Cleavage and polyadenylation specificity factor subunit 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleotide hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HEN7_LEIBR

TriTrypDb:

LbrM.26.0320 , LBRM2903_260008000

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005849	mRNA cleavage factor complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	11
GO:0140513	nuclear protein-containing complex	2	11

Expansion

Sequence features

A4HEN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEN7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006378	mRNA polyadenylation	7	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0031123	RNA 3'-end processing	7	11
GO:0031124	mRNA 3'-end processing	8	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043631	RNA polyadenylation	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003729	mRNA binding	5	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.276
CLV_NRD_NRD_1	131	133	PF00675	0.206
CLV_NRD_NRD_1	31	33	PF00675	0.562
CLV_PCSK_FUR_1	119	123	PF00082	0.332
CLV_PCSK_KEX2_1	121	123	PF00082	0.332
CLV_PCSK_KEX2_1	58	60	PF00082	0.333
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.333
CLV_PCSK_SKI1_1	136	140	PF00082	0.247
DOC_CDC14_PxL_1	252	260	PF14671	0.444
DOC_CYCLIN_RxL_1	132	141	PF00134	0.518
DOC_MAPK_gen_1	208	218	PF00069	0.504
DOC_MAPK_gen_1	57	66	PF00069	0.375
DOC_MAPK_RevD_3	18	33	PF00069	0.462
DOC_USP7_MATH_1	146	150	PF00917	0.514
DOC_USP7_MATH_1	203	207	PF00917	0.508
DOC_WW_Pin1_4	141	146	PF00397	0.550
DOC_WW_Pin1_4	188	193	PF00397	0.518
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BIR_III_4	95	99	PF00653	0.555
LIG_BRCT_MDC1_1	267	271	PF00533	0.583
LIG_Clathr_ClatBox_1	215	219	PF01394	0.532
LIG_FHA_1	210	216	PF00498	0.444
LIG_FHA_2	157	163	PF00498	0.473
LIG_LIR_Apic_2	110	116	PF02991	0.468
LIG_LIR_Apic_2	183	188	PF02991	0.485
LIG_LIR_Gen_1	221	231	PF02991	0.532
LIG_LIR_Nem_3	221	227	PF02991	0.532
LIG_LIR_Nem_3	245	251	PF02991	0.465
LIG_LYPXL_S_1	194	198	PF13949	0.252
LIG_LYPXL_yS_3	195	198	PF13949	0.452
LIG_REV1ctd_RIR_1	173	181	PF16727	0.462
LIG_SH2_CRK	113	117	PF00017	0.504
LIG_SH2_CRK	248	252	PF00017	0.452
LIG_SH2_GRB2like	223	226	PF00017	0.481
LIG_SH2_GRB2like	242	245	PF00017	0.440
LIG_SH2_NCK_1	15	19	PF00017	0.332
LIG_SH2_SRC	197	200	PF00017	0.452
LIG_SH2_SRC	242	245	PF00017	0.504
LIG_SH2_STAT5	15	18	PF00017	0.422
LIG_SH2_STAT5	197	200	PF00017	0.441
LIG_SH2_STAT5	214	217	PF00017	0.535
LIG_SH2_STAT5	223	226	PF00017	0.459
LIG_SH2_STAT5	266	269	PF00017	0.494
LIG_SH3_3	193	199	PF00018	0.444
LIG_SH3_3	231	237	PF00018	0.532
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.555
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.443
LIG_SUMO_SIM_par_1	253	260	PF11976	0.516
LIG_UBA3_1	53	58	PF00899	0.483
MOD_CK2_1	203	209	PF00069	0.530
MOD_Cter_Amidation	30	33	PF01082	0.489
MOD_GlcNHglycan	29	32	PF01048	0.609
MOD_GlcNHglycan	40	43	PF01048	0.674
MOD_GSK3_1	16	23	PF00069	0.596
MOD_GSK3_1	98	105	PF00069	0.500
MOD_N-GLC_1	13	18	PF02516	0.506
MOD_N-GLC_1	167	172	PF02516	0.282
MOD_N-GLC_1	243	248	PF02516	0.305
MOD_N-GLC_2	265	267	PF02516	0.355
MOD_NEK2_2	203	208	PF00069	0.532
MOD_PIKK_1	13	19	PF00454	0.541
MOD_Plk_4	156	162	PF00069	0.483
MOD_Plk_4	181	187	PF00069	0.518
MOD_Plk_4	218	224	PF00069	0.512
MOD_ProDKin_1	141	147	PF00069	0.550
MOD_ProDKin_1	188	194	PF00069	0.518
TRG_DiLeu_BaEn_1	126	131	PF01217	0.466
TRG_DiLeu_BaEn_1	229	234	PF01217	0.555
TRG_DiLeu_BaEn_1	70	75	PF01217	0.466
TRG_DiLeu_BaEn_4	126	132	PF01217	0.483
TRG_ENDOCYTIC_2	195	198	PF00928	0.452
TRG_ENDOCYTIC_2	223	226	PF00928	0.504
TRG_ENDOCYTIC_2	248	251	PF00928	0.452
TRG_ER_diArg_1	119	122	PF00400	0.532
TRG_ER_diArg_1	44	47	PF00400	0.405
TRG_ER_diArg_1	91	94	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I415	Leptomonas seymouri	76%	100%
A0A0S4IS07	Bodo saltans	40%	94%
A0A1X0NU79	Trypanosomatidae	51%	93%
A0A3R7NXV8	Trypanosoma rangeli	52%	92%
A0A3S7WZJ5	Leishmania donovani	86%	100%
A4I1W6	Leishmania infantum	86%	100%
C9ZS54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	90%
E9AY11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O43809	Homo sapiens	31%	100%
Q3ZCA2	Bos taurus	31%	100%
Q4KM65	Rattus norvegicus	31%	100%
Q4Q9G2	Leishmania major	87%	100%
Q55E68	Dictyostelium discoideum	32%	100%
Q5RAI8	Pongo abelii	31%	100%
Q6DJE4	Xenopus laevis	31%	100%
Q7T3C6	Danio rerio	31%	100%
Q8GXS3	Arabidopsis thaliana	30%	100%
Q94AF0	Arabidopsis thaliana	32%	100%
Q9CQF3	Mus musculus	31%	100%