Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HER1_LEIBR

TriTrypDb:

LbrM.26.0570 , LBRM2903_260010500

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HER1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HER1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.718
CLV_C14_Caspase3-7	3	7	PF00656	0.657
CLV_C14_Caspase3-7	8	12	PF00656	0.699
CLV_MEL_PAP_1	414	420	PF00089	0.489
CLV_NRD_NRD_1	146	148	PF00675	0.407
CLV_NRD_NRD_1	236	238	PF00675	0.670
CLV_NRD_NRD_1	453	455	PF00675	0.477
CLV_PCSK_KEX2_1	146	148	PF00082	0.407
CLV_PCSK_KEX2_1	174	176	PF00082	0.633
CLV_PCSK_KEX2_1	236	238	PF00082	0.670
CLV_PCSK_KEX2_1	453	455	PF00082	0.464
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.633
CLV_PCSK_SKI1_1	167	171	PF00082	0.541
CLV_Separin_Metazoa	315	319	PF03568	0.682
DEG_APCC_DBOX_1	138	146	PF00400	0.607
DEG_APCC_DBOX_1	219	227	PF00400	0.542
DEG_SPOP_SBC_1	351	355	PF00917	0.735
DOC_CKS1_1	333	338	PF01111	0.737
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.475
DOC_MAPK_gen_1	137	144	PF00069	0.548
DOC_MAPK_gen_1	236	242	PF00069	0.462
DOC_MAPK_MEF2A_6	281	290	PF00069	0.275
DOC_PP2B_LxvP_1	210	213	PF13499	0.469
DOC_PP2B_LxvP_1	290	293	PF13499	0.312
DOC_USP7_MATH_1	184	188	PF00917	0.546
DOC_USP7_MATH_1	308	312	PF00917	0.596
DOC_USP7_MATH_1	339	343	PF00917	0.807
DOC_USP7_MATH_1	351	355	PF00917	0.657
DOC_USP7_MATH_1	371	375	PF00917	0.696
DOC_USP7_MATH_1	416	420	PF00917	0.641
DOC_USP7_MATH_1	435	439	PF00917	0.684
DOC_USP7_MATH_1	48	52	PF00917	0.682
DOC_USP7_MATH_1	491	495	PF00917	0.693
DOC_USP7_MATH_1	512	516	PF00917	0.749
DOC_USP7_MATH_1	538	542	PF00917	0.653
DOC_USP7_MATH_1	62	66	PF00917	0.688
DOC_USP7_MATH_1	89	93	PF00917	0.676
DOC_WW_Pin1_4	113	118	PF00397	0.659
DOC_WW_Pin1_4	332	337	PF00397	0.690
DOC_WW_Pin1_4	345	350	PF00397	0.677
DOC_WW_Pin1_4	358	363	PF00397	0.741
DOC_WW_Pin1_4	398	403	PF00397	0.751
DOC_WW_Pin1_4	409	414	PF00397	0.700
DOC_WW_Pin1_4	424	429	PF00397	0.735
DOC_WW_Pin1_4	485	490	PF00397	0.755
DOC_WW_Pin1_4	510	515	PF00397	0.689
LIG_14-3-3_CanoR_1	115	125	PF00244	0.656
LIG_14-3-3_CanoR_1	139	143	PF00244	0.613
LIG_14-3-3_CanoR_1	167	173	PF00244	0.512
LIG_14-3-3_CanoR_1	220	224	PF00244	0.418
LIG_14-3-3_CanoR_1	417	426	PF00244	0.714
LIG_14-3-3_CanoR_1	441	449	PF00244	0.716
LIG_APCC_ABBA_1	26	31	PF00400	0.696
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_BIR_III_4	6	10	PF00653	0.634
LIG_BRCT_BRCA1_1	121	125	PF00533	0.641
LIG_BRCT_BRCA1_1	89	93	PF00533	0.705
LIG_deltaCOP1_diTrp_1	274	279	PF00928	0.463
LIG_FHA_1	312	318	PF00498	0.678
LIG_FHA_1	530	536	PF00498	0.649
LIG_FHA_2	106	112	PF00498	0.604
LIG_FHA_2	6	12	PF00498	0.634
LIG_Integrin_isoDGR_2	439	441	PF01839	0.461
LIG_Integrin_RGD_1	544	546	PF01839	0.416
LIG_LIR_Gen_1	122	130	PF02991	0.632
LIG_LIR_Gen_1	207	216	PF02991	0.474
LIG_LIR_Gen_1	51	62	PF02991	0.730
LIG_LIR_Nem_3	101	107	PF02991	0.701
LIG_LIR_Nem_3	122	128	PF02991	0.632
LIG_LIR_Nem_3	207	212	PF02991	0.426
LIG_LIR_Nem_3	51	57	PF02991	0.737
LIG_Pex14_2	172	176	PF04695	0.519
LIG_Pex14_2	291	295	PF04695	0.312
LIG_SH2_CRK	104	108	PF00017	0.704
LIG_SH2_CRK	238	242	PF00017	0.351
LIG_SH2_CRK	54	58	PF00017	0.745
LIG_SH2_GRB2like	130	133	PF00017	0.617
LIG_SH2_GRB2like	84	87	PF00017	0.669
LIG_SH2_NCK_1	54	58	PF00017	0.675
LIG_SH2_SRC	38	41	PF00017	0.836
LIG_SH2_STAP1	130	134	PF00017	0.618
LIG_SH2_STAT3	481	484	PF00017	0.638
LIG_SH2_STAT5	134	137	PF00017	0.665
LIG_SH2_STAT5	151	154	PF00017	0.348
LIG_SH2_STAT5	209	212	PF00017	0.474
LIG_SH2_STAT5	481	484	PF00017	0.638
LIG_SH2_STAT5	77	80	PF00017	0.629
LIG_SH3_1	281	287	PF00018	0.275
LIG_SH3_3	281	287	PF00018	0.275
LIG_SH3_3	330	336	PF00018	0.737
LIG_SH3_3	410	416	PF00018	0.682
LIG_SH3_3	425	431	PF00018	0.760
LIG_SH3_3	517	523	PF00018	0.706
LIG_SUMO_SIM_anti_2	366	374	PF11976	0.633
LIG_SUMO_SIM_par_1	15	25	PF11976	0.741
LIG_SUMO_SIM_par_1	396	401	PF11976	0.641
LIG_TRAF2_1	30	33	PF00917	0.695
LIG_TYR_ITIM	52	57	PF00017	0.758
MOD_CDK_SPK_2	487	492	PF00069	0.712
MOD_CDK_SPxxK_3	485	492	PF00069	0.713
MOD_CK1_1	116	122	PF00069	0.654
MOD_CK1_1	179	185	PF00069	0.505
MOD_CK1_1	194	200	PF00069	0.409
MOD_CK1_1	201	207	PF00069	0.470
MOD_CK1_1	222	228	PF00069	0.348
MOD_CK1_1	24	30	PF00069	0.800
MOD_CK1_1	311	317	PF00069	0.614
MOD_CK1_1	356	362	PF00069	0.688
MOD_CK1_1	373	379	PF00069	0.655
MOD_CK1_1	42	48	PF00069	0.648
MOD_CK1_1	427	433	PF00069	0.750
MOD_CK1_1	442	448	PF00069	0.660
MOD_CK1_1	483	489	PF00069	0.731
MOD_CK1_1	510	516	PF00069	0.792
MOD_CK1_1	55	61	PF00069	0.620
MOD_CK1_1	65	71	PF00069	0.768
MOD_CK1_1	82	88	PF00069	0.651
MOD_CK2_1	208	214	PF00069	0.459
MOD_CK2_1	222	228	PF00069	0.398
MOD_CK2_1	27	33	PF00069	0.695
MOD_CK2_1	352	358	PF00069	0.634
MOD_CMANNOS	276	279	PF00535	0.659
MOD_GlcNHglycan	101	104	PF01048	0.434
MOD_GlcNHglycan	111	114	PF01048	0.484
MOD_GlcNHglycan	158	161	PF01048	0.312
MOD_GlcNHglycan	178	181	PF01048	0.717
MOD_GlcNHglycan	193	196	PF01048	0.602
MOD_GlcNHglycan	206	209	PF01048	0.613
MOD_GlcNHglycan	228	232	PF01048	0.594
MOD_GlcNHglycan	253	256	PF01048	0.715
MOD_GlcNHglycan	295	298	PF01048	0.278
MOD_GlcNHglycan	355	358	PF01048	0.542
MOD_GlcNHglycan	373	376	PF01048	0.417
MOD_GlcNHglycan	377	380	PF01048	0.455
MOD_GlcNHglycan	418	421	PF01048	0.439
MOD_GlcNHglycan	493	496	PF01048	0.448
MOD_GlcNHglycan	509	512	PF01048	0.442
MOD_GlcNHglycan	67	70	PF01048	0.546
MOD_GSK3_1	109	116	PF00069	0.660
MOD_GSK3_1	120	127	PF00069	0.638
MOD_GSK3_1	152	159	PF00069	0.255
MOD_GSK3_1	194	201	PF00069	0.444
MOD_GSK3_1	204	211	PF00069	0.494
MOD_GSK3_1	263	270	PF00069	0.444
MOD_GSK3_1	275	282	PF00069	0.524
MOD_GSK3_1	352	359	PF00069	0.663
MOD_GSK3_1	369	376	PF00069	0.746
MOD_GSK3_1	38	45	PF00069	0.697
MOD_GSK3_1	435	442	PF00069	0.802
MOD_GSK3_1	48	55	PF00069	0.680
MOD_GSK3_1	483	490	PF00069	0.732
MOD_GSK3_1	5	12	PF00069	0.681
MOD_GSK3_1	510	517	PF00069	0.754
MOD_GSK3_1	60	67	PF00069	0.712
MOD_GSK3_1	71	78	PF00069	0.723
MOD_GSK3_1	99	106	PF00069	0.640
MOD_N-GLC_1	13	18	PF02516	0.491
MOD_N-GLC_1	308	313	PF02516	0.493
MOD_N-GLC_1	529	534	PF02516	0.448
MOD_N-GLC_1	539	544	PF02516	0.408
MOD_NEK2_1	121	126	PF00069	0.644
MOD_NEK2_1	138	143	PF00069	0.702
MOD_NEK2_1	152	157	PF00069	0.234
MOD_NEK2_1	168	173	PF00069	0.496
MOD_NEK2_1	176	181	PF00069	0.457
MOD_NEK2_1	227	232	PF00069	0.342
MOD_NEK2_1	275	280	PF00069	0.448
MOD_NEK2_1	52	57	PF00069	0.676
MOD_OFUCOSY	191	198	PF10250	0.644
MOD_PIKK_1	263	269	PF00454	0.407
MOD_PIKK_1	39	45	PF00454	0.749
MOD_PIKK_1	443	449	PF00454	0.715
MOD_PIKK_1	480	486	PF00454	0.639
MOD_PKA_2	138	144	PF00069	0.610
MOD_PKA_2	219	225	PF00069	0.416
MOD_PKA_2	416	422	PF00069	0.641
MOD_PKA_2	442	448	PF00069	0.770
MOD_PKA_2	491	497	PF00069	0.652
MOD_PKA_2	65	71	PF00069	0.808
MOD_PKB_1	441	449	PF00069	0.722
MOD_Plk_1	13	19	PF00069	0.690
MOD_Plk_1	21	27	PF00069	0.691
MOD_Plk_1	52	58	PF00069	0.693
MOD_Plk_1	539	545	PF00069	0.684
MOD_Plk_4	124	130	PF00069	0.707
MOD_Plk_4	222	228	PF00069	0.483
MOD_Plk_4	24	30	PF00069	0.750
MOD_Plk_4	339	345	PF00069	0.709
MOD_Plk_4	79	85	PF00069	0.673
MOD_ProDKin_1	113	119	PF00069	0.657
MOD_ProDKin_1	332	338	PF00069	0.689
MOD_ProDKin_1	345	351	PF00069	0.674
MOD_ProDKin_1	358	364	PF00069	0.740
MOD_ProDKin_1	398	404	PF00069	0.752
MOD_ProDKin_1	409	415	PF00069	0.699
MOD_ProDKin_1	424	430	PF00069	0.736
MOD_ProDKin_1	485	491	PF00069	0.754
MOD_ProDKin_1	510	516	PF00069	0.690
MOD_SUMO_rev_2	494	501	PF00179	0.672
TRG_ENDOCYTIC_2	104	107	PF00928	0.680
TRG_ENDOCYTIC_2	151	154	PF00928	0.312
TRG_ENDOCYTIC_2	209	212	PF00928	0.420
TRG_ENDOCYTIC_2	54	57	PF00928	0.741
TRG_ER_diArg_1	145	147	PF00400	0.689
TRG_ER_diArg_1	235	237	PF00400	0.459
TRG_ER_diArg_1	317	320	PF00400	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A2	Leptomonas seymouri	49%	78%
A0A3S7WZN2	Leishmania donovani	74%	79%
A4I1Y8	Leishmania infantum	74%	79%
E9AY35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	79%
Q4Q9D8	Leishmania major	74%	100%