	687	696	PF16727	0.426
LIG_SH2_CRK	143	147	PF00017	0.441
LIG_SH2_CRK	174	178	PF00017	0.523
LIG_SH2_CRK	193	197	PF00017	0.363
LIG_SH2_CRK	266	270	PF00017	0.456
LIG_SH2_CRK	344	348	PF00017	0.414
LIG_SH2_CRK	53	57	PF00017	0.572
LIG_SH2_CRK	555	559	PF00017	0.351
LIG_SH2_CRK	679	683	PF00017	0.426
LIG_SH2_GRB2like	12	15	PF00017	0.426
LIG_SH2_NCK_1	143	147	PF00017	0.441
LIG_SH2_NCK_1	266	270	PF00017	0.372
LIG_SH2_NCK_1	53	57	PF00017	0.572
LIG_SH2_STAP1	193	197	PF00017	0.428
LIG_SH2_STAP1	408	412	PF00017	0.438
LIG_SH2_STAP1	746	750	PF00017	0.280
LIG_SH2_STAP1	838	842	PF00017	0.507
LIG_SH2_STAT3	838	841	PF00017	0.546
LIG_SH2_STAT5	12	15	PF00017	0.506
LIG_SH2_STAT5	276	279	PF00017	0.351
LIG_SH2_STAT5	29	32	PF00017	0.312
LIG_SH2_STAT5	408	411	PF00017	0.333
LIG_SH2_STAT5	580	583	PF00017	0.409
LIG_SH2_STAT5	679	682	PF00017	0.327
LIG_SH2_STAT5	698	701	PF00017	0.351
LIG_SH2_STAT5	710	713	PF00017	0.246
LIG_SH2_STAT5	769	772	PF00017	0.330
LIG_SH3_3	113	119	PF00018	0.547
LIG_SH3_3	228	234	PF00018	0.465
LIG_SH3_3	343	349	PF00018	0.445
LIG_SH3_3	497	503	PF00018	0.327
LIG_SH3_3	625	631	PF00018	0.360
LIG_SH3_3	724	730	PF00018	0.438
LIG_SH3_3	96	102	PF00018	0.407
LIG_SUMO_SIM_anti_2	804	811	PF11976	0.357
LIG_SUMO_SIM_par_1	441	447	PF11976	0.521
LIG_SUMO_SIM_par_1	463	468	PF11976	0.376
LIG_SUMO_SIM_par_1	630	635	PF11976	0.431
LIG_SUMO_SIM_par_1	729	735	PF11976	0.365
LIG_SUMO_SIM_par_1	804	811	PF11976	0.400
LIG_UBA3_1	633	638	PF00899	0.456
MOD_CDK_SPxK_1	677	683	PF00069	0.351
MOD_CK1_1	151	157	PF00069	0.224
MOD_CK1_1	19	25	PF00069	0.497
MOD_CK1_1	191	197	PF00069	0.367
MOD_CK1_1	233	239	PF00069	0.523
MOD_CK1_1	274	280	PF00069	0.402
MOD_CK1_1	315	321	PF00069	0.294
MOD_CK1_1	415	421	PF00069	0.403
MOD_CK1_1	444	450	PF00069	0.593
MOD_CK1_1	472	478	PF00069	0.351
MOD_CK1_1	576	582	PF00069	0.349
MOD_CK1_1	593	599	PF00069	0.460
MOD_CK1_1	621	627	PF00069	0.424
MOD_CK1_1	768	774	PF00069	0.519
MOD_CK2_1	10	16	PF00069	0.413
MOD_CK2_1	527	533	PF00069	0.486
MOD_CK2_1	776	782	PF00069	0.593
MOD_Cter_Amidation	304	307	PF01082	0.280
MOD_Cter_Amidation	356	359	PF01082	0.343
MOD_GlcNHglycan	139	142	PF01048	0.448
MOD_GlcNHglycan	19	22	PF01048	0.516
MOD_GlcNHglycan	200	203	PF01048	0.414
MOD_GlcNHglycan	260	263	PF01048	0.420
MOD_GlcNHglycan	282	285	PF01048	0.410
MOD_GlcNHglycan	30	33	PF01048	0.499
MOD_GlcNHglycan	414	417	PF01048	0.361
MOD_GlcNHglycan	585	588	PF01048	0.436
MOD_GlcNHglycan	619	623	PF01048	0.565
MOD_GlcNHglycan	758	761	PF01048	0.381
MOD_GSK3_1	144	151	PF00069	0.219
MOD_GSK3_1	267	274	PF00069	0.458
MOD_GSK3_1	406	413	PF00069	0.356
MOD_GSK3_1	415	422	PF00069	0.365
MOD_GSK3_1	461	468	PF00069	0.357
MOD_GSK3_1	511	518	PF00069	0.357
MOD_GSK3_1	523	530	PF00069	0.210
MOD_GSK3_1	744	751	PF00069	0.383
MOD_GSK3_1	752	759	PF00069	0.367
MOD_GSK3_1	763	770	PF00069	0.440
MOD_N-GLC_1	16	21	PF02516	0.449
MOD_N-GLC_1	167	172	PF02516	0.416
MOD_N-GLC_1	191	196	PF02516	0.356
MOD_N-GLC_1	352	357	PF02516	0.343
MOD_N-GLC_1	406	411	PF02516	0.368
MOD_N-GLC_1	427	432	PF02516	0.382
MOD_N-GLC_1	539	544	PF02516	0.437
MOD_N-GLC_2	158	160	PF02516	0.413
MOD_N-GLC_2	169	171	PF02516	0.402
MOD_NEK2_1	148	153	PF00069	0.390
MOD_NEK2_1	167	172	PF00069	0.367
MOD_NEK2_1	196	201	PF00069	0.340
MOD_NEK2_1	258	263	PF00069	0.477
MOD_NEK2_1	368	373	PF00069	0.380
MOD_NEK2_1	421	426	PF00069	0.380
MOD_NEK2_1	465	470	PF00069	0.381
MOD_NEK2_1	511	516	PF00069	0.342
MOD_NEK2_1	523	528	PF00069	0.303
MOD_NEK2_1	583	588	PF00069	0.364
MOD_NEK2_1	748	753	PF00069	0.335
MOD_NEK2_1	756	761	PF00069	0.334
MOD_NEK2_1	764	769	PF00069	0.462
MOD_NEK2_2	144	149	PF00069	0.354
MOD_NEK2_2	312	317	PF00069	0.351
MOD_PIKK_1	125	131	PF00454	0.564
MOD_PIKK_1	492	498	PF00454	0.378
MOD_PIKK_1	556	562	PF00454	0.426
MOD_PKA_1	469	475	PF00069	0.351
MOD_PKA_2	469	475	PF00069	0.351
MOD_PKA_2	556	562	PF00069	0.431
MOD_PKA_2	682	688	PF00069	0.343
MOD_Plk_1	191	197	PF00069	0.355
MOD_Plk_1	208	214	PF00069	0.446
MOD_Plk_1	342	348	PF00069	0.457
MOD_Plk_1	406	412	PF00069	0.367
MOD_Plk_1	427	433	PF00069	0.381
MOD_Plk_1	539	545	PF00069	0.429
MOD_Plk_1	562	568	PF00069	0.327
MOD_Plk_2-3	776	782	PF00069	0.462
MOD_Plk_4	148	154	PF00069	0.221
MOD_Plk_4	191	197	PF00069	0.286
MOD_Plk_4	208	214	PF00069	0.241
MOD_Plk_4	271	277	PF00069	0.401
MOD_Plk_4	315	321	PF00069	0.410
MOD_Plk_4	368	374	PF00069	0.314
MOD_Plk_4	407	413	PF00069	0.388
MOD_Plk_4	427	433	PF00069	0.292
MOD_Plk_4	576	582	PF00069	0.354
MOD_Plk_4	728	734	PF00069	0.292
MOD_Plk_4	74	80	PF00069	0.349
MOD_Plk_4	820	826	PF00069	0.540
MOD_ProDKin_1	230	236	PF00069	0.559
MOD_ProDKin_1	54	60	PF00069	0.459
MOD_ProDKin_1	627	633	PF00069	0.463
MOD_ProDKin_1	677	683	PF00069	0.309
MOD_ProDKin_1	726	732	PF00069	0.482
MOD_SUMO_for_1	784	787	PF00179	0.462
MOD_SUMO_rev_2	249	256	PF00179	0.503
MOD_SUMO_rev_2	605	611	PF00179	0.442
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.382
TRG_ENDOCYTIC_2	12	15	PF00928	0.445
TRG_ENDOCYTIC_2	143	146	PF00928	0.440
TRG_ENDOCYTIC_2	174	177	PF00928	0.481
TRG_ENDOCYTIC_2	193	196	PF00928	0.368
TRG_ENDOCYTIC_2	266	269	PF00928	0.455
TRG_ENDOCYTIC_2	408	411	PF00928	0.306
TRG_ENDOCYTIC_2	53	56	PF00928	0.567
TRG_ENDOCYTIC_2	555	558	PF00928	0.351
TRG_ENDOCYTIC_2	580	583	PF00928	0.383
TRG_ENDOCYTIC_2	679	682	PF00928	0.426
TRG_ENDOCYTIC_2	745	748	PF00928	0.345
TRG_ER_diArg_1	706	709	PF00400	0.232
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P531	Leptomonas seymouri	80%	98%
A0A1X0NSD6	Trypanosomatidae	50%	99%
A0A1X0NT20	Trypanosomatidae	28%	72%
A0A3S7WZR9	Leishmania donovani	92%	100%
A0A422NN30	Trypanosoma rangeli	48%	100%
A4I206	Leishmania infantum	92%	100%
C9ZS06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	73%
C9ZS09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AY53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9C0	Leishmania major	92%	100%
V5BPX5	Trypanosoma cruzi	50%	100%
V5BUH8	Trypanosoma cruzi	28%	74%