Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HEP6_LEIBR

TriTrypDb:

LbrM.26.0420 , LBRM2903_260009100

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HEP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.405
CLV_NRD_NRD_1	325	327	PF00675	0.352
CLV_NRD_NRD_1	372	374	PF00675	0.416
CLV_NRD_NRD_1	379	381	PF00675	0.395
CLV_NRD_NRD_1	518	520	PF00675	0.230
CLV_NRD_NRD_1	541	543	PF00675	0.470
CLV_PCSK_KEX2_1	325	327	PF00082	0.352
CLV_PCSK_KEX2_1	371	373	PF00082	0.439
CLV_PCSK_KEX2_1	379	381	PF00082	0.391
CLV_PCSK_KEX2_1	518	520	PF00082	0.317
CLV_PCSK_KEX2_1	541	543	PF00082	0.470
CLV_PCSK_SKI1_1	20	24	PF00082	0.497
CLV_PCSK_SKI1_1	379	383	PF00082	0.558
DEG_APCC_DBOX_1	378	386	PF00400	0.564
DEG_COP1_1	328	335	PF00400	0.473
DEG_Kelch_Keap1_1	315	320	PF01344	0.517
DEG_SPOP_SBC_1	243	247	PF00917	0.665
DOC_CDC14_PxL_1	286	294	PF14671	0.467
DOC_CYCLIN_yCln2_LP_2	285	291	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	61	64	PF00134	0.571
DOC_MAPK_DCC_7	330	340	PF00069	0.376
DOC_MAPK_gen_1	251	259	PF00069	0.520
DOC_PP1_RVXF_1	349	355	PF00149	0.322
DOC_PP2B_LxvP_1	142	145	PF13499	0.515
DOC_PP2B_LxvP_1	15	18	PF13499	0.579
DOC_PP2B_LxvP_1	229	232	PF13499	0.499
DOC_PP2B_LxvP_1	285	288	PF13499	0.372
DOC_PP2B_LxvP_1	61	64	PF13499	0.571
DOC_PP4_FxxP_1	275	278	PF00568	0.401
DOC_USP7_MATH_1	106	110	PF00917	0.718
DOC_USP7_MATH_1	120	124	PF00917	0.562
DOC_USP7_MATH_1	177	181	PF00917	0.399
DOC_USP7_MATH_1	185	189	PF00917	0.670
DOC_USP7_MATH_1	218	222	PF00917	0.527
DOC_USP7_MATH_1	233	237	PF00917	0.528
DOC_USP7_MATH_1	243	247	PF00917	0.616
DOC_USP7_MATH_1	25	29	PF00917	0.446
DOC_USP7_MATH_1	266	270	PF00917	0.555
DOC_USP7_MATH_1	312	316	PF00917	0.767
DOC_USP7_MATH_1	397	401	PF00917	0.440
DOC_USP7_MATH_1	43	47	PF00917	0.359
DOC_WW_Pin1_4	116	121	PF00397	0.580
DOC_WW_Pin1_4	183	188	PF00397	0.625
DOC_WW_Pin1_4	204	209	PF00397	0.785
DOC_WW_Pin1_4	80	85	PF00397	0.499
LIG_14-3-3_CanoR_1	107	115	PF00244	0.716
LIG_14-3-3_CanoR_1	311	317	PF00244	0.768
LIG_14-3-3_CanoR_1	325	333	PF00244	0.354
LIG_14-3-3_CanoR_1	35	42	PF00244	0.379
LIG_14-3-3_CanoR_1	518	526	PF00244	0.457
LIG_14-3-3_CanoR_1	535	541	PF00244	0.511
LIG_14-3-3_CanoR_1	542	547	PF00244	0.494
LIG_14-3-3_CanoR_1	88	92	PF00244	0.494
LIG_BIR_II_1	1	5	PF00653	0.756
LIG_BRCT_BRCA1_1	206	210	PF00533	0.537
LIG_Clathr_ClatBox_1	338	342	PF01394	0.541
LIG_Dynein_DLC8_1	545	551	PF01221	0.376
LIG_EVH1_1	287	291	PF00568	0.460
LIG_FHA_1	232	238	PF00498	0.522
LIG_FHA_1	37	43	PF00498	0.416
LIG_FHA_1	462	468	PF00498	0.430
LIG_FHA_1	486	492	PF00498	0.481
LIG_FHA_1	510	516	PF00498	0.517
LIG_FHA_1	518	524	PF00498	0.517
LIG_FHA_1	67	73	PF00498	0.570
LIG_FHA_2	344	350	PF00498	0.421
LIG_FHA_2	472	478	PF00498	0.517
LIG_FHA_2	520	526	PF00498	0.555
LIG_FHA_2	547	553	PF00498	0.569
LIG_FHA_2	81	87	PF00498	0.444
LIG_Integrin_RGD_1	532	534	PF01839	0.355
LIG_LIR_Gen_1	255	264	PF02991	0.447
LIG_LIR_Gen_1	400	409	PF02991	0.475
LIG_LIR_Gen_1	442	451	PF02991	0.517
LIG_LIR_Gen_1	472	479	PF02991	0.555
LIG_LIR_Gen_1	52	62	PF02991	0.550
LIG_LIR_Gen_1	69	79	PF02991	0.265
LIG_LIR_Nem_3	255	259	PF02991	0.451
LIG_LIR_Nem_3	437	443	PF02991	0.516
LIG_LIR_Nem_3	52	57	PF02991	0.565
LIG_LIR_Nem_3	552	558	PF02991	0.544
LIG_LIR_Nem_3	69	74	PF02991	0.372
LIG_LYPXL_yS_3	555	558	PF13949	0.614
LIG_MAD2	225	233	PF02301	0.374
LIG_Pex14_1	32	36	PF04695	0.471
LIG_Pex14_2	377	381	PF04695	0.405
LIG_SH2_SRC	441	444	PF00017	0.555
LIG_SH2_STAT5	258	261	PF00017	0.393
LIG_SH2_STAT5	26	29	PF00017	0.318
LIG_SH2_STAT5	368	371	PF00017	0.533
LIG_SH2_STAT5	402	405	PF00017	0.471
LIG_SH2_STAT5	473	476	PF00017	0.529
LIG_SH2_STAT5	494	497	PF00017	0.555
LIG_SH3_1	330	336	PF00018	0.387
LIG_SH3_3	285	291	PF00018	0.494
LIG_SH3_3	330	336	PF00018	0.501
LIG_SH3_3	422	428	PF00018	0.517
LIG_SH3_3	484	490	PF00018	0.555
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.561
LIG_SUMO_SIM_anti_2	462	469	PF11976	0.474
LIG_SUMO_SIM_anti_2	499	504	PF11976	0.517
LIG_SUMO_SIM_par_1	462	469	PF11976	0.514
LIG_TRAF2_1	297	300	PF00917	0.719
LIG_TRAF2_1	346	349	PF00917	0.474
LIG_WRC_WIRS_1	158	163	PF05994	0.398
LIG_WRC_WIRS_1	527	532	PF05994	0.606
LIG_WRC_WIRS_1	96	101	PF05994	0.395
LIG_WW_3	104	108	PF00397	0.515
LIG_WW_3	17	21	PF00397	0.563
MOD_CK1_1	109	115	PF00069	0.778
MOD_CK1_1	116	122	PF00069	0.684
MOD_CK1_1	159	165	PF00069	0.503
MOD_CK1_1	242	248	PF00069	0.640
MOD_CK1_1	307	313	PF00069	0.573
MOD_CK1_1	400	406	PF00069	0.346
MOD_CK1_1	469	475	PF00069	0.560
MOD_CK2_1	166	172	PF00069	0.322
MOD_CK2_1	183	189	PF00069	0.507
MOD_CK2_1	314	320	PF00069	0.519
MOD_CK2_1	343	349	PF00069	0.428
MOD_CK2_1	471	477	PF00069	0.527
MOD_CK2_1	519	525	PF00069	0.520
MOD_CK2_1	546	552	PF00069	0.621
MOD_Cter_Amidation	323	326	PF01082	0.412
MOD_GlcNHglycan	116	119	PF01048	0.767
MOD_GlcNHglycan	183	186	PF01048	0.718
MOD_GlcNHglycan	241	244	PF01048	0.713
MOD_GlcNHglycan	248	251	PF01048	0.717
MOD_GlcNHglycan	294	297	PF01048	0.599
MOD_GlcNHglycan	458	461	PF01048	0.278
MOD_GSK3_1	109	116	PF00069	0.747
MOD_GSK3_1	121	128	PF00069	0.538
MOD_GSK3_1	157	164	PF00069	0.630
MOD_GSK3_1	177	184	PF00069	0.360
MOD_GSK3_1	204	211	PF00069	0.772
MOD_GSK3_1	216	223	PF00069	0.512
MOD_GSK3_1	239	246	PF00069	0.671
MOD_GSK3_1	517	524	PF00069	0.511
MOD_GSK3_1	542	549	PF00069	0.607
MOD_N-GLC_1	219	224	PF02516	0.458
MOD_NEK2_1	161	166	PF00069	0.468
MOD_NEK2_1	176	181	PF00069	0.353
MOD_NEK2_1	292	297	PF00069	0.586
MOD_NEK2_1	304	309	PF00069	0.481
MOD_NEK2_1	36	41	PF00069	0.417
MOD_NEK2_1	461	466	PF00069	0.533
MOD_NEK2_1	536	541	PF00069	0.555
MOD_NEK2_1	57	62	PF00069	0.329
MOD_NEK2_1	87	92	PF00069	0.421
MOD_NEK2_2	25	30	PF00069	0.312
MOD_PIKK_1	546	552	PF00454	0.554
MOD_PKA_1	325	331	PF00069	0.343
MOD_PKA_2	106	112	PF00069	0.707
MOD_PKA_2	325	331	PF00069	0.405
MOD_PKA_2	397	403	PF00069	0.494
MOD_PKA_2	517	523	PF00069	0.457
MOD_PKA_2	534	540	PF00069	0.507
MOD_PKA_2	546	552	PF00069	0.496
MOD_PKA_2	87	93	PF00069	0.500
MOD_Plk_1	219	225	PF00069	0.448
MOD_Plk_1	461	467	PF00069	0.474
MOD_Plk_4	233	239	PF00069	0.543
MOD_Plk_4	252	258	PF00069	0.307
MOD_Plk_4	281	287	PF00069	0.333
MOD_Plk_4	397	403	PF00069	0.494
MOD_Plk_4	461	467	PF00069	0.504
MOD_Plk_4	471	477	PF00069	0.535
MOD_Plk_4	57	63	PF00069	0.469
MOD_ProDKin_1	116	122	PF00069	0.573
MOD_ProDKin_1	183	189	PF00069	0.630
MOD_ProDKin_1	204	210	PF00069	0.786
MOD_ProDKin_1	80	86	PF00069	0.501
MOD_SUMO_for_1	297	300	PF00179	0.524
MOD_SUMO_rev_2	343	353	PF00179	0.452
TRG_DiLeu_BaEn_4	299	305	PF01217	0.531
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.509
TRG_ENDOCYTIC_2	402	405	PF00928	0.482
TRG_ENDOCYTIC_2	443	446	PF00928	0.553
TRG_ENDOCYTIC_2	473	476	PF00928	0.555
TRG_ENDOCYTIC_2	555	558	PF00928	0.614
TRG_ER_diArg_1	371	373	PF00400	0.410
TRG_ER_diArg_1	379	381	PF00400	0.320
TRG_ER_diArg_1	405	408	PF00400	0.389
TRG_ER_diArg_1	540	542	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB74	Leptomonas seymouri	51%	100%
A0A3Q8IGV6	Leishmania donovani	73%	100%
A4I1X6	Leishmania infantum	73%	100%
E9AY22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q9F1	Leishmania major	72%	100%
V5BZD6	Trypanosoma cruzi	39%	100%