Alpha-taxilin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alpha-taxilin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HER5_LEIBR

TriTrypDb:

LbrM.26.0610 , LBRM2903_260010900

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HER5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HER5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0019905	syntaxin binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.405
CLV_NRD_NRD_1	153	155	PF00675	0.334
CLV_NRD_NRD_1	221	223	PF00675	0.296
CLV_NRD_NRD_1	93	95	PF00675	0.306
CLV_PCSK_KEX2_1	116	118	PF00082	0.308
CLV_PCSK_KEX2_1	152	154	PF00082	0.394
CLV_PCSK_KEX2_1	221	223	PF00082	0.281
CLV_PCSK_KEX2_1	305	307	PF00082	0.289
CLV_PCSK_KEX2_1	77	79	PF00082	0.388
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.277
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.369
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.284
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.413
CLV_PCSK_SKI1_1	216	220	PF00082	0.241
CLV_PCSK_SKI1_1	35	39	PF00082	0.521
CLV_PCSK_SKI1_1	60	64	PF00082	0.458
CLV_PCSK_SKI1_1	94	98	PF00082	0.466
CLV_Separin_Metazoa	228	232	PF03568	0.190
DOC_CYCLIN_yClb5_NLxxxL_5	229	238	PF00134	0.190
DOC_USP7_MATH_1	15	19	PF00917	0.698
DOC_USP7_MATH_1	325	329	PF00917	0.322
DOC_USP7_UBL2_3	66	70	PF12436	0.246
DOC_WW_Pin1_4	20	25	PF00397	0.621
LIG_14-3-3_CanoR_1	224	228	PF00244	0.333
LIG_FHA_1	213	219	PF00498	0.190
LIG_FHA_1	292	298	PF00498	0.190
LIG_FHA_2	8	14	PF00498	0.543
LIG_LIR_Gen_1	179	189	PF02991	0.415
LIG_LIR_LC3C_4	198	201	PF02991	0.190
LIG_LIR_Nem_3	179	185	PF02991	0.305
LIG_LIR_Nem_3	242	248	PF02991	0.305
LIG_Pex14_2	178	182	PF04695	0.362
LIG_SH2_SRC	203	206	PF00017	0.441
LIG_SH2_STAP1	241	245	PF00017	0.328
LIG_SH2_STAT3	241	244	PF00017	0.303
LIG_SH2_STAT5	105	108	PF00017	0.337
LIG_SH3_3	249	255	PF00018	0.376
LIG_SUMO_SIM_anti_2	214	221	PF11976	0.397
LIG_TRAF2_1	10	13	PF00917	0.571
LIG_TRAF2_1	109	112	PF00917	0.350
LIG_TRAF2_1	202	205	PF00917	0.413
LIG_TRAF2_1	23	26	PF00917	0.453
LIG_TRAF2_1	328	331	PF00917	0.578
LIG_TRAF2_1	98	101	PF00917	0.369
MOD_CK1_1	18	24	PF00069	0.654
MOD_CK2_1	106	112	PF00069	0.239
MOD_CK2_1	178	184	PF00069	0.244
MOD_CK2_1	20	26	PF00069	0.511
MOD_CK2_1	325	331	PF00069	0.738
MOD_CK2_1	7	13	PF00069	0.659
MOD_GlcNHglycan	132	135	PF01048	0.190
MOD_GlcNHglycan	5	8	PF01048	0.635
MOD_GSK3_1	106	113	PF00069	0.376
MOD_GSK3_1	174	181	PF00069	0.345
MOD_GSK3_1	3	10	PF00069	0.628
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	106	111	PF00069	0.324
MOD_NEK2_1	167	172	PF00069	0.336
MOD_NEK2_1	178	183	PF00069	0.406
MOD_NEK2_1	248	253	PF00069	0.315
MOD_NEK2_1	53	58	PF00069	0.388
MOD_PKA_1	174	180	PF00069	0.423
MOD_PKA_2	223	229	PF00069	0.441
MOD_Plk_1	167	173	PF00069	0.336
MOD_Plk_1	178	184	PF00069	0.379
MOD_Plk_2-3	223	229	PF00069	0.362
MOD_Plk_4	248	254	PF00069	0.282
MOD_Plk_4	53	59	PF00069	0.285
MOD_ProDKin_1	20	26	PF00069	0.618
MOD_SUMO_for_1	304	307	PF00179	0.303
MOD_SUMO_rev_2	158	167	PF00179	0.262
MOD_SUMO_rev_2	251	261	PF00179	0.190
TRG_ENDOCYTIC_2	196	199	PF00928	0.378
TRG_ER_diArg_1	220	222	PF00400	0.323
TRG_NES_CRM1_1	209	223	PF08389	0.190
TRG_NES_CRM1_1	228	242	PF08389	0.190
TRG_NES_CRM1_1	71	83	PF08389	0.337
TRG_NLS_Bipartite_1	76	98	PF00514	0.190
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W3	Leptomonas seymouri	64%	99%
A0A0S4JT11	Bodo saltans	30%	91%
A0A1X0NSF2	Trypanosomatidae	37%	94%
A0A3Q8IFN3	Leishmania donovani	82%	100%
A0A3R7M749	Trypanosoma rangeli	38%	92%
A4I1Z2	Leishmania infantum	82%	100%
C9ZS22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9AY39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q9D4	Leishmania major	82%	100%
V5BZC0	Trypanosoma cruzi	38%	91%