LeishMANIAdb
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Putative mitotic cyclin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitotic cyclin
Gene product:
mitotic cyclin, putative
Species:
Leishmania braziliensis
UniProt:
A4HEP0_LEIBR
TriTrypDb:
LbrM.26.0360 , LBRM2903_260008400 *
Length:
438

Annotations

LeishMANIAdb annotations

Cyclin protein, certainly non-TM

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0000307 cyclin-dependent protein kinase holoenzyme complex 7 1
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 1
GO:1902494 catalytic complex 2 1
GO:1902554 serine/threonine protein kinase complex 6 1
GO:1902911 protein kinase complex 5 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A4HEP0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEP0

Function

Biological processes
Term Name Level Count
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6 1
GO:0001932 regulation of protein phosphorylation 7 1
GO:0009987 cellular process 1 1
GO:0019220 regulation of phosphate metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0022402 cell cycle process 2 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031399 regulation of protein modification process 6 1
GO:0042325 regulation of phosphorylation 7 1
GO:0043549 regulation of kinase activity 5 1
GO:0044770 cell cycle phase transition 3 1
GO:0044772 mitotic cell cycle phase transition 4 1
GO:0045859 regulation of protein kinase activity 6 1
GO:0050789 regulation of biological process 2 1
GO:0050790 regulation of catalytic activity 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051174 regulation of phosphorus metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051338 regulation of transferase activity 4 1
GO:0051726 regulation of cell cycle 4 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0071900 regulation of protein serine/threonine kinase activity 7 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903047 mitotic cell cycle process 3 1
GO:1904029 regulation of cyclin-dependent protein kinase activity 5 1
Molecular functions
Term Name Level Count
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5 1
GO:0019207 kinase regulator activity 3 1
GO:0019887 protein kinase regulator activity 4 1
GO:0030234 enzyme regulator activity 2 1
GO:0098772 molecular function regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 151 155 PF00656 0.517
CLV_MEL_PAP_1 166 172 PF00089 0.550
CLV_NRD_NRD_1 248 250 PF00675 0.454
CLV_NRD_NRD_1 77 79 PF00675 0.533
CLV_NRD_NRD_1 90 92 PF00675 0.341
CLV_PCSK_KEX2_1 248 250 PF00082 0.422
CLV_PCSK_KEX2_1 90 92 PF00082 0.428
CLV_PCSK_PC7_1 244 250 PF00082 0.456
CLV_PCSK_SKI1_1 109 113 PF00082 0.476
CLV_PCSK_SKI1_1 370 374 PF00082 0.594
CLV_PCSK_SKI1_1 381 385 PF00082 0.426
CLV_PCSK_SKI1_1 39 43 PF00082 0.467
CLV_PCSK_SKI1_1 49 53 PF00082 0.431
CLV_PCSK_SKI1_1 6 10 PF00082 0.617
CLV_Separin_Metazoa 299 303 PF03568 0.266
DEG_APCC_DBOX_1 380 388 PF00400 0.498
DEG_Nend_UBRbox_2 1 3 PF02207 0.480
DOC_AGCK_PIF_1 170 175 PF00069 0.593
DOC_CYCLIN_RxL_1 299 308 PF00134 0.383
DOC_CYCLIN_yCln2_LP_2 116 122 PF00134 0.517
DOC_MAPK_DCC_7 6 14 PF00069 0.571
DOC_MAPK_FxFP_2 50 53 PF00069 0.516
DOC_MAPK_gen_1 212 221 PF00069 0.476
DOC_MAPK_gen_1 90 96 PF00069 0.515
DOC_PP1_RVXF_1 300 307 PF00149 0.383
DOC_PP1_RVXF_1 8 15 PF00149 0.596
DOC_PP4_FxxP_1 50 53 PF00568 0.516
DOC_USP7_MATH_1 152 156 PF00917 0.435
DOC_USP7_MATH_1 194 198 PF00917 0.612
DOC_USP7_MATH_1 247 251 PF00917 0.449
DOC_USP7_MATH_1 361 365 PF00917 0.478
DOC_USP7_MATH_1 376 380 PF00917 0.509
DOC_USP7_UBL2_3 6 10 PF12436 0.550
DOC_WW_Pin1_4 248 253 PF00397 0.493
DOC_WW_Pin1_4 326 331 PF00397 0.531
DOC_WW_Pin1_4 396 401 PF00397 0.552
LIG_14-3-3_CanoR_1 193 199 PF00244 0.594
LIG_14-3-3_CanoR_1 248 252 PF00244 0.428
LIG_14-3-3_CanoR_1 257 262 PF00244 0.378
LIG_14-3-3_CanoR_1 39 47 PF00244 0.458
LIG_14-3-3_CanoR_1 413 419 PF00244 0.548
LIG_14-3-3_CanoR_1 431 435 PF00244 0.488
LIG_14-3-3_CanoR_1 78 87 PF00244 0.484
LIG_Actin_WH2_2 149 165 PF00022 0.523
LIG_APCC_ABBA_1 320 325 PF00400 0.505
LIG_APCC_Cbox_1 243 249 PF00515 0.480
LIG_APCC_Cbox_2 243 249 PF00515 0.408
LIG_Clathr_ClatBox_1 187 191 PF01394 0.500
LIG_deltaCOP1_diTrp_1 138 143 PF00928 0.321
LIG_deltaCOP1_diTrp_1 271 281 PF00928 0.447
LIG_DLG_GKlike_1 257 264 PF00625 0.447
LIG_EH1_1 258 266 PF00400 0.447
LIG_eIF4E_1 259 265 PF01652 0.480
LIG_FHA_1 11 17 PF00498 0.466
LIG_FHA_1 419 425 PF00498 0.519
LIG_FHA_2 100 106 PF00498 0.430
LIG_FHA_2 119 125 PF00498 0.301
LIG_FHA_2 180 186 PF00498 0.464
LIG_FHA_2 2 8 PF00498 0.453
LIG_FHA_2 249 255 PF00498 0.449
LIG_LIR_Apic_2 48 53 PF02991 0.531
LIG_LIR_Gen_1 233 242 PF02991 0.342
LIG_LIR_Gen_1 278 289 PF02991 0.449
LIG_LIR_Nem_3 13 17 PF02991 0.470
LIG_LIR_Nem_3 174 178 PF02991 0.483
LIG_LIR_Nem_3 223 228 PF02991 0.353
LIG_LIR_Nem_3 233 239 PF02991 0.292
LIG_LIR_Nem_3 271 277 PF02991 0.430
LIG_LIR_Nem_3 278 284 PF02991 0.443
LIG_LIR_Nem_3 347 352 PF02991 0.419
LIG_LYPXL_yS_3 180 183 PF13949 0.504
LIG_MYND_1 275 279 PF01753 0.447
LIG_PCNA_PIPBox_1 18 27 PF02747 0.526
LIG_PCNA_PIPBox_1 332 341 PF02747 0.479
LIG_SH2_NCK_1 259 263 PF00017 0.474
LIG_SH2_NCK_1 408 412 PF00017 0.504
LIG_SH2_SRC 338 341 PF00017 0.458
LIG_SH2_STAP1 259 263 PF00017 0.432
LIG_SH2_STAT3 348 351 PF00017 0.495
LIG_SH2_STAT5 235 238 PF00017 0.392
LIG_SH2_STAT5 338 341 PF00017 0.347
LIG_SH2_STAT5 40 43 PF00017 0.516
LIG_SH3_3 175 181 PF00018 0.524
LIG_SH3_3 196 202 PF00018 0.568
LIG_SH3_3 324 330 PF00018 0.516
LIG_SH3_3 379 385 PF00018 0.473
LIG_SH3_3 420 426 PF00018 0.517
LIG_SUMO_SIM_anti_2 108 114 PF11976 0.369
LIG_SUMO_SIM_anti_2 99 105 PF11976 0.528
LIG_SUMO_SIM_par_1 228 233 PF11976 0.411
LIG_SUMO_SIM_par_1 81 89 PF11976 0.496
LIG_SxIP_EBH_1 413 425 PF03271 0.327
LIG_TRAF2_1 252 255 PF00917 0.454
LIG_TRAF2_1 295 298 PF00917 0.447
LIG_TYR_ITIM 178 183 PF00017 0.308
LIG_UBA3_1 103 109 PF00899 0.518
MOD_CDK_SPK_2 248 253 PF00069 0.480
MOD_CK1_1 207 213 PF00069 0.356
MOD_CK1_1 273 279 PF00069 0.480
MOD_CK1_1 344 350 PF00069 0.457
MOD_CK1_1 429 435 PF00069 0.615
MOD_CK2_1 1 7 PF00069 0.620
MOD_CK2_1 118 124 PF00069 0.379
MOD_CK2_1 248 254 PF00069 0.430
MOD_CK2_1 99 105 PF00069 0.414
MOD_GlcNHglycan 206 209 PF01048 0.505
MOD_GlcNHglycan 434 437 PF01048 0.684
MOD_GSK3_1 30 37 PF00069 0.496
MOD_GSK3_1 305 312 PF00069 0.513
MOD_GSK3_1 370 377 PF00069 0.549
MOD_GSK3_1 392 399 PF00069 0.544
MOD_GSK3_1 414 421 PF00069 0.517
MOD_GSK3_1 426 433 PF00069 0.608
MOD_GSK3_1 70 77 PF00069 0.620
MOD_NEK2_1 1 6 PF00069 0.475
MOD_NEK2_1 204 209 PF00069 0.500
MOD_NEK2_1 220 225 PF00069 0.340
MOD_NEK2_1 265 270 PF00069 0.376
MOD_NEK2_1 339 344 PF00069 0.457
MOD_NEK2_1 362 367 PF00069 0.490
MOD_NEK2_2 309 314 PF00069 0.379
MOD_NEK2_2 341 346 PF00069 0.462
MOD_NEK2_2 376 381 PF00069 0.428
MOD_NEK2_2 426 431 PF00069 0.560
MOD_PIKK_1 1 7 PF00454 0.549
MOD_PKA_1 78 84 PF00069 0.523
MOD_PKA_2 247 253 PF00069 0.411
MOD_PKA_2 352 358 PF00069 0.447
MOD_PKA_2 430 436 PF00069 0.639
MOD_PKB_1 72 80 PF00069 0.602
MOD_Plk_1 270 276 PF00069 0.447
MOD_Plk_1 99 105 PF00069 0.495
MOD_Plk_4 179 185 PF00069 0.470
MOD_Plk_4 194 200 PF00069 0.535
MOD_Plk_4 344 350 PF00069 0.463
MOD_Plk_4 414 420 PF00069 0.329
MOD_Plk_4 99 105 PF00069 0.514
MOD_ProDKin_1 248 254 PF00069 0.493
MOD_ProDKin_1 326 332 PF00069 0.523
MOD_ProDKin_1 396 402 PF00069 0.547
MOD_SUMO_for_1 252 255 PF00179 0.337
MOD_SUMO_rev_2 28 37 PF00179 0.391
TRG_DiLeu_BaEn_1 108 113 PF01217 0.264
TRG_DiLeu_BaEn_1 331 336 PF01217 0.503
TRG_DiLeu_LyEn_5 331 336 PF01217 0.405
TRG_ENDOCYTIC_2 180 183 PF00928 0.414
TRG_ER_diArg_1 211 214 PF00400 0.526
TRG_Pf-PMV_PEXEL_1 126 131 PF00026 0.566
TRG_Pf-PMV_PEXEL_1 15 19 PF00026 0.536
TRG_Pf-PMV_PEXEL_1 27 31 PF00026 0.524
TRG_Pf-PMV_PEXEL_1 302 307 PF00026 0.383
TRG_Pf-PMV_PEXEL_1 64 68 PF00026 0.505
TRG_Pf-PMV_PEXEL_1 78 82 PF00026 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q6 Leptomonas seymouri 79% 88%
A0A0S4JSJ6 Bodo saltans 24% 88%
A0A3Q8ICR6 Leishmania donovani 91% 98%
A0A422NVH3 Trypanosoma rangeli 33% 94%
A4I1W9 Leishmania infantum 91% 98%
C9ZS50 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 93%
E9AY15 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 98%
Q4Q9F8 Leishmania major 90% 100%
V5BQ13 Trypanosoma cruzi 32% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS