Cytosolic Fe-S cluster assembly factor NUBP2 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleotide binding protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEP9_LEIBR

TriTrypDb:

LbrM.26.0450 , LBRM2903_260009400

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HEP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEP9

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0044237	cellular metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0002097	tRNA wobble base modification	7	1
GO:0002101	tRNA wobble cytosine modification	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016530	metallochaperone activity	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051539	4 iron, 4 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140104	molecular carrier activity	1	11
GO:0140657	ATP-dependent activity	1	11
GO:0140663	ATP-dependent FeS chaperone activity	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.311
CLV_NRD_NRD_1	226	228	PF00675	0.315
CLV_PCSK_KEX2_1	226	228	PF00082	0.281
CLV_PCSK_SKI1_1	129	133	PF00082	0.330
CLV_Separin_Metazoa	160	164	PF03568	0.384
DEG_APCC_DBOX_1	192	200	PF00400	0.207
DEG_SCF_FBW7_1	144	151	PF00400	0.311
DOC_CDC14_PxL_1	231	239	PF14671	0.330
DOC_CKS1_1	145	150	PF01111	0.311
DOC_CKS1_1	173	178	PF01111	0.311
DOC_MAPK_gen_1	68	78	PF00069	0.384
DOC_MAPK_HePTP_8	38	50	PF00069	0.311
DOC_MAPK_MEF2A_6	41	50	PF00069	0.309
DOC_MAPK_MEF2A_6	71	78	PF00069	0.207
DOC_PP4_FxxP_1	208	211	PF00568	0.311
DOC_USP7_MATH_1	149	153	PF00917	0.311
DOC_WW_Pin1_4	144	149	PF00397	0.311
DOC_WW_Pin1_4	172	177	PF00397	0.311
DOC_WW_Pin1_4	84	89	PF00397	0.371
LIG_Clathr_ClatBox_1	45	49	PF01394	0.311
LIG_FHA_1	179	185	PF00498	0.309
LIG_FHA_1	2	8	PF00498	0.473
LIG_FHA_2	149	155	PF00498	0.311
LIG_FHA_2	173	179	PF00498	0.311
LIG_GBD_Chelix_1	27	35	PF00786	0.311
LIG_LIR_Apic_2	105	111	PF02991	0.330
LIG_LIR_Apic_2	206	211	PF02991	0.311
LIG_LIR_Apic_2	230	235	PF02991	0.330
LIG_LIR_Gen_1	141	149	PF02991	0.313
LIG_LIR_Nem_3	134	140	PF02991	0.284
LIG_LIR_Nem_3	141	145	PF02991	0.391
LIG_LIR_Nem_3	70	76	PF02991	0.295
LIG_SH2_NCK_1	232	236	PF00017	0.422
LIG_SH2_SRC	142	145	PF00017	0.319
LIG_SH2_STAT5	108	111	PF00017	0.422
LIG_SH2_STAT5	142	145	PF00017	0.295
LIG_SH2_STAT5	212	215	PF00017	0.207
LIG_SH3_3	170	176	PF00018	0.387
LIG_SH3_3	238	244	PF00018	0.311
LIG_SH3_3	50	56	PF00018	0.286
LIG_SUMO_SIM_par_1	11	17	PF11976	0.311
LIG_SUMO_SIM_par_1	44	49	PF11976	0.311
LIG_TYR_ITIM	140	145	PF00017	0.311
LIG_UBA3_1	12	19	PF00899	0.354
MOD_CK2_1	148	154	PF00069	0.311
MOD_CK2_1	244	250	PF00069	0.330
MOD_Cter_Amidation	224	227	PF01082	0.311
MOD_GlcNHglycan	16	19	PF01048	0.303
MOD_GlcNHglycan	167	170	PF01048	0.414
MOD_GlcNHglycan	205	208	PF01048	0.311
MOD_GlcNHglycan	84	87	PF01048	0.420
MOD_GlcNHglycan	97	100	PF01048	0.334
MOD_GSK3_1	144	151	PF00069	0.311
MOD_GSK3_1	214	221	PF00069	0.311
MOD_N-GLC_1	203	208	PF02516	0.311
MOD_N-GLC_1	244	249	PF02516	0.455
MOD_NEK2_1	1	6	PF00069	0.400
MOD_NEK2_1	14	19	PF00069	0.304
MOD_NEK2_1	33	38	PF00069	0.209
MOD_NEK2_2	92	97	PF00069	0.207
MOD_PIKK_1	259	265	PF00454	0.416
MOD_PK_1	102	108	PF00069	0.311
MOD_Plk_1	133	139	PF00069	0.365
MOD_Plk_1	186	192	PF00069	0.311
MOD_Plk_1	244	250	PF00069	0.455
MOD_Plk_1	92	98	PF00069	0.334
MOD_Plk_2-3	154	160	PF00069	0.311
MOD_Plk_2-3	178	184	PF00069	0.311
MOD_ProDKin_1	144	150	PF00069	0.311
MOD_ProDKin_1	172	178	PF00069	0.311
MOD_ProDKin_1	84	90	PF00069	0.371
MOD_SUMO_for_1	184	187	PF00179	0.330
MOD_SUMO_rev_2	98	104	PF00179	0.431
TRG_ENDOCYTIC_2	142	145	PF00928	0.302
TRG_ER_diArg_1	226	228	PF00400	0.330
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT32	Leptomonas seymouri	41%	100%
A0A0N1I422	Leptomonas seymouri	80%	94%
A0A0N1I939	Leptomonas seymouri	41%	87%
A0A0S4IUN9	Bodo saltans	36%	99%
A0A0S4JE42	Bodo saltans	46%	88%
A0A1X0NQL6	Trypanosomatidae	41%	100%
A0A1X0NSI2	Trypanosomatidae	72%	96%
A0A1X0NZ57	Trypanosomatidae	42%	91%
A0A3Q8IBU2	Leishmania donovani	41%	87%
A0A3Q8IET9	Leishmania donovani	38%	97%
A0A3Q8IFM3	Leishmania donovani	85%	92%
A0A3R7KED8	Trypanosoma rangeli	43%	91%
A0A422NVG5	Trypanosoma rangeli	72%	100%
A1C4X8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	47%	90%
A1C7T4	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	48%	83%
A4HBR3	Leishmania braziliensis	43%	100%
A4HGU9	Leishmania braziliensis	40%	97%
A4HZ65	Leishmania infantum	41%	87%
A4I1X9	Leishmania infantum	85%	92%
A4I3X9	Leishmania infantum	38%	97%
A4QNM5	Xenopus tropicalis	52%	100%
A7RUD5	Nematostella vectensis	47%	89%
A7SE07	Nematostella vectensis	53%	100%
A8PW87	Brugia malayi	45%	92%
A8WWQ7	Caenorhabditis briggsae	47%	91%
A9V7A1	Monosiga brevicollis	49%	100%
B0X4N8	Culex quinquefasciatus	46%	85%
B0XDJ0	Culex quinquefasciatus	56%	100%
B3M9R3	Drosophila ananassae	51%	100%
B3MU92	Drosophila ananassae	42%	92%
B3NIP2	Drosophila erecta	52%	100%
B3NNJ9	Drosophila erecta	40%	91%
B3RPX4	Trichoplax adhaerens	52%	100%
B4G8R5	Drosophila persimilis	41%	91%
B4H7P4	Drosophila persimilis	50%	100%
B4I540	Drosophila sechellia	41%	91%
B4IAD1	Drosophila sechellia	52%	100%
B4IUH5	Drosophila yakuba	52%	100%
B4IYG8	Drosophila grimshawi	52%	100%
B4JBI7	Drosophila grimshawi	41%	91%
B4KHX1	Drosophila mojavensis	40%	92%
B4KY56	Drosophila mojavensis	53%	100%
B4LGB4	Drosophila virilis	52%	100%
B4LUF5	Drosophila virilis	40%	92%
B4N1C3	Drosophila willistoni	41%	92%
B4N4D9	Drosophila willistoni	53%	100%
B4P9A8	Drosophila yakuba	41%	91%
B4PES4	Drosophila yakuba	52%	100%
B4Q7F5	Drosophila simulans	40%	91%
B4QJ46	Drosophila simulans	52%	100%
C9ZS40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	98%
D0A1H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	91%
D0A946	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AV32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	87%
E9AY25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	92%
E9B069	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	97%
O24999	Helicobacter pylori (strain ATCC 700392 / 26695)	35%	77%
O49472	Arabidopsis thaliana	37%	91%
O58667	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	40%	96%
O66946	Aquifex aeolicus (strain VF5)	41%	78%
O94442	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	90%
P0AF08	Escherichia coli (strain K12)	43%	77%
P0AF09	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	43%	77%
P0C8Q1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	45%	85%
P0CO88	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	44%	85%
P0CO89	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	44%	85%
P0CO90	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	43%	86%
P0CO91	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	43%	86%
P40558	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	97%
P45135	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	39%	77%
P50863	Bacillus subtilis (strain 168)	36%	81%
P52920	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	87%
P53381	Clostridium perfringens (strain 13 / Type A)	38%	100%
P53382	Mycobacterium leprae (strain TN)	36%	74%
P53383	Synechocystis sp. (strain PCC 6803 / Kazusa)	40%	80%
P53384	Homo sapiens	49%	89%
P56346	Chlorella vulgaris	24%	100%
P65442	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	36%	75%
P72190	Pseudomonas fragi	39%	99%
P9WJN6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	36%	75%
P9WJN7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	36%	75%
Q0CE30	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	47%	91%
Q0CVD6	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	48%	82%
Q0UAM9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	52%	96%
Q0UI56	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	47%	84%
Q16H50	Aedes aegypti	54%	100%
Q16T79	Aedes aegypti	46%	89%
Q1DSY6	Coccidioides immitis (strain RS)	46%	83%
Q1EAU8	Coccidioides immitis (strain RS)	47%	83%
Q1RHB0	Rickettsia bellii (strain RML369-C)	38%	89%
Q24K00	Bos taurus	49%	89%
Q29DB7	Drosophila pseudoobscura pseudoobscura	51%	100%
Q29MT7	Drosophila pseudoobscura pseudoobscura	41%	91%
Q2GWZ4	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	53%	94%
Q2H317	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	49%	83%
Q2UA27	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	48%	90%
Q2UDE2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	49%	87%
Q3B7Q7	Danio rerio	49%	100%
Q3KQF0	Xenopus laevis	47%	90%
Q3MHY6	Bos taurus	50%	100%
Q4HZ34	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	47%	83%
Q4I174	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	54%	95%
Q4P8S7	Ustilago maydis (strain 521 / FGSC 9021)	52%	79%
Q4Q816	Leishmania major	39%	100%
Q4Q9E8	Leishmania major	86%	100%
Q4QCE9	Leishmania major	41%	100%
Q4UKB5	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	39%	89%
Q4WEN1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	90%
Q4WZS2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	82%
Q54F15	Dictyostelium discoideum	37%	88%
Q57731	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	46%	98%
Q59MP1	Candida albicans (strain SC5314 / ATCC MYA-2876)	46%	86%
Q59YD9	Candida albicans (strain SC5314 / ATCC MYA-2876)	52%	97%
Q5BBC5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	48%	83%
Q5EB25	Xenopus tropicalis	47%	89%
Q5I050	Xenopus laevis	47%	90%
Q5I0L4	Rattus norvegicus	49%	89%
Q5ZKV4	Gallus gallus	51%	100%
Q68FS1	Rattus norvegicus	51%	100%
Q68XP6	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	36%	89%
Q6BTZ6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	45%	86%
Q6BWQ9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	45%	95%
Q6C5D0	Yarrowia lipolytica (strain CLIB 122 / E 150)	52%	98%
Q6C7A6	Yarrowia lipolytica (strain CLIB 122 / E 150)	46%	84%
Q6CE48	Yarrowia lipolytica (strain CLIB 122 / E 150)	40%	91%
Q6CMN0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	42%	87%
Q6CQV4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	56%	100%
Q6DEE4	Xenopus laevis	52%	100%
Q6FPP7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	54%	100%
Q6LZC5	Methanococcus maripaludis (strain S2 / LL)	40%	98%
Q6P298	Danio rerio	49%	88%
Q754X6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	46%	85%
Q75AC3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	51%	100%
Q76NZ7	Dictyostelium discoideum	53%	100%
Q7PV10	Anopheles gambiae	46%	87%
Q7QGS3	Anopheles gambiae	55%	100%
Q7S8Z0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	46%	83%
Q874M2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	43%	85%
Q8H1Q2	Arabidopsis thaliana	40%	81%
Q8T2F3	Dictyostelium discoideum	47%	90%
Q8TB37	Homo sapiens	39%	89%
Q8U1R0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	39%	96%
Q8X0F1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	53%	93%
Q8ZNN5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	44%	77%
Q92JA4	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	37%	89%
Q93459	Caenorhabditis elegans	47%	91%
Q97ZW4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	41%	96%
Q9CWD8	Mus musculus	37%	89%
Q9R060	Mus musculus	48%	89%
Q9R061	Mus musculus	50%	100%
Q9RVM9	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	37%	81%
Q9V0D9	Pyrococcus abyssi (strain GE5 / Orsay)	38%	96%
Q9VJI9	Drosophila melanogaster	41%	91%
Q9VPD2	Drosophila melanogaster	51%	100%
Q9X2I3	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	30%	100%
Q9Y5Y2	Homo sapiens	52%	100%
Q9ZE27	Rickettsia prowazekii (strain Madrid E)	36%	89%
Q9ZMA8	Helicobacter pylori (strain J99 / ATCC 700824)	26%	100%
Q9ZMM5	Helicobacter pylori (strain J99 / ATCC 700824)	35%	77%
V5BGR5	Trypanosoma cruzi	40%	100%
V5DEP1	Trypanosoma cruzi	41%	91%
V5DR48	Trypanosoma cruzi	74%	100%