Vps8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps52 / Sac2 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HEP1_LEIBR

TriTrypDb:

LbrM.26.0370 , LBRM2903_260008600

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0000938	GARP complex	3	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4HEP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEP1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006896	Golgi to vacuole transport	5	1
GO:0007034	vacuolar transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0032456	endocytic recycling	5	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.493
CLV_C14_Caspase3-7	212	216	PF00656	0.249
CLV_C14_Caspase3-7	624	628	PF00656	0.578
CLV_C14_Caspase3-7	735	739	PF00656	0.337
CLV_NRD_NRD_1	160	162	PF00675	0.301
CLV_NRD_NRD_1	230	232	PF00675	0.374
CLV_NRD_NRD_1	28	30	PF00675	0.407
CLV_NRD_NRD_1	310	312	PF00675	0.366
CLV_NRD_NRD_1	507	509	PF00675	0.220
CLV_NRD_NRD_1	674	676	PF00675	0.504
CLV_NRD_NRD_1	768	770	PF00675	0.587
CLV_NRD_NRD_1	811	813	PF00675	0.325
CLV_PCSK_KEX2_1	28	30	PF00082	0.524
CLV_PCSK_KEX2_1	380	382	PF00082	0.204
CLV_PCSK_KEX2_1	529	531	PF00082	0.337
CLV_PCSK_KEX2_1	673	675	PF00082	0.510
CLV_PCSK_KEX2_1	768	770	PF00082	0.587
CLV_PCSK_KEX2_1	810	812	PF00082	0.309
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.253
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.337
CLV_PCSK_SKI1_1	152	156	PF00082	0.353
CLV_PCSK_SKI1_1	226	230	PF00082	0.256
CLV_PCSK_SKI1_1	280	284	PF00082	0.573
CLV_PCSK_SKI1_1	37	41	PF00082	0.478
CLV_PCSK_SKI1_1	412	416	PF00082	0.366
CLV_PCSK_SKI1_1	468	472	PF00082	0.366
CLV_PCSK_SKI1_1	560	564	PF00082	0.389
CLV_PCSK_SKI1_1	718	722	PF00082	0.505
DEG_APCC_DBOX_1	151	159	PF00400	0.449
DEG_APCC_DBOX_1	36	44	PF00400	0.405
DEG_APCC_DBOX_1	411	419	PF00400	0.389
DEG_APCC_DBOX_1	444	452	PF00400	0.158
DOC_CDC14_PxL_1	261	269	PF14671	0.472
DOC_CYCLIN_RxL_1	192	203	PF00134	0.347
DOC_MAPK_gen_1	192	201	PF00069	0.226
DOC_MAPK_gen_1	231	238	PF00069	0.256
DOC_MAPK_gen_1	673	679	PF00069	0.355
DOC_MAPK_MEF2A_6	192	201	PF00069	0.356
DOC_MAPK_MEF2A_6	252	260	PF00069	0.353
DOC_MAPK_RevD_3	147	162	PF00069	0.302
DOC_PP1_RVXF_1	114	120	PF00149	0.389
DOC_PP2B_LxvP_1	125	128	PF13499	0.277
DOC_PP2B_LxvP_1	197	200	PF13499	0.305
DOC_PP2B_LxvP_1	236	239	PF13499	0.337
DOC_PP2B_LxvP_1	636	639	PF13499	0.460
DOC_PP4_FxxP_1	389	392	PF00568	0.302
DOC_USP7_MATH_1	102	106	PF00917	0.389
DOC_USP7_MATH_1	170	174	PF00917	0.415
DOC_USP7_MATH_1	175	179	PF00917	0.344
DOC_USP7_MATH_1	475	479	PF00917	0.487
DOC_USP7_MATH_1	538	542	PF00917	0.240
DOC_USP7_MATH_1	603	607	PF00917	0.650
DOC_USP7_MATH_1	658	662	PF00917	0.706
DOC_USP7_MATH_1	732	736	PF00917	0.590
DOC_USP7_MATH_2	602	608	PF00917	0.493
DOC_USP7_UBL2_3	505	509	PF12436	0.305
DOC_USP7_UBL2_3	82	86	PF12436	0.158
DOC_WW_Pin1_4	178	183	PF00397	0.435
DOC_WW_Pin1_4	641	646	PF00397	0.694
LIG_14-3-3_CanoR_1	112	119	PF00244	0.295
LIG_14-3-3_CanoR_1	198	207	PF00244	0.315
LIG_14-3-3_CanoR_1	269	273	PF00244	0.526
LIG_14-3-3_CanoR_1	280	285	PF00244	0.594
LIG_14-3-3_CanoR_1	404	408	PF00244	0.315
LIG_14-3-3_CanoR_1	560	565	PF00244	0.407
LIG_14-3-3_CanoR_1	569	578	PF00244	0.384
LIG_14-3-3_CanoR_1	591	595	PF00244	0.392
LIG_14-3-3_CanoR_1	651	656	PF00244	0.632
LIG_Actin_WH2_2	254	271	PF00022	0.326
LIG_APCC_ABBA_1	204	209	PF00400	0.337
LIG_BIR_II_1	1	5	PF00653	0.371
LIG_BRCT_BRCA1_1	329	333	PF00533	0.389
LIG_Clathr_ClatBox_1	427	431	PF01394	0.337
LIG_CtBP_PxDLS_1	128	132	PF00389	0.305
LIG_eIF4E_1	488	494	PF01652	0.266
LIG_FHA_1	11	17	PF00498	0.515
LIG_FHA_1	112	118	PF00498	0.322
LIG_FHA_1	206	212	PF00498	0.396
LIG_FHA_1	288	294	PF00498	0.318
LIG_FHA_1	326	332	PF00498	0.176
LIG_FHA_1	549	555	PF00498	0.261
LIG_FHA_1	789	795	PF00498	0.384
LIG_FHA_2	102	108	PF00498	0.301
LIG_FHA_2	148	154	PF00498	0.389
LIG_FHA_2	191	197	PF00498	0.255
LIG_FHA_2	513	519	PF00498	0.403
LIG_FHA_2	69	75	PF00498	0.393
LIG_FHA_2	76	82	PF00498	0.392
LIG_LIR_Apic_2	353	359	PF02991	0.304
LIG_LIR_Apic_2	388	392	PF02991	0.208
LIG_LIR_Apic_2	661	667	PF02991	0.575
LIG_LIR_Gen_1	205	214	PF02991	0.439
LIG_LIR_Gen_1	218	228	PF02991	0.307
LIG_LIR_Gen_1	343	352	PF02991	0.371
LIG_LIR_Gen_1	429	434	PF02991	0.248
LIG_LIR_Gen_1	437	448	PF02991	0.266
LIG_LIR_Gen_1	514	524	PF02991	0.272
LIG_LIR_Gen_1	648	655	PF02991	0.503
LIG_LIR_Gen_1	703	712	PF02991	0.310
LIG_LIR_Gen_1	778	786	PF02991	0.342
LIG_LIR_Gen_1	804	809	PF02991	0.477
LIG_LIR_LC3C_4	123	127	PF02991	0.337
LIG_LIR_Nem_3	202	207	PF02991	0.307
LIG_LIR_Nem_3	218	223	PF02991	0.283
LIG_LIR_Nem_3	330	336	PF02991	0.349
LIG_LIR_Nem_3	343	347	PF02991	0.337
LIG_LIR_Nem_3	429	433	PF02991	0.244
LIG_LIR_Nem_3	437	443	PF02991	0.259
LIG_LIR_Nem_3	485	491	PF02991	0.273
LIG_LIR_Nem_3	499	503	PF02991	0.248
LIG_LIR_Nem_3	514	520	PF02991	0.205
LIG_LIR_Nem_3	648	652	PF02991	0.510
LIG_LIR_Nem_3	703	707	PF02991	0.318
LIG_LIR_Nem_3	778	782	PF02991	0.318
LIG_LIR_Nem_3	784	789	PF02991	0.310
LIG_LIR_Nem_3	799	805	PF02991	0.410
LIG_MYND_1	391	395	PF01753	0.277
LIG_NRBOX	150	156	PF00104	0.344
LIG_NRBOX	519	525	PF00104	0.259
LIG_NRBOX	793	799	PF00104	0.392
LIG_NRP_CendR_1	812	815	PF00754	0.338
LIG_PCNA_yPIPBox_3	148	162	PF02747	0.389
LIG_Pex14_2	385	389	PF04695	0.389
LIG_Pex14_2	428	432	PF04695	0.251
LIG_Pex14_2	47	51	PF04695	0.384
LIG_Pex14_2	528	532	PF04695	0.302
LIG_PTB_Apo_2	698	705	PF02174	0.404
LIG_SH2_CRK	301	305	PF00017	0.287
LIG_SH2_CRK	356	360	PF00017	0.389
LIG_SH2_CRK	488	492	PF00017	0.270
LIG_SH2_CRK	571	575	PF00017	0.389
LIG_SH2_CRK	649	653	PF00017	0.456
LIG_SH2_GRB2like	157	160	PF00017	0.414
LIG_SH2_NCK_1	356	360	PF00017	0.389
LIG_SH2_PTP2	440	443	PF00017	0.215
LIG_SH2_SRC	440	443	PF00017	0.277
LIG_SH2_STAP1	207	211	PF00017	0.305
LIG_SH2_STAP1	407	411	PF00017	0.244
LIG_SH2_STAP1	712	716	PF00017	0.436
LIG_SH2_STAT5	157	160	PF00017	0.382
LIG_SH2_STAT5	207	210	PF00017	0.357
LIG_SH2_STAT5	301	304	PF00017	0.300
LIG_SH2_STAT5	309	312	PF00017	0.308
LIG_SH2_STAT5	316	319	PF00017	0.321
LIG_SH2_STAT5	356	359	PF00017	0.327
LIG_SH2_STAT5	360	363	PF00017	0.331
LIG_SH2_STAT5	426	429	PF00017	0.417
LIG_SH2_STAT5	440	443	PF00017	0.308
LIG_SH2_STAT5	454	457	PF00017	0.224
LIG_SH2_STAT5	571	574	PF00017	0.305
LIG_SH2_STAT5	746	749	PF00017	0.348
LIG_SH2_STAT5	801	804	PF00017	0.293
LIG_SH3_1	346	352	PF00018	0.389
LIG_SH3_3	123	129	PF00018	0.326
LIG_SH3_3	169	175	PF00018	0.277
LIG_SH3_3	346	352	PF00018	0.389
LIG_SH3_3	389	395	PF00018	0.241
LIG_SH3_3	440	446	PF00018	0.259
LIG_SH3_5	645	649	PF00018	0.449
LIG_SUMO_SIM_anti_2	208	216	PF11976	0.302
LIG_SUMO_SIM_anti_2	518	525	PF11976	0.259
LIG_SUMO_SIM_anti_2	68	75	PF11976	0.409
LIG_SUMO_SIM_par_1	12	19	PF11976	0.527
LIG_SUMO_SIM_par_1	208	216	PF11976	0.249
LIG_SUMO_SIM_par_1	535	541	PF11976	0.182
LIG_TRAF2_1	406	409	PF00917	0.337
LIG_TRAF2_1	663	666	PF00917	0.426
LIG_TRAF2_1	764	767	PF00917	0.452
LIG_UBA3_1	154	162	PF00899	0.316
LIG_UBA3_1	304	312	PF00899	0.368
LIG_UBA3_1	393	399	PF00899	0.389
LIG_UBA3_1	520	529	PF00899	0.337
LIG_WRC_WIRS_1	341	346	PF05994	0.158
LIG_WRC_WIRS_1	427	432	PF05994	0.244
LIG_WRC_WIRS_1	48	53	PF05994	0.421
LIG_WRC_WIRS_1	513	518	PF05994	0.439
MOD_CDK_SPK_2	180	185	PF00069	0.147
MOD_CDK_SPxxK_3	178	185	PF00069	0.305
MOD_CK1_1	178	184	PF00069	0.439
MOD_CK1_1	326	332	PF00069	0.326
MOD_CK1_1	335	341	PF00069	0.333
MOD_CK1_1	606	612	PF00069	0.616
MOD_CK1_1	614	620	PF00069	0.594
MOD_CK2_1	101	107	PF00069	0.277
MOD_CK2_1	147	153	PF00069	0.304
MOD_CK2_1	16	22	PF00069	0.485
MOD_CK2_1	190	196	PF00069	0.256
MOD_CK2_1	403	409	PF00069	0.352
MOD_CK2_1	553	559	PF00069	0.342
MOD_CK2_1	62	68	PF00069	0.389
MOD_CK2_1	75	81	PF00069	0.402
MOD_Cter_Amidation	378	381	PF01082	0.204
MOD_GlcNHglycan	177	180	PF01048	0.356
MOD_GlcNHglycan	262	265	PF01048	0.378
MOD_GlcNHglycan	463	466	PF01048	0.502
MOD_GlcNHglycan	540	543	PF01048	0.170
MOD_GlcNHglycan	544	547	PF01048	0.168
MOD_GlcNHglycan	617	620	PF01048	0.737
MOD_GlcNHglycan	632	635	PF01048	0.677
MOD_GlcNHglycan	725	728	PF01048	0.628
MOD_GlcNHglycan	734	737	PF01048	0.462
MOD_GlcNHglycan	756	759	PF01048	0.339
MOD_GSK3_1	10	17	PF00069	0.537
MOD_GSK3_1	205	212	PF00069	0.249
MOD_GSK3_1	234	241	PF00069	0.337
MOD_GSK3_1	276	283	PF00069	0.619
MOD_GSK3_1	323	330	PF00069	0.306
MOD_GSK3_1	332	339	PF00069	0.314
MOD_GSK3_1	403	410	PF00069	0.335
MOD_GSK3_1	416	423	PF00069	0.359
MOD_GSK3_1	512	519	PF00069	0.443
MOD_GSK3_1	524	531	PF00069	0.399
MOD_GSK3_1	538	545	PF00069	0.413
MOD_GSK3_1	58	65	PF00069	0.389
MOD_GSK3_1	603	610	PF00069	0.667
MOD_GSK3_1	611	618	PF00069	0.639
MOD_GSK3_1	719	726	PF00069	0.413
MOD_GSK3_1	777	784	PF00069	0.485
MOD_GSK3_1	97	104	PF00069	0.316
MOD_N-GLC_1	185	190	PF02516	0.167
MOD_N-GLC_1	569	574	PF02516	0.383
MOD_N-GLC_2	242	244	PF02516	0.389
MOD_NEK2_1	1	6	PF00069	0.364
MOD_NEK2_1	101	106	PF00069	0.325
MOD_NEK2_1	118	123	PF00069	0.231
MOD_NEK2_1	147	152	PF00069	0.298
MOD_NEK2_1	16	21	PF00069	0.532
MOD_NEK2_1	260	265	PF00069	0.287
MOD_NEK2_1	268	273	PF00069	0.427
MOD_NEK2_1	303	308	PF00069	0.402
MOD_NEK2_1	323	328	PF00069	0.184
MOD_NEK2_1	340	345	PF00069	0.266
MOD_NEK2_1	385	390	PF00069	0.158
MOD_NEK2_1	460	465	PF00069	0.389
MOD_NEK2_1	47	52	PF00069	0.428
MOD_NEK2_1	516	521	PF00069	0.244
MOD_NEK2_1	62	67	PF00069	0.277
MOD_NEK2_1	754	759	PF00069	0.354
MOD_NEK2_1	777	782	PF00069	0.425
MOD_NEK2_1	785	790	PF00069	0.344
MOD_NEK2_2	360	365	PF00069	0.158
MOD_NEK2_2	407	412	PF00069	0.244
MOD_NEK2_2	435	440	PF00069	0.244
MOD_NEK2_2	503	508	PF00069	0.379
MOD_NEK2_2	512	517	PF00069	0.403
MOD_NEK2_2	58	63	PF00069	0.324
MOD_PIKK_1	1	7	PF00454	0.358
MOD_PIKK_1	133	139	PF00454	0.277
MOD_PIKK_1	688	694	PF00454	0.535
MOD_PIKK_1	727	733	PF00454	0.557
MOD_PIKK_1	777	783	PF00454	0.371
MOD_PKA_1	161	167	PF00069	0.393
MOD_PKA_1	768	774	PF00069	0.440
MOD_PKA_2	111	117	PF00069	0.345
MOD_PKA_2	268	274	PF00069	0.559
MOD_PKA_2	287	293	PF00069	0.399
MOD_PKA_2	403	409	PF00069	0.207
MOD_PKA_2	444	450	PF00069	0.158
MOD_PKA_2	590	596	PF00069	0.450
MOD_PKA_2	607	613	PF00069	0.692
MOD_PKA_2	768	774	PF00069	0.578
MOD_PKA_2	97	103	PF00069	0.408
MOD_Plk_1	202	208	PF00069	0.357
MOD_Plk_1	247	253	PF00069	0.344
MOD_Plk_1	407	413	PF00069	0.244
MOD_Plk_1	435	441	PF00069	0.244
MOD_Plk_1	569	575	PF00069	0.389
MOD_Plk_1	777	783	PF00069	0.435
MOD_Plk_2-3	10	16	PF00069	0.584
MOD_Plk_2-3	209	215	PF00069	0.249
MOD_Plk_2-3	68	74	PF00069	0.305
MOD_Plk_2-3	75	81	PF00069	0.242
MOD_Plk_4	16	22	PF00069	0.582
MOD_Plk_4	209	215	PF00069	0.357
MOD_Plk_4	280	286	PF00069	0.507
MOD_Plk_4	304	310	PF00069	0.386
MOD_Plk_4	336	342	PF00069	0.314
MOD_Plk_4	435	441	PF00069	0.240
MOD_Plk_4	47	53	PF00069	0.452
MOD_Plk_4	512	518	PF00069	0.270
MOD_Plk_4	68	74	PF00069	0.409
MOD_Plk_4	75	81	PF00069	0.365
MOD_Plk_4	804	810	PF00069	0.373
MOD_ProDKin_1	178	184	PF00069	0.435
MOD_ProDKin_1	641	647	PF00069	0.693
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.342
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.344
TRG_DiLeu_BaLyEn_6	789	794	PF01217	0.504
TRG_ENDOCYTIC_2	207	210	PF00928	0.337
TRG_ENDOCYTIC_2	294	297	PF00928	0.254
TRG_ENDOCYTIC_2	301	304	PF00928	0.283
TRG_ENDOCYTIC_2	440	443	PF00928	0.376
TRG_ENDOCYTIC_2	488	491	PF00928	0.270
TRG_ENDOCYTIC_2	571	574	PF00928	0.253
TRG_ENDOCYTIC_2	649	652	PF00928	0.458
TRG_ENDOCYTIC_2	803	806	PF00928	0.466
TRG_ER_diArg_1	672	675	PF00400	0.511
TRG_ER_diArg_1	789	792	PF00400	0.466
TRG_ER_diArg_1	809	812	PF00400	0.270
TRG_NES_CRM1_1	142	153	PF08389	0.389
TRG_NES_CRM1_1	196	209	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	792	796	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E7	Leptomonas seymouri	63%	87%
A0A0S4JNN4	Bodo saltans	31%	67%
A0A1X0NSI1	Trypanosomatidae	37%	89%
A0A3S5H7F6	Leishmania donovani	81%	89%
A0A422NVH8	Trypanosoma rangeli	40%	97%
A4I1X1	Leishmania infantum	81%	89%
C9ZS49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	91%
E9AY17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	88%
P39904	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	20%	100%
Q4Q9F6	Leishmania major	80%	100%
V5BUK9	Trypanosoma cruzi	37%	97%