ApaG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF525), putative

Species:

Leishmania braziliensis

UniProt:

A4HER3_LEIBR

TriTrypDb:

LbrM.26.0590 , LBRM2903_260010700

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0009295	nucleoid	2	1
GO:0042645	mitochondrial nucleoid	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HER3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HER3

Function

Biological processes
Term	Name	Level	Count
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006301	postreplication repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0070987	error-free translesion synthesis	8	1
GO:0071704	organic substance metabolic process	2	1
GO:0071897	DNA biosynthetic process	5	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.570
CLV_C14_Caspase3-7	573	577	PF00656	0.590
CLV_NRD_NRD_1	102	104	PF00675	0.629
CLV_NRD_NRD_1	182	184	PF00675	0.653
CLV_NRD_NRD_1	298	300	PF00675	0.701
CLV_NRD_NRD_1	84	86	PF00675	0.517
CLV_PCSK_KEX2_1	102	104	PF00082	0.629
CLV_PCSK_KEX2_1	181	183	PF00082	0.660
CLV_PCSK_KEX2_1	395	397	PF00082	0.552
CLV_PCSK_KEX2_1	439	441	PF00082	0.513
CLV_PCSK_KEX2_1	84	86	PF00082	0.517
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.552
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.513
CLV_PCSK_PC7_1	178	184	PF00082	0.652
CLV_PCSK_SKI1_1	396	400	PF00082	0.563
CLV_PCSK_SKI1_1	9	13	PF00082	0.500
CLV_Separin_Metazoa	336	340	PF03568	0.600
DEG_APCC_DBOX_1	330	338	PF00400	0.511
DEG_Nend_Nbox_1	1	3	PF02207	0.407
DEG_SPOP_SBC_1	285	289	PF00917	0.590
DOC_MAPK_MEF2A_6	497	504	PF00069	0.411
DOC_PP4_FxxP_1	206	209	PF00568	0.615
DOC_PP4_FxxP_1	589	592	PF00568	0.571
DOC_PP4_FxxP_1	59	62	PF00568	0.499
DOC_SPAK_OSR1_1	205	209	PF12202	0.607
DOC_USP7_MATH_1	109	113	PF00917	0.667
DOC_USP7_MATH_1	118	122	PF00917	0.772
DOC_USP7_MATH_1	137	141	PF00917	0.595
DOC_USP7_MATH_1	210	214	PF00917	0.720
DOC_USP7_MATH_1	217	221	PF00917	0.529
DOC_USP7_MATH_1	257	261	PF00917	0.570
DOC_USP7_MATH_1	285	289	PF00917	0.804
DOC_USP7_MATH_1	387	391	PF00917	0.748
DOC_USP7_MATH_1	477	481	PF00917	0.411
DOC_USP7_MATH_1	556	560	PF00917	0.589
DOC_USP7_MATH_1	74	78	PF00917	0.619
DOC_USP7_MATH_2	279	285	PF00917	0.591
DOC_USP7_UBL2_3	17	21	PF12436	0.413
DOC_WW_Pin1_4	128	133	PF00397	0.699
DOC_WW_Pin1_4	305	310	PF00397	0.710
DOC_WW_Pin1_4	369	374	PF00397	0.790
DOC_WW_Pin1_4	389	394	PF00397	0.643
DOC_WW_Pin1_4	557	562	PF00397	0.632
LIG_14-3-3_CanoR_1	522	526	PF00244	0.440
LIG_14-3-3_CanoR_1	75	83	PF00244	0.514
LIG_Actin_WH2_2	48	63	PF00022	0.488
LIG_Actin_WH2_2	76	92	PF00022	0.626
LIG_APCC_ABBA_1	502	507	PF00400	0.502
LIG_BRCT_BRCA1_1	143	147	PF00533	0.763
LIG_BRCT_BRCA1_1	197	201	PF00533	0.521
LIG_BRCT_BRCA1_1	479	483	PF00533	0.411
LIG_BRCT_BRCA1_1	76	80	PF00533	0.520
LIG_Clathr_ClatBox_1	450	454	PF01394	0.411
LIG_CtBP_PxDLS_1	196	200	PF00389	0.632
LIG_EVH1_2	202	206	PF00568	0.612
LIG_FHA_1	112	118	PF00498	0.541
LIG_FHA_1	153	159	PF00498	0.681
LIG_FHA_1	226	232	PF00498	0.447
LIG_FHA_1	316	322	PF00498	0.666
LIG_FHA_1	341	347	PF00498	0.476
LIG_FHA_1	356	362	PF00498	0.467
LIG_FHA_1	389	395	PF00498	0.650
LIG_FHA_1	522	528	PF00498	0.496
LIG_FHA_1	55	61	PF00498	0.481
LIG_FHA_1	553	559	PF00498	0.585
LIG_FHA_2	327	333	PF00498	0.500
LIG_FHA_2	537	543	PF00498	0.563
LIG_LIR_Apic_2	19	25	PF02991	0.537
LIG_LIR_Apic_2	57	62	PF02991	0.488
LIG_LIR_Gen_1	27	37	PF02991	0.493
LIG_LIR_Gen_1	77	86	PF02991	0.516
LIG_LIR_LC3C_4	447	452	PF02991	0.411
LIG_LIR_Nem_3	198	204	PF02991	0.548
LIG_LIR_Nem_3	220	225	PF02991	0.499
LIG_LIR_Nem_3	27	33	PF02991	0.495
LIG_LIR_Nem_3	49	54	PF02991	0.483
LIG_LIR_Nem_3	6	11	PF02991	0.485
LIG_LIR_Nem_3	77	83	PF02991	0.516
LIG_MYND_1	473	477	PF01753	0.411
LIG_PTB_Apo_2	41	48	PF02174	0.576
LIG_PTB_Phospho_1	41	47	PF10480	0.574
LIG_SH2_CRK	8	12	PF00017	0.488
LIG_SH2_NCK_1	22	26	PF00017	0.540
LIG_SH2_PTP2	426	429	PF00017	0.411
LIG_SH2_SRC	22	25	PF00017	0.541
LIG_SH2_SRC	426	429	PF00017	0.411
LIG_SH2_STAT3	247	250	PF00017	0.480
LIG_SH2_STAT5	2	5	PF00017	0.368
LIG_SH2_STAT5	214	217	PF00017	0.613
LIG_SH2_STAT5	247	250	PF00017	0.441
LIG_SH2_STAT5	360	363	PF00017	0.555
LIG_SH2_STAT5	426	429	PF00017	0.355
LIG_SH3_3	155	161	PF00018	0.758
LIG_SH3_3	190	196	PF00018	0.627
LIG_SH3_3	206	212	PF00018	0.621
LIG_SH3_3	308	314	PF00018	0.560
LIG_SH3_3	555	561	PF00018	0.590
LIG_SUMO_SIM_par_1	213	221	PF11976	0.657
LIG_SUMO_SIM_par_1	228	235	PF11976	0.327
LIG_SUMO_SIM_par_1	349	355	PF11976	0.499
LIG_SUMO_SIM_par_1	449	455	PF11976	0.411
LIG_SUMO_SIM_par_1	523	529	PF11976	0.560
LIG_TRAF2_1	330	333	PF00917	0.565
LIG_TRAF2_1	539	542	PF00917	0.616
LIG_TYR_ITIM	424	429	PF00017	0.411
MOD_CDK_SPxK_1	389	395	PF00069	0.650
MOD_CDK_SPxxK_3	389	396	PF00069	0.506
MOD_CK1_1	121	127	PF00069	0.771
MOD_CK1_1	130	136	PF00069	0.613
MOD_CK1_1	146	152	PF00069	0.775
MOD_CK1_1	235	241	PF00069	0.479
MOD_CK1_1	284	290	PF00069	0.590
MOD_CK1_1	326	332	PF00069	0.445
MOD_CK1_1	363	369	PF00069	0.657
MOD_CK1_1	406	412	PF00069	0.672
MOD_CK1_1	485	491	PF00069	0.411
MOD_CK1_1	536	542	PF00069	0.525
MOD_CK1_1	547	553	PF00069	0.632
MOD_CK2_1	326	332	PF00069	0.509
MOD_CK2_1	487	493	PF00069	0.411
MOD_CK2_1	536	542	PF00069	0.572
MOD_CK2_1	556	562	PF00069	0.513
MOD_Cter_Amidation	14	17	PF01082	0.395
MOD_GlcNHglycan	120	123	PF01048	0.723
MOD_GlcNHglycan	139	142	PF01048	0.786
MOD_GlcNHglycan	234	237	PF01048	0.454
MOD_GlcNHglycan	268	271	PF01048	0.660
MOD_GlcNHglycan	283	286	PF01048	0.675
MOD_GlcNHglycan	365	368	PF01048	0.681
MOD_GlcNHglycan	454	457	PF01048	0.261
MOD_GlcNHglycan	484	487	PF01048	0.411
MOD_GlcNHglycan	489	492	PF01048	0.411
MOD_GlcNHglycan	5	8	PF01048	0.489
MOD_GlcNHglycan	528	531	PF01048	0.704
MOD_GlcNHglycan	549	553	PF01048	0.753
MOD_GlcNHglycan	573	576	PF01048	0.615
MOD_GlcNHglycan	76	79	PF01048	0.516
MOD_GSK3_1	127	134	PF00069	0.641
MOD_GSK3_1	137	144	PF00069	0.793
MOD_GSK3_1	149	156	PF00069	0.688
MOD_GSK3_1	235	242	PF00069	0.337
MOD_GSK3_1	251	258	PF00069	0.525
MOD_GSK3_1	277	284	PF00069	0.648
MOD_GSK3_1	323	330	PF00069	0.500
MOD_GSK3_1	342	349	PF00069	0.630
MOD_GSK3_1	405	412	PF00069	0.734
MOD_GSK3_1	46	53	PF00069	0.386
MOD_GSK3_1	521	528	PF00069	0.469
MOD_GSK3_1	532	539	PF00069	0.611
MOD_GSK3_1	544	551	PF00069	0.614
MOD_GSK3_1	552	559	PF00069	0.527
MOD_GSK3_1	69	76	PF00069	0.641
MOD_N-GLC_1	185	190	PF02516	0.744
MOD_N-GLC_1	409	414	PF02516	0.626
MOD_N-GLC_1	587	592	PF02516	0.576
MOD_NEK2_1	232	237	PF00069	0.450
MOD_NEK2_1	388	393	PF00069	0.646
MOD_NEK2_1	496	501	PF00069	0.513
MOD_NEK2_1	533	538	PF00069	0.657
MOD_NEK2_1	89	94	PF00069	0.654
MOD_NEK2_2	79	84	PF00069	0.399
MOD_PIKK_1	246	252	PF00454	0.483
MOD_PIKK_1	255	261	PF00454	0.457
MOD_PK_1	403	409	PF00069	0.571
MOD_PKA_1	16	22	PF00069	0.411
MOD_PKA_2	170	176	PF00069	0.623
MOD_PKA_2	177	183	PF00069	0.657
MOD_PKA_2	266	272	PF00069	0.774
MOD_PKA_2	496	502	PF00069	0.411
MOD_PKA_2	521	527	PF00069	0.454
MOD_PKA_2	60	66	PF00069	0.519
MOD_PKA_2	74	80	PF00069	0.518
MOD_Plk_1	409	415	PF00069	0.620
MOD_Plk_2-3	272	278	PF00069	0.793
MOD_Plk_4	170	176	PF00069	0.623
MOD_Plk_4	210	216	PF00069	0.725
MOD_Plk_4	235	241	PF00069	0.479
MOD_Plk_4	50	56	PF00069	0.357
MOD_ProDKin_1	128	134	PF00069	0.698
MOD_ProDKin_1	305	311	PF00069	0.709
MOD_ProDKin_1	369	375	PF00069	0.788
MOD_ProDKin_1	389	395	PF00069	0.650
MOD_ProDKin_1	557	563	PF00069	0.633
MOD_SUMO_rev_2	121	129	PF00179	0.570
MOD_SUMO_rev_2	275	285	PF00179	0.588
MOD_SUMO_rev_2	412	420	PF00179	0.397
TRG_DiLeu_BaEn_1	165	170	PF01217	0.613
TRG_DiLeu_BaEn_1	211	216	PF01217	0.622
TRG_DiLeu_BaEn_1	333	338	PF01217	0.637
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.411
TRG_ENDOCYTIC_2	426	429	PF00928	0.405
TRG_ENDOCYTIC_2	8	11	PF00928	0.487
TRG_ER_diArg_1	101	103	PF00400	0.632
TRG_ER_diArg_1	181	183	PF00400	0.660
TRG_ER_diArg_1	429	432	PF00400	0.411
TRG_ER_diArg_1	83	85	PF00400	0.522
TRG_ER_diArg_1	96	99	PF00400	0.609
TRG_ER_diLys_1	591	596	PF00400	0.827
TRG_NES_CRM1_1	27	41	PF08389	0.490
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I464	Leptomonas seymouri	52%	100%
A0A3Q8IGW6	Leishmania donovani	80%	100%
A4I1Z0	Leishmania infantum	81%	100%
E9AY37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q9D6	Leishmania major	79%	97%