Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HER8_LEIBR

TriTrypDb:

LbrM.26.0640 , LBRM2903_260011200

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HER8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HER8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006633	fatty acid biosynthetic process	5	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072330	monocarboxylic acid biosynthetic process	6	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016790	thiolester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.388
CLV_C14_Caspase3-7	188	192	PF00656	0.307
CLV_C14_Caspase3-7	4	8	PF00656	0.452
CLV_C14_Caspase3-7	80	84	PF00656	0.622
CLV_NRD_NRD_1	253	255	PF00675	0.317
CLV_NRD_NRD_1	310	312	PF00675	0.281
CLV_PCSK_FUR_1	194	198	PF00082	0.284
CLV_PCSK_KEX2_1	196	198	PF00082	0.511
CLV_PCSK_KEX2_1	253	255	PF00082	0.334
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.279
CLV_PCSK_SKI1_1	145	149	PF00082	0.316
CLV_PCSK_SKI1_1	172	176	PF00082	0.350
CLV_PCSK_SKI1_1	295	299	PF00082	0.394
DEG_APCC_DBOX_1	294	302	PF00400	0.264
DEG_Nend_Nbox_1	1	3	PF02207	0.430
DEG_ODPH_VHL_1	371	384	PF01847	0.300
DEG_SPOP_SBC_1	122	126	PF00917	0.305
DEG_SPOP_SBC_1	347	351	PF00917	0.419
DOC_ANK_TNKS_1	2	9	PF00023	0.448
DOC_CKS1_1	50	55	PF01111	0.507
DOC_CYCLIN_yCln2_LP_2	371	377	PF00134	0.387
DOC_MAPK_DCC_7	295	303	PF00069	0.268
DOC_MAPK_FxFP_2	331	334	PF00069	0.307
DOC_MAPK_MEF2A_6	295	303	PF00069	0.268
DOC_MAPK_RevD_3	296	312	PF00069	0.433
DOC_PP1_RVXF_1	339	345	PF00149	0.262
DOC_PP2B_LxvP_1	162	165	PF13499	0.302
DOC_PP2B_LxvP_1	227	230	PF13499	0.450
DOC_PP2B_LxvP_1	296	299	PF13499	0.299
DOC_PP2B_LxvP_1	371	374	PF13499	0.413
DOC_PP4_FxxP_1	102	105	PF00568	0.544
DOC_PP4_FxxP_1	331	334	PF00568	0.307
DOC_USP7_MATH_1	215	219	PF00917	0.366
DOC_USP7_MATH_1	364	368	PF00917	0.574
DOC_USP7_MATH_1	395	399	PF00917	0.428
DOC_USP7_MATH_1	6	10	PF00917	0.380
DOC_USP7_UBL2_3	182	186	PF12436	0.387
DOC_WW_Pin1_4	222	227	PF00397	0.581
DOC_WW_Pin1_4	49	54	PF00397	0.492
DOC_WW_Pin1_4	57	62	PF00397	0.532
LIG_14-3-3_CanoR_1	197	205	PF00244	0.497
LIG_14-3-3_CanoR_1	253	259	PF00244	0.324
LIG_14-3-3_CanoR_1	35	40	PF00244	0.223
LIG_14-3-3_CanoR_1	400	406	PF00244	0.424
LIG_Actin_WH2_2	161	179	PF00022	0.266
LIG_Actin_WH2_2	244	261	PF00022	0.468
LIG_Actin_WH2_2	26	44	PF00022	0.226
LIG_APCC_Cbox_2	399	405	PF00515	0.342
LIG_BRCT_BRCA1_1	108	112	PF00533	0.345
LIG_BRCT_BRCA1_1	206	210	PF00533	0.352
LIG_BRCT_BRCA1_1	397	401	PF00533	0.303
LIG_BRCT_BRCA1_1	83	87	PF00533	0.286
LIG_BRCT_BRCA1_2	108	114	PF00533	0.241
LIG_Clathr_ClatBox_1	276	280	PF01394	0.277
LIG_FHA_1	108	114	PF00498	0.335
LIG_FHA_1	193	199	PF00498	0.432
LIG_FHA_1	402	408	PF00498	0.346
LIG_FHA_1	410	416	PF00498	0.429
LIG_FHA_1	89	95	PF00498	0.319
LIG_FHA_2	133	139	PF00498	0.432
LIG_FHA_2	141	147	PF00498	0.477
LIG_FHA_2	50	56	PF00498	0.473
LIG_FHA_2	78	84	PF00498	0.406
LIG_LIR_Apic_2	328	334	PF02991	0.408
LIG_LIR_Apic_2	76	82	PF02991	0.485
LIG_LIR_Gen_1	128	137	PF02991	0.399
LIG_LIR_Nem_3	124	130	PF02991	0.306
LIG_LIR_Nem_3	131	137	PF02991	0.345
LIG_LIR_Nem_3	381	387	PF02991	0.302
LIG_MLH1_MIPbox_1	83	87	PF16413	0.286
LIG_PCNA_yPIPBox_3	270	283	PF02747	0.305
LIG_SH2_CRK	130	134	PF00017	0.301
LIG_SH2_CRK	224	228	PF00017	0.594
LIG_SH2_CRK	293	297	PF00017	0.432
LIG_SH2_SRC	136	139	PF00017	0.528
LIG_SH2_STAP1	130	134	PF00017	0.515
LIG_SH2_STAP1	293	297	PF00017	0.422
LIG_SH2_STAT5	118	121	PF00017	0.492
LIG_SH2_STAT5	130	133	PF00017	0.365
LIG_SH2_STAT5	134	137	PF00017	0.340
LIG_SH2_STAT5	317	320	PF00017	0.320
LIG_SH2_STAT5	39	42	PF00017	0.413
LIG_SH2_STAT5	79	82	PF00017	0.457
LIG_SH3_2	334	339	PF14604	0.355
LIG_SH3_3	13	19	PF00018	0.308
LIG_SH3_3	234	240	PF00018	0.407
LIG_SH3_3	296	302	PF00018	0.370
LIG_SH3_3	331	337	PF00018	0.329
LIG_TRFH_1	102	106	PF08558	0.451
LIG_UBA3_1	175	182	PF00899	0.283
LIG_WRC_WIRS_1	148	153	PF05994	0.399
LIG_WRC_WIRS_1	279	284	PF05994	0.226
MOD_CAAXbox	413	416	PF01239	0.378
MOD_CK1_1	125	131	PF00069	0.294
MOD_CK1_1	189	195	PF00069	0.422
MOD_CK1_1	225	231	PF00069	0.589
MOD_CK1_1	346	352	PF00069	0.521
MOD_CK2_1	254	260	PF00069	0.407
MOD_GlcNHglycan	188	191	PF01048	0.456
MOD_GlcNHglycan	206	209	PF01048	0.323
MOD_GlcNHglycan	227	230	PF01048	0.601
MOD_GlcNHglycan	243	246	PF01048	0.397
MOD_GlcNHglycan	7	11	PF01048	0.296
MOD_GSK3_1	121	128	PF00069	0.328
MOD_GSK3_1	147	154	PF00069	0.333
MOD_GSK3_1	185	192	PF00069	0.344
MOD_GSK3_1	342	349	PF00069	0.449
MOD_GSK3_1	73	80	PF00069	0.706
MOD_LATS_1	252	258	PF00433	0.282
MOD_NEK2_1	147	152	PF00069	0.301
MOD_NEK2_1	175	180	PF00069	0.269
MOD_NEK2_1	204	209	PF00069	0.353
MOD_NEK2_1	235	240	PF00069	0.396
MOD_NEK2_1	401	406	PF00069	0.415
MOD_NEK2_2	82	87	PF00069	0.374
MOD_PK_1	196	202	PF00069	0.428
MOD_PKA_1	196	202	PF00069	0.273
MOD_PKA_2	196	202	PF00069	0.377
MOD_PKA_2	34	40	PF00069	0.477
MOD_Plk_1	28	34	PF00069	0.279
MOD_Plk_1	82	88	PF00069	0.357
MOD_Plk_4	107	113	PF00069	0.328
MOD_Plk_4	125	131	PF00069	0.459
MOD_Plk_4	132	138	PF00069	0.398
MOD_Plk_4	82	88	PF00069	0.440
MOD_ProDKin_1	222	228	PF00069	0.570
MOD_ProDKin_1	49	55	PF00069	0.497
MOD_ProDKin_1	57	63	PF00069	0.538
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.287
TRG_ENDOCYTIC_2	130	133	PF00928	0.297
TRG_ENDOCYTIC_2	134	137	PF00928	0.331
TRG_ENDOCYTIC_2	224	227	PF00928	0.607
TRG_ENDOCYTIC_2	293	296	PF00928	0.433
TRG_NES_CRM1_1	378	393	PF08389	0.437
TRG_NLS_MonoExtC_3	310	316	PF00514	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG55	Leptomonas seymouri	56%	98%
A0A1X0NSG4	Trypanosomatidae	36%	100%
A0A3Q8INZ4	Leishmania donovani	75%	100%
A0A3R7M5A1	Trypanosoma rangeli	34%	100%
A4I1Z5	Leishmania infantum	74%	100%
C9ZS19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AY42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q9D1	Leishmania major	71%	100%
V5B9E8	Trypanosoma cruzi	38%	100%