Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4HES2_LEIBR

TriTrypDb:

LbrM.26.0680 , LBRM2903_260011600

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	1
GO:0016020	membrane	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HES2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HES2

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	4
GO:0003824	catalytic activity	1	6
GO:0016853	isomerase activity	2	5
GO:0016860	intramolecular oxidoreductase activity	3	4
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	4
GO:0140096	catalytic activity, acting on a protein	2	5
GO:0015035	protein-disulfide reductase activity	3	1
GO:0015036	disulfide oxidoreductase activity	4	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.173
CLV_NRD_NRD_1	118	120	PF00675	0.269
CLV_NRD_NRD_1	79	81	PF00675	0.173
CLV_PCSK_KEX2_1	118	120	PF00082	0.362
CLV_PCSK_KEX2_1	34	36	PF00082	0.456
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.423
CLV_PCSK_SKI1_1	11	15	PF00082	0.493
DEG_APCC_DBOX_1	10	18	PF00400	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.419
DOC_CYCLIN_yCln2_LP_2	130	133	PF00134	0.269
DOC_MAPK_MEF2A_6	121	130	PF00069	0.223
DOC_PP2B_LxvP_1	130	133	PF13499	0.271
DOC_USP7_MATH_1	33	37	PF00917	0.415
DOC_WW_Pin1_4	80	85	PF00397	0.173
LIG_EH1_1	19	27	PF00400	0.381
LIG_eIF4E_1	125	131	PF01652	0.269
LIG_FHA_1	125	131	PF00498	0.236
LIG_FHA_1	21	27	PF00498	0.508
LIG_LIR_Gen_1	162	167	PF02991	0.555
LIG_LIR_Gen_1	55	66	PF02991	0.310
LIG_LIR_Gen_1	8	17	PF02991	0.463
LIG_LIR_Gen_1	83	93	PF02991	0.369
LIG_LIR_Nem_3	123	128	PF02991	0.456
LIG_LIR_Nem_3	162	166	PF02991	0.569
LIG_LIR_Nem_3	54	60	PF02991	0.294
LIG_LIR_Nem_3	64	69	PF02991	0.299
LIG_LIR_Nem_3	70	74	PF02991	0.307
LIG_LIR_Nem_3	8	12	PF02991	0.632
LIG_LIR_Nem_3	83	89	PF02991	0.428
LIG_LYPXL_yS_3	125	128	PF13949	0.269
LIG_PCNA_PIPBox_1	65	74	PF02747	0.207
LIG_Pex14_2	71	75	PF04695	0.294
LIG_SH2_CRK	58	62	PF00017	0.191
LIG_SH2_NCK_1	163	167	PF00017	0.383
LIG_SH2_NCK_1	58	62	PF00017	0.215
LIG_SH2_PTP2	92	95	PF00017	0.207
LIG_SH2_SRC	163	166	PF00017	0.382
LIG_SH2_SRC	58	61	PF00017	0.207
LIG_SH2_STAT5	92	95	PF00017	0.285
LIG_SH3_3	105	111	PF00018	0.269
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.329
MOD_CDC14_SPxK_1	3	6	PF00782	0.385
MOD_GlcNHglycan	122	125	PF01048	0.382
MOD_GSK3_1	120	127	PF00069	0.456
MOD_NEK2_1	20	25	PF00069	0.523
MOD_PKA_2	120	126	PF00069	0.173
MOD_Plk_4	124	130	PF00069	0.329
MOD_Plk_4	20	26	PF00069	0.563
MOD_ProDKin_1	80	86	PF00069	0.173
MOD_SUMO_for_1	159	162	PF00179	0.492
MOD_SUMO_rev_2	31	36	PF00179	0.471
TRG_ENDOCYTIC_2	125	128	PF00928	0.269
TRG_ENDOCYTIC_2	163	166	PF00928	0.382
TRG_ENDOCYTIC_2	57	60	PF00928	0.237
TRG_ENDOCYTIC_2	86	89	PF00928	0.456
TRG_ENDOCYTIC_2	92	95	PF00928	0.382
TRG_ER_diArg_1	118	120	PF00400	0.269
TRG_ER_diArg_1	93	96	PF00400	0.207

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5T9	Leptomonas seymouri	26%	100%
A0A0N1IJS7	Leptomonas seymouri	57%	100%
A0A0S4JA26	Bodo saltans	27%	100%
A0A1X0NT33	Trypanosomatidae	27%	100%
A4H4R8	Leishmania braziliensis	25%	100%
A4HSZ7	Leishmania infantum	25%	100%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AY46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q9C7	Leishmania major	60%	100%
Q8GYD1	Arabidopsis thaliana	26%	100%
Q8I7Z7	Leishmania donovani	25%	100%