t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HES4_LEIBR

TriTrypDb:

LbrM.26.0700 , LBRM2903_260011800

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HES4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HES4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0016192	vesicle-mediated transport	4	8
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.602
CLV_NRD_NRD_1	128	130	PF00675	0.353
CLV_PCSK_KEX2_1	130	132	PF00082	0.357
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.412
CLV_PCSK_SKI1_1	202	206	PF00082	0.308
CLV_PCSK_SKI1_1	80	84	PF00082	0.380
DOC_MAPK_gen_1	178	186	PF00069	0.608
DOC_MAPK_gen_1	228	236	PF00069	0.450
DOC_MAPK_MEF2A_6	228	236	PF00069	0.448
DOC_USP7_UBL2_3	216	220	PF12436	0.379
LIG_14-3-3_CanoR_1	171	179	PF00244	0.703
LIG_14-3-3_CanoR_1	50	60	PF00244	0.488
LIG_Actin_RPEL_3	221	240	PF02755	0.519
LIG_AP2alpha_2	28	30	PF02296	0.578
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_EH1_1	237	245	PF00400	0.395
LIG_FHA_1	146	152	PF00498	0.678
LIG_FHA_1	243	249	PF00498	0.218
LIG_FHA_2	23	29	PF00498	0.694
LIG_FHA_2	83	89	PF00498	0.552
LIG_FHA_2	94	100	PF00498	0.540
LIG_LIR_Nem_3	245	249	PF02991	0.201
LIG_LIR_Nem_3	27	33	PF02991	0.566
LIG_SUMO_SIM_par_1	239	245	PF11976	0.173
LIG_TRAF2_1	96	99	PF00917	0.564
LIG_WRC_WIRS_1	243	248	PF05994	0.201
MOD_CK1_1	2	8	PF00069	0.543
MOD_CK1_1	55	61	PF00069	0.682
MOD_CK1_1	68	74	PF00069	0.584
MOD_CK2_1	68	74	PF00069	0.596
MOD_CK2_1	82	88	PF00069	0.568
MOD_CK2_1	93	99	PF00069	0.598
MOD_GlcNHglycan	173	176	PF01048	0.484
MOD_GSK3_1	141	148	PF00069	0.539
MOD_GSK3_1	2	9	PF00069	0.564
MOD_GSK3_1	51	58	PF00069	0.592
MOD_GSK3_1	89	96	PF00069	0.672
MOD_N-GLC_1	141	146	PF02516	0.435
MOD_N-GLC_1	52	57	PF02516	0.294
MOD_NEK2_1	221	226	PF00069	0.475
MOD_NEK2_1	51	56	PF00069	0.627
MOD_PIKK_1	189	195	PF00454	0.630
MOD_PKA_1	216	222	PF00069	0.502
MOD_PKA_2	170	176	PF00069	0.682
MOD_PKA_2	179	185	PF00069	0.608
MOD_Plk_1	165	171	PF00069	0.618
MOD_Plk_1	52	58	PF00069	0.493
MOD_Plk_2-3	165	171	PF00069	0.618
MOD_Plk_4	242	248	PF00069	0.205
MOD_Plk_4	55	61	PF00069	0.555
MOD_SUMO_rev_2	188	192	PF00179	0.509
TRG_DiLeu_BaEn_2	145	151	PF01217	0.606
TRG_ER_diArg_1	129	132	PF00400	0.607
TRG_NES_CRM1_1	198	212	PF08389	0.519
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C8	Leptomonas seymouri	27%	100%
A0A0N1IK90	Leptomonas seymouri	76%	97%
A0A0S4JJL1	Bodo saltans	40%	100%
A0A1X0NSP4	Trypanosomatidae	57%	100%
A0A3Q8IDN9	Leishmania donovani	84%	100%
A0A3R7KG01	Trypanosoma rangeli	57%	100%
A0A3R7M3G3	Trypanosoma rangeli	30%	100%
A4HBK1	Leishmania braziliensis	37%	100%
A4I201	Leishmania infantum	84%	100%
E9AY48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O43752	Homo sapiens	29%	98%
O60499	Homo sapiens	25%	100%
Q4Q9C5	Leishmania major	82%	100%
Q5R6Q2	Pongo abelii	29%	98%
Q63635	Rattus norvegicus	30%	98%
Q946Y7	Arabidopsis thaliana	27%	100%
Q9JKK1	Mus musculus	31%	98%
V5BUP0	Trypanosoma cruzi	56%	100%