Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEQ3_LEIBR

TriTrypDb:

LbrM.26.0490 , LBRM2903_260009800

Length:

896

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005829	cytosol	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEQ3

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	1
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	3
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0033036	macromolecule localization	2	3
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	3
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031267	small GTPase binding	5	2
GO:0051020	GTPase binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.482
CLV_C14_Caspase3-7	266	270	PF00656	0.569
CLV_C14_Caspase3-7	525	529	PF00656	0.437
CLV_NRD_NRD_1	175	177	PF00675	0.537
CLV_NRD_NRD_1	24	26	PF00675	0.415
CLV_NRD_NRD_1	39	41	PF00675	0.504
CLV_NRD_NRD_1	419	421	PF00675	0.356
CLV_PCSK_KEX2_1	175	177	PF00082	0.537
CLV_PCSK_KEX2_1	36	38	PF00082	0.529
CLV_PCSK_KEX2_1	419	421	PF00082	0.356
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.566
CLV_PCSK_SKI1_1	11	15	PF00082	0.548
CLV_PCSK_SKI1_1	141	145	PF00082	0.409
CLV_PCSK_SKI1_1	257	261	PF00082	0.390
CLV_PCSK_SKI1_1	278	282	PF00082	0.533
CLV_PCSK_SKI1_1	532	536	PF00082	0.431
CLV_PCSK_SKI1_1	638	642	PF00082	0.475
CLV_PCSK_SKI1_1	725	729	PF00082	0.399
CLV_PCSK_SKI1_1	886	890	PF00082	0.388
CLV_Separin_Metazoa	628	632	PF03568	0.269
DEG_APCC_DBOX_1	475	483	PF00400	0.315
DEG_APCC_DBOX_1	531	539	PF00400	0.282
DEG_Nend_UBRbox_3	1	3	PF02207	0.376
DEG_SPOP_SBC_1	238	242	PF00917	0.481
DEG_SPOP_SBC_1	298	302	PF00917	0.588
DOC_CYCLIN_RxL_1	250	260	PF00134	0.411
DOC_CYCLIN_RxL_1	395	408	PF00134	0.459
DOC_CYCLIN_RxL_1	8	16	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.302
DOC_MAPK_DCC_7	532	541	PF00069	0.288
DOC_MAPK_gen_1	25	33	PF00069	0.404
DOC_MAPK_gen_1	254	263	PF00069	0.262
DOC_MAPK_MEF2A_6	197	205	PF00069	0.501
DOC_MAPK_MEF2A_6	4	12	PF00069	0.436
DOC_MAPK_MEF2A_6	532	541	PF00069	0.288
DOC_MAPK_MEF2A_6	658	667	PF00069	0.428
DOC_MAPK_MEF2A_6	73	81	PF00069	0.498
DOC_MAPK_MEF2A_6	862	871	PF00069	0.512
DOC_MAPK_RevD_3	10	26	PF00069	0.322
DOC_PP1_RVXF_1	252	259	PF00149	0.503
DOC_PP2B_LxvP_1	201	204	PF13499	0.494
DOC_PP2B_LxvP_1	533	536	PF13499	0.526
DOC_PP4_FxxP_1	534	537	PF00568	0.494
DOC_PP4_FxxP_1	640	643	PF00568	0.547
DOC_USP7_MATH_1	17	21	PF00917	0.367
DOC_USP7_MATH_1	348	352	PF00917	0.459
DOC_USP7_MATH_1	464	468	PF00917	0.438
DOC_USP7_MATH_1	634	638	PF00917	0.444
DOC_USP7_MATH_1	778	782	PF00917	0.570
DOC_USP7_MATH_1	784	788	PF00917	0.486
DOC_USP7_MATH_1	807	811	PF00917	0.276
DOC_USP7_MATH_1	842	846	PF00917	0.632
DOC_USP7_MATH_1	847	851	PF00917	0.753
DOC_WW_Pin1_4	167	172	PF00397	0.618
DOC_WW_Pin1_4	216	221	PF00397	0.740
DOC_WW_Pin1_4	223	228	PF00397	0.583
DOC_WW_Pin1_4	299	304	PF00397	0.540
DOC_WW_Pin1_4	411	416	PF00397	0.446
DOC_WW_Pin1_4	500	505	PF00397	0.485
DOC_WW_Pin1_4	610	615	PF00397	0.564
DOC_WW_Pin1_4	683	688	PF00397	0.581
DOC_WW_Pin1_4	799	804	PF00397	0.422
DOC_WW_Pin1_4	878	883	PF00397	0.466
LIG_14-3-3_CanoR_1	257	262	PF00244	0.428
LIG_14-3-3_CanoR_1	278	288	PF00244	0.474
LIG_14-3-3_CanoR_1	40	48	PF00244	0.571
LIG_14-3-3_CanoR_1	476	486	PF00244	0.310
LIG_14-3-3_CanoR_1	668	674	PF00244	0.422
LIG_14-3-3_CanoR_1	718	724	PF00244	0.486
LIG_14-3-3_CanoR_1	73	77	PF00244	0.514
LIG_14-3-3_CanoR_1	820	825	PF00244	0.589
LIG_14-3-3_CanoR_1	886	892	PF00244	0.353
LIG_Actin_WH2_2	576	594	PF00022	0.543
LIG_Actin_WH2_2	710	727	PF00022	0.410
LIG_BIR_III_2	16	20	PF00653	0.345
LIG_BIR_III_4	563	567	PF00653	0.537
LIG_BRCT_BRCA1_1	108	112	PF00533	0.382
LIG_BRCT_BRCA1_1	281	285	PF00533	0.489
LIG_BRCT_BRCA1_1	636	640	PF00533	0.507
LIG_Clathr_ClatBox_1	12	16	PF01394	0.320
LIG_EH1_1	228	236	PF00400	0.292
LIG_EH1_1	491	499	PF00400	0.302
LIG_eIF4E_1	9	15	PF01652	0.303
LIG_FHA_1	117	123	PF00498	0.557
LIG_FHA_1	154	160	PF00498	0.381
LIG_FHA_1	258	264	PF00498	0.470
LIG_FHA_1	370	376	PF00498	0.403
LIG_FHA_1	407	413	PF00498	0.382
LIG_FHA_1	453	459	PF00498	0.409
LIG_FHA_1	54	60	PF00498	0.406
LIG_FHA_1	617	623	PF00498	0.519
LIG_FHA_1	637	643	PF00498	0.237
LIG_FHA_1	670	676	PF00498	0.453
LIG_FHA_1	711	717	PF00498	0.455
LIG_FHA_1	73	79	PF00498	0.381
LIG_FHA_1	746	752	PF00498	0.476
LIG_FHA_1	819	825	PF00498	0.495
LIG_FHA_2	299	305	PF00498	0.546
LIG_FHA_2	431	437	PF00498	0.549
LIG_FHA_2	476	482	PF00498	0.464
LIG_FHA_2	483	489	PF00498	0.437
LIG_FHA_2	491	497	PF00498	0.398
LIG_FHA_2	523	529	PF00498	0.571
LIG_FHA_2	548	554	PF00498	0.378
LIG_FHA_2	642	648	PF00498	0.537
LIG_FHA_2	654	660	PF00498	0.529
LIG_FHA_2	694	700	PF00498	0.317
LIG_FHA_2	850	856	PF00498	0.736
LIG_GBD_Chelix_1	316	324	PF00786	0.614
LIG_GBD_Chelix_1	576	584	PF00786	0.305
LIG_LIR_Apic_2	637	643	PF02991	0.538
LIG_LIR_Gen_1	109	116	PF02991	0.427
LIG_LIR_Gen_1	145	154	PF02991	0.529
LIG_LIR_Gen_1	282	293	PF02991	0.284
LIG_LIR_Gen_1	335	346	PF02991	0.541
LIG_LIR_Gen_1	354	363	PF02991	0.240
LIG_LIR_Gen_1	391	401	PF02991	0.441
LIG_LIR_Gen_1	624	634	PF02991	0.376
LIG_LIR_Gen_1	659	667	PF02991	0.329
LIG_LIR_Gen_1	712	721	PF02991	0.332
LIG_LIR_Gen_1	75	84	PF02991	0.467
LIG_LIR_Gen_1	785	796	PF02991	0.523
LIG_LIR_Gen_1	889	896	PF02991	0.441
LIG_LIR_Gen_1	95	105	PF02991	0.202
LIG_LIR_Nem_3	109	115	PF02991	0.420
LIG_LIR_Nem_3	145	151	PF02991	0.435
LIG_LIR_Nem_3	281	287	PF02991	0.528
LIG_LIR_Nem_3	3	8	PF02991	0.450
LIG_LIR_Nem_3	335	341	PF02991	0.473
LIG_LIR_Nem_3	354	359	PF02991	0.230
LIG_LIR_Nem_3	391	396	PF02991	0.451
LIG_LIR_Nem_3	624	630	PF02991	0.379
LIG_LIR_Nem_3	659	663	PF02991	0.532
LIG_LIR_Nem_3	712	717	PF02991	0.288
LIG_LIR_Nem_3	75	79	PF02991	0.469
LIG_LIR_Nem_3	785	791	PF02991	0.536
LIG_LIR_Nem_3	889	894	PF02991	0.427
LIG_LIR_Nem_3	95	100	PF02991	0.208
LIG_MLH1_MIPbox_1	281	285	PF16413	0.555
LIG_MYND_1	403	407	PF01753	0.504
LIG_NRBOX	579	585	PF00104	0.432
LIG_NRBOX	810	816	PF00104	0.417
LIG_NRBOX	867	873	PF00104	0.585
LIG_PCNA_PIPBox_1	290	299	PF02747	0.498
LIG_PCNA_yPIPBox_3	52	64	PF02747	0.535
LIG_Pex14_2	144	148	PF04695	0.386
LIG_SH2_CRK	671	675	PF00017	0.351
LIG_SH2_CRK	788	792	PF00017	0.531
LIG_SH2_NCK_1	383	387	PF00017	0.502
LIG_SH2_PTP2	76	79	PF00017	0.457
LIG_SH2_PTP2	9	12	PF00017	0.525
LIG_SH2_SRC	80	83	PF00017	0.498
LIG_SH2_STAP1	125	129	PF00017	0.425
LIG_SH2_STAP1	671	675	PF00017	0.395
LIG_SH2_STAP1	788	792	PF00017	0.531
LIG_SH2_STAT3	545	548	PF00017	0.527
LIG_SH2_STAT5	130	133	PF00017	0.372
LIG_SH2_STAT5	279	282	PF00017	0.538
LIG_SH2_STAT5	284	287	PF00017	0.505
LIG_SH2_STAT5	296	299	PF00017	0.280
LIG_SH2_STAT5	383	386	PF00017	0.425
LIG_SH2_STAT5	393	396	PF00017	0.399
LIG_SH2_STAT5	58	61	PF00017	0.489
LIG_SH2_STAT5	671	674	PF00017	0.421
LIG_SH2_STAT5	76	79	PF00017	0.468
LIG_SH2_STAT5	80	83	PF00017	0.463
LIG_SH2_STAT5	9	12	PF00017	0.432
LIG_SH3_3	140	146	PF00018	0.448
LIG_SH3_3	165	171	PF00018	0.549
LIG_SH3_3	189	195	PF00018	0.506
LIG_SH3_3	604	610	PF00018	0.411
LIG_SH3_3	681	687	PF00018	0.576
LIG_SUMO_SIM_anti_2	672	677	PF11976	0.392
LIG_SUMO_SIM_anti_2	793	800	PF11976	0.400
LIG_SUMO_SIM_par_1	11	16	PF11976	0.486
LIG_SUMO_SIM_par_1	259	264	PF11976	0.407
LIG_SUMO_SIM_par_1	408	414	PF11976	0.315
LIG_SUMO_SIM_par_1	461	469	PF11976	0.424
LIG_SUMO_SIM_par_1	793	800	PF11976	0.400
LIG_TRAF2_1	493	496	PF00917	0.555
LIG_TRFH_1	112	116	PF08558	0.516
LIG_TYR_ITIM	669	674	PF00017	0.459
LIG_TYR_ITIM	74	79	PF00017	0.476
LIG_UBA3_1	461	466	PF00899	0.256
LIG_UBA3_1	78	86	PF00899	0.360
LIG_WRC_WIRS_1	888	893	PF05994	0.374
MOD_CDC14_SPxK_1	686	689	PF00782	0.357
MOD_CDK_SPxK_1	683	689	PF00069	0.344
MOD_CK1_1	117	123	PF00069	0.361
MOD_CK1_1	218	224	PF00069	0.726
MOD_CK1_1	307	313	PF00069	0.602
MOD_CK1_1	329	335	PF00069	0.447
MOD_CK1_1	351	357	PF00069	0.413
MOD_CK1_1	39	45	PF00069	0.585
MOD_CK1_1	503	509	PF00069	0.488
MOD_CK1_1	57	63	PF00069	0.478
MOD_CK1_1	578	584	PF00069	0.471
MOD_CK1_1	636	642	PF00069	0.484
MOD_CK1_1	692	698	PF00069	0.417
MOD_CK1_1	758	764	PF00069	0.537
MOD_CK1_1	802	808	PF00069	0.556
MOD_CK2_1	117	123	PF00069	0.299
MOD_CK2_1	298	304	PF00069	0.542
MOD_CK2_1	329	335	PF00069	0.419
MOD_CK2_1	430	436	PF00069	0.557
MOD_CK2_1	440	446	PF00069	0.453
MOD_CK2_1	490	496	PF00069	0.520
MOD_CK2_1	641	647	PF00069	0.324
MOD_CK2_1	693	699	PF00069	0.469
MOD_CK2_1	92	98	PF00069	0.339
MOD_Cter_Amidation	173	176	PF01082	0.333
MOD_DYRK1A_RPxSP_1	500	504	PF00069	0.587
MOD_GlcNHglycan	108	111	PF01048	0.431
MOD_GlcNHglycan	235	238	PF01048	0.468
MOD_GlcNHglycan	263	266	PF01048	0.462
MOD_GlcNHglycan	281	284	PF01048	0.497
MOD_GlcNHglycan	348	351	PF01048	0.536
MOD_GlcNHglycan	442	445	PF01048	0.491
MOD_GlcNHglycan	65	68	PF01048	0.344
MOD_GlcNHglycan	701	704	PF01048	0.559
MOD_GlcNHglycan	706	709	PF01048	0.455
MOD_GlcNHglycan	719	722	PF01048	0.327
MOD_GlcNHglycan	760	763	PF01048	0.521
MOD_GlcNHglycan	784	787	PF01048	0.619
MOD_GlcNHglycan	844	847	PF01048	0.570
MOD_GlcNHglycan	849	852	PF01048	0.447
MOD_GSK3_1	183	190	PF00069	0.417
MOD_GSK3_1	211	218	PF00069	0.605
MOD_GSK3_1	219	226	PF00069	0.657
MOD_GSK3_1	233	240	PF00069	0.330
MOD_GSK3_1	257	264	PF00069	0.407
MOD_GSK3_1	342	349	PF00069	0.440
MOD_GSK3_1	384	391	PF00069	0.591
MOD_GSK3_1	406	413	PF00069	0.470
MOD_GSK3_1	428	435	PF00069	0.424
MOD_GSK3_1	482	489	PF00069	0.493
MOD_GSK3_1	496	503	PF00069	0.455
MOD_GSK3_1	53	60	PF00069	0.500
MOD_GSK3_1	689	696	PF00069	0.379
MOD_GSK3_1	737	744	PF00069	0.529
MOD_GSK3_1	778	785	PF00069	0.596
MOD_GSK3_1	801	808	PF00069	0.471
MOD_GSK3_1	820	827	PF00069	0.357
MOD_NEK2_1	132	137	PF00069	0.466
MOD_NEK2_1	152	157	PF00069	0.179
MOD_NEK2_1	292	297	PF00069	0.473
MOD_NEK2_1	339	344	PF00069	0.381
MOD_NEK2_1	410	415	PF00069	0.524
MOD_NEK2_1	486	491	PF00069	0.460
MOD_NEK2_1	576	581	PF00069	0.505
MOD_NEK2_1	587	592	PF00069	0.451
MOD_NEK2_1	633	638	PF00069	0.396
MOD_NEK2_1	653	658	PF00069	0.454
MOD_NEK2_1	697	702	PF00069	0.493
MOD_NEK2_1	755	760	PF00069	0.457
MOD_NEK2_1	818	823	PF00069	0.518
MOD_NEK2_2	125	130	PF00069	0.512
MOD_NEK2_2	693	698	PF00069	0.303
MOD_PIKK_1	39	45	PF00454	0.418
MOD_PIKK_1	452	458	PF00454	0.542
MOD_PIKK_1	522	528	PF00454	0.553
MOD_PIKK_1	786	792	PF00454	0.524
MOD_PK_1	92	98	PF00069	0.461
MOD_PKA_1	25	31	PF00069	0.544
MOD_PKA_1	36	42	PF00069	0.559
MOD_PKA_2	36	42	PF00069	0.596
MOD_PKA_2	475	481	PF00069	0.326
MOD_PKA_2	63	69	PF00069	0.400
MOD_PKA_2	697	703	PF00069	0.585
MOD_PKA_2	717	723	PF00069	0.231
MOD_PKA_2	72	78	PF00069	0.512
MOD_PKA_2	737	743	PF00069	0.251
MOD_PKA_2	819	825	PF00069	0.604
MOD_Plk_1	117	123	PF00069	0.299
MOD_Plk_1	125	131	PF00069	0.429
MOD_Plk_1	187	193	PF00069	0.470
MOD_Plk_1	227	233	PF00069	0.458
MOD_Plk_1	326	332	PF00069	0.466
MOD_Plk_1	388	394	PF00069	0.563
MOD_Plk_4	117	123	PF00069	0.402
MOD_Plk_4	125	131	PF00069	0.429
MOD_Plk_4	17	23	PF00069	0.441
MOD_Plk_4	187	193	PF00069	0.421
MOD_Plk_4	227	233	PF00069	0.434
MOD_Plk_4	292	298	PF00069	0.358
MOD_Plk_4	326	332	PF00069	0.441
MOD_Plk_4	389	395	PF00069	0.488
MOD_Plk_4	482	488	PF00069	0.482
MOD_Plk_4	54	60	PF00069	0.435
MOD_Plk_4	578	584	PF00069	0.356
MOD_Plk_4	669	675	PF00069	0.385
MOD_Plk_4	72	78	PF00069	0.455
MOD_Plk_4	92	98	PF00069	0.257
MOD_ProDKin_1	167	173	PF00069	0.609
MOD_ProDKin_1	216	222	PF00069	0.741
MOD_ProDKin_1	223	229	PF00069	0.569
MOD_ProDKin_1	299	305	PF00069	0.538
MOD_ProDKin_1	411	417	PF00069	0.440
MOD_ProDKin_1	500	506	PF00069	0.477
MOD_ProDKin_1	610	616	PF00069	0.566
MOD_ProDKin_1	683	689	PF00069	0.581
MOD_ProDKin_1	799	805	PF00069	0.423
MOD_ProDKin_1	878	884	PF00069	0.458
MOD_SUMO_rev_2	827	833	PF00179	0.358
TRG_DiLeu_BaEn_1	793	798	PF01217	0.391
TRG_DiLeu_BaEn_3	828	834	PF01217	0.351
TRG_DiLeu_BaEn_4	766	772	PF01217	0.594
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.434
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.488
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.419
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.552
TRG_DiLeu_BaLyEn_6	810	815	PF01217	0.444
TRG_ENDOCYTIC_2	284	287	PF00928	0.300
TRG_ENDOCYTIC_2	382	385	PF00928	0.432
TRG_ENDOCYTIC_2	393	396	PF00928	0.437
TRG_ENDOCYTIC_2	671	674	PF00928	0.349
TRG_ENDOCYTIC_2	76	79	PF00928	0.468
TRG_ENDOCYTIC_2	788	791	PF00928	0.537
TRG_ENDOCYTIC_2	80	83	PF00928	0.463
TRG_ENDOCYTIC_2	9	12	PF00928	0.413
TRG_ER_diArg_1	175	178	PF00400	0.476
TRG_ER_diArg_1	419	421	PF00400	0.360
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A0	Leptomonas seymouri	59%	90%
A0A1X0NSG1	Trypanosomatidae	36%	90%
A0A3Q8INY0	Leishmania donovani	80%	91%
A0A3S5IS01	Trypanosoma rangeli	37%	95%
A4I1Y2	Leishmania infantum	81%	91%
C9ZS36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	93%
E9AY29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	87%
Q4Q9E4	Leishmania major	81%	100%
V5BUJ9	Trypanosoma cruzi	32%	94%