Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HER2_LEIBR

TriTrypDb:

LbrM.26.0580 , LBRM2903_260010600

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HER2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HER2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.519
CLV_PCSK_SKI1_1	19	23	PF00082	0.259
CLV_Separin_Metazoa	140	144	PF03568	0.434
DEG_Nend_UBRbox_2	1	3	PF02207	0.595
DOC_CKS1_1	38	43	PF01111	0.619
DOC_CKS1_1	84	89	PF01111	0.487
DOC_PP4_FxxP_1	38	41	PF00568	0.550
DOC_USP7_MATH_1	63	67	PF00917	0.702
DOC_WW_Pin1_4	37	42	PF00397	0.596
DOC_WW_Pin1_4	83	88	PF00397	0.460
LIG_14-3-3_CanoR_1	19	26	PF00244	0.328
LIG_BIR_III_4	2	6	PF00653	0.545
LIG_FHA_1	120	126	PF00498	0.421
LIG_FHA_1	137	143	PF00498	0.493
LIG_FHA_1	20	26	PF00498	0.324
LIG_FHA_2	4	10	PF00498	0.399
LIG_LIR_Gen_1	135	145	PF02991	0.393
LIG_LIR_Gen_1	9	20	PF02991	0.353
LIG_LIR_Nem_3	135	141	PF02991	0.372
LIG_LIR_Nem_3	9	15	PF02991	0.349
LIG_SH2_GRB2like	11	14	PF00017	0.359
LIG_SH2_STAP1	138	142	PF00017	0.512
LIG_SH2_STAT3	11	14	PF00017	0.344
LIG_SH2_STAT5	11	14	PF00017	0.344
LIG_SH2_STAT5	138	141	PF00017	0.491
LIG_SH2_STAT5	75	78	PF00017	0.449
LIG_SH2_STAT5	89	92	PF00017	0.292
LIG_SUMO_SIM_anti_2	108	115	PF11976	0.393
MOD_CK1_1	105	111	PF00069	0.547
MOD_CK1_1	66	72	PF00069	0.556
MOD_CK2_1	3	9	PF00069	0.416
MOD_GlcNHglycan	104	107	PF01048	0.276
MOD_GlcNHglycan	51	54	PF01048	0.692
MOD_GlcNHglycan	70	73	PF01048	0.421
MOD_GSK3_1	108	115	PF00069	0.368
MOD_GSK3_1	132	139	PF00069	0.446
MOD_LATS_1	17	23	PF00433	0.326
MOD_N-GLC_1	66	71	PF02516	0.566
MOD_NEK2_1	102	107	PF00069	0.427
MOD_NEK2_1	112	117	PF00069	0.425
MOD_PIKK_1	19	25	PF00454	0.336
MOD_Plk_1	66	72	PF00069	0.491
MOD_Plk_4	105	111	PF00069	0.425
MOD_Plk_4	124	130	PF00069	0.461
MOD_Plk_4	30	36	PF00069	0.403
MOD_Plk_4	85	91	PF00069	0.483
MOD_ProDKin_1	37	43	PF00069	0.606
MOD_ProDKin_1	83	89	PF00069	0.456
TRG_AP2beta_CARGO_1	9	19	PF09066	0.266
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.306
TRG_ENDOCYTIC_2	138	141	PF00928	0.403
TRG_NES_CRM1_1	14	28	PF08389	0.371
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P5	Leptomonas seymouri	78%	97%
A0A0S4JUR6	Bodo saltans	41%	100%
A0A1X0NSG3	Trypanosomatidae	57%	100%
A0A3Q8IC22	Leishmania donovani	94%	100%
A0A422N5D6	Trypanosoma rangeli	61%	100%
A4I1Y9	Leishmania infantum	94%	100%
C9ZS26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
E9AY36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9D7	Leishmania major	93%	100%
V5BQ40	Trypanosoma cruzi	59%	100%