PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HER6_LEIBR

TriTrypDb:

LbrM.26.0620 , LBRM2903_260011000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HER6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HER6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.515
CLV_NRD_NRD_1	11	13	PF00675	0.548
CLV_NRD_NRD_1	138	140	PF00675	0.382
CLV_NRD_NRD_1	21	23	PF00675	0.555
CLV_NRD_NRD_1	26	28	PF00675	0.547
CLV_NRD_NRD_1	269	271	PF00675	0.432
CLV_NRD_NRD_1	307	309	PF00675	0.394
CLV_NRD_NRD_1	334	336	PF00675	0.346
CLV_PCSK_FUR_1	305	309	PF00082	0.424
CLV_PCSK_KEX2_1	11	13	PF00082	0.548
CLV_PCSK_KEX2_1	138	140	PF00082	0.393
CLV_PCSK_KEX2_1	231	233	PF00082	0.319
CLV_PCSK_KEX2_1	257	259	PF00082	0.392
CLV_PCSK_KEX2_1	26	28	PF00082	0.547
CLV_PCSK_KEX2_1	307	309	PF00082	0.413
CLV_PCSK_KEX2_1	334	336	PF00082	0.350
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.319
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.265
CLV_PCSK_PC7_1	22	28	PF00082	0.404
CLV_PCSK_SKI1_1	38	42	PF00082	0.568
DEG_COP1_1	77	85	PF00400	0.787
DEG_SCF_FBW7_1	344	351	PF00400	0.630
DEG_SPOP_SBC_1	384	388	PF00917	0.499
DEG_SPOP_SBC_1	85	89	PF00917	0.743
DEG_SPOP_SBC_1	98	102	PF00917	0.710
DOC_CKS1_1	113	118	PF01111	0.685
DOC_CKS1_1	56	61	PF01111	0.711
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.631
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.618
DOC_MAPK_gen_1	11	19	PF00069	0.715
DOC_MAPK_gen_1	157	166	PF00069	0.562
DOC_MAPK_gen_1	305	313	PF00069	0.584
DOC_MAPK_MEF2A_6	305	313	PF00069	0.571
DOC_USP7_MATH_1	221	225	PF00917	0.606
DOC_USP7_MATH_1	348	352	PF00917	0.640
DOC_USP7_MATH_1	385	389	PF00917	0.452
DOC_USP7_MATH_1	81	85	PF00917	0.725
DOC_USP7_MATH_1	98	102	PF00917	0.630
DOC_USP7_MATH_2	312	318	PF00917	0.623
DOC_WW_Pin1_4	112	117	PF00397	0.648
DOC_WW_Pin1_4	197	202	PF00397	0.508
DOC_WW_Pin1_4	344	349	PF00397	0.622
DOC_WW_Pin1_4	42	47	PF00397	0.694
DOC_WW_Pin1_4	55	60	PF00397	0.761
LIG_14-3-3_CanoR_1	165	171	PF00244	0.558
LIG_14-3-3_CanoR_1	185	189	PF00244	0.395
LIG_14-3-3_CanoR_1	273	279	PF00244	0.631
LIG_14-3-3_CanoR_1	38	46	PF00244	0.756
LIG_14-3-3_CanoR_1	55	59	PF00244	0.723
LIG_Actin_WH2_2	149	167	PF00022	0.651
LIG_Actin_WH2_2	171	187	PF00022	0.515
LIG_AP2alpha_2	290	292	PF02296	0.658
LIG_BIR_III_2	61	65	PF00653	0.604
LIG_BRCT_BRCA1_1	350	354	PF00533	0.598
LIG_EH1_1	353	361	PF00400	0.465
LIG_FHA_1	77	83	PF00498	0.806
LIG_FHA_1	8	14	PF00498	0.649
LIG_FHA_1	98	104	PF00498	0.729
LIG_FHA_2	100	106	PF00498	0.674
LIG_FHA_2	113	119	PF00498	0.554
LIG_FHA_2	56	62	PF00498	0.784
LIG_LIR_Gen_1	170	179	PF02991	0.559
LIG_LIR_Gen_1	189	199	PF02991	0.359
LIG_LIR_Gen_1	205	214	PF02991	0.402
LIG_LIR_Gen_1	224	234	PF02991	0.611
LIG_LIR_Gen_1	261	269	PF02991	0.580
LIG_LIR_Gen_1	276	287	PF02991	0.531
LIG_LIR_Gen_1	316	325	PF02991	0.520
LIG_LIR_Gen_1	341	349	PF02991	0.626
LIG_LIR_Gen_1	351	360	PF02991	0.513
LIG_LIR_Gen_1	363	372	PF02991	0.372
LIG_LIR_Nem_3	170	174	PF02991	0.561
LIG_LIR_Nem_3	205	209	PF02991	0.413
LIG_LIR_Nem_3	224	229	PF02991	0.420
LIG_LIR_Nem_3	261	266	PF02991	0.591
LIG_LIR_Nem_3	276	282	PF02991	0.531
LIG_LIR_Nem_3	293	297	PF02991	0.491
LIG_LIR_Nem_3	314	318	PF02991	0.541
LIG_LIR_Nem_3	341	346	PF02991	0.555
LIG_LIR_Nem_3	351	355	PF02991	0.482
LIG_LIR_Nem_3	363	367	PF02991	0.335
LIG_PCNA_yPIPBox_3	130	141	PF02747	0.570
LIG_PCNA_yPIPBox_3	350	360	PF02747	0.502
LIG_Pex14_1	294	298	PF04695	0.526
LIG_SH2_CRK	206	210	PF00017	0.482
LIG_SH2_CRK	279	283	PF00017	0.518
LIG_SH2_GRB2like	286	289	PF00017	0.520
LIG_SH2_SRC	140	143	PF00017	0.674
LIG_SH2_SRC	339	342	PF00017	0.559
LIG_SH2_STAP1	149	153	PF00017	0.605
LIG_SH2_STAP1	171	175	PF00017	0.562
LIG_SH2_STAP1	206	210	PF00017	0.496
LIG_SH2_STAP1	241	245	PF00017	0.527
LIG_SH2_STAP1	380	384	PF00017	0.445
LIG_SH2_STAP1	9	13	PF00017	0.604
LIG_SH2_STAT5	140	143	PF00017	0.571
LIG_SH2_STAT5	318	321	PF00017	0.557
LIG_SH2_STAT5	332	335	PF00017	0.514
LIG_SH2_STAT5	339	342	PF00017	0.539
LIG_SH2_STAT5	361	364	PF00017	0.369
LIG_SH2_STAT5	374	377	PF00017	0.355
LIG_SH2_STAT5	9	12	PF00017	0.622
LIG_SH3_3	29	35	PF00018	0.590
LIG_SH3_3	306	312	PF00018	0.655
LIG_SH3_5	145	149	PF00018	0.699
LIG_TYR_ITIM	169	174	PF00017	0.405
LIG_UBA3_1	225	231	PF00899	0.499
LIG_UBA3_1	262	271	PF00899	0.486
LIG_UBA3_1	365	369	PF00899	0.325
LIG_WRC_WIRS_1	361	366	PF05994	0.266
MOD_CDK_SPxK_1	344	350	PF00069	0.629
MOD_CK1_1	167	173	PF00069	0.591
MOD_CK1_1	177	183	PF00069	0.467
MOD_CK1_1	247	253	PF00069	0.560
MOD_CK1_1	272	278	PF00069	0.632
MOD_CK1_1	383	389	PF00069	0.473
MOD_CK1_1	42	48	PF00069	0.786
MOD_CK1_1	68	74	PF00069	0.784
MOD_CK1_1	84	90	PF00069	0.626
MOD_CK2_1	112	118	PF00069	0.615
MOD_GlcNHglycan	166	169	PF01048	0.360
MOD_GlcNHglycan	179	182	PF01048	0.393
MOD_GlcNHglycan	236	239	PF01048	0.361
MOD_GlcNHglycan	3	6	PF01048	0.427
MOD_GlcNHglycan	41	44	PF01048	0.596
MOD_GlcNHglycan	83	86	PF01048	0.485
MOD_GSK3_1	170	177	PF00069	0.597
MOD_GSK3_1	243	250	PF00069	0.581
MOD_GSK3_1	269	276	PF00069	0.591
MOD_GSK3_1	344	351	PF00069	0.576
MOD_GSK3_1	38	45	PF00069	0.792
MOD_GSK3_1	380	387	PF00069	0.404
MOD_GSK3_1	46	53	PF00069	0.748
MOD_GSK3_1	81	88	PF00069	0.761
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	123	128	PF00069	0.575
MOD_NEK2_1	164	169	PF00069	0.572
MOD_NEK2_1	174	179	PF00069	0.585
MOD_NEK2_1	243	248	PF00069	0.578
MOD_NEK2_1	360	365	PF00069	0.391
MOD_NEK2_1	367	372	PF00069	0.399
MOD_NEK2_2	221	226	PF00069	0.605
MOD_PKA_2	164	170	PF00069	0.560
MOD_PKA_2	184	190	PF00069	0.394
MOD_PKA_2	234	240	PF00069	0.522
MOD_PKA_2	269	275	PF00069	0.607
MOD_PKA_2	54	60	PF00069	0.787
MOD_Plk_1	147	153	PF00069	0.642
MOD_Plk_1	380	386	PF00069	0.471
MOD_Plk_4	170	176	PF00069	0.550
MOD_Plk_4	221	227	PF00069	0.570
MOD_Plk_4	314	320	PF00069	0.587
MOD_Plk_4	360	366	PF00069	0.406
MOD_Plk_4	387	393	PF00069	0.403
MOD_ProDKin_1	112	118	PF00069	0.644
MOD_ProDKin_1	197	203	PF00069	0.508
MOD_ProDKin_1	344	350	PF00069	0.629
MOD_ProDKin_1	42	48	PF00069	0.695
MOD_ProDKin_1	55	61	PF00069	0.769
MOD_SUMO_rev_2	264	272	PF00179	0.672
TRG_DiLeu_BaEn_1	189	194	PF01217	0.405
TRG_ENDOCYTIC_2	171	174	PF00928	0.562
TRG_ENDOCYTIC_2	191	194	PF00928	0.350
TRG_ENDOCYTIC_2	206	209	PF00928	0.453
TRG_ENDOCYTIC_2	241	244	PF00928	0.581
TRG_ENDOCYTIC_2	279	282	PF00928	0.506
TRG_ENDOCYTIC_2	286	289	PF00928	0.520
TRG_ENDOCYTIC_2	301	304	PF00928	0.529
TRG_ENDOCYTIC_2	318	321	PF00928	0.519
TRG_ENDOCYTIC_2	361	364	PF00928	0.406
TRG_ENDOCYTIC_2	374	377	PF00928	0.355
TRG_ENDOCYTIC_2	379	382	PF00928	0.312
TRG_ER_diArg_1	11	13	PF00400	0.689
TRG_ER_diArg_1	137	139	PF00400	0.588
TRG_ER_diArg_1	25	27	PF00400	0.752
TRG_ER_diArg_1	304	307	PF00400	0.559
TRG_ER_diArg_1	308	311	PF00400	0.596
TRG_ER_diArg_1	333	335	PF00400	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW81	Leptomonas seymouri	69%	100%
A0A0S4JWX5	Bodo saltans	44%	100%
A0A1X0NSQ2	Trypanosomatidae	55%	100%
A0A3Q8ICT6	Leishmania donovani	81%	100%
A4I1Z3	Leishmania infantum	81%	100%
C9ZS21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AY40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q9D3	Leishmania major	79%	100%
V5BUJ1	Trypanosoma cruzi	54%	100%