Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEQ9_LEIBR

TriTrypDb:

LbrM.26.0550 , LBRM2903_260010300

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.559
CLV_NRD_NRD_1	265	267	PF00675	0.499
CLV_NRD_NRD_1	317	319	PF00675	0.762
CLV_NRD_NRD_1	398	400	PF00675	0.407
CLV_NRD_NRD_1	55	57	PF00675	0.533
CLV_NRD_NRD_1	609	611	PF00675	0.528
CLV_NRD_NRD_1	777	779	PF00675	0.618
CLV_NRD_NRD_1	834	836	PF00675	0.581
CLV_NRD_NRD_1	924	926	PF00675	0.489
CLV_NRD_NRD_1	964	966	PF00675	0.602
CLV_PCSK_FUR_1	315	319	PF00082	0.675
CLV_PCSK_FUR_1	53	57	PF00082	0.556
CLV_PCSK_KEX2_1	265	267	PF00082	0.499
CLV_PCSK_KEX2_1	317	319	PF00082	0.770
CLV_PCSK_KEX2_1	398	400	PF00082	0.407
CLV_PCSK_KEX2_1	55	57	PF00082	0.536
CLV_PCSK_KEX2_1	609	611	PF00082	0.528
CLV_PCSK_KEX2_1	924	926	PF00082	0.489
CLV_PCSK_KEX2_1	964	966	PF00082	0.602
CLV_PCSK_SKI1_1	166	170	PF00082	0.569
CLV_PCSK_SKI1_1	55	59	PF00082	0.473
CLV_PCSK_SKI1_1	89	93	PF00082	0.662
CLV_PCSK_SKI1_1	924	928	PF00082	0.499
CLV_Separin_Metazoa	921	925	PF03568	0.479
DEG_APCC_DBOX_1	54	62	PF00400	0.524
DEG_MDM2_SWIB_1	800	807	PF02201	0.490
DEG_Nend_UBRbox_1	1	4	PF02207	0.492
DEG_SPOP_SBC_1	184	188	PF00917	0.447
DEG_SPOP_SBC_1	514	518	PF00917	0.522
DEG_SPOP_SBC_1	909	913	PF00917	0.412
DOC_CKS1_1	495	500	PF01111	0.438
DOC_CKS1_1	783	788	PF01111	0.434
DOC_CKS1_1	891	896	PF01111	0.523
DOC_CYCLIN_RxL_1	161	171	PF00134	0.440
DOC_CYCLIN_RxL_1	288	300	PF00134	0.664
DOC_CYCLIN_yClb5_NLxxxL_5	502	511	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	60	66	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	636	642	PF00134	0.567
DOC_MAPK_DCC_7	142	151	PF00069	0.465
DOC_MAPK_DCC_7	56	66	PF00069	0.362
DOC_MAPK_gen_1	53	61	PF00069	0.488
DOC_MAPK_gen_1	964	971	PF00069	0.471
DOC_MAPK_MEF2A_6	39	48	PF00069	0.487
DOC_MAPK_MEF2A_6	432	441	PF00069	0.465
DOC_MAPK_MEF2A_6	522	531	PF00069	0.501
DOC_PP1_RVXF_1	483	489	PF00149	0.370
DOC_PP1_RVXF_1	731	738	PF00149	0.549
DOC_PP1_RVXF_1	833	840	PF00149	0.453
DOC_PP2B_LxvP_1	275	278	PF13499	0.618
DOC_PP2B_LxvP_1	462	465	PF13499	0.504
DOC_PP2B_LxvP_1	857	860	PF13499	0.676
DOC_PP4_FxxP_1	479	482	PF00568	0.531
DOC_USP7_MATH_1	195	199	PF00917	0.529
DOC_USP7_MATH_1	256	260	PF00917	0.642
DOC_USP7_MATH_1	27	31	PF00917	0.613
DOC_USP7_MATH_1	309	313	PF00917	0.522
DOC_USP7_MATH_1	433	437	PF00917	0.543
DOC_USP7_MATH_1	480	484	PF00917	0.546
DOC_USP7_MATH_1	514	518	PF00917	0.522
DOC_USP7_MATH_1	611	615	PF00917	0.623
DOC_USP7_MATH_1	648	652	PF00917	0.473
DOC_USP7_MATH_1	721	725	PF00917	0.515
DOC_USP7_MATH_1	763	767	PF00917	0.431
DOC_USP7_MATH_1	827	831	PF00917	0.552
DOC_USP7_MATH_1	897	901	PF00917	0.538
DOC_USP7_MATH_1	909	913	PF00917	0.601
DOC_WW_Pin1_4	286	291	PF00397	0.584
DOC_WW_Pin1_4	412	417	PF00397	0.663
DOC_WW_Pin1_4	456	461	PF00397	0.623
DOC_WW_Pin1_4	494	499	PF00397	0.585
DOC_WW_Pin1_4	609	614	PF00397	0.611
DOC_WW_Pin1_4	777	782	PF00397	0.543
DOC_WW_Pin1_4	822	827	PF00397	0.474
DOC_WW_Pin1_4	861	866	PF00397	0.682
DOC_WW_Pin1_4	890	895	PF00397	0.649
DOC_WW_Pin1_4	899	904	PF00397	0.540
DOC_WW_Pin1_4	90	95	PF00397	0.405
LIG_14-3-3_CanoR_1	156	165	PF00244	0.563
LIG_14-3-3_CanoR_1	321	330	PF00244	0.600
LIG_14-3-3_CanoR_1	403	410	PF00244	0.607
LIG_14-3-3_CanoR_1	432	438	PF00244	0.480
LIG_14-3-3_CanoR_1	522	528	PF00244	0.524
LIG_14-3-3_CanoR_1	565	571	PF00244	0.454
LIG_14-3-3_CanoR_1	641	650	PF00244	0.488
LIG_Actin_WH2_2	731	748	PF00022	0.440
LIG_BRCT_BRCA1_1	288	292	PF00533	0.437
LIG_BRCT_BRCA1_1	577	581	PF00533	0.580
LIG_CSL_BTD_1	837	840	PF09270	0.481
LIG_deltaCOP1_diTrp_1	284	292	PF00928	0.592
LIG_EVH1_2	278	282	PF00568	0.531
LIG_FHA_1	124	130	PF00498	0.609
LIG_FHA_1	237	243	PF00498	0.583
LIG_FHA_1	32	38	PF00498	0.509
LIG_FHA_1	322	328	PF00498	0.457
LIG_FHA_1	366	372	PF00498	0.551
LIG_FHA_1	41	47	PF00498	0.472
LIG_FHA_1	456	462	PF00498	0.602
LIG_FHA_1	502	508	PF00498	0.544
LIG_FHA_1	524	530	PF00498	0.496
LIG_FHA_1	537	543	PF00498	0.464
LIG_FHA_1	565	571	PF00498	0.450
LIG_FHA_1	692	698	PF00498	0.371
LIG_FHA_1	729	735	PF00498	0.464
LIG_FHA_1	791	797	PF00498	0.355
LIG_FHA_1	815	821	PF00498	0.367
LIG_FHA_2	217	223	PF00498	0.468
LIG_FHA_2	625	631	PF00498	0.581
LIG_FHA_2	785	791	PF00498	0.508
LIG_FHA_2	913	919	PF00498	0.576
LIG_GBD_Chelix_1	226	234	PF00786	0.460
LIG_IRF3_LxIS_1	22	29	PF10401	0.432
LIG_LIR_Apic_2	478	482	PF02991	0.543
LIG_LIR_Apic_2	822	826	PF02991	0.541
LIG_LIR_Gen_1	790	800	PF02991	0.353
LIG_LIR_Gen_1	918	928	PF02991	0.474
LIG_LIR_Nem_3	174	180	PF02991	0.551
LIG_LIR_Nem_3	209	215	PF02991	0.428
LIG_LIR_Nem_3	509	515	PF02991	0.524
LIG_LIR_Nem_3	548	552	PF02991	0.475
LIG_LIR_Nem_3	790	795	PF02991	0.451
LIG_LIR_Nem_3	801	807	PF02991	0.458
LIG_LIR_Nem_3	918	923	PF02991	0.457
LIG_NRBOX	164	170	PF00104	0.601
LIG_NRBOX	678	684	PF00104	0.556
LIG_PCNA_yPIPBox_3	156	169	PF02747	0.537
LIG_PCNA_yPIPBox_3	916	925	PF02747	0.387
LIG_PDZ_Class_2	966	971	PF00595	0.474
LIG_Pex14_2	282	286	PF04695	0.520
LIG_Pex14_2	800	804	PF04695	0.411
LIG_Rb_pABgroove_1	794	802	PF01858	0.431
LIG_SH2_CRK	512	516	PF00017	0.361
LIG_SH2_CRK	549	553	PF00017	0.478
LIG_SH2_CRK	823	827	PF00017	0.469
LIG_SH2_GRB2like	914	917	PF00017	0.406
LIG_SH2_NCK_1	512	516	PF00017	0.361
LIG_SH2_NCK_1	914	918	PF00017	0.457
LIG_SH2_STAP1	238	242	PF00017	0.501
LIG_SH2_STAT5	203	206	PF00017	0.520
LIG_SH2_STAT5	238	241	PF00017	0.493
LIG_SH2_STAT5	346	349	PF00017	0.383
LIG_SH2_STAT5	384	387	PF00017	0.472
LIG_SH2_STAT5	523	526	PF00017	0.518
LIG_SH2_STAT5	823	826	PF00017	0.461
LIG_SH2_STAT5	914	917	PF00017	0.460
LIG_SH3_3	208	214	PF00018	0.460
LIG_SH3_3	273	279	PF00018	0.503
LIG_SH3_3	45	51	PF00018	0.566
LIG_SH3_3	492	498	PF00018	0.402
LIG_SH3_3	526	532	PF00018	0.550
LIG_SH3_3	780	786	PF00018	0.486
LIG_SH3_3	885	891	PF00018	0.615
LIG_SUMO_SIM_anti_2	124	129	PF11976	0.441
LIG_SUMO_SIM_anti_2	43	48	PF11976	0.474
LIG_SUMO_SIM_anti_2	458	465	PF11976	0.435
LIG_SUMO_SIM_par_1	415	421	PF11976	0.655
LIG_TYR_ITSM	508	515	PF00017	0.529
MOD_CDK_SPxxK_3	822	829	PF00069	0.468
MOD_CK1_1	117	123	PF00069	0.574
MOD_CK1_1	171	177	PF00069	0.446
MOD_CK1_1	229	235	PF00069	0.447
MOD_CK1_1	30	36	PF00069	0.492
MOD_CK1_1	349	355	PF00069	0.570
MOD_CK1_1	40	46	PF00069	0.540
MOD_CK1_1	412	418	PF00069	0.661
MOD_CK1_1	468	474	PF00069	0.441
MOD_CK1_1	537	543	PF00069	0.604
MOD_CK1_1	612	618	PF00069	0.541
MOD_CK1_1	651	657	PF00069	0.478
MOD_CK1_1	825	831	PF00069	0.388
MOD_CK1_1	864	870	PF00069	0.617
MOD_CK1_1	912	918	PF00069	0.481
MOD_CK2_1	185	191	PF00069	0.539
MOD_CK2_1	216	222	PF00069	0.542
MOD_CK2_1	255	261	PF00069	0.474
MOD_CK2_1	26	32	PF00069	0.449
MOD_CK2_1	624	630	PF00069	0.537
MOD_CK2_1	784	790	PF00069	0.521
MOD_CK2_1	912	918	PF00069	0.591
MOD_CMANNOS	789	792	PF00535	0.540
MOD_Cter_Amidation	315	318	PF01082	0.629
MOD_GlcNHglycan	119	122	PF01048	0.557
MOD_GlcNHglycan	142	145	PF01048	0.612
MOD_GlcNHglycan	158	161	PF01048	0.500
MOD_GlcNHglycan	187	190	PF01048	0.580
MOD_GlcNHglycan	29	32	PF01048	0.469
MOD_GlcNHglycan	302	305	PF01048	0.611
MOD_GlcNHglycan	306	309	PF01048	0.662
MOD_GlcNHglycan	311	314	PF01048	0.632
MOD_GlcNHglycan	411	414	PF01048	0.627
MOD_GlcNHglycan	420	423	PF01048	0.552
MOD_GlcNHglycan	492	495	PF01048	0.543
MOD_GlcNHglycan	517	520	PF01048	0.604
MOD_GlcNHglycan	577	580	PF01048	0.592
MOD_GlcNHglycan	757	761	PF01048	0.595
MOD_GlcNHglycan	774	777	PF01048	0.498
MOD_GlcNHglycan	878	881	PF01048	0.706
MOD_GlcNHglycan	932	935	PF01048	0.567
MOD_GSK3_1	1	8	PF00069	0.525
MOD_GSK3_1	111	118	PF00069	0.541
MOD_GSK3_1	12	19	PF00069	0.550
MOD_GSK3_1	164	171	PF00069	0.427
MOD_GSK3_1	202	209	PF00069	0.408
MOD_GSK3_1	226	233	PF00069	0.512
MOD_GSK3_1	252	259	PF00069	0.468
MOD_GSK3_1	26	33	PF00069	0.562
MOD_GSK3_1	296	303	PF00069	0.616
MOD_GSK3_1	346	353	PF00069	0.584
MOD_GSK3_1	408	415	PF00069	0.670
MOD_GSK3_1	428	435	PF00069	0.705
MOD_GSK3_1	442	449	PF00069	0.454
MOD_GSK3_1	451	458	PF00069	0.725
MOD_GSK3_1	467	474	PF00069	0.555
MOD_GSK3_1	490	497	PF00069	0.496
MOD_GSK3_1	501	508	PF00069	0.509
MOD_GSK3_1	530	537	PF00069	0.574
MOD_GSK3_1	566	573	PF00069	0.564
MOD_GSK3_1	600	607	PF00069	0.620
MOD_GSK3_1	768	775	PF00069	0.545
MOD_GSK3_1	777	784	PF00069	0.678
MOD_GSK3_1	810	817	PF00069	0.389
MOD_GSK3_1	886	893	PF00069	0.567
MOD_GSK3_1	908	915	PF00069	0.502
MOD_N-GLC_1	321	326	PF02516	0.493
MOD_N-GLC_1	505	510	PF02516	0.567
MOD_N-GLC_1	768	773	PF02516	0.516
MOD_N-GLC_2	252	254	PF02516	0.469
MOD_NEK2_1	1	6	PF00069	0.488
MOD_NEK2_1	102	107	PF00069	0.520
MOD_NEK2_1	129	134	PF00069	0.560
MOD_NEK2_1	168	173	PF00069	0.476
MOD_NEK2_1	183	188	PF00069	0.440
MOD_NEK2_1	216	221	PF00069	0.481
MOD_NEK2_1	246	251	PF00069	0.559
MOD_NEK2_1	26	31	PF00069	0.461
MOD_NEK2_1	296	301	PF00069	0.453
MOD_NEK2_1	328	333	PF00069	0.399
MOD_NEK2_1	338	343	PF00069	0.346
MOD_NEK2_1	373	378	PF00069	0.498
MOD_NEK2_1	440	445	PF00069	0.459
MOD_NEK2_1	466	471	PF00069	0.514
MOD_NEK2_1	507	512	PF00069	0.641
MOD_NEK2_1	570	575	PF00069	0.682
MOD_NEK2_1	624	629	PF00069	0.452
MOD_NEK2_1	675	680	PF00069	0.452
MOD_NEK2_1	768	773	PF00069	0.346
MOD_NEK2_1	929	934	PF00069	0.609
MOD_NEK2_2	76	81	PF00069	0.573
MOD_OFUCOSY	14	21	PF10250	0.434
MOD_PIKK_1	260	266	PF00454	0.559
MOD_PIKK_1	340	346	PF00454	0.473
MOD_PIKK_1	402	408	PF00454	0.485
MOD_PK_1	323	329	PF00069	0.597
MOD_PK_1	530	536	PF00069	0.546
MOD_PKA_2	129	135	PF00069	0.562
MOD_PKA_2	171	177	PF00069	0.623
MOD_PKA_2	322	328	PF00069	0.626
MOD_PKA_2	402	408	PF00069	0.551
MOD_PKA_2	564	570	PF00069	0.459
MOD_PKA_2	642	648	PF00069	0.493
MOD_PKB_1	321	329	PF00069	0.618
MOD_Plk_1	121	127	PF00069	0.453
MOD_Plk_1	230	236	PF00069	0.442
MOD_Plk_1	373	379	PF00069	0.355
MOD_Plk_1	651	657	PF00069	0.478
MOD_Plk_1	756	762	PF00069	0.526
MOD_Plk_1	768	774	PF00069	0.398
MOD_Plk_4	102	108	PF00069	0.524
MOD_Plk_4	123	129	PF00069	0.564
MOD_Plk_4	206	212	PF00069	0.435
MOD_Plk_4	232	238	PF00069	0.621
MOD_Plk_4	323	329	PF00069	0.597
MOD_Plk_4	497	503	PF00069	0.620
MOD_Plk_4	507	513	PF00069	0.437
MOD_Plk_4	530	536	PF00069	0.632
MOD_Plk_4	537	543	PF00069	0.576
MOD_Plk_4	663	669	PF00069	0.452
MOD_ProDKin_1	286	292	PF00069	0.578
MOD_ProDKin_1	412	418	PF00069	0.661
MOD_ProDKin_1	456	462	PF00069	0.621
MOD_ProDKin_1	494	500	PF00069	0.587
MOD_ProDKin_1	609	615	PF00069	0.609
MOD_ProDKin_1	777	783	PF00069	0.541
MOD_ProDKin_1	822	828	PF00069	0.468
MOD_ProDKin_1	861	867	PF00069	0.682
MOD_ProDKin_1	890	896	PF00069	0.649
MOD_ProDKin_1	899	905	PF00069	0.536
MOD_ProDKin_1	90	96	PF00069	0.398
MOD_SUMO_rev_2	842	852	PF00179	0.557
TRG_DiLeu_BaEn_1	206	211	PF01217	0.476
TRG_DiLeu_BaEn_1	620	625	PF01217	0.476
TRG_DiLeu_BaEn_1	790	795	PF01217	0.472
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.548
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.412
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.610
TRG_DiLeu_BaLyEn_6	934	939	PF01217	0.389
TRG_ENDOCYTIC_2	512	515	PF00928	0.454
TRG_ENDOCYTIC_2	549	552	PF00928	0.475
TRG_ENDOCYTIC_2	920	923	PF00928	0.461
TRG_ER_diArg_1	169	172	PF00400	0.527
TRG_ER_diArg_1	178	181	PF00400	0.531
TRG_ER_diArg_1	265	268	PF00400	0.500
TRG_ER_diArg_1	315	318	PF00400	0.812
TRG_ER_diArg_1	398	400	PF00400	0.369
TRG_ER_diArg_1	485	488	PF00400	0.448
TRG_ER_diArg_1	53	56	PF00400	0.570
TRG_ER_diArg_1	608	610	PF00400	0.526
TRG_ER_diArg_1	640	643	PF00400	0.496
TRG_ER_diArg_1	923	925	PF00400	0.485
TRG_ER_diArg_1	964	966	PF00400	0.602
TRG_NES_CRM1_1	918	930	PF08389	0.556
TRG_NLS_Bipartite_1	55	74	PF00514	0.549
TRG_NLS_MonoExtN_4	67	74	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	937	941	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAP0	Leptomonas seymouri	35%	82%
A0A3S7WZP9	Leishmania donovani	70%	84%
A4I1Y6	Leishmania infantum	70%	84%
E9AY33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	84%
Q4Q9E0	Leishmania major	70%	100%