Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEQ1_LEIBR

TriTrypDb:

LbrM.26.0470 , LBRM2903_260009600

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 2
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HEQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.501
CLV_NRD_NRD_1	107	109	PF00675	0.350
CLV_NRD_NRD_1	126	128	PF00675	0.701
CLV_NRD_NRD_1	138	140	PF00675	0.439
CLV_NRD_NRD_1	317	319	PF00675	0.483
CLV_NRD_NRD_1	388	390	PF00675	0.611
CLV_PCSK_FUR_1	94	98	PF00082	0.373
CLV_PCSK_KEX2_1	107	109	PF00082	0.315
CLV_PCSK_KEX2_1	126	128	PF00082	0.439
CLV_PCSK_KEX2_1	138	140	PF00082	0.392
CLV_PCSK_KEX2_1	317	319	PF00082	0.569
CLV_PCSK_KEX2_1	96	98	PF00082	0.487
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.355
CLV_PCSK_SKI1_1	148	152	PF00082	0.458
CLV_PCSK_SKI1_1	445	449	PF00082	0.486
DEG_APCC_DBOX_1	137	145	PF00400	0.557
DEG_APCC_DBOX_1	285	293	PF00400	0.460
DEG_SPOP_SBC_1	229	233	PF00917	0.354
DOC_CKS1_1	257	262	PF01111	0.561
DOC_CKS1_1	59	64	PF01111	0.543
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.402
DOC_MAPK_gen_1	138	144	PF00069	0.505
DOC_MAPK_gen_1	234	242	PF00069	0.280
DOC_MAPK_MEF2A_6	234	243	PF00069	0.398
DOC_MAPK_MEF2A_6	74	83	PF00069	0.389
DOC_PP2B_LxvP_1	355	358	PF13499	0.422
DOC_USP7_MATH_1	130	134	PF00917	0.560
DOC_USP7_MATH_1	229	233	PF00917	0.431
DOC_USP7_MATH_1	249	253	PF00917	0.474
DOC_USP7_MATH_1	336	340	PF00917	0.447
DOC_USP7_MATH_1	54	58	PF00917	0.450
DOC_WW_Pin1_4	256	261	PF00397	0.554
DOC_WW_Pin1_4	433	438	PF00397	0.510
DOC_WW_Pin1_4	58	63	PF00397	0.526
LIG_14-3-3_CanoR_1	120	124	PF00244	0.616
LIG_14-3-3_CanoR_1	183	188	PF00244	0.351
LIG_14-3-3_CanoR_1	280	289	PF00244	0.467
LIG_14-3-3_CanoR_1	385	389	PF00244	0.610
LIG_14-3-3_CanoR_1	49	54	PF00244	0.595
LIG_14-3-3_CanoR_1	56	62	PF00244	0.497
LIG_APCC_ABBA_1	142	147	PF00400	0.376
LIG_BIR_II_1	1	5	PF00653	0.426
LIG_BIR_III_2	169	173	PF00653	0.315
LIG_BRCT_BRCA1_1	338	342	PF00533	0.537
LIG_BRCT_BRCA1_1	425	429	PF00533	0.478
LIG_CaM_IQ_9	112	128	PF13499	0.378
LIG_FHA_1	277	283	PF00498	0.367
LIG_FHA_1	363	369	PF00498	0.422
LIG_FHA_1	420	426	PF00498	0.471
LIG_FHA_1	8	14	PF00498	0.409
LIG_FHA_2	184	190	PF00498	0.590
LIG_IRF3_LxIS_1	151	158	PF10401	0.339
LIG_LIR_Gen_1	162	172	PF02991	0.492
LIG_LIR_Gen_1	367	377	PF02991	0.443
LIG_LIR_Gen_1	378	388	PF02991	0.443
LIG_LIR_LC3C_4	237	241	PF02991	0.384
LIG_LIR_Nem_3	162	167	PF02991	0.418
LIG_LIR_Nem_3	294	300	PF02991	0.327
LIG_LIR_Nem_3	367	372	PF02991	0.403
LIG_LIR_Nem_3	378	384	PF02991	0.397
LIG_LIR_Nem_3	398	404	PF02991	0.495
LIG_Pex14_2	210	214	PF04695	0.277
LIG_Pex14_2	342	346	PF04695	0.525
LIG_PTB_Apo_2	290	297	PF02174	0.280
LIG_PTB_Phospho_1	290	296	PF10480	0.282
LIG_SH2_CRK	164	168	PF00017	0.407
LIG_SH2_GRB2like	291	294	PF00017	0.327
LIG_SH2_NCK_1	369	373	PF00017	0.375
LIG_SH2_STAP1	443	447	PF00017	0.464
LIG_SH2_STAT3	296	299	PF00017	0.387
LIG_SH2_STAT5	184	187	PF00017	0.490
LIG_SH2_STAT5	209	212	PF00017	0.489
LIG_SH2_STAT5	281	284	PF00017	0.401
LIG_SH2_STAT5	291	294	PF00017	0.381
LIG_SH2_STAT5	297	300	PF00017	0.408
LIG_SH2_STAT5	58	61	PF00017	0.350
LIG_SH2_STAT5	8	11	PF00017	0.512
LIG_SH3_3	168	174	PF00018	0.498
LIG_SH3_3	330	336	PF00018	0.456
LIG_SH3_3	355	361	PF00018	0.511
LIG_SH3_3	56	62	PF00018	0.492
LIG_SUMO_SIM_anti_2	237	243	PF11976	0.428
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.292
LIG_SUMO_SIM_par_1	153	158	PF11976	0.341
LIG_SUMO_SIM_par_1	216	223	PF11976	0.298
LIG_SUMO_SIM_par_1	239	245	PF11976	0.425
LIG_SUMO_SIM_par_1	79	85	PF11976	0.425
LIG_TYR_ITSM	160	167	PF00017	0.456
LIG_WRC_WIRS_1	391	396	PF05994	0.543
MOD_CDK_SPxK_1	58	64	PF00069	0.369
MOD_CK1_1	227	233	PF00069	0.516
MOD_CK1_1	392	398	PF00069	0.582
MOD_CK1_1	57	63	PF00069	0.536
MOD_CK1_1	66	72	PF00069	0.517
MOD_CK1_1	89	95	PF00069	0.589
MOD_CK2_1	183	189	PF00069	0.547
MOD_CK2_1	367	373	PF00069	0.393
MOD_Cter_Amidation	94	97	PF01082	0.385
MOD_GlcNHglycan	377	380	PF01048	0.597
MOD_GSK3_1	155	162	PF00069	0.340
MOD_GSK3_1	172	179	PF00069	0.364
MOD_GSK3_1	224	231	PF00069	0.582
MOD_GSK3_1	281	288	PF00069	0.411
MOD_GSK3_1	389	396	PF00069	0.653
MOD_GSK3_1	407	414	PF00069	0.452
MOD_GSK3_1	419	426	PF00069	0.581
MOD_GSK3_1	54	61	PF00069	0.571
MOD_GSK3_1	63	70	PF00069	0.498
MOD_N-GLC_1	159	164	PF02516	0.403
MOD_N-GLC_1	326	331	PF02516	0.674
MOD_N-GLC_1	336	341	PF02516	0.520
MOD_N-GLC_1	350	355	PF02516	0.559
MOD_N-GLC_1	416	421	PF02516	0.581
MOD_NEK2_1	155	160	PF00069	0.472
MOD_NEK2_1	182	187	PF00069	0.513
MOD_NEK2_1	307	312	PF00069	0.561
MOD_NEK2_1	384	389	PF00069	0.509
MOD_NEK2_1	394	399	PF00069	0.629
MOD_NEK2_1	411	416	PF00069	0.414
MOD_NEK2_2	249	254	PF00069	0.515
MOD_NEK2_2	281	286	PF00069	0.547
MOD_OGLYCOS	50	55	PF02709	0.393
MOD_PIKK_1	201	207	PF00454	0.462
MOD_PKA_1	389	395	PF00069	0.635
MOD_PKA_1	96	102	PF00069	0.331
MOD_PKA_2	119	125	PF00069	0.519
MOD_PKA_2	182	188	PF00069	0.428
MOD_PKA_2	285	291	PF00069	0.449
MOD_PKA_2	384	390	PF00069	0.605
MOD_PKA_2	48	54	PF00069	0.601
MOD_PKA_2	63	69	PF00069	0.466
MOD_PKA_2	96	102	PF00069	0.407
MOD_Plk_1	159	165	PF00069	0.389
MOD_Plk_1	201	207	PF00069	0.477
MOD_Plk_1	265	271	PF00069	0.331
MOD_Plk_1	336	342	PF00069	0.658
MOD_Plk_1	350	356	PF00069	0.404
MOD_Plk_1	67	73	PF00069	0.454
MOD_Plk_4	119	125	PF00069	0.380
MOD_Plk_4	86	92	PF00069	0.553
MOD_ProDKin_1	256	262	PF00069	0.556
MOD_ProDKin_1	433	439	PF00069	0.503
MOD_ProDKin_1	58	64	PF00069	0.536
TRG_ENDOCYTIC_2	164	167	PF00928	0.432
TRG_ENDOCYTIC_2	369	372	PF00928	0.504
TRG_ENDOCYTIC_2	381	384	PF00928	0.474
TRG_ENDOCYTIC_2	391	394	PF00928	0.527
TRG_ENDOCYTIC_2	404	407	PF00928	0.520
TRG_ER_diArg_1	106	108	PF00400	0.463
TRG_ER_diArg_1	126	128	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P2	Leptomonas seymouri	39%	97%
A0A3Q8ICS7	Leishmania donovani	72%	100%
A0A3R7NPG1	Trypanosoma rangeli	24%	100%
A4I1Y1	Leishmania infantum	72%	100%
C9ZS38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AY27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q9E6	Leishmania major	70%	100%