Ribonuclease inhibitor-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEQ6_LEIBR

TriTrypDb:

LbrM.26.0520 , LBRM2903_260010100

Length:

417

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A4HEQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.398
CLV_C14_Caspase3-7	333	337	PF00656	0.468
CLV_C14_Caspase3-7	95	99	PF00656	0.258
CLV_NRD_NRD_1	22	24	PF00675	0.342
CLV_PCSK_KEX2_1	198	200	PF00082	0.496
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.333
CLV_PCSK_SKI1_1	195	199	PF00082	0.383
CLV_PCSK_SKI1_1	238	242	PF00082	0.199
CLV_PCSK_SKI1_1	281	285	PF00082	0.504
DEG_APCC_DBOX_1	280	288	PF00400	0.525
DEG_Nend_UBRbox_3	1	3	PF02207	0.479
DOC_ANK_TNKS_1	120	127	PF00023	0.452
DOC_CYCLIN_RxL_1	250	263	PF00134	0.199
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.294
DOC_MAPK_gen_1	192	202	PF00069	0.405
DOC_MAPK_MEF2A_6	304	312	PF00069	0.260
DOC_MIT_MIM_1	226	235	PF04212	0.366
DOC_PP1_RVXF_1	28	35	PF00149	0.290
DOC_USP7_MATH_1	412	416	PF00917	0.596
DOC_WW_Pin1_4	51	56	PF00397	0.447
LIG_14-3-3_CanoR_1	104	109	PF00244	0.423
LIG_14-3-3_CanoR_1	163	172	PF00244	0.518
LIG_14-3-3_CanoR_1	199	203	PF00244	0.511
LIG_14-3-3_CanoR_1	23	29	PF00244	0.440
LIG_14-3-3_CanoR_1	231	236	PF00244	0.290
LIG_14-3-3_CanoR_1	255	260	PF00244	0.199
LIG_14-3-3_CanoR_1	304	309	PF00244	0.404
LIG_14-3-3_CanoR_1	46	55	PF00244	0.267
LIG_14-3-3_CanoR_1	93	103	PF00244	0.494
LIG_Actin_WH2_2	298	315	PF00022	0.425
LIG_Actin_WH2_2	32	48	PF00022	0.271
LIG_DLG_GKlike_1	104	112	PF00625	0.512
LIG_DLG_GKlike_1	304	312	PF00625	0.314
LIG_FHA_1	235	241	PF00498	0.352
LIG_FHA_1	271	277	PF00498	0.482
LIG_FHA_1	40	46	PF00498	0.357
LIG_FHA_1	55	61	PF00498	0.329
LIG_FHA_2	191	197	PF00498	0.480
LIG_PCNA_yPIPBox_3	364	372	PF02747	0.447
LIG_PCNA_yPIPBox_3	380	390	PF02747	0.264
LIG_PDZ_Class_1	412	417	PF00595	0.574
LIG_PTB_Apo_2	217	224	PF02174	0.245
LIG_PTB_Phospho_1	217	223	PF10480	0.244
LIG_SH2_NCK_1	63	67	PF00017	0.389
LIG_SH2_STAT3	407	410	PF00017	0.574
LIG_SH2_STAT5	139	142	PF00017	0.319
LIG_SH2_STAT5	157	160	PF00017	0.352
LIG_SH2_STAT5	178	181	PF00017	0.461
LIG_SH2_STAT5	223	226	PF00017	0.331
LIG_SUMO_SIM_anti_2	339	344	PF11976	0.362
LIG_SUMO_SIM_par_1	255	260	PF11976	0.385
LIG_SUMO_SIM_par_1	341	346	PF11976	0.329
LIG_TYR_ITIM	61	66	PF00017	0.382
LIG_UBA3_1	305	313	PF00899	0.260
MOD_CDK_SPxxK_3	51	58	PF00069	0.258
MOD_CK1_1	107	113	PF00069	0.362
MOD_CK1_1	401	407	PF00069	0.363
MOD_CK1_1	54	60	PF00069	0.469
MOD_CK2_1	143	149	PF00069	0.315
MOD_CK2_1	150	156	PF00069	0.320
MOD_CK2_1	190	196	PF00069	0.486
MOD_CK2_1	257	263	PF00069	0.452
MOD_CK2_1	308	314	PF00069	0.339
MOD_CK2_1	343	349	PF00069	0.204
MOD_CK2_1	46	52	PF00069	0.435
MOD_GlcNHglycan	152	155	PF01048	0.390
MOD_GlcNHglycan	166	169	PF01048	0.446
MOD_GlcNHglycan	212	215	PF01048	0.377
MOD_GlcNHglycan	259	262	PF01048	0.346
MOD_GlcNHglycan	281	284	PF01048	0.366
MOD_GlcNHglycan	296	299	PF01048	0.441
MOD_GlcNHglycan	414	417	PF01048	0.660
MOD_GlcNHglycan	94	97	PF01048	0.482
MOD_GSK3_1	102	109	PF00069	0.374
MOD_GSK3_1	135	142	PF00069	0.327
MOD_GSK3_1	275	282	PF00069	0.452
MOD_GSK3_1	288	295	PF00069	0.281
MOD_GSK3_1	304	311	PF00069	0.337
MOD_GSK3_1	330	337	PF00069	0.356
MOD_GSK3_1	46	53	PF00069	0.439
MOD_N-GLC_1	250	255	PF02516	0.390
MOD_N-GLC_1	315	320	PF02516	0.305
MOD_N-GLC_1	376	381	PF02516	0.484
MOD_N-GLC_1	78	83	PF02516	0.395
MOD_NEK2_1	102	107	PF00069	0.371
MOD_NEK2_1	108	113	PF00069	0.320
MOD_NEK2_1	143	148	PF00069	0.304
MOD_NEK2_1	150	155	PF00069	0.302
MOD_NEK2_1	179	184	PF00069	0.280
MOD_NEK2_1	257	262	PF00069	0.372
MOD_NEK2_1	287	292	PF00069	0.328
MOD_NEK2_1	294	299	PF00069	0.323
MOD_NEK2_1	306	311	PF00069	0.260
MOD_NEK2_1	330	335	PF00069	0.244
MOD_NEK2_1	80	85	PF00069	0.492
MOD_PIKK_1	353	359	PF00454	0.343
MOD_PKA_1	198	204	PF00069	0.511
MOD_PKA_2	198	204	PF00069	0.511
MOD_PKA_2	22	28	PF00069	0.488
MOD_PKA_2	392	398	PF00069	0.343
MOD_PKA_2	401	407	PF00069	0.360
MOD_PKA_2	92	98	PF00069	0.261
MOD_Plk_1	143	149	PF00069	0.294
MOD_Plk_1	250	256	PF00069	0.390
MOD_Plk_1	270	276	PF00069	0.482
MOD_Plk_1	376	382	PF00069	0.424
MOD_Plk_4	135	141	PF00069	0.349
MOD_Plk_4	182	188	PF00069	0.399
MOD_ProDKin_1	51	57	PF00069	0.447
TRG_DiLeu_BaEn_1	125	130	PF01217	0.219
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.239
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.479
TRG_ENDOCYTIC_2	63	66	PF00928	0.391
TRG_NES_CRM1_1	301	314	PF08389	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N0	Leptomonas seymouri	29%	100%
A0A0N0P7L1	Leptomonas seymouri	24%	80%
A0A0N1HUH0	Leptomonas seymouri	74%	89%
A0A0N1PD72	Leptomonas seymouri	26%	93%
A0A0S4IK39	Bodo saltans	24%	66%
A0A0S4JGH2	Bodo saltans	27%	100%
A0A0S4JHR1	Bodo saltans	25%	67%
A0A0S4JL85	Bodo saltans	23%	98%
A0A0S4JPV3	Bodo saltans	39%	86%
A0A0S4JXN4	Bodo saltans	28%	97%
A0A1X0NTY3	Trypanosomatidae	55%	93%
A0A1X0P2M5	Trypanosomatidae	29%	100%
A0A1X0P364	Trypanosomatidae	25%	97%
A0A3Q8IDE6	Leishmania donovani	25%	100%
A0A3R7L7Y9	Trypanosoma rangeli	54%	94%
A0A3R7P015	Trypanosoma rangeli	25%	88%
A0A3S5H5G2	Leishmania donovani	26%	95%
A0A3S7WXH1	Leishmania donovani	26%	100%
A0A3S7WZL6	Leishmania donovani	79%	97%
A0JPI9	Rattus norvegicus	29%	87%
A4H461	Leishmania braziliensis	29%	100%
A4HCM9	Leishmania braziliensis	27%	100%
A4HFQ6	Leishmania braziliensis	25%	100%
A4HHW0	Leishmania braziliensis	27%	100%
A4HSD0	Leishmania infantum	26%	95%
A4I053	Leishmania infantum	26%	100%
A4I1Y5	Leishmania infantum	79%	97%
A4I2T1	Leishmania infantum	25%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	93%
D0A5Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ADA9	Leishmania major	24%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	94%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	88%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O13066	Xenopus laevis	26%	72%
P10775	Sus scrofa	29%	91%
P13489	Homo sapiens	26%	90%
P29315	Rattus norvegicus	27%	91%
P46060	Homo sapiens	27%	71%
P46061	Mus musculus	27%	71%
Q0VAA2	Homo sapiens	29%	85%
Q14BP6	Mus musculus	31%	100%
Q4Q9E1	Leishmania major	79%	100%
Q4QBG0	Leishmania major	26%	100%
Q4QJI8	Leishmania major	25%	100%
Q6ZQY2	Homo sapiens	28%	100%
Q8HZP9	Pan troglodytes	26%	90%
Q8IZ02	Homo sapiens	28%	90%
Q91VI7	Mus musculus	27%	91%
Q9LE82	Arabidopsis thaliana	27%	78%
Q9M651	Arabidopsis thaliana	26%	77%
Q9VIW3	Drosophila melanogaster	24%	70%
V5BJF0	Trypanosoma cruzi	25%	84%
V5BN36	Trypanosoma cruzi	28%	100%
V5BPZ7	Trypanosoma cruzi	56%	93%
V5DHF2	Trypanosoma cruzi	28%	100%