DUF2012 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2012), putative

Species:

Leishmania braziliensis

UniProt:

A4HES3_LEIBR

TriTrypDb:

LbrM.26.0690 , LBRM2903_260011700

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0032991	protein-containing complex	1	1
GO:0072546	EMC complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4HES3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HES3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0030246	carbohydrate binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.287
CLV_NRD_NRD_1	222	224	PF00675	0.497
CLV_PCSK_KEX2_1	221	223	PF00082	0.456
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.482
CLV_PCSK_SKI1_1	223	227	PF00082	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.623
DOC_CYCLIN_yCln2_LP_2	168	174	PF00134	0.385
DOC_MAPK_FxFP_2	99	102	PF00069	0.301
DOC_MAPK_MEF2A_6	169	178	PF00069	0.385
DOC_PP2B_LxvP_1	37	40	PF13499	0.382
DOC_PP4_FxxP_1	70	73	PF00568	0.337
DOC_PP4_FxxP_1	99	102	PF00568	0.301
DOC_USP7_MATH_1	151	155	PF00917	0.306
DOC_WW_Pin1_4	140	145	PF00397	0.309
DOC_WW_Pin1_4	167	172	PF00397	0.378
LIG_14-3-3_CanoR_1	211	217	PF00244	0.554
LIG_14-3-3_CanoR_1	3	9	PF00244	0.537
LIG_14-3-3_CterR_2	222	227	PF00244	0.596
LIG_Actin_WH2_2	179	197	PF00022	0.496
LIG_APCC_ABBA_1	186	191	PF00400	0.671
LIG_FHA_1	101	107	PF00498	0.145
LIG_FHA_1	77	83	PF00498	0.228
LIG_FHA_1	87	93	PF00498	0.337
LIG_FHA_2	72	78	PF00498	0.287
LIG_HP1_1	171	175	PF01393	0.475
LIG_IRF3_LxIS_1	173	179	PF10401	0.390
LIG_LIR_Apic_2	154	158	PF02991	0.280
LIG_LIR_Apic_2	81	86	PF02991	0.358
LIG_LIR_Apic_2	98	102	PF02991	0.297
LIG_LIR_Gen_1	48	58	PF02991	0.381
LIG_LIR_Gen_1	95	104	PF02991	0.281
LIG_LIR_Nem_3	150	155	PF02991	0.368
LIG_LIR_Nem_3	32	37	PF02991	0.375
LIG_LIR_Nem_3	48	53	PF02991	0.437
LIG_LIR_Nem_3	77	83	PF02991	0.315
LIG_LIR_Nem_3	95	99	PF02991	0.277
LIG_NRBOX	163	169	PF00104	0.200
LIG_NRBOX	181	187	PF00104	0.153
LIG_PCNA_yPIPBox_3	159	168	PF02747	0.317
LIG_SH2_CRK	34	38	PF00017	0.349
LIG_SH2_CRK	83	87	PF00017	0.326
LIG_SH2_STAT3	64	67	PF00017	0.353
LIG_SH2_STAT3	90	93	PF00017	0.362
LIG_SH2_STAT5	156	159	PF00017	0.277
LIG_SH2_STAT5	43	46	PF00017	0.438
LIG_SH2_STAT5	90	93	PF00017	0.302
LIG_SUMO_SIM_anti_2	163	170	PF11976	0.381
LIG_SUMO_SIM_par_1	174	179	PF11976	0.388
LIG_SUMO_SIM_par_1	20	25	PF11976	0.574
LIG_TRAF2_1	190	193	PF00917	0.664
LIG_TRAF2_1	26	29	PF00917	0.545
LIG_TRAF2_2	158	163	PF00917	0.381
LIG_UBA3_1	181	187	PF00899	0.410
LIG_WW_1	40	43	PF00397	0.449
MOD_CK2_1	22	28	PF00069	0.589
MOD_GlcNHglycan	112	116	PF01048	0.473
MOD_GlcNHglycan	135	139	PF01048	0.541
MOD_GlcNHglycan	149	152	PF01048	0.485
MOD_GlcNHglycan	178	181	PF01048	0.474
MOD_GlcNHglycan	24	27	PF01048	0.678
MOD_GSK3_1	147	154	PF00069	0.358
MOD_GSK3_1	163	170	PF00069	0.311
MOD_GSK3_1	194	201	PF00069	0.683
MOD_NEK2_1	121	126	PF00069	0.325
MOD_NEK2_1	134	139	PF00069	0.250
MOD_NEK2_1	176	181	PF00069	0.320
MOD_NEK2_1	194	199	PF00069	0.600
MOD_NEK2_1	2	7	PF00069	0.602
MOD_NEK2_1	22	27	PF00069	0.567
MOD_NEK2_2	78	83	PF00069	0.358
MOD_PIKK_1	194	200	PF00454	0.673
MOD_PKA_1	221	227	PF00069	0.715
MOD_PKA_2	110	116	PF00069	0.344
MOD_PKA_2	194	200	PF00069	0.685
MOD_PKA_2	2	8	PF00069	0.601
MOD_PKA_2	210	216	PF00069	0.493
MOD_PKA_2	221	227	PF00069	0.633
MOD_Plk_1	27	33	PF00069	0.284
MOD_Plk_4	151	157	PF00069	0.304
MOD_Plk_4	163	169	PF00069	0.295
MOD_Plk_4	29	35	PF00069	0.381
MOD_Plk_4	57	63	PF00069	0.308
MOD_Plk_4	86	92	PF00069	0.305
MOD_ProDKin_1	140	146	PF00069	0.309
MOD_ProDKin_1	167	173	PF00069	0.378
TRG_ENDOCYTIC_2	34	37	PF00928	0.342
TRG_ENDOCYTIC_2	96	99	PF00928	0.290
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU9	Leptomonas seymouri	68%	99%
A0A0S4JJC6	Bodo saltans	31%	91%
A0A1X0NSE7	Trypanosomatidae	43%	91%
A0A3Q8IDJ8	Leishmania donovani	78%	100%
A0A422N2I9	Trypanosoma rangeli	38%	97%
A4I200	Leishmania infantum	78%	100%
C9ZS15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	94%
E9AY47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q9C6	Leishmania major	77%	100%
V5DR28	Trypanosoma cruzi	41%	100%