Pentapeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pentapeptide repeats (9 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HES5_LEIBR

TriTrypDb:

LbrM.26.0710 , LBRM2903_260011900

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HES5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HES5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.304
CLV_C14_Caspase3-7	306	310	PF00656	0.613
CLV_C14_Caspase3-7	57	61	PF00656	0.518
CLV_NRD_NRD_1	111	113	PF00675	0.541
CLV_NRD_NRD_1	284	286	PF00675	0.367
CLV_NRD_NRD_1	3	5	PF00675	0.500
CLV_NRD_NRD_1	410	412	PF00675	0.462
CLV_NRD_NRD_1	68	70	PF00675	0.515
CLV_NRD_NRD_1	90	92	PF00675	0.614
CLV_PCSK_KEX2_1	111	113	PF00082	0.541
CLV_PCSK_KEX2_1	30	32	PF00082	0.510
CLV_PCSK_KEX2_1	410	412	PF00082	0.462
CLV_PCSK_KEX2_1	67	69	PF00082	0.521
CLV_PCSK_KEX2_1	90	92	PF00082	0.614
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.485
CLV_PCSK_PC7_1	63	69	PF00082	0.509
CLV_PCSK_SKI1_1	285	289	PF00082	0.413
CLV_PCSK_SKI1_1	30	34	PF00082	0.509
CLV_PCSK_SKI1_1	356	360	PF00082	0.478
CLV_PCSK_SKI1_1	361	365	PF00082	0.399
CLV_PCSK_SKI1_1	396	400	PF00082	0.462
CLV_PCSK_SKI1_1	5	9	PF00082	0.455
DEG_APCC_DBOX_1	135	143	PF00400	0.452
DEG_APCC_DBOX_1	284	292	PF00400	0.411
DEG_APCC_DBOX_1	400	408	PF00400	0.210
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DEG_SPOP_SBC_1	191	195	PF00917	0.532
DEG_SPOP_SBC_1	265	269	PF00917	0.444
DEG_SPOP_SBC_1	339	343	PF00917	0.472
DOC_CYCLIN_RxL_1	282	292	PF00134	0.323
DOC_CYCLIN_RxL_1	367	378	PF00134	0.262
DOC_CYCLIN_RxL_1	393	403	PF00134	0.227
DOC_MAPK_DCC_7	12	22	PF00069	0.471
DOC_MAPK_gen_1	235	244	PF00069	0.608
DOC_MAPK_gen_1	285	293	PF00069	0.411
DOC_MAPK_gen_1	93	102	PF00069	0.526
DOC_MAPK_MEF2A_6	235	244	PF00069	0.799
DOC_MAPK_MEF2A_6	472	479	PF00069	0.451
DOC_PP1_RVXF_1	284	291	PF00149	0.407
DOC_PP2B_LxvP_1	348	351	PF13499	0.408
DOC_PP2B_LxvP_1	447	450	PF13499	0.326
DOC_PP4_FxxP_1	276	279	PF00568	0.348
DOC_USP7_MATH_1	119	123	PF00917	0.562
DOC_USP7_MATH_1	153	157	PF00917	0.498
DOC_USP7_MATH_1	173	177	PF00917	0.556
DOC_USP7_MATH_1	191	195	PF00917	0.572
DOC_USP7_MATH_1	211	215	PF00917	0.589
DOC_USP7_MATH_1	260	264	PF00917	0.646
DOC_USP7_MATH_1	265	269	PF00917	0.591
DOC_USP7_MATH_1	339	343	PF00917	0.392
DOC_USP7_MATH_1	450	454	PF00917	0.542
DOC_USP7_MATH_1	516	520	PF00917	0.454
DOC_USP7_MATH_1	84	88	PF00917	0.620
DOC_WW_Pin1_4	121	126	PF00397	0.655
DOC_WW_Pin1_4	15	20	PF00397	0.514
DOC_WW_Pin1_4	245	250	PF00397	0.553
DOC_WW_Pin1_4	275	280	PF00397	0.347
DOC_WW_Pin1_4	295	300	PF00397	0.447
DOC_WW_Pin1_4	426	431	PF00397	0.368
LIG_14-3-3_CanoR_1	118	126	PF00244	0.580
LIG_14-3-3_CanoR_1	127	135	PF00244	0.545
LIG_14-3-3_CanoR_1	136	140	PF00244	0.483
LIG_14-3-3_CanoR_1	370	375	PF00244	0.262
LIG_14-3-3_CanoR_1	383	389	PF00244	0.262
LIG_14-3-3_CanoR_1	502	512	PF00244	0.331
LIG_14-3-3_CanoR_1	90	100	PF00244	0.600
LIG_14-3-3_CterR_2	517	521	PF00244	0.464
LIG_BRCT_BRCA1_1	122	126	PF00533	0.537
LIG_BRCT_BRCA1_1	475	479	PF00533	0.409
LIG_CaM_NSCaTE_8	28	35	PF13499	0.483
LIG_FHA_1	246	252	PF00498	0.550
LIG_FHA_1	27	33	PF00498	0.480
LIG_FHA_1	413	419	PF00498	0.299
LIG_FHA_2	205	211	PF00498	0.517
LIG_FHA_2	386	392	PF00498	0.262
LIG_FHA_2	430	436	PF00498	0.349
LIG_LIR_Apic_2	275	279	PF02991	0.343
LIG_LIR_Gen_1	181	190	PF02991	0.495
LIG_LIR_Gen_1	209	220	PF02991	0.494
LIG_LIR_Gen_1	378	387	PF02991	0.262
LIG_LIR_Nem_3	18	24	PF02991	0.500
LIG_LIR_Nem_3	181	185	PF02991	0.500
LIG_LIR_Nem_3	209	215	PF02991	0.497
LIG_LIR_Nem_3	378	382	PF02991	0.262
LIG_LIR_Nem_3	397	402	PF02991	0.262
LIG_MYND_1	426	430	PF01753	0.384
LIG_PTB_Apo_2	403	410	PF02174	0.210
LIG_REV1ctd_RIR_1	19	27	PF16727	0.476
LIG_SH2_STAT5	6	9	PF00017	0.452
LIG_SH3_3	246	252	PF00018	0.506
LIG_SH3_3	256	262	PF00018	0.528
LIG_SH3_3	276	282	PF00018	0.303
LIG_SH3_3	59	65	PF00018	0.513
LIG_SUMO_SIM_par_1	149	156	PF11976	0.385
LIG_TRAF2_1	207	210	PF00917	0.497
LIG_WRC_WIRS_1	273	278	PF05994	0.521
MOD_CDC14_SPxK_1	124	127	PF00782	0.531
MOD_CDK_SPK_2	295	300	PF00069	0.373
MOD_CDK_SPxK_1	121	127	PF00069	0.623
MOD_CK1_1	117	123	PF00069	0.617
MOD_CK1_1	268	274	PF00069	0.479
MOD_CK1_1	295	301	PF00069	0.458
MOD_CK1_1	329	335	PF00069	0.550
MOD_CK1_1	385	391	PF00069	0.262
MOD_CK1_1	429	435	PF00069	0.416
MOD_CK1_1	453	459	PF00069	0.528
MOD_CK1_1	467	473	PF00069	0.472
MOD_CK2_1	204	210	PF00069	0.519
MOD_CK2_1	37	43	PF00069	0.636
MOD_CK2_1	429	435	PF00069	0.368
MOD_Cter_Amidation	88	91	PF01082	0.623
MOD_DYRK1A_RPxSP_1	121	125	PF00069	0.560
MOD_GlcNHglycan	155	158	PF01048	0.529
MOD_GlcNHglycan	170	173	PF01048	0.595
MOD_GlcNHglycan	195	198	PF01048	0.551
MOD_GlcNHglycan	316	319	PF01048	0.502
MOD_GlcNHglycan	33	36	PF01048	0.491
MOD_GlcNHglycan	39	42	PF01048	0.486
MOD_GlcNHglycan	455	458	PF01048	0.470
MOD_GlcNHglycan	472	475	PF01048	0.428
MOD_GSK3_1	113	120	PF00069	0.594
MOD_GSK3_1	131	138	PF00069	0.551
MOD_GSK3_1	22	29	PF00069	0.538
MOD_GSK3_1	260	267	PF00069	0.580
MOD_GSK3_1	268	275	PF00069	0.549
MOD_GSK3_1	294	301	PF00069	0.475
MOD_GSK3_1	305	312	PF00069	0.549
MOD_GSK3_1	33	40	PF00069	0.503
MOD_GSK3_1	331	338	PF00069	0.567
MOD_GSK3_1	424	431	PF00069	0.470
MOD_GSK3_1	466	473	PF00069	0.480
MOD_GSK3_1	503	510	PF00069	0.478
MOD_LATS_1	368	374	PF00433	0.262
MOD_N-GLC_1	173	178	PF02516	0.482
MOD_N-GLC_1	412	417	PF02516	0.499
MOD_NEK2_1	103	108	PF00069	0.517
MOD_NEK2_1	126	131	PF00069	0.601
MOD_NEK2_1	152	157	PF00069	0.388
MOD_NEK2_1	192	197	PF00069	0.565
MOD_NEK2_1	22	27	PF00069	0.480
MOD_NEK2_1	244	249	PF00069	0.588
MOD_NEK2_1	293	298	PF00069	0.360
MOD_NEK2_1	33	38	PF00069	0.502
MOD_NEK2_1	394	399	PF00069	0.299
MOD_NEK2_1	489	494	PF00069	0.369
MOD_PIKK_1	309	315	PF00454	0.633
MOD_PIKK_1	450	456	PF00454	0.438
MOD_PIKK_1	489	495	PF00454	0.423
MOD_PIKK_1	84	90	PF00454	0.622
MOD_PIKK_1	91	97	PF00454	0.517
MOD_PKA_2	117	123	PF00069	0.627
MOD_PKA_2	126	132	PF00069	0.611
MOD_PKA_2	135	141	PF00069	0.558
MOD_PKA_2	22	28	PF00069	0.500
MOD_PKA_2	382	388	PF00069	0.262
MOD_PKA_2	501	507	PF00069	0.296
MOD_PKA_2	55	61	PF00069	0.609
MOD_Plk_1	377	383	PF00069	0.262
MOD_Plk_1	43	49	PF00069	0.577
MOD_Plk_4	135	141	PF00069	0.520
MOD_Plk_4	268	274	PF00069	0.500
MOD_Plk_4	370	376	PF00069	0.281
MOD_ProDKin_1	121	127	PF00069	0.656
MOD_ProDKin_1	15	21	PF00069	0.515
MOD_ProDKin_1	245	251	PF00069	0.553
MOD_ProDKin_1	275	281	PF00069	0.340
MOD_ProDKin_1	295	301	PF00069	0.459
MOD_ProDKin_1	426	432	PF00069	0.352
MOD_SUMO_rev_2	278	288	PF00179	0.381
TRG_DiLeu_BaEn_2	495	501	PF01217	0.302
TRG_DiLeu_BaEn_4	43	49	PF01217	0.512
TRG_ENDOCYTIC_2	182	185	PF00928	0.501
TRG_ENDOCYTIC_2	212	215	PF00928	0.503
TRG_ER_diArg_1	409	411	PF00400	0.262
TRG_ER_diArg_1	514	517	PF00400	0.492
TRG_ER_diArg_1	67	69	PF00400	0.517
TRG_ER_diArg_1	90	93	PF00400	0.527
TRG_NES_CRM1_1	393	405	PF08389	0.210
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M8	Leptomonas seymouri	40%	100%
A0A3Q8IC33	Leishmania donovani	65%	100%
A4I202	Leishmania infantum	65%	100%
E9AY49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q9C4	Leishmania major	64%	98%