Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEQ0_LEIBR

TriTrypDb:

LbrM.26.0460 , LBRM2903_260009500

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A4HEQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.336
CLV_C14_Caspase3-7	59	63	PF00656	0.590
CLV_NRD_NRD_1	27	29	PF00675	0.468
CLV_PCSK_KEX2_1	27	29	PF00082	0.468
CLV_PCSK_SKI1_1	146	150	PF00082	0.468
CLV_PCSK_SKI1_1	16	20	PF00082	0.426
CLV_PCSK_SKI1_1	212	216	PF00082	0.433
CLV_PCSK_SKI1_1	217	221	PF00082	0.383
CLV_PCSK_SKI1_1	223	227	PF00082	0.283
DEG_Nend_UBRbox_3	1	3	PF02207	0.614
DEG_SPOP_SBC_1	170	174	PF00917	0.583
DEG_SPOP_SBC_1	64	68	PF00917	0.757
DOC_CYCLIN_RxL_1	217	229	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.318
DOC_MAPK_JIP1_4	16	22	PF00069	0.586
DOC_PP1_RVXF_1	221	228	PF00149	0.430
DOC_PP4_FxxP_1	142	145	PF00568	0.617
DOC_PP4_FxxP_1	190	193	PF00568	0.642
DOC_PP4_MxPP_1	43	46	PF00568	0.590
DOC_USP7_MATH_1	12	16	PF00917	0.572
DOC_USP7_MATH_1	46	50	PF00917	0.700
DOC_USP7_MATH_1	64	68	PF00917	0.694
DOC_WW_Pin1_4	100	105	PF00397	0.699
DOC_WW_Pin1_4	201	206	PF00397	0.703
DOC_WW_Pin1_4	44	49	PF00397	0.725
LIG_14-3-3_CanoR_1	16	21	PF00244	0.603
LIG_14-3-3_CanoR_1	269	274	PF00244	0.463
LIG_14-3-3_CanoR_1	27	32	PF00244	0.681
LIG_14-3-3_CanoR_1	38	46	PF00244	0.670
LIG_deltaCOP1_diTrp_1	301	310	PF00928	0.419
LIG_FHA_1	1	7	PF00498	0.606
LIG_FHA_1	17	23	PF00498	0.584
LIG_FHA_1	180	186	PF00498	0.636
LIG_FHA_1	241	247	PF00498	0.256
LIG_FHA_2	122	128	PF00498	0.669
LIG_FHA_2	277	283	PF00498	0.328
LIG_FHA_2	285	291	PF00498	0.493
LIG_FHA_2	57	63	PF00498	0.696
LIG_GSK3_LRP6_1	44	49	PF00069	0.587
LIG_LIR_Apic_2	139	145	PF02991	0.568
LIG_LIR_Gen_1	229	238	PF02991	0.275
LIG_LIR_Gen_1	301	309	PF02991	0.321
LIG_LIR_Gen_1	39	48	PF02991	0.639
LIG_LIR_Nem_3	229	234	PF02991	0.275
LIG_LIR_Nem_3	301	306	PF02991	0.352
LIG_LIR_Nem_3	308	313	PF02991	0.290
LIG_MYND_1	83	87	PF01753	0.597
LIG_Pex14_1	227	231	PF04695	0.275
LIG_PTB_Apo_2	184	191	PF02174	0.533
LIG_SH2_CRK	231	235	PF00017	0.209
LIG_SH2_STAT5	245	248	PF00017	0.419
LIG_SH2_STAT5	292	295	PF00017	0.388
LIG_SH3_3	11	17	PF00018	0.573
LIG_SH3_3	42	48	PF00018	0.730
LIG_SH3_3	71	77	PF00018	0.705
LIG_SH3_3	80	86	PF00018	0.659
LIG_SUMO_SIM_par_1	15	21	PF11976	0.582
LIG_SUMO_SIM_par_1	292	297	PF11976	0.350
LIG_TRAF2_1	124	127	PF00917	0.686
LIG_TRFH_1	100	104	PF08558	0.563
MOD_CK1_1	147	153	PF00069	0.651
MOD_CK1_1	155	161	PF00069	0.679
MOD_CK1_1	171	177	PF00069	0.717
MOD_CK1_1	49	55	PF00069	0.712
MOD_CK2_1	111	117	PF00069	0.614
MOD_CK2_1	121	127	PF00069	0.619
MOD_CK2_1	147	153	PF00069	0.702
MOD_CK2_1	284	290	PF00069	0.417
MOD_CK2_1	65	71	PF00069	0.620
MOD_Cter_Amidation	25	28	PF01082	0.389
MOD_GlcNHglycan	113	116	PF01048	0.470
MOD_GlcNHglycan	149	152	PF01048	0.483
MOD_GlcNHglycan	153	157	PF01048	0.525
MOD_GlcNHglycan	195	199	PF01048	0.444
MOD_GlcNHglycan	236	239	PF01048	0.431
MOD_GlcNHglycan	40	43	PF01048	0.488
MOD_GlcNHglycan	48	51	PF01048	0.483
MOD_GlcNHglycan	95	98	PF01048	0.400
MOD_GSK3_1	12	19	PF00069	0.576
MOD_GSK3_1	155	162	PF00069	0.677
MOD_GSK3_1	166	173	PF00069	0.763
MOD_GSK3_1	236	243	PF00069	0.487
MOD_GSK3_1	46	53	PF00069	0.689
MOD_LATS_1	25	31	PF00433	0.657
MOD_NEK2_1	178	183	PF00069	0.606
MOD_NEK2_1	226	231	PF00069	0.302
MOD_NEK2_1	234	239	PF00069	0.241
MOD_NEK2_2	248	253	PF00069	0.369
MOD_NEK2_2	65	70	PF00069	0.604
MOD_PIKK_1	102	108	PF00454	0.726
MOD_PIKK_1	206	212	PF00454	0.649
MOD_PK_1	27	33	PF00069	0.685
MOD_PK_1	70	76	PF00069	0.610
MOD_PKA_1	27	33	PF00069	0.732
MOD_PKA_2	27	33	PF00069	0.732
MOD_Plk_1	194	200	PF00069	0.586
MOD_Plk_1	70	76	PF00069	0.610
MOD_Plk_4	144	150	PF00069	0.549
MOD_Plk_4	173	179	PF00069	0.628
MOD_Plk_4	236	242	PF00069	0.433
MOD_Plk_4	284	290	PF00069	0.457
MOD_ProDKin_1	100	106	PF00069	0.695
MOD_ProDKin_1	201	207	PF00069	0.699
MOD_ProDKin_1	44	50	PF00069	0.726
MOD_SUMO_for_1	193	196	PF00179	0.570
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.501
TRG_ENDOCYTIC_2	231	234	PF00928	0.209
TRG_ENDOCYTIC_2	249	252	PF00928	0.424
TRG_ER_diArg_1	27	29	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P498	Leptomonas seymouri	48%	100%
A0A0S4KLN6	Bodo saltans	30%	100%
A0A1X0NSG9	Trypanosomatidae	33%	100%
A0A3R7MX83	Trypanosoma rangeli	29%	100%
A0A3S7WZN6	Leishmania donovani	63%	96%
A4I1Y0	Leishmania infantum	63%	96%
C9ZS39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AY26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	96%
Q4Q9E7	Leishmania major	61%	100%
V5B9G1	Trypanosoma cruzi	34%	100%