LeishMANIAdb
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Cysteine-rich DPF motif domain-containing protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Cysteine-rich DPF motif domain-containing protein 1
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HEP7_LEIBR
TriTrypDb:
LbrM.26.0430 , LBRM2903_260009200 *
Length:
98

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEP7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEP7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 32 34 PF00082 0.401
CLV_PCSK_KEX2_1 46 48 PF00082 0.382
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.401
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.476
DOC_MAPK_MEF2A_6 68 76 PF00069 0.444
LIG_BIR_II_1 1 5 PF00653 0.508
LIG_FHA_1 39 45 PF00498 0.452
LIG_LIR_Nem_3 78 83 PF02991 0.475
LIG_Pex14_1 79 83 PF04695 0.373
LIG_SH2_SRC 42 45 PF00017 0.454
LIG_SH2_STAT5 30 33 PF00017 0.485
LIG_SH2_STAT5 80 83 PF00017 0.346
MOD_CK1_1 50 56 PF00069 0.379
MOD_N-GLC_1 3 8 PF02516 0.550
MOD_PIKK_1 15 21 PF00454 0.502
MOD_PK_1 47 53 PF00069 0.451
MOD_Plk_4 47 53 PF00069 0.440
TRG_ENDOCYTIC_2 83 86 PF00928 0.433
TRG_ER_diLys_1 94 98 PF00400 0.358

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK67 Leptomonas seymouri 66% 98%
A0A3S7WZQ3 Leishmania donovani 84% 98%
A4I1X7 Leishmania infantum 84% 98%
C9ZS42 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AY23 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 98%
Q4Q9F0 Leishmania major 85% 100%
V5BQ50 Trypanosoma cruzi 42% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS