Putative spliced leader RNA PSE-promoter transcription factor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliced leader RNA PSE-promoter transcription factor, putative

Species:

Leishmania braziliensis

UniProt:

A4HER4_LEIBR

TriTrypDb:

LbrM.26.0600 , LBRM2903_260010800

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HER4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HER4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.542
CLV_C14_Caspase3-7	362	366	PF00656	0.583
CLV_C14_Caspase3-7	427	431	PF00656	0.557
CLV_C14_Caspase3-7	647	651	PF00656	0.647
CLV_NRD_NRD_1	125	127	PF00675	0.705
CLV_NRD_NRD_1	28	30	PF00675	0.576
CLV_NRD_NRD_1	295	297	PF00675	0.479
CLV_NRD_NRD_1	314	316	PF00675	0.317
CLV_NRD_NRD_1	388	390	PF00675	0.422
CLV_NRD_NRD_1	472	474	PF00675	0.579
CLV_NRD_NRD_1	538	540	PF00675	0.576
CLV_NRD_NRD_1	549	551	PF00675	0.454
CLV_NRD_NRD_1	61	63	PF00675	0.487
CLV_NRD_NRD_1	625	627	PF00675	0.540
CLV_PCSK_FUR_1	26	30	PF00082	0.575
CLV_PCSK_FUR_1	58	62	PF00082	0.559
CLV_PCSK_KEX2_1	125	127	PF00082	0.673
CLV_PCSK_KEX2_1	28	30	PF00082	0.577
CLV_PCSK_KEX2_1	314	316	PF00082	0.484
CLV_PCSK_KEX2_1	387	389	PF00082	0.463
CLV_PCSK_KEX2_1	43	45	PF00082	0.553
CLV_PCSK_KEX2_1	471	473	PF00082	0.613
CLV_PCSK_KEX2_1	538	540	PF00082	0.576
CLV_PCSK_KEX2_1	549	551	PF00082	0.454
CLV_PCSK_KEX2_1	60	62	PF00082	0.361
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.644
CLV_PCSK_PC7_1	24	30	PF00082	0.579
CLV_PCSK_PC7_1	384	390	PF00082	0.325
CLV_PCSK_PC7_1	468	474	PF00082	0.650
CLV_PCSK_SKI1_1	228	232	PF00082	0.511
CLV_PCSK_SKI1_1	319	323	PF00082	0.446
CLV_PCSK_SKI1_1	347	351	PF00082	0.491
CLV_PCSK_SKI1_1	389	393	PF00082	0.488
DEG_APCC_DBOX_1	227	235	PF00400	0.498
DEG_APCC_DBOX_1	327	335	PF00400	0.470
DEG_Nend_UBRbox_1	1	4	PF02207	0.563
DEG_ODPH_VHL_1	503	514	PF01847	0.324
DEG_SCF_FBW7_2	399	406	PF00400	0.456
DEG_SPOP_SBC_1	417	421	PF00917	0.665
DOC_CDC14_PxL_1	236	244	PF14671	0.529
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	422	425	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	611	617	PF00134	0.655
DOC_MAPK_gen_1	26	34	PF00069	0.561
DOC_MAPK_gen_1	536	544	PF00069	0.585
DOC_MAPK_gen_1	665	675	PF00069	0.669
DOC_MAPK_JIP1_4	26	32	PF00069	0.568
DOC_MAPK_MEF2A_6	262	269	PF00069	0.452
DOC_PP2B_LxvP_1	211	214	PF13499	0.581
DOC_PP2B_LxvP_1	30	33	PF13499	0.558
DOC_PP2B_LxvP_1	422	425	PF13499	0.740
DOC_PP2B_LxvP_1	503	506	PF13499	0.523
DOC_USP7_MATH_1	142	146	PF00917	0.766
DOC_USP7_MATH_1	174	178	PF00917	0.624
DOC_USP7_MATH_1	360	364	PF00917	0.433
DOC_USP7_MATH_1	412	416	PF00917	0.661
DOC_USP7_MATH_1	417	421	PF00917	0.634
DOC_USP7_MATH_1	620	624	PF00917	0.658
DOC_WW_Pin1_4	100	105	PF00397	0.461
DOC_WW_Pin1_4	131	136	PF00397	0.686
DOC_WW_Pin1_4	14	19	PF00397	0.583
DOC_WW_Pin1_4	159	164	PF00397	0.558
DOC_WW_Pin1_4	169	174	PF00397	0.573
DOC_WW_Pin1_4	206	211	PF00397	0.448
DOC_WW_Pin1_4	399	404	PF00397	0.529
DOC_WW_Pin1_4	413	418	PF00397	0.607
DOC_WW_Pin1_4	610	615	PF00397	0.564
DOC_WW_Pin1_4	616	621	PF00397	0.679
LIG_14-3-3_CanoR_1	2	8	PF00244	0.643
LIG_14-3-3_CanoR_1	388	398	PF00244	0.507
LIG_14-3-3_CanoR_1	612	618	PF00244	0.658
LIG_14-3-3_CanoR_1	636	645	PF00244	0.683
LIG_APCC_ABBA_1	332	337	PF00400	0.437
LIG_BRCT_BRCA1_1	165	169	PF00533	0.654
LIG_BRCT_BRCA1_1	18	22	PF00533	0.700
LIG_CaM_IQ_9	300	316	PF13499	0.524
LIG_CaM_NSCaTE_8	318	325	PF13499	0.441
LIG_FHA_1	191	197	PF00498	0.598
LIG_FHA_1	253	259	PF00498	0.508
LIG_FHA_1	417	423	PF00498	0.734
LIG_FHA_1	483	489	PF00498	0.590
LIG_FHA_1	91	97	PF00498	0.574
LIG_FHA_2	104	110	PF00498	0.568
LIG_FHA_2	360	366	PF00498	0.557
LIG_FHA_2	449	455	PF00498	0.511
LIG_FHA_2	623	629	PF00498	0.678
LIG_FHA_2	642	648	PF00498	0.599
LIG_Integrin_RGD_1	222	224	PF01839	0.526
LIG_LIR_Gen_1	200	211	PF02991	0.526
LIG_LIR_Gen_1	365	375	PF02991	0.473
LIG_LIR_Gen_1	557	566	PF02991	0.545
LIG_LIR_Nem_3	19	25	PF02991	0.653
LIG_LIR_Nem_3	200	206	PF02991	0.457
LIG_LIR_Nem_3	233	239	PF02991	0.460
LIG_LIR_Nem_3	271	275	PF02991	0.438
LIG_LIR_Nem_3	365	370	PF02991	0.495
LIG_LIR_Nem_3	498	503	PF02991	0.624
LIG_LIR_Nem_3	557	563	PF02991	0.529
LIG_LIR_Nem_3	82	87	PF02991	0.561
LIG_LYPXL_SIV_4	116	124	PF13949	0.571
LIG_LYPXL_yS_3	239	242	PF13949	0.449
LIG_MLH1_MIPbox_1	18	22	PF16413	0.700
LIG_PCNA_PIPBox_1	603	612	PF02747	0.443
LIG_PDZ_Class_2	670	675	PF00595	0.626
LIG_Pex14_1	345	349	PF04695	0.508
LIG_Pex14_2	349	353	PF04695	0.493
LIG_PTB_Apo_2	44	51	PF02174	0.574
LIG_SH2_CRK	367	371	PF00017	0.551
LIG_SH2_CRK	560	564	PF00017	0.563
LIG_SH2_NCK_1	117	121	PF00017	0.494
LIG_SH2_NCK_1	165	169	PF00017	0.654
LIG_SH2_STAP1	165	169	PF00017	0.654
LIG_SH2_STAT3	529	532	PF00017	0.612
LIG_SH2_STAT5	21	24	PF00017	0.718
LIG_SH2_STAT5	272	275	PF00017	0.461
LIG_SH2_STAT5	574	577	PF00017	0.413
LIG_SH2_STAT5	584	587	PF00017	0.444
LIG_SH2_STAT5	610	613	PF00017	0.436
LIG_SH3_1	528	534	PF00018	0.400
LIG_SH3_2	531	536	PF14604	0.374
LIG_SH3_3	30	36	PF00018	0.579
LIG_SH3_3	528	534	PF00018	0.400
LIG_SH3_3	656	662	PF00018	0.767
LIG_Sin3_3	523	530	PF02671	0.549
LIG_SUMO_SIM_par_1	103	109	PF11976	0.374
LIG_SUMO_SIM_par_1	192	198	PF11976	0.601
LIG_SUMO_SIM_par_1	229	235	PF11976	0.524
LIG_SUMO_SIM_par_1	540	545	PF11976	0.455
LIG_SUMO_SIM_par_1	550	557	PF11976	0.497
LIG_TRAF2_1	403	406	PF00917	0.503
LIG_TRAF2_1	452	455	PF00917	0.616
LIG_WRC_WIRS_1	346	351	PF05994	0.502
MOD_CDC14_SPxK_1	134	137	PF00782	0.542
MOD_CDC14_SPxK_1	17	20	PF00782	0.584
MOD_CDK_SPK_2	399	404	PF00069	0.435
MOD_CDK_SPxK_1	131	137	PF00069	0.541
MOD_CDK_SPxK_1	14	20	PF00069	0.587
MOD_CK1_1	177	183	PF00069	0.699
MOD_CK1_1	416	422	PF00069	0.683
MOD_CK1_1	562	568	PF00069	0.524
MOD_CK1_1	613	619	PF00069	0.657
MOD_CK1_1	640	646	PF00069	0.712
MOD_CK2_1	103	109	PF00069	0.472
MOD_CK2_1	142	148	PF00069	0.826
MOD_CK2_1	192	198	PF00069	0.583
MOD_CK2_1	448	454	PF00069	0.531
MOD_CK2_1	616	622	PF00069	0.678
MOD_GlcNHglycan	140	143	PF01048	0.640
MOD_GlcNHglycan	144	147	PF01048	0.640
MOD_GlcNHglycan	155	158	PF01048	0.637
MOD_GlcNHglycan	182	185	PF01048	0.673
MOD_GlcNHglycan	236	239	PF01048	0.546
MOD_GlcNHglycan	323	326	PF01048	0.436
MOD_GlcNHglycan	361	365	PF01048	0.440
MOD_GlcNHglycan	410	413	PF01048	0.734
MOD_GlcNHglycan	477	481	PF01048	0.599
MOD_GlcNHglycan	564	567	PF01048	0.449
MOD_GlcNHglycan	595	598	PF01048	0.561
MOD_GlcNHglycan	615	618	PF01048	0.377
MOD_GlcNHglycan	655	658	PF01048	0.676
MOD_GSK3_1	138	145	PF00069	0.743
MOD_GSK3_1	149	156	PF00069	0.628
MOD_GSK3_1	159	166	PF00069	0.601
MOD_GSK3_1	174	181	PF00069	0.634
MOD_GSK3_1	182	189	PF00069	0.709
MOD_GSK3_1	34	41	PF00069	0.527
MOD_GSK3_1	408	415	PF00069	0.651
MOD_GSK3_1	616	623	PF00069	0.623
MOD_GSK3_1	637	644	PF00069	0.671
MOD_N-GLC_1	153	158	PF02516	0.660
MOD_N-GLC_1	637	642	PF02516	0.681
MOD_NEK2_1	1	6	PF00069	0.707
MOD_NEK2_1	158	163	PF00069	0.479
MOD_NEK2_1	179	184	PF00069	0.733
MOD_NEK2_1	226	231	PF00069	0.431
MOD_NEK2_1	232	237	PF00069	0.433
MOD_NEK2_1	251	256	PF00069	0.273
MOD_NEK2_1	377	382	PF00069	0.319
MOD_NEK2_1	476	481	PF00069	0.596
MOD_NEK2_1	512	517	PF00069	0.525
MOD_NEK2_1	621	626	PF00069	0.626
MOD_NEK2_1	7	12	PF00069	0.693
MOD_PIKK_1	1	7	PF00454	0.485
MOD_PIKK_1	377	383	PF00454	0.428
MOD_PIKK_1	482	488	PF00454	0.590
MOD_PIKK_1	90	96	PF00454	0.573
MOD_PK_1	76	82	PF00069	0.573
MOD_PKA_2	1	7	PF00069	0.647
MOD_PKB_1	387	395	PF00069	0.338
MOD_Plk_1	153	159	PF00069	0.640
MOD_Plk_1	232	238	PF00069	0.498
MOD_Plk_1	572	578	PF00069	0.424
MOD_Plk_1	599	605	PF00069	0.483
MOD_Plk_1	641	647	PF00069	0.682
MOD_Plk_1	76	82	PF00069	0.465
MOD_Plk_2-3	201	207	PF00069	0.570
MOD_Plk_4	109	115	PF00069	0.539
MOD_Plk_4	394	400	PF00069	0.473
MOD_Plk_4	418	424	PF00069	0.502
MOD_Plk_4	590	596	PF00069	0.467
MOD_ProDKin_1	100	106	PF00069	0.456
MOD_ProDKin_1	131	137	PF00069	0.691
MOD_ProDKin_1	14	20	PF00069	0.587
MOD_ProDKin_1	159	165	PF00069	0.556
MOD_ProDKin_1	169	175	PF00069	0.575
MOD_ProDKin_1	206	212	PF00069	0.449
MOD_ProDKin_1	399	405	PF00069	0.541
MOD_ProDKin_1	413	419	PF00069	0.605
MOD_ProDKin_1	610	616	PF00069	0.571
MOD_SUMO_for_1	403	406	PF00179	0.503
MOD_SUMO_for_1	667	670	PF00179	0.665
TRG_DiLeu_BaEn_1	109	114	PF01217	0.324
TRG_DiLeu_BaEn_1	253	258	PF01217	0.420
TRG_DiLeu_BaEn_1	522	527	PF01217	0.308
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.403
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.561
TRG_ENDOCYTIC_2	239	242	PF00928	0.429
TRG_ENDOCYTIC_2	272	275	PF00928	0.287
TRG_ENDOCYTIC_2	367	370	PF00928	0.572
TRG_ENDOCYTIC_2	375	378	PF00928	0.488
TRG_ENDOCYTIC_2	500	503	PF00928	0.610
TRG_ENDOCYTIC_2	560	563	PF00928	0.548
TRG_ENDOCYTIC_2	569	572	PF00928	0.458
TRG_ER_diArg_1	124	126	PF00400	0.685
TRG_ER_diArg_1	240	243	PF00400	0.401
TRG_ER_diArg_1	25	28	PF00400	0.593
TRG_ER_diArg_1	291	294	PF00400	0.547
TRG_ER_diArg_1	314	316	PF00400	0.465
TRG_ER_diArg_1	369	372	PF00400	0.561
TRG_ER_diArg_1	386	389	PF00400	0.411
TRG_ER_diArg_1	436	439	PF00400	0.596
TRG_ER_diArg_1	471	473	PF00400	0.680
TRG_ER_diArg_1	537	539	PF00400	0.569
TRG_ER_diArg_1	548	550	PF00400	0.473
TRG_ER_diArg_1	58	61	PF00400	0.492
TRG_ER_diArg_1	662	665	PF00400	0.693
TRG_NES_CRM1_1	284	298	PF08389	0.505
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A3	Leptomonas seymouri	63%	99%
A0A0S4JUQ3	Bodo saltans	36%	100%
A0A1X0NT43	Trypanosomatidae	48%	100%
A0A3Q8ICN9	Leishmania donovani	81%	96%
A0A422N5D7	Trypanosoma rangeli	48%	100%
A4I1Z1	Leishmania infantum	81%	96%
C9ZS25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AY38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q9D5	Leishmania major	82%	100%
V5BPZ1	Trypanosoma cruzi	48%	100%