TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HEP3_LEIBR

TriTrypDb:

LbrM.26.0390 , LBRM2903_260008800

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HEP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEP3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010965	regulation of mitotic sister chromatid separation	6	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0033043	regulation of organelle organization	5	1
GO:0033044	regulation of chromosome organization	6	1
GO:0033045	regulation of sister chromatid segregation	5	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044784	metaphase/anaphase transition of cell cycle	4	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0045840	positive regulation of mitotic nuclear division	7	1
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	1
GO:0045931	positive regulation of mitotic cell cycle	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051301	cell division	2	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051785	positive regulation of nuclear division	7	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901970	positive regulation of mitotic sister chromatid separation	7	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901989	positive regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	1
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	1
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	1
GO:1903047	mitotic cell cycle process	3	1
GO:1905818	regulation of chromosome separation	5	1
GO:1905820	positive regulation of chromosome separation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	464	468	PF00656	0.450
CLV_C14_Caspase3-7	655	659	PF00656	0.317
CLV_NRD_NRD_1	554	556	PF00675	0.470
CLV_PCSK_KEX2_1	521	523	PF00082	0.538
CLV_PCSK_KEX2_1	554	556	PF00082	0.470
CLV_PCSK_KEX2_1	797	799	PF00082	0.388
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.538
CLV_PCSK_PC1ET2_1	797	799	PF00082	0.388
CLV_PCSK_SKI1_1	109	113	PF00082	0.471
CLV_PCSK_SKI1_1	180	184	PF00082	0.438
CLV_PCSK_SKI1_1	352	356	PF00082	0.320
CLV_PCSK_SKI1_1	789	793	PF00082	0.312
CLV_PCSK_SKI1_1	794	798	PF00082	0.312
CLV_PCSK_SKI1_1	83	87	PF00082	0.303
DEG_APCC_DBOX_1	351	359	PF00400	0.320
DEG_SCF_SKP2-CKS1_1	300	307	PF00560	0.484
DOC_CYCLIN_RxL_1	174	186	PF00134	0.564
DOC_CYCLIN_RxL_1	596	605	PF00134	0.455
DOC_CYCLIN_RxL_1	786	795	PF00134	0.312
DOC_CYCLIN_yClb1_LxF_4	81	86	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	766	772	PF00134	0.231
DOC_MAPK_gen_1	174	183	PF00069	0.469
DOC_MAPK_gen_1	267	277	PF00069	0.362
DOC_MAPK_gen_1	521	527	PF00069	0.528
DOC_MAPK_gen_1	554	563	PF00069	0.484
DOC_MAPK_HePTP_8	345	357	PF00069	0.468
DOC_MAPK_HePTP_8	551	563	PF00069	0.526
DOC_MAPK_MEF2A_6	270	279	PF00069	0.382
DOC_MAPK_MEF2A_6	348	357	PF00069	0.465
DOC_MAPK_MEF2A_6	554	563	PF00069	0.640
DOC_MAPK_NFAT4_5	270	278	PF00069	0.293
DOC_PP1_RVXF_1	597	604	PF00149	0.450
DOC_PP1_RVXF_1	81	87	PF00149	0.319
DOC_PP2B_LxvP_1	525	528	PF13499	0.553
DOC_PP2B_LxvP_1	766	769	PF13499	0.388
DOC_PP2B_LxvP_1	834	837	PF13499	0.432
DOC_USP7_MATH_1	249	253	PF00917	0.300
DOC_USP7_MATH_1	310	314	PF00917	0.304
DOC_USP7_MATH_1	330	334	PF00917	0.461
DOC_USP7_MATH_1	371	375	PF00917	0.482
DOC_USP7_MATH_1	486	490	PF00917	0.640
DOC_USP7_MATH_1	582	586	PF00917	0.551
DOC_USP7_MATH_1	656	660	PF00917	0.389
DOC_USP7_MATH_1	66	70	PF00917	0.465
DOC_USP7_MATH_1	778	782	PF00917	0.306
DOC_USP7_MATH_1	809	813	PF00917	0.508
DOC_USP7_UBL2_3	303	307	PF12436	0.466
DOC_WW_Pin1_4	301	306	PF00397	0.753
DOC_WW_Pin1_4	482	487	PF00397	0.640
DOC_WW_Pin1_4	491	496	PF00397	0.641
DOC_WW_Pin1_4	512	517	PF00397	0.751
DOC_WW_Pin1_4	538	543	PF00397	0.583
DOC_WW_Pin1_4	761	766	PF00397	0.280
LIG_14-3-3_CanoR_1	168	176	PF00244	0.310
LIG_14-3-3_CanoR_1	17	27	PF00244	0.371
LIG_14-3-3_CanoR_1	221	229	PF00244	0.421
LIG_14-3-3_CanoR_1	370	379	PF00244	0.397
LIG_14-3-3_CanoR_1	396	406	PF00244	0.580
LIG_14-3-3_CanoR_1	457	465	PF00244	0.602
LIG_14-3-3_CanoR_1	51	55	PF00244	0.495
LIG_14-3-3_CanoR_1	522	528	PF00244	0.586
LIG_14-3-3_CanoR_1	531	537	PF00244	0.601
LIG_14-3-3_CanoR_1	759	766	PF00244	0.264
LIG_14-3-3_CanoR_1	779	784	PF00244	0.330
LIG_14-3-3_CanoR_1	789	794	PF00244	0.302
LIG_Actin_WH2_2	324	342	PF00022	0.338
LIG_Actin_WH2_2	95	111	PF00022	0.297
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BRCT_BRCA1_1	476	480	PF00533	0.504
LIG_eIF4E_1	596	602	PF01652	0.293
LIG_eIF4E_1	678	684	PF01652	0.363
LIG_FHA_1	225	231	PF00498	0.415
LIG_FHA_1	294	300	PF00498	0.461
LIG_FHA_1	340	346	PF00498	0.571
LIG_FHA_1	397	403	PF00498	0.484
LIG_FHA_1	501	507	PF00498	0.541
LIG_FHA_1	515	521	PF00498	0.503
LIG_FHA_1	565	571	PF00498	0.425
LIG_FHA_1	581	587	PF00498	0.626
LIG_FHA_1	60	66	PF00498	0.389
LIG_FHA_1	659	665	PF00498	0.419
LIG_FHA_1	696	702	PF00498	0.406
LIG_FHA_1	7	13	PF00498	0.513
LIG_FHA_1	765	771	PF00498	0.261
LIG_FHA_2	143	149	PF00498	0.366
LIG_FHA_2	170	176	PF00498	0.356
LIG_FHA_2	212	218	PF00498	0.398
LIG_FHA_2	221	227	PF00498	0.474
LIG_FHA_2	701	707	PF00498	0.349
LIG_FHA_2	790	796	PF00498	0.312
LIG_FHA_2	820	826	PF00498	0.459
LIG_GBD_Chelix_1	686	694	PF00786	0.465
LIG_LIR_Apic_2	825	830	PF02991	0.425
LIG_LIR_Gen_1	148	157	PF02991	0.429
LIG_LIR_Gen_1	423	434	PF02991	0.523
LIG_LIR_Gen_1	753	758	PF02991	0.316
LIG_LIR_Gen_1	828	839	PF02991	0.459
LIG_LIR_Nem_3	148	154	PF02991	0.420
LIG_LIR_Nem_3	347	353	PF02991	0.309
LIG_LIR_Nem_3	423	429	PF02991	0.531
LIG_LIR_Nem_3	677	683	PF02991	0.387
LIG_LIR_Nem_3	753	757	PF02991	0.316
LIG_LIR_Nem_3	781	786	PF02991	0.388
LIG_LIR_Nem_3	828	834	PF02991	0.473
LIG_SH2_CRK	350	354	PF00017	0.443
LIG_SH2_CRK	680	684	PF00017	0.430
LIG_SH2_CRK	741	745	PF00017	0.402
LIG_SH2_CRK	754	758	PF00017	0.242
LIG_SH2_GRB2like	44	47	PF00017	0.327
LIG_SH2_GRB2like	596	599	PF00017	0.298
LIG_SH2_NCK_1	799	803	PF00017	0.312
LIG_SH2_NCK_1	827	831	PF00017	0.474
LIG_SH2_SRC	101	104	PF00017	0.394
LIG_SH2_SRC	246	249	PF00017	0.465
LIG_SH2_SRC	44	47	PF00017	0.454
LIG_SH2_SRC	609	612	PF00017	0.457
LIG_SH2_SRC	678	681	PF00017	0.447
LIG_SH2_SRC	747	750	PF00017	0.388
LIG_SH2_SRC	799	802	PF00017	0.312
LIG_SH2_STAP1	246	250	PF00017	0.498
LIG_SH2_STAP1	426	430	PF00017	0.420
LIG_SH2_STAP1	44	48	PF00017	0.339
LIG_SH2_STAP1	609	613	PF00017	0.453
LIG_SH2_STAP1	747	751	PF00017	0.312
LIG_SH2_STAP1	799	803	PF00017	0.312
LIG_SH2_STAT3	640	643	PF00017	0.458
LIG_SH2_STAT5	101	104	PF00017	0.358
LIG_SH2_STAT5	19	22	PF00017	0.364
LIG_SH2_STAT5	206	209	PF00017	0.476
LIG_SH2_STAT5	218	221	PF00017	0.352
LIG_SH2_STAT5	320	323	PF00017	0.368
LIG_SH2_STAT5	426	429	PF00017	0.472
LIG_SH2_STAT5	641	644	PF00017	0.375
LIG_SH2_STAT5	831	834	PF00017	0.394
LIG_SH3_2	492	497	PF14604	0.565
LIG_SH3_3	489	495	PF00018	0.778
LIG_SH3_5	674	678	PF00018	0.303
LIG_SUMO_SIM_anti_2	237	244	PF11976	0.460
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.402
LIG_SUMO_SIM_par_1	410	415	PF11976	0.379
LIG_SUMO_SIM_par_1	503	509	PF11976	0.541
LIG_SUMO_SIM_par_1	611	618	PF11976	0.300
LIG_SUMO_SIM_par_1	767	775	PF11976	0.340
LIG_TRAF2_1	145	148	PF00917	0.394
LIG_TRAF2_1	391	394	PF00917	0.529
LIG_TYR_ITIM	829	834	PF00017	0.472
MOD_CDC14_SPxK_1	494	497	PF00782	0.563
MOD_CDK_SPxK_1	301	307	PF00069	0.637
MOD_CDK_SPxK_1	491	497	PF00069	0.565
MOD_CK1_1	169	175	PF00069	0.297
MOD_CK1_1	2	8	PF00069	0.495
MOD_CK1_1	211	217	PF00069	0.305
MOD_CK1_1	388	394	PF00069	0.661
MOD_CK1_1	397	403	PF00069	0.588
MOD_CK1_1	485	491	PF00069	0.724
MOD_CK1_1	500	506	PF00069	0.718
MOD_CK1_1	512	518	PF00069	0.556
MOD_CK1_1	564	570	PF00069	0.489
MOD_CK1_1	581	587	PF00069	0.491
MOD_CK1_1	695	701	PF00069	0.304
MOD_CK1_1	764	770	PF00069	0.238
MOD_CK1_1	812	818	PF00069	0.567
MOD_CK1_1	820	826	PF00069	0.513
MOD_CK2_1	142	148	PF00069	0.330
MOD_CK2_1	169	175	PF00069	0.297
MOD_CK2_1	211	217	PF00069	0.310
MOD_CK2_1	249	255	PF00069	0.363
MOD_CK2_1	388	394	PF00069	0.639
MOD_CK2_1	458	464	PF00069	0.548
MOD_CK2_1	478	484	PF00069	0.461
MOD_CK2_1	512	518	PF00069	0.585
MOD_CK2_1	538	544	PF00069	0.412
MOD_CK2_1	621	627	PF00069	0.547
MOD_CK2_1	656	662	PF00069	0.396
MOD_CK2_1	700	706	PF00069	0.334
MOD_CK2_1	789	795	PF00069	0.312
MOD_GlcNHglycan	109	112	PF01048	0.383
MOD_GlcNHglycan	328	331	PF01048	0.490
MOD_GlcNHglycan	373	376	PF01048	0.352
MOD_GlcNHglycan	388	391	PF01048	0.704
MOD_GlcNHglycan	480	483	PF01048	0.527
MOD_GlcNHglycan	488	491	PF01048	0.641
MOD_GlcNHglycan	499	502	PF01048	0.558
MOD_GlcNHglycan	511	514	PF01048	0.703
MOD_GlcNHglycan	580	583	PF01048	0.476
MOD_GlcNHglycan	62	65	PF01048	0.422
MOD_GlcNHglycan	694	697	PF01048	0.306
MOD_GlcNHglycan	714	717	PF01048	0.433
MOD_GlcNHglycan	761	764	PF01048	0.241
MOD_GlcNHglycan	813	817	PF01048	0.467
MOD_GlcNHglycan	843	846	PF01048	0.503
MOD_GSK3_1	103	110	PF00069	0.436
MOD_GSK3_1	166	173	PF00069	0.368
MOD_GSK3_1	2	9	PF00069	0.476
MOD_GSK3_1	207	214	PF00069	0.370
MOD_GSK3_1	220	227	PF00069	0.450
MOD_GSK3_1	301	308	PF00069	0.633
MOD_GSK3_1	326	333	PF00069	0.471
MOD_GSK3_1	339	346	PF00069	0.379
MOD_GSK3_1	382	389	PF00069	0.548
MOD_GSK3_1	474	481	PF00069	0.527
MOD_GSK3_1	482	489	PF00069	0.603
MOD_GSK3_1	534	541	PF00069	0.688
MOD_GSK3_1	574	581	PF00069	0.522
MOD_GSK3_1	695	702	PF00069	0.318
MOD_GSK3_1	708	715	PF00069	0.419
MOD_LATS_1	129	135	PF00433	0.299
MOD_N-GLC_2	93	95	PF02516	0.405
MOD_NEK2_1	142	147	PF00069	0.343
MOD_NEK2_1	207	212	PF00069	0.462
MOD_NEK2_1	234	239	PF00069	0.391
MOD_NEK2_1	287	292	PF00069	0.495
MOD_NEK2_1	293	298	PF00069	0.515
MOD_NEK2_1	379	384	PF00069	0.588
MOD_NEK2_1	412	417	PF00069	0.562
MOD_NEK2_1	458	463	PF00069	0.413
MOD_NEK2_1	50	55	PF00069	0.547
MOD_NEK2_1	561	566	PF00069	0.506
MOD_NEK2_1	758	763	PF00069	0.310
MOD_NEK2_1	817	822	PF00069	0.490
MOD_NEK2_1	841	846	PF00069	0.544
MOD_NEK2_2	471	476	PF00069	0.525
MOD_PIKK_1	458	464	PF00454	0.391
MOD_PIKK_1	534	540	PF00454	0.490
MOD_PK_1	131	137	PF00069	0.319
MOD_PKA_2	220	226	PF00069	0.437
MOD_PKA_2	339	345	PF00069	0.360
MOD_PKA_2	379	385	PF00069	0.582
MOD_PKA_2	50	56	PF00069	0.493
MOD_PKA_2	574	580	PF00069	0.482
MOD_PKA_2	758	764	PF00069	0.231
MOD_PKA_2	778	784	PF00069	0.231
MOD_PKB_1	476	484	PF00069	0.530
MOD_Plk_1	66	72	PF00069	0.384
MOD_Plk_4	288	294	PF00069	0.429
MOD_Plk_4	772	778	PF00069	0.249
MOD_ProDKin_1	301	307	PF00069	0.745
MOD_ProDKin_1	482	488	PF00069	0.644
MOD_ProDKin_1	491	497	PF00069	0.642
MOD_ProDKin_1	512	518	PF00069	0.752
MOD_ProDKin_1	538	544	PF00069	0.575
MOD_ProDKin_1	761	767	PF00069	0.280
MOD_SUMO_rev_2	169	179	PF00179	0.382
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.307
TRG_ENDOCYTIC_2	350	353	PF00928	0.445
TRG_ENDOCYTIC_2	426	429	PF00928	0.457
TRG_ENDOCYTIC_2	680	683	PF00928	0.432
TRG_ENDOCYTIC_2	741	744	PF00928	0.312
TRG_ENDOCYTIC_2	754	757	PF00928	0.312
TRG_ENDOCYTIC_2	831	834	PF00928	0.475
TRG_ER_diArg_1	475	478	PF00400	0.534
TRG_ER_diArg_1	553	555	PF00400	0.459
TRG_NES_CRM1_1	410	423	PF08389	0.452
TRG_NLS_MonoExtN_4	174	181	PF00514	0.399
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P507	Leptomonas seymouri	47%	100%
A0A3Q8IDI5	Leishmania donovani	74%	99%
A4I1X3	Leishmania infantum	74%	99%
E9AY19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
Q4Q9F4	Leishmania major	73%	100%