Regulator of Vps4 activity in the MVB pathway protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of Vps4 activity in the MVB pathway, putative

Species:

Leishmania braziliensis

UniProt:

A4HEP4_LEIBR

TriTrypDb:

LbrM.26.0400 , LBRM2903_260008900

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEP4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.324
CLV_NRD_NRD_1	45	47	PF00675	0.286
CLV_PCSK_KEX2_1	45	47	PF00082	0.297
CLV_PCSK_SKI1_1	2	6	PF00082	0.614
CLV_PCSK_SKI1_1	24	28	PF00082	0.333
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DOC_CKS1_1	238	243	PF01111	0.467
DOC_MAPK_gen_1	142	149	PF00069	0.428
DOC_PP2B_LxvP_1	244	247	PF13499	0.484
DOC_PP4_MxPP_1	249	252	PF00568	0.473
DOC_USP7_MATH_1	120	124	PF00917	0.524
DOC_USP7_MATH_1	215	219	PF00917	0.574
DOC_WW_Pin1_4	237	242	PF00397	0.484
LIG_14-3-3_CanoR_1	24	32	PF00244	0.554
LIG_Actin_WH2_2	134	150	PF00022	0.402
LIG_Actin_WH2_2	87	103	PF00022	0.402
LIG_APCC_ABBA_1	80	85	PF00400	0.457
LIG_BRCT_BRCA1_1	10	14	PF00533	0.569
LIG_Clathr_ClatBox_1	51	55	PF01394	0.560
LIG_eIF4E_1	77	83	PF01652	0.524
LIG_FHA_1	120	126	PF00498	0.461
LIG_FHA_1	25	31	PF00498	0.537
LIG_FHA_2	195	201	PF00498	0.550
LIG_LIR_Apic_2	242	248	PF02991	0.509
LIG_LIR_Gen_1	152	161	PF02991	0.482
LIG_LIR_Gen_1	75	84	PF02991	0.480
LIG_LIR_Nem_3	11	17	PF02991	0.534
LIG_LIR_Nem_3	75	80	PF02991	0.480
LIG_LIR_Nem_3	81	86	PF02991	0.455
LIG_Pex14_2	145	149	PF04695	0.485
LIG_SH2_CRK	176	180	PF00017	0.560
LIG_SH2_NCK_1	176	180	PF00017	0.560
LIG_SH2_NCK_1	253	257	PF00017	0.534
LIG_SH2_PTP2	245	248	PF00017	0.574
LIG_SH2_SRC	176	179	PF00017	0.402
LIG_SH2_SRC	245	248	PF00017	0.574
LIG_SH2_STAT5	144	147	PF00017	0.442
LIG_SH2_STAT5	186	189	PF00017	0.457
LIG_SH2_STAT5	245	248	PF00017	0.574
LIG_SH3_1	245	251	PF00018	0.570
LIG_SH3_3	235	241	PF00018	0.628
LIG_SH3_3	245	251	PF00018	0.570
LIG_SUMO_SIM_par_1	50	55	PF11976	0.560
LIG_UBA3_1	51	56	PF00899	0.457
MOD_CK1_1	237	243	PF00069	0.529
MOD_CK2_1	131	137	PF00069	0.538
MOD_CK2_1	156	162	PF00069	0.517
MOD_GlcNHglycan	10	13	PF01048	0.595
MOD_GlcNHglycan	110	113	PF01048	0.355
MOD_GlcNHglycan	127	130	PF01048	0.244
MOD_GlcNHglycan	212	215	PF01048	0.516
MOD_GlcNHglycan	217	220	PF01048	0.546
MOD_GlcNHglycan	224	227	PF01048	0.572
MOD_GlcNHglycan	241	244	PF01048	0.536
MOD_GlcNHglycan	58	61	PF01048	0.282
MOD_NEK2_1	100	105	PF00069	0.577
MOD_NEK2_1	125	130	PF00069	0.485
MOD_NEK2_1	156	161	PF00069	0.454
MOD_NEK2_1	194	199	PF00069	0.609
MOD_NEK2_1	210	215	PF00069	0.452
MOD_NEK2_1	222	227	PF00069	0.566
MOD_NEK2_1	25	30	PF00069	0.476
MOD_NEK2_1	37	42	PF00069	0.527
MOD_PIKK_1	228	234	PF00454	0.553
MOD_PKA_2	100	106	PF00069	0.465
MOD_PKA_2	19	25	PF00069	0.216
MOD_PKB_1	61	69	PF00069	0.402
MOD_Plk_1	136	142	PF00069	0.442
MOD_Plk_1	161	167	PF00069	0.438
MOD_Plk_4	120	126	PF00069	0.457
MOD_Plk_4	78	84	PF00069	0.486
MOD_ProDKin_1	237	243	PF00069	0.485
MOD_SUMO_rev_2	110	120	PF00179	0.524
MOD_SUMO_rev_2	95	100	PF00179	0.402
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.414
TRG_ENDOCYTIC_2	144	147	PF00928	0.482
TRG_ENDOCYTIC_2	253	256	PF00928	0.593
TRG_ENDOCYTIC_2	77	80	PF00928	0.535
TRG_ER_diArg_1	61	64	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.203

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVR2	Leptomonas seymouri	81%	100%
A0A0S4IPS2	Bodo saltans	45%	100%
A0A1X0P8G8	Trypanosomatidae	56%	100%
A0A3Q8IDL4	Leishmania donovani	89%	100%
A0A422N7B4	Trypanosoma rangeli	57%	99%
A4I1X4	Leishmania infantum	89%	100%
D0A1V0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
E9AY20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P53843	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	89%
P53990	Homo sapiens	32%	73%
Q3ZBV1	Bos taurus	31%	73%
Q4Q9F3	Leishmania major	88%	100%
Q54I39	Dictyostelium discoideum	28%	72%
Q568Z6	Rattus norvegicus	32%	73%
Q5R6G8	Pongo abelii	31%	73%
Q9CX00	Mus musculus	32%	73%
V5DIL5	Trypanosoma cruzi	56%	100%