GPN-loop GTPase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GPN-loop GTPase 2

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEQ4_LEIBR

TriTrypDb:

LbrM.26.0500 , LBRM2903_260009900

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEQ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003924	GTPase activity	7	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.247
CLV_NRD_NRD_1	240	242	PF00675	0.247
CLV_NRD_NRD_1	246	248	PF00675	0.208
CLV_PCSK_KEX2_1	100	102	PF00082	0.237
CLV_PCSK_KEX2_1	157	159	PF00082	0.257
CLV_PCSK_KEX2_1	21	23	PF00082	0.214
CLV_PCSK_KEX2_1	240	242	PF00082	0.238
CLV_PCSK_KEX2_1	245	247	PF00082	0.213
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.257
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.225
CLV_PCSK_PC7_1	153	159	PF00082	0.255
CLV_PCSK_PC7_1	241	247	PF00082	0.255
CLV_PCSK_SKI1_1	22	26	PF00082	0.225
DEG_Nend_Nbox_1	1	3	PF02207	0.306
DOC_CKS1_1	265	270	PF01111	0.468
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.510
DOC_MAPK_FxFP_2	47	50	PF00069	0.414
DOC_MAPK_gen_1	21	27	PF00069	0.425
DOC_MAPK_gen_1	291	299	PF00069	0.446
DOC_MAPK_MEF2A_6	32	39	PF00069	0.396
DOC_PP2B_LxvP_1	126	129	PF13499	0.516
DOC_PP4_FxxP_1	47	50	PF00568	0.414
DOC_WW_Pin1_4	264	269	PF00397	0.489
LIG_14-3-3_CanoR_1	158	164	PF00244	0.463
LIG_14-3-3_CanoR_1	22	28	PF00244	0.425
LIG_Actin_WH2_2	306	323	PF00022	0.478
LIG_eIF4E_1	290	296	PF01652	0.491
LIG_FHA_1	150	156	PF00498	0.453
LIG_FHA_1	163	169	PF00498	0.415
LIG_FHA_1	173	179	PF00498	0.452
LIG_FHA_1	188	194	PF00498	0.392
LIG_FHA_1	29	35	PF00498	0.433
LIG_FHA_1	291	297	PF00498	0.436
LIG_FHA_1	321	327	PF00498	0.360
LIG_FHA_2	14	20	PF00498	0.414
LIG_FHA_2	189	195	PF00498	0.425
LIG_FHA_2	215	221	PF00498	0.548
LIG_FHA_2	265	271	PF00498	0.467
LIG_FHA_2	61	67	PF00498	0.545
LIG_FHA_2	90	96	PF00498	0.477
LIG_GBD_Chelix_1	155	163	PF00786	0.316
LIG_HP1_1	33	37	PF01393	0.439
LIG_KLC1_Yacidic_2	140	144	PF13176	0.516
LIG_LIR_Apic_2	44	50	PF02991	0.414
LIG_LIR_Gen_1	204	214	PF02991	0.414
LIG_LIR_Nem_3	204	209	PF02991	0.414
LIG_LIR_Nem_3	301	306	PF02991	0.419
LIG_LYPXL_SIV_4	223	231	PF13949	0.356
LIG_MYND_1	264	268	PF01753	0.481
LIG_SH2_CRK	292	296	PF00017	0.406
LIG_SH2_CRK	303	307	PF00017	0.330
LIG_SH2_GRB2like	224	227	PF00017	0.425
LIG_SH2_PTP2	308	311	PF00017	0.382
LIG_SH2_SRC	142	145	PF00017	0.465
LIG_SH2_SRC	224	227	PF00017	0.500
LIG_SH2_STAP1	292	296	PF00017	0.386
LIG_SH2_STAT5	130	133	PF00017	0.414
LIG_SH2_STAT5	142	145	PF00017	0.414
LIG_SH2_STAT5	17	20	PF00017	0.421
LIG_SH2_STAT5	181	184	PF00017	0.432
LIG_SH2_STAT5	224	227	PF00017	0.480
LIG_SH2_STAT5	292	295	PF00017	0.517
LIG_SH2_STAT5	308	311	PF00017	0.464
LIG_SH2_STAT5	76	79	PF00017	0.414
LIG_SH3_3	24	30	PF00018	0.427
LIG_SUMO_SIM_par_1	183	191	PF11976	0.416
LIG_TRAF2_1	267	270	PF00917	0.516
LIG_TYR_ITIM	306	311	PF00017	0.397
MOD_CDK_SPxxK_3	264	271	PF00069	0.394
MOD_CK1_1	12	18	PF00069	0.266
MOD_CK1_1	162	168	PF00069	0.313
MOD_CK1_1	188	194	PF00069	0.279
MOD_CK2_1	13	19	PF00069	0.251
MOD_CK2_1	264	270	PF00069	0.325
MOD_CK2_1	60	66	PF00069	0.378
MOD_CK2_1	89	95	PF00069	0.325
MOD_Cter_Amidation	19	22	PF01082	0.266
MOD_GlcNHglycan	11	14	PF01048	0.306
MOD_GlcNHglycan	120	123	PF01048	0.294
MOD_GlcNHglycan	227	230	PF01048	0.358
MOD_GSK3_1	118	125	PF00069	0.292
MOD_GSK3_1	177	184	PF00069	0.303
MOD_GSK3_1	201	208	PF00069	0.295
MOD_GSK3_1	225	232	PF00069	0.405
MOD_GSK3_1	9	16	PF00069	0.303
MOD_N-GLC_1	225	230	PF02516	0.371
MOD_N-GLC_1	72	77	PF02516	0.266
MOD_NEK2_1	159	164	PF00069	0.276
MOD_NEK2_1	187	192	PF00069	0.228
MOD_NEK2_1	225	230	PF00069	0.303
MOD_NEK2_2	122	127	PF00069	0.361
MOD_PIKK_1	320	326	PF00454	0.384
MOD_PKA_2	290	296	PF00069	0.441
MOD_PKA_2	320	326	PF00069	0.361
MOD_Plk_1	225	231	PF00069	0.389
MOD_Plk_2-3	269	275	PF00069	0.349
MOD_Plk_2-3	60	66	PF00069	0.170
MOD_Plk_4	177	183	PF00069	0.272
MOD_Plk_4	188	194	PF00069	0.254
MOD_Plk_4	23	29	PF00069	0.270
MOD_Plk_4	60	66	PF00069	0.341
MOD_Plk_4	72	78	PF00069	0.191
MOD_ProDKin_1	264	270	PF00069	0.355
TRG_DiLeu_BaEn_1	301	306	PF01217	0.457
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.498
TRG_ENDOCYTIC_2	130	133	PF00928	0.251
TRG_ENDOCYTIC_2	224	227	PF00928	0.452
TRG_ENDOCYTIC_2	292	295	PF00928	0.438
TRG_ENDOCYTIC_2	303	306	PF00928	0.354
TRG_ENDOCYTIC_2	308	311	PF00928	0.236
TRG_ER_diArg_1	100	102	PF00400	0.283
TRG_ER_diArg_1	239	241	PF00400	0.288
TRG_ER_diArg_1	245	247	PF00400	0.244
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.183
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L3	Leptomonas seymouri	81%	98%
A0A0S4JJ66	Bodo saltans	38%	100%
A0A1X0NSR0	Trypanosomatidae	60%	100%
A0A3S5H7F7	Leishmania donovani	90%	100%
A0A3S7WSM7	Leishmania donovani	25%	100%
A0A3S7WZ40	Leishmania donovani	28%	100%
A0A422NVI7	Trypanosoma rangeli	63%	100%
A0A422P226	Trypanosoma rangeli	27%	100%
A4HVQ6	Leishmania infantum	25%	100%
A4I1I3	Leishmania infantum	28%	100%
A4I1Y3	Leishmania infantum	90%	100%
A6H7F2	Bos taurus	32%	100%
C9ZJY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZS35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
D4A7C0	Rattus norvegicus	33%	100%
E9AXL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AY30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O14443	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P0CN94	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CN95	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P47122	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	87%
Q06543	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q08726	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	96%
Q0P5E2	Bos taurus	27%	100%
Q4IQT8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	100%
Q4PF70	Ustilago maydis (strain 521 / FGSC 9021)	25%	100%
Q4Q9E3	Leishmania major	88%	98%
Q4Q9V4	Leishmania major	28%	100%
Q4R579	Macaca fascicularis	32%	100%
Q4WT40	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	100%
Q54NK8	Dictyostelium discoideum	28%	100%
Q54TE7	Dictyostelium discoideum	28%	100%
Q56XY2	Arabidopsis thaliana	33%	100%
Q58DD9	Sus scrofa	33%	100%
Q5BJ53	Xenopus tropicalis	31%	100%
Q66KF6	Xenopus laevis	32%	100%
Q6CQA6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	100%
Q6FSS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	31%	100%
Q6PUR6	Danio rerio	34%	100%
Q750Q9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
Q8VEJ1	Mus musculus	33%	100%
Q9H9Y4	Homo sapiens	32%	100%
Q9UTL7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
V5DR44	Trypanosoma cruzi	60%	100%