TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEN5_LEIBR

TriTrypDb:

LbrM.26.0290 , LBRM2903_260007700

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.516
CLV_NRD_NRD_1	173	175	PF00675	0.517
CLV_NRD_NRD_1	346	348	PF00675	0.372
CLV_NRD_NRD_1	38	40	PF00675	0.390
CLV_NRD_NRD_1	403	405	PF00675	0.491
CLV_NRD_NRD_1	488	490	PF00675	0.494
CLV_NRD_NRD_1	529	531	PF00675	0.396
CLV_PCSK_FUR_1	401	405	PF00082	0.513
CLV_PCSK_KEX2_1	136	138	PF00082	0.575
CLV_PCSK_KEX2_1	145	147	PF00082	0.511
CLV_PCSK_KEX2_1	173	175	PF00082	0.527
CLV_PCSK_KEX2_1	38	40	PF00082	0.522
CLV_PCSK_KEX2_1	403	405	PF00082	0.456
CLV_PCSK_KEX2_1	488	490	PF00082	0.494
CLV_PCSK_KEX2_1	529	531	PF00082	0.396
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.660
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.653
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.527
CLV_PCSK_SKI1_1	175	179	PF00082	0.612
CLV_PCSK_SKI1_1	189	193	PF00082	0.455
CLV_PCSK_SKI1_1	230	234	PF00082	0.459
CLV_PCSK_SKI1_1	265	269	PF00082	0.432
CLV_PCSK_SKI1_1	272	276	PF00082	0.336
CLV_PCSK_SKI1_1	326	330	PF00082	0.471
CLV_PCSK_SKI1_1	369	373	PF00082	0.473
CLV_PCSK_SKI1_1	39	43	PF00082	0.533
CLV_PCSK_SKI1_1	404	408	PF00082	0.560
CLV_PCSK_SKI1_1	415	419	PF00082	0.643
CLV_PCSK_SKI1_1	469	473	PF00082	0.544
DEG_APCC_DBOX_1	229	237	PF00400	0.415
DEG_APCC_DBOX_1	257	265	PF00400	0.518
DEG_APCC_DBOX_1	402	410	PF00400	0.505
DOC_ANK_TNKS_1	68	75	PF00023	0.415
DOC_CDC14_PxL_1	376	384	PF14671	0.433
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.388
DOC_MAPK_gen_1	145	153	PF00069	0.556
DOC_MAPK_gen_1	263	270	PF00069	0.468
DOC_MAPK_MEF2A_6	334	343	PF00069	0.265
DOC_MAPK_MEF2A_6	369	376	PF00069	0.297
DOC_MAPK_NFAT4_5	369	377	PF00069	0.297
DOC_PP1_RVXF_1	228	235	PF00149	0.433
DOC_PP2B_LxvP_1	124	127	PF13499	0.682
DOC_PP2B_LxvP_1	370	373	PF13499	0.457
DOC_PP4_FxxP_1	184	187	PF00568	0.570
DOC_USP7_MATH_1	218	222	PF00917	0.533
DOC_USP7_MATH_1	394	398	PF00917	0.337
DOC_USP7_MATH_1	424	428	PF00917	0.618
DOC_USP7_MATH_1	492	496	PF00917	0.645
DOC_USP7_MATH_1	536	540	PF00917	0.581
DOC_USP7_MATH_1	99	103	PF00917	0.547
DOC_WW_Pin1_4	223	228	PF00397	0.417
DOC_WW_Pin1_4	422	427	PF00397	0.707
DOC_WW_Pin1_4	584	589	PF00397	0.319
LIG_14-3-3_CanoR_1	121	125	PF00244	0.560
LIG_14-3-3_CanoR_1	182	187	PF00244	0.556
LIG_14-3-3_CanoR_1	251	257	PF00244	0.563
LIG_14-3-3_CanoR_1	283	289	PF00244	0.588
LIG_14-3-3_CanoR_1	404	410	PF00244	0.443
LIG_14-3-3_CanoR_1	46	55	PF00244	0.574
LIG_14-3-3_CanoR_1	537	541	PF00244	0.557
LIG_14-3-3_CanoR_1	549	555	PF00244	0.340
LIG_APCC_ABBA_1	156	161	PF00400	0.559
LIG_APCC_ABBA_1	53	58	PF00400	0.458
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.464
LIG_BIR_III_4	217	221	PF00653	0.543
LIG_BRCT_BRCA1_1	438	442	PF00533	0.385
LIG_Clathr_ClatBox_1	461	465	PF01394	0.342
LIG_eIF4E_1	103	109	PF01652	0.474
LIG_eIF4E_1	435	441	PF01652	0.469
LIG_FHA_1	211	217	PF00498	0.274
LIG_FHA_1	551	557	PF00498	0.366
LIG_FHA_1	585	591	PF00498	0.578
LIG_FHA_2	212	218	PF00498	0.504
LIG_FHA_2	244	250	PF00498	0.490
LIG_FHA_2	40	46	PF00498	0.505
LIG_FHA_2	406	412	PF00498	0.470
LIG_FHA_2	472	478	PF00498	0.564
LIG_FHA_2	569	575	PF00498	0.481
LIG_GBD_Chelix_1	100	108	PF00786	0.397
LIG_LIR_Gen_1	226	236	PF02991	0.405
LIG_LIR_Gen_1	241	252	PF02991	0.339
LIG_LIR_Gen_1	558	569	PF02991	0.489
LIG_LIR_Gen_1	57	68	PF02991	0.435
LIG_LIR_Nem_3	179	184	PF02991	0.672
LIG_LIR_Nem_3	217	222	PF02991	0.476
LIG_LIR_Nem_3	226	231	PF02991	0.400
LIG_LIR_Nem_3	241	247	PF02991	0.375
LIG_LIR_Nem_3	310	315	PF02991	0.520
LIG_LIR_Nem_3	51	56	PF02991	0.468
LIG_LIR_Nem_3	558	564	PF02991	0.505
LIG_LIR_Nem_3	94	100	PF02991	0.579
LIG_MYND_1	494	498	PF01753	0.563
LIG_NRBOX	232	238	PF00104	0.519
LIG_NRBOX	263	269	PF00104	0.282
LIG_NRBOX	446	452	PF00104	0.416
LIG_NRBOX	482	488	PF00104	0.482
LIG_NRBOX	82	88	PF00104	0.436
LIG_Pex14_2	467	471	PF04695	0.402
LIG_SH2_CRK	219	223	PF00017	0.481
LIG_SH2_CRK	228	232	PF00017	0.461
LIG_SH2_CRK	364	368	PF00017	0.308
LIG_SH2_NCK_1	364	368	PF00017	0.281
LIG_SH2_NCK_1	56	60	PF00017	0.377
LIG_SH2_NCK_1	579	583	PF00017	0.506
LIG_SH2_PTP2	209	212	PF00017	0.488
LIG_SH2_STAP1	118	122	PF00017	0.603
LIG_SH2_STAP1	228	232	PF00017	0.543
LIG_SH2_STAP1	248	252	PF00017	0.559
LIG_SH2_STAP1	292	296	PF00017	0.545
LIG_SH2_STAP1	56	60	PF00017	0.482
LIG_SH2_STAT5	103	106	PF00017	0.467
LIG_SH2_STAT5	209	212	PF00017	0.500
LIG_SH2_STAT5	315	318	PF00017	0.531
LIG_SH2_STAT5	364	367	PF00017	0.254
LIG_SH2_STAT5	385	388	PF00017	0.489
LIG_SH2_STAT5	435	438	PF00017	0.466
LIG_SH2_STAT5	485	488	PF00017	0.587
LIG_SH2_STAT5	524	527	PF00017	0.370
LIG_SH2_STAT5	56	59	PF00017	0.420
LIG_SH2_STAT5	579	582	PF00017	0.511
LIG_SH3_1	488	494	PF00018	0.615
LIG_SH3_3	148	154	PF00018	0.535
LIG_SH3_3	488	494	PF00018	0.615
LIG_SH3_3	497	503	PF00018	0.409
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.445
LIG_SUMO_SIM_par_1	449	455	PF11976	0.381
LIG_SUMO_SIM_par_1	593	603	PF11976	0.472
LIG_TRAF2_1	138	141	PF00917	0.594
LIG_TRAF2_1	274	277	PF00917	0.521
LIG_TRAF2_1	42	45	PF00917	0.536
LIG_UBA3_1	183	189	PF00899	0.642
LIG_UBA3_1	409	415	PF00899	0.442
LIG_WW_1	361	364	PF00397	0.283
MOD_CDK_SPK_2	584	589	PF00069	0.333
MOD_CDK_SPxxK_3	223	230	PF00069	0.408
MOD_CK1_1	25	31	PF00069	0.558
MOD_CK1_1	425	431	PF00069	0.668
MOD_CK2_1	114	120	PF00069	0.625
MOD_CK2_1	135	141	PF00069	0.570
MOD_CK2_1	25	31	PF00069	0.431
MOD_CK2_1	39	45	PF00069	0.452
MOD_CK2_1	471	477	PF00069	0.467
MOD_GlcNHglycan	294	297	PF01048	0.470
MOD_GlcNHglycan	322	325	PF01048	0.523
MOD_GlcNHglycan	419	422	PF01048	0.624
MOD_GlcNHglycan	48	51	PF01048	0.584
MOD_GlcNHglycan	562	567	PF01048	0.361
MOD_GSK3_1	116	123	PF00069	0.581
MOD_GSK3_1	157	164	PF00069	0.450
MOD_GSK3_1	22	29	PF00069	0.417
MOD_GSK3_1	413	420	PF00069	0.570
MOD_GSK3_1	424	431	PF00069	0.690
MOD_GSK3_1	467	474	PF00069	0.482
MOD_GSK3_1	573	580	PF00069	0.559
MOD_NEK2_1	22	27	PF00069	0.397
MOD_NEK2_1	243	248	PF00069	0.382
MOD_NEK2_1	275	280	PF00069	0.440
MOD_NEK2_1	413	418	PF00069	0.501
MOD_NEK2_1	436	441	PF00069	0.492
MOD_NEK2_1	467	472	PF00069	0.462
MOD_NEK2_1	509	514	PF00069	0.480
MOD_NEK2_1	79	84	PF00069	0.518
MOD_NEK2_2	218	223	PF00069	0.536
MOD_NEK2_2	536	541	PF00069	0.491
MOD_NEK2_2	550	555	PF00069	0.225
MOD_PKA_2	120	126	PF00069	0.556
MOD_PKA_2	250	256	PF00069	0.530
MOD_PKA_2	536	542	PF00069	0.571
MOD_Plk_1	394	400	PF00069	0.323
MOD_Plk_1	562	568	PF00069	0.293
MOD_Plk_2-3	135	141	PF00069	0.522
MOD_Plk_4	120	126	PF00069	0.591
MOD_Plk_4	161	167	PF00069	0.682
MOD_Plk_4	243	249	PF00069	0.302
MOD_Plk_4	284	290	PF00069	0.485
MOD_Plk_4	362	368	PF00069	0.366
MOD_Plk_4	405	411	PF00069	0.451
MOD_Plk_4	431	437	PF00069	0.361
MOD_Plk_4	452	458	PF00069	0.389
MOD_Plk_4	492	498	PF00069	0.557
MOD_Plk_4	550	556	PF00069	0.354
MOD_Plk_4	99	105	PF00069	0.482
MOD_ProDKin_1	223	229	PF00069	0.408
MOD_ProDKin_1	422	428	PF00069	0.699
MOD_ProDKin_1	584	590	PF00069	0.325
TRG_AP2beta_CARGO_1	241	251	PF09066	0.312
TRG_DiLeu_BaEn_1	120	125	PF01217	0.584
TRG_DiLeu_BaEn_1	452	457	PF01217	0.477
TRG_DiLeu_BaEn_3	477	483	PF01217	0.584
TRG_DiLeu_BaEn_4	478	484	PF01217	0.580
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.466
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.344
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.430
TRG_ENDOCYTIC_2	181	184	PF00928	0.592
TRG_ENDOCYTIC_2	209	212	PF00928	0.390
TRG_ENDOCYTIC_2	219	222	PF00928	0.442
TRG_ENDOCYTIC_2	228	231	PF00928	0.460
TRG_ENDOCYTIC_2	364	367	PF00928	0.266
TRG_ENDOCYTIC_2	506	509	PF00928	0.496
TRG_ER_diArg_1	262	265	PF00400	0.291
TRG_ER_diArg_1	401	404	PF00400	0.482
TRG_ER_diArg_1	487	489	PF00400	0.516
TRG_ER_diArg_1	529	531	PF00400	0.505
TRG_NES_CRM1_1	452	465	PF08389	0.293
TRG_NLS_MonoCore_2	171	176	PF00514	0.509
TRG_NLS_MonoExtC_3	171	176	PF00514	0.525
TRG_NLS_MonoExtN_4	171	177	PF00514	0.511
TRG_NLS_MonoExtN_4	401	408	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	529	534	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P504	Leptomonas seymouri	67%	88%
A0A0S4IN30	Bodo saltans	27%	68%
A0A1X0NT69	Trypanosomatidae	33%	80%
A0A3Q8IGU6	Leishmania donovani	86%	100%
A0A3S5IS00	Trypanosoma rangeli	34%	86%
A4I1W3	Leishmania infantum	86%	100%
C9ZS57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	82%
E9AY08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q9G5	Leishmania major	84%	100%
V5BZE7	Trypanosoma cruzi	35%	86%