DNA polymerase sigma-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase sigma-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEQ5_LEIBR

TriTrypDb:

LbrM.26.0510 , LBRM2903_260010000

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0031499	TRAMP complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HEQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0031123	RNA 3'-end processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043631	RNA polyadenylation	6	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071076	RNA 3' uridylation	8	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	12
GO:0005488	binding	1	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0050265	RNA uridylyltransferase activity	4	12
GO:0070566	adenylyltransferase activity	5	12
GO:0070569	uridylyltransferase activity	5	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.704
CLV_MEL_PAP_1	374	380	PF00089	0.551
CLV_NRD_NRD_1	276	278	PF00675	0.521
CLV_NRD_NRD_1	300	302	PF00675	0.526
CLV_NRD_NRD_1	494	496	PF00675	0.504
CLV_NRD_NRD_1	95	97	PF00675	0.717
CLV_PCSK_FUR_1	274	278	PF00082	0.394
CLV_PCSK_FUR_1	298	302	PF00082	0.509
CLV_PCSK_FUR_1	92	96	PF00082	0.783
CLV_PCSK_KEX2_1	276	278	PF00082	0.427
CLV_PCSK_KEX2_1	300	302	PF00082	0.526
CLV_PCSK_KEX2_1	494	496	PF00082	0.508
CLV_PCSK_KEX2_1	92	94	PF00082	0.725
CLV_PCSK_KEX2_1	95	97	PF00082	0.686
CLV_PCSK_PC7_1	490	496	PF00082	0.543
CLV_PCSK_SKI1_1	149	153	PF00082	0.605
CLV_PCSK_SKI1_1	16	20	PF00082	0.791
CLV_PCSK_SKI1_1	414	418	PF00082	0.383
CLV_PCSK_SKI1_1	438	442	PF00082	0.494
CLV_PCSK_SKI1_1	481	485	PF00082	0.350
DEG_SPOP_SBC_1	46	50	PF00917	0.555
DOC_CYCLIN_RxL_1	146	156	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	151	154	PF00134	0.612
DOC_MAPK_gen_1	258	268	PF00069	0.431
DOC_MAPK_gen_1	298	306	PF00069	0.444
DOC_MAPK_gen_1	375	382	PF00069	0.505
DOC_MAPK_MEF2A_6	261	268	PF00069	0.308
DOC_MAPK_MEF2A_6	300	308	PF00069	0.433
DOC_PP2B_LxvP_1	151	154	PF13499	0.612
DOC_PP2B_LxvP_1	213	216	PF13499	0.389
DOC_PP4_FxxP_1	325	328	PF00568	0.352
DOC_PP4_FxxP_1	416	419	PF00568	0.449
DOC_SPAK_OSR1_1	377	381	PF12202	0.307
DOC_USP7_MATH_1	128	132	PF00917	0.686
DOC_USP7_MATH_1	243	247	PF00917	0.515
DOC_USP7_MATH_1	8	12	PF00917	0.736
DOC_USP7_UBL2_3	414	418	PF12436	0.437
DOC_WW_Pin1_4	120	125	PF00397	0.749
DOC_WW_Pin1_4	16	21	PF00397	0.665
DOC_WW_Pin1_4	173	178	PF00397	0.438
DOC_WW_Pin1_4	42	47	PF00397	0.731
DOC_WW_Pin1_4	78	83	PF00397	0.708
LIG_14-3-3_CanoR_1	116	126	PF00244	0.786
LIG_14-3-3_CanoR_1	142	151	PF00244	0.666
LIG_14-3-3_CanoR_1	23	33	PF00244	0.722
LIG_14-3-3_CanoR_1	261	267	PF00244	0.481
LIG_14-3-3_CanoR_1	274	284	PF00244	0.431
LIG_14-3-3_CanoR_1	375	381	PF00244	0.511
LIG_14-3-3_CanoR_1	77	82	PF00244	0.695
LIG_BH_BH3_1	260	276	PF00452	0.300
LIG_BRCT_BRCA1_1	130	134	PF00533	0.655
LIG_BRCT_BRCA1_1	144	148	PF00533	0.540
LIG_BRCT_BRCA1_1	277	281	PF00533	0.444
LIG_BRCT_BRCA1_1	454	458	PF00533	0.508
LIG_EH_1	131	135	PF12763	0.456
LIG_EH1_1	359	367	PF00400	0.357
LIG_FHA_1	120	126	PF00498	0.760
LIG_FHA_1	157	163	PF00498	0.547
LIG_FHA_1	389	395	PF00498	0.320
LIG_FHA_1	443	449	PF00498	0.427
LIG_FHA_2	176	182	PF00498	0.482
LIG_FHA_2	268	274	PF00498	0.360
LIG_FHA_2	397	403	PF00498	0.378
LIG_FHA_2	467	473	PF00498	0.340
LIG_LIR_Apic_2	415	419	PF02991	0.475
LIG_LIR_Gen_1	131	141	PF02991	0.640
LIG_LIR_Gen_1	278	287	PF02991	0.439
LIG_LIR_Nem_3	131	137	PF02991	0.446
LIG_LIR_Nem_3	145	151	PF02991	0.360
LIG_LIR_Nem_3	204	209	PF02991	0.349
LIG_LIR_Nem_3	278	284	PF02991	0.400
LIG_LIR_Nem_3	391	396	PF02991	0.421
LIG_LIR_Nem_3	400	406	PF02991	0.438
LIG_LIR_Nem_3	455	461	PF02991	0.417
LIG_LIR_Nem_3	487	492	PF02991	0.388
LIG_NRBOX	167	173	PF00104	0.474
LIG_SH2_CRK	206	210	PF00017	0.461
LIG_SH2_STAT3	410	413	PF00017	0.441
LIG_SH2_STAT5	173	176	PF00017	0.504
LIG_SH2_STAT5	210	213	PF00017	0.358
LIG_SH2_STAT5	320	323	PF00017	0.462
LIG_SH2_STAT5	369	372	PF00017	0.477
LIG_SH2_STAT5	410	413	PF00017	0.407
LIG_SH2_STAT5	425	428	PF00017	0.307
LIG_SH2_STAT5	478	481	PF00017	0.538
LIG_SH2_STAT5	514	517	PF00017	0.427
LIG_SH3_3	426	432	PF00018	0.421
LIG_SUMO_SIM_anti_2	363	368	PF11976	0.368
LIG_SUMO_SIM_par_1	125	131	PF11976	0.510
LIG_SUMO_SIM_par_1	159	165	PF11976	0.285
LIG_TRAF2_1	178	181	PF00917	0.466
LIG_TRAF2_1	70	73	PF00917	0.568
LIG_TRFH_1	173	177	PF08558	0.497
LIG_UBA3_1	161	167	PF00899	0.263
LIG_UBA3_1	336	341	PF00899	0.358
MOD_CDK_SPxxK_3	16	23	PF00069	0.568
MOD_CK1_1	156	162	PF00069	0.548
MOD_CK1_1	176	182	PF00069	0.460
MOD_CK1_1	208	214	PF00069	0.359
MOD_CK1_1	246	252	PF00069	0.523
MOD_CK1_1	37	43	PF00069	0.673
MOD_CK1_1	376	382	PF00069	0.545
MOD_CK1_1	45	51	PF00069	0.621
MOD_CK1_1	75	81	PF00069	0.808
MOD_CK2_1	175	181	PF00069	0.366
MOD_CK2_1	224	230	PF00069	0.523
MOD_CK2_1	466	472	PF00069	0.403
MOD_CK2_1	485	491	PF00069	0.316
MOD_CK2_1	67	73	PF00069	0.707
MOD_Cter_Amidation	90	93	PF01082	0.701
MOD_DYRK1A_RPxSP_1	16	20	PF00069	0.567
MOD_GlcNHglycan	10	13	PF01048	0.740
MOD_GlcNHglycan	16	19	PF01048	0.765
MOD_GlcNHglycan	198	201	PF01048	0.405
MOD_GlcNHglycan	226	229	PF01048	0.536
MOD_GlcNHglycan	233	236	PF01048	0.468
MOD_GlcNHglycan	248	251	PF01048	0.595
MOD_GlcNHglycan	36	39	PF01048	0.489
MOD_GlcNHglycan	454	457	PF01048	0.521
MOD_GSK3_1	152	159	PF00069	0.496
MOD_GSK3_1	192	199	PF00069	0.454
MOD_GSK3_1	211	218	PF00069	0.204
MOD_GSK3_1	242	249	PF00069	0.388
MOD_GSK3_1	275	282	PF00069	0.465
MOD_GSK3_1	34	41	PF00069	0.665
MOD_GSK3_1	356	363	PF00069	0.363
MOD_GSK3_1	42	49	PF00069	0.609
MOD_GSK3_1	438	445	PF00069	0.406
MOD_GSK3_1	466	473	PF00069	0.423
MOD_GSK3_1	73	80	PF00069	0.764
MOD_GSK3_1	8	15	PF00069	0.740
MOD_GSK3_1	81	88	PF00069	0.714
MOD_LATS_1	117	123	PF00433	0.536
MOD_N-GLC_1	38	43	PF02516	0.567
MOD_N-GLC_1	484	489	PF02516	0.311
MOD_N-GLC_2	345	347	PF02516	0.486
MOD_NEK2_1	224	229	PF00069	0.422
MOD_NEK2_1	275	280	PF00069	0.445
MOD_NEK2_1	382	387	PF00069	0.451
MOD_NEK2_1	442	447	PF00069	0.383
MOD_NEK2_1	484	489	PF00069	0.318
MOD_PIKK_1	253	259	PF00454	0.433
MOD_PIKK_1	275	281	PF00454	0.532
MOD_PIKK_1	59	65	PF00454	0.649
MOD_PIKK_1	81	87	PF00454	0.804
MOD_PKA_1	95	101	PF00069	0.781
MOD_PKA_2	12	18	PF00069	0.793
MOD_PKA_2	141	147	PF00069	0.683
MOD_PKA_2	181	187	PF00069	0.538
MOD_PKA_2	192	198	PF00069	0.505
MOD_PKA_2	260	266	PF00069	0.424
MOD_PKA_2	275	281	PF00069	0.428
MOD_PKA_2	376	382	PF00069	0.491
MOD_PKA_2	54	60	PF00069	0.794
MOD_PKA_2	95	101	PF00069	0.781
MOD_PKB_1	93	101	PF00069	0.662
MOD_Plk_1	107	113	PF00069	0.532
MOD_Plk_1	306	312	PF00069	0.386
MOD_Plk_1	484	490	PF00069	0.525
MOD_Plk_2-3	108	114	PF00069	0.697
MOD_Plk_4	147	153	PF00069	0.584
MOD_Plk_4	205	211	PF00069	0.424
MOD_Plk_4	438	444	PF00069	0.386
MOD_Plk_4	470	476	PF00069	0.418
MOD_ProDKin_1	120	126	PF00069	0.749
MOD_ProDKin_1	16	22	PF00069	0.664
MOD_ProDKin_1	173	179	PF00069	0.449
MOD_ProDKin_1	42	48	PF00069	0.733
MOD_ProDKin_1	78	84	PF00069	0.709
MOD_SUMO_rev_2	302	306	PF00179	0.550
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.427
TRG_ENDOCYTIC_2	206	209	PF00928	0.459
TRG_ENDOCYTIC_2	210	213	PF00928	0.435
TRG_ER_diArg_1	274	277	PF00400	0.363
TRG_ER_diArg_1	298	301	PF00400	0.512
TRG_ER_diArg_1	374	377	PF00400	0.552
TRG_ER_diArg_1	92	95	PF00400	0.750
TRG_NES_CRM1_1	204	219	PF08389	0.488
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	404	409	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD64	Leptomonas seymouri	56%	92%
A0A0S4IQ72	Bodo saltans	31%	94%
A0A1X0NU61	Trypanosomatidae	38%	100%
A0A3Q8IDQ5	Leishmania donovani	70%	87%
A0A3S5IS02	Trypanosoma rangeli	38%	100%
A4I1Y4	Leishmania infantum	70%	87%
C9ZS34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AY31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q9E2	Leishmania major	71%	100%
V5B9F7	Trypanosoma cruzi	39%	100%